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PET Imaging in Bone and Non-Bone Diseases
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PET Imaging in Bone and Non-Bone Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nuclear Medicine & Radiology".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 1341

Special Issue Editors

Dr. Tanuj Puri

E-Mail Website
Guest Editor
Faculty of Biology, Medicine and Health, School of Medical Sciences, Division of Cancer Sciences, The Christie NHS Foundation Trust, Radiotherapy Related Research, Wilmslow Road, Manchester M20 4BX, UK
Interests: PET imaging; bone metabolism; metastatic bone diseases; metabolic bone diseases; image analysis; radiomics; artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Glen Blake

E-Mail Website
Guest Editor
Department of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King’s College London, St. Thomas’ Hospital, London SE1 7EH, UK
Interests: imaging sciences; bone densitometry; radionuclide measurements of bone
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Welcome to this Special Issue entitled "PET Imaging in Bone and Non-Bone Diseases". PET imaging is a powerful tool for diagnosing and monitoring various health conditions. This Special Issue highlights its applications in the following aspects:

(1) Bone Diseases:

  • Metabolic Disorders: Osteoporosis, Paget's disease, and CKD-related bone conditions.
  • Cancer-Related: Bone metastases from breast and prostate cancers.
  • Rare Diseases: Fibrodysplasia ossificans progressiva, Gorham-Stout disease, and Jansen metaphyseal chondrodysplasia.
  • Other Disorders: Osteonecrosis of the jaw, chronic nonbacterial osteitis, Charcot joint disease.

(2) Non-Bone Diseases:

  • Cardiovascular: Coronary artery disease, aortic syndromes, and plaque calcification.
  • Autoimmune and Inflammatory: Rheumatoid arthritis and systemic sclerosis.
  • Sports Medicine: Assessing acute bone stress and injuries.

We also invite reviews or original research articles using [18F]NaF PET for detecting and monitoring calcium buildup in conditions such as pseudoxanthoma elasticum, systemic sclerosis, and aortic valve sclerosis. Additionally, we are interested in applications for plaque calcification in carotid atherosclerosis, microcalcifications in atherosclerotic plaques, and detecting hidden changes in blood vessels. Other areas of focus include assessing bone involvement in rare conditions like Gorham-Stout disease, osteoarthritis, Charcot joint disease in Charcot–Marie–Tooth disease, and Jansen metaphyseal chondrodysplasia. [18F]NaF PET is also valuable for detecting synchronous thyroid carcinoma and parathyroid adenoma with brown tumors, the early degeneration of transcatheter aortic valves, and skull-base bone invasion in nasopharyngeal carcinoma.

Focus Areas:

  • New tracers like [18F]NaF, [18F]FDG or other tracers.
  • Advancing multi-center research and global collaborations.
  • Standardizing imaging protocols and validating biomarkers.
  • Leveraging artificial intelligence and machine learning for automated analysis.

We look forward to your contributions as we explore cutting-edge PET imaging research for better disease diagnosis and management.

Dr. Tanuj Puri
Prof. Dr. Glen Blake
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • PET
  • bone metabolism
  • bone diseases
  • metabolic bone diseases
  • image analysis
  • radiomics
  • artificial intelligence

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Published Papers (2 papers)

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Review

20 pages, 3963 KiB  
Review
Role of Positron Emission Tomography (PET) in the Diagnosis of Musculoskeletal Disorders
by Raju Vaishya, Jena Amarnath, Prerana Rana, Rajesh Botchu and Abhishek Vaish
J. Clin. Med. 2025, 14(9), 3080; https://doi.org/10.3390/jcm14093080 - 29 Apr 2025
Viewed by 392
Abstract
Musculoskeletal disorders (MSDs) represent a broad spectrum of diseases and injuries that significantly affect the musculoskeletal system and impose a considerable burden on global public health. This review focuses on the landscape of MSD diagnoses and emphasizes the high prevalence of these conditions. [...] Read more.
Musculoskeletal disorders (MSDs) represent a broad spectrum of diseases and injuries that significantly affect the musculoskeletal system and impose a considerable burden on global public health. This review focuses on the landscape of MSD diagnoses and emphasizes the high prevalence of these conditions. Additionally, it recognizes the inadequacies of conventional evaluation methods, including radiography and subjective assessments, when addressing their complex pathophysiology. It also attempts to highlight the promise of positron emission tomography (PET), which offers quantitative insights into metabolic and molecular activities before structural changes become evident. The review focuses on key radiotracers, specifically, fluorodeoxyglucose ([18F]-FDG) and sodium fluoride ([18F]-NaF), discussing their efficacy in assessing inflammatory processes and bone metabolism. By exploring the abilities of these advanced imaging modalities, we aim to identify the potential of using PET in the early detection and more accurate assessment of MSDs. Furthermore, we provide a brief outline of directions for future research, advocating for the development of novel radiotracers, the integration of multiple imaging modalities, and the application of artificial intelligence in imaging analysis. This review contributes to a deeper understanding of MSDs and underscores the urgent need for innovative diagnostic strategies to improve patient care and outcomes in musculoskeletal health. Full article
(This article belongs to the Special Issue PET Imaging in Bone and Non-Bone Diseases)
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13 pages, 9334 KiB  
Review
The Role of Positron Emission Tomography Imaging in Primary Bone Tumours: A Narrative Review
by Shihabul Hassan, Rishabh Suvarna, Hasaam Uldin, Mohsin Hussein and Rajesh Botchu
J. Clin. Med. 2025, 14(8), 2624; https://doi.org/10.3390/jcm14082624 - 11 Apr 2025
Viewed by 492
Abstract
Primary malignant bone tumours can pose significant diagnostic and therapeutic challenges due to inter-tumour heterogeneity. While traditional imaging modalities such as radiography, MRI (magnetic resonance imaging), and CT (computed tomography) remain essential for initial evaluation and staging, emerging evidence underscores the evolving role [...] Read more.
Primary malignant bone tumours can pose significant diagnostic and therapeutic challenges due to inter-tumour heterogeneity. While traditional imaging modalities such as radiography, MRI (magnetic resonance imaging), and CT (computed tomography) remain essential for initial evaluation and staging, emerging evidence underscores the evolving role of positron emission tomography (PET), particularly PET/CT with Fluorodeoxyglucose ([18F] FDG), in the comprehensive management of bone sarcomas. This narrative review aims to critically summarise the available literature on PET imaging’s utility in the management of primary bone tumours including osteosarcoma, chondrosarcoma, and Ewing sarcoma. Despite limitations like inconsistencies in standard uptake value (SUV) cutoffs and reduced pulmonary resolution, PET/CT is valuable for staging, assessing response to neoadjuvant chemotherapy, predicting histological outcomes, detecting recurrence, and guiding biopsy in metabolically active tumour sites. Further large-scale, prospective studies are warranted to standardise protocols and establish PET’s definitive role in sarcoma management. Full article
(This article belongs to the Special Issue PET Imaging in Bone and Non-Bone Diseases)
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