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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Thyroid-Related Diseases: Molecular Pathology, Diagnosis and Treatment (3rd Edition)

edited by

Vincenzo Fiorentino

and

Maurizio Martini

submission deadline 20 Apr 2027 | Viewed by 47 | Submission Open

Keywords: thyroid disease; thyroid nodules; thyroid cancer; thyroid carcinoma; thyroid radiology; thyroid–gut axis; autoimmune thyroid disorders; thyroid hormone; molecular mechanisms; molecular tests

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Cellular and Molecular Mechanisms in the Progression of Cardiovascular Diseases

edited by

Eglė Mazgelytė

submission deadline 22 Apr 2027 | Viewed by 93 | Submission Open

Keywords: cardiovascular diseases; molecular mechanisms; cellular signaling; inflammation; oxidative stress; cardiac remodeling; endothelial dysfunction; biomarkers; precision medicine; translational cardiovascular research

(This special issue belongs to the Section Molecular Biology)

Molecular Genetics and Genomics of Aquatic Crustaceans

edited by

Xianhong Meng

Falin Zhou

and Lingbo Ma

submission deadline 23 Apr 2027 | 4 articles | Viewed by 4069 | Submission Open

Keywords: genome sequencing; epigenomics; CRISPR/Cas9 gene editing; transcriptomics; gene expression profiling; genome-wide association studies (GWASs); quantitative trait loci (QTL) mapping; genomic selection; marker-assisted selection (MAS); molecular markers

(This special issue belongs to the Section Molecular Genetics and Genomics)

Neurodegenerative Diseases: Molecular Mechanisms and Therapies, 4th Edition

edited by

Zhidong Zhou

and

Alexandre Hiroaki Kihara

submission deadline 23 Apr 2027 | 1 articles | Viewed by 1338 | Submission Open

Keywords: neurodegeneration; neurodegenerative diseases; protein aggregation; pathogenesis; therapy; mitochondria; neuroinflammation; oxidative stress; cell therapy; clinical trial

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Molecular Biology of Haematology

edited by Valéria Tavares

submission deadline 23 Apr 2027 | 1 articles | Viewed by 951 | Submission Open

Keywords: haematopoiesis; molecular biology; genomics; epigenomics; computational biology; hematologic neoplasms; biomarkers; liquid biopsy; precision medicine

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Innate Immunity and Disease Resistance in Animals

edited by

Sutian Wang

submission deadline 23 Apr 2027 | 1 articles | Viewed by 710 | Submission Open

Keywords: innate immunity; pathogenic microorganism; animals; pathogenesis; mechanism of disease-resistance; disease-resistant/therapeutic target

(This special issue belongs to the Section Molecular Immunology)

Biosynthetic Pathways, Regulation, and Metabolic Engineering of Plant Bioactive Compounds

edited by

Fei Zhou

submission deadline 25 Apr 2027 | Viewed by 46 | Submission Open

Keywords: plant bioactive compounds; specialized metabolism; biosynthetic pathways; metabolic regulation; metabolic engineering; synthetic biology; heterologous production; multi-omics

(This special issue belongs to the Section Molecular Plant Sciences)

Novel Biomarkers and Therapeutics for Alzheimer's Disease

edited by

Lindsay H. Burns

submission deadline 28 Apr 2027 | Viewed by 55 | Submission Open

Keywords: Alzheimer’s disease; biomarkers; neuroprotection; secretase modulators; homeostasis regulators; mitochondrial enhancers; neuroinflammation; tau; small molecules; stem cells; RNAi

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Approaches in Molecular and Cellular Cancer Biology: Translating Basic Research to the Clinic

edited by

Rafael Coveñas Rodríguez

and

Maruan Hijazi Vega

submission deadline 29 Apr 2027 | Viewed by 113 | Submission Open

Keywords: cell signaling; proteomics; phosphoproteomics; mass spectrometry; kinase inhibitors; kinase activity; signaling networks; computational biology; peptide receptor antagonists; anticancer and cancer peptides

(This special issue belongs to the Section Molecular Oncology)

Male Infertility: Emerging Trends and Future Directions

edited by

Monica Muratori

and

Oumaima Ammar

submission deadline 29 Apr 2027 | Viewed by 110 | Submission Open

Keywords: male infertility; epigenetics; multi-omics; spermatogenesis; assisted reproduction; phytotherapy; artificial intelligence

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

25th Anniversary of IJMS: Updates and Advances in “Molecular Immunology”

edited by

Julia Kzhyshkowska

submission deadline 30 Apr 2027 | 12 articles | Viewed by 22496 | Submission Open

Keywords: inflammation; innate immunity; adaptive immunity; genetics; epigenetics; immunometabolism; receptors; cytokines; cell therapy; immune checkpoint inhibitors

(This special issue belongs to the Section Molecular Immunology)

Inner Ear Disorders: From Molecular Mechanisms to Treatment

edited by

Srdjan Vlajkovic

submission deadline 30 Apr 2027 | 5 articles | Viewed by 14503 | Submission Open

Keywords: hearing loss; balance disorders; stem cell approaches; precision gene therapy; molecular reprogramming; targeted delivery systems; molecular biomarkers; suppression of oxidative stress and inflammation; tissue engineering; immune response and off-target effects

(This special issue belongs to the Section Molecular Immunology)

Epigenetic Regulation and Molecular Mechanisms in Cardiovascular Diseases

edited by

Paschalis Karakasis

submission deadline 30 Apr 2027 | 6 articles | Viewed by 12302 | Submission Open

Keywords: epigenetic regulation; cardiovascular disease; DNA methylation; histone modifications; non-coding RNAs; vascular inflammation; myocardial remodeling; molecular mechanisms; thera-peutic targets

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms Driving Liver Disease: From Cellular Stress to Therapeutic Targets

edited by

Konstantinos Arvanitakis

submission deadline 30 Apr 2027 | 6 articles | Viewed by 8874 | Submission Open

Keywords: liver disease; molecular mechanisms; hepatocellular stress; fibrosis; non-coding RNAs; metabolism; MASLD; liver fibrosis; hepatocellular carcinoma; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bee Products and Their Flavonoids: Recent Advances in Molecular Mechanisms, Therapeutic Applications, and Innovative Delivery Systems

edited by

Nada Orsolic

and

Maja Jazvinšćak Jembrek

submission deadline 30 Apr 2027 | 2 articles | Viewed by 8812 | Submission Open

Keywords: honeybee products; flavonoids; bioactive compounds; biological activity; pharmacological activity; health benefits; side effects; disease prevention; antioxidant activity; apitherapy; nutritional properties; innovative technical approaches

(This special issue belongs to the Section Molecular Biology)

New Insights into Network Pharmacology

edited by

Mi Hye Kim

submission deadline 30 Apr 2027 | 4 articles | Viewed by 7408 | Submission Open

Keywords: network pharmacology; traditional medicine; drug discovery; computational biology; molecular mechanisms; protein–protein interaction; enrichment analysis; herb–compound–gene network

(This special issue belongs to the Section Molecular Pharmacology)

New Horizons in Structure and AI-Based Drug Design

edited by

Huiyong Sun

submission deadline 30 Apr 2027 | 3 articles | Viewed by 6257 | Submission Open

Keywords: artificial intelligence; machine learning; MD simulation; free energy calculation; drug design

(This special issue belongs to the Section Molecular Informatics)

DNA Damage and Repair: Current Research

edited by

Mahara A. Valverde Ramírez

and Emilio Rojas

submission deadline 30 Apr 2027 | 8 articles | Viewed by 5926 | Submission Open

Keywords: DNA damage; DNA repair; endogenous compounds; exogenous compounds; therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Colitis Research: Exploring Molecular Mechanisms and Immune Regulation

edited by

Jochen Mattner

submission deadline 30 Apr 2027 | 4 articles | Viewed by 5433 | Submission Open

Keywords: colitis; inflammation; infection; autoimmunity; mucosal tolerance; colonization resistance; intestinal microbiota; host-microbe interactions

(This special issue belongs to the Section Molecular Immunology)

Advances in Inflammasomes

edited by

Roberto Negro

submission deadline 30 Apr 2027 | 4 articles | Viewed by 5215 | Submission Open

Keywords: inflammasome; pyroptosis; innate immunity; cancer; neurodegenerative diseases; microbiota; gasdermin; ninjurin; drug screening; personalized treatments; multi-omics analysis

(This special issue belongs to the Section Molecular Immunology)

Antibiotics Science: Molecular Insights, Detection Strategies, Resistance Challenges and Interdisciplinary Applications

edited by

Lidia Magerusan

submission deadline 30 Apr 2027 | 4 articles | Viewed by 4710 | Submission Open

Keywords: antibiotics; antibiotic molecular design and synthesis; antibiotic action mechanism; antibiotics resistance; environmental contamination; therapeutic monitoring; antibiotic sensing and detection; food and environmental safety

(This special issue belongs to the Section Molecular Microbiology)

Advances in the Synthesis and Study of Novel Bioactive Molecules

edited by

Adriana Georgieva Bakalova

and

Emiliya Demireva Cherneva

submission deadline 30 Apr 2027 | 4 articles | Viewed by 4304 | Submission Open

Keywords: organic compounds; metal complexes; bioactive molecules

(This special issue belongs to the Section Biochemistry)

MicroRNA and Non-Coding RNA: From Basic Research to Potential Clinical Application—2nd Edition

edited by

Erika Cione

and

Diana Abrego-Guandique

submission deadline 30 Apr 2027 | 5 articles | Viewed by 4241 | Submission Open

Keywords: microRNA; non-coding RNA; gene regulation; biomarkers; RNA therapeutics; extracellular vesicles; microarray; NGS

(This special issue belongs to the Section Molecular Genetics and Genomics)

Targeting Epilepsy: Molecular Mechanisms, Neuroinflammation and Emerging Therapies

edited by

Karoly Orban-Kis

submission deadline 30 Apr 2027 | 4 articles | Viewed by 3940 | Submission Open

Keywords: epilepsy; molecular targets; antiepileptic drug discovery; neuroinflammation; epileptogenesis; ion channels; pharmacoresistance; translational neuroscience

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Mechanisms to Medicine: Cellular Insights into Pulmonary Hypertension

edited by

Swati Dabral

submission deadline 30 Apr 2027 | 3 articles | Viewed by 3938 | Submission Open

Keywords: vascular remodeling; cellular mechanisms; hypoxia; growth factors; inflammation

(This special issue belongs to the Section Molecular Biology)

Recent Advances of Novel Pharmaceutical Designs for Anticancer Therapies, 4th Edition

edited by

Bernhard Biersack

submission deadline 30 Apr 2027 | 3 articles | Viewed by 3651 | Submission Open

Keywords: cancer; anticancer drugs; drug design; targeted therapy; immunotherapy; molecular target; molecular mechanism; drug resistance

(This special issue belongs to the Section Molecular Pharmacology)

Natural Compounds in Cancer Treatment and Prevention: Mechanisms, Evidence, and Clinical Perspectives

edited by

Vitor Engracia Valenti

submission deadline 30 Apr 2027 | 2 articles | Viewed by 3536 | Submission Open

Keywords: natural compounds; cancer treatment; cancer prevention; bioactive phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Functional Foods: Molecular Insights into Nutrition and Health

edited by

Patroklos Vareltzis

submission deadline 30 Apr 2027 | 3 articles | Viewed by 3486 | Submission Open

Keywords: functional foods; bioactive compounds; disease prevention; nutritional health; food innovation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Unraveling the Molecular Landscape of Systemic Lupus Erythematosus

edited by Yoshinori Matsumoto

submission deadline 30 Apr 2027 | 2 articles | Viewed by 3348 | Submission Open

Keywords: systemic lupus erythematosus; autoimmunity; molecular mechanisms; immune regulation; type I interferon; biomarkers; multi-omics; signal transduction; precision medicine; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Research on Gut Microbiota in Health and Disease

edited by Li Cui

submission deadline 30 Apr 2027 | 3 articles | Viewed by 3298 | Submission Open

Keywords: microbiota-host crosstalk; HMA models; microbial metabolites; gut–brain axis; translational microbiome

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights in Antimicrobial Resistance

edited by

Maria Teresa Mascellino

submission deadline 30 Apr 2027 | 1 articles | Viewed by 3136 | Submission Open

Keywords: drug resistance; microorganisms; molecular mechanisms; mobile genetic elements; CRISPR/Cas9; nucleic acid hybriditation; probes; LAMP

(This special issue belongs to the Section Molecular Microbiology)

Skin Cancer: A Focus from Pathophysiology to Novel Therapeutic Strategies

edited by

Piotr Sobolewski

submission deadline 30 Apr 2027 | 2 articles | Viewed by 3042 | Submission Open

Keywords: skin cancer; melanoma; keratinocyte carcinoma; pathophysiology; biomarkers; immunotherapy; targeted therapy; nanomedicine; resistance; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Toxicity Caused by Environmental Pollutants

edited by Ivan Girón-Perez

submission deadline 30 Apr 2027 | 4 articles | Viewed by 2967 | Submission Open

Keywords: environmental pollutant; molecular toxicity; immunotoxicology; neurotoxicity

(This special issue belongs to the Section Molecular Toxicology)

Molecular Research on Zoonotic Diseases: Current Advances and Perspectives

edited by

Gabriela Goujgoulova

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2853 | Submission Open

Keywords: emerging zoonoses; re-emerging zoonoses; zoonotic pathogens; control strategies and measures; animal and public health; worldwide

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbial Pathways for Sustainable Bioenergy Production and Environmental Protection

edited by Fiaz Ahmad

submission deadline 30 Apr 2027 | 1 articles | Viewed by 2676 | Submission Open

Keywords: microbial pathways; bioenergy production; bioremediation; metabolic engineering; synthetic biology

(This special issue belongs to the Section Molecular Microbiology)

Protein–Protein Interactions in Human Cancer

edited by

Geng Wu

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2637 | Submission Open

Keywords: protein–protein interactions; protein–protein complexes; human cancer; signal transduction pathways; protein structure and function

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Advances in Aquatic Genetic Improvement

edited by Jun Qiang,

Yifan Tao

and Wenjing Tao

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2554 | Submission Open

Keywords: aquaculture genetic breeding; genomic selection; gene editing; disease-resistant breeding; multi-omics analysis; stress resistance enhancement; smart aquaculture; artificial intelligence

(This special issue belongs to the Section Molecular Genetics and Genomics)

Schiff Bases and Their Metal Complexes: Structure, Synthesis, and Biological Application

edited by Nenad Filipovic

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2515 | Submission Open

Keywords: hydrazones; (thio/seleno)semicarbazones; oximes; antimicrobial activity; anticancer activity; enzyme inhibition; metal complexes; diagnostic agents; photothermal therapy; photodynamic therapy

(This special issue belongs to the Section Biochemistry)

Recent Advances in Non-Coding RNAs in Human Research

edited by

Jesús Adrián López

submission deadline 30 Apr 2027 | 4 articles | Viewed by 2495 | Submission Open

Keywords: microRNAs; lncRNAs; mRNA regulation; cell signaling pathways; RNA methylation; RNA phosphorylation; RNA deamidation; cell communication; chemoresistance; RNA inhibitors or activators

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Role of Lipids in Health and Diseases: 2nd Volume

edited by

Yutang Wang

submission deadline 30 Apr 2027 | 3 articles | Viewed by 2494 | Submission Open

Keywords: lipids; triglycerides; phospholipids; cholesterol; sphingolipids; steroids; fatty acids; lipid metabolism

(This special issue belongs to the Section Biochemistry)

Kidney Disease: Molecular Insights and Emerging Therapies

edited by

Yaochun Zhang

submission deadline 30 Apr 2027 | 3 articles | Viewed by 2476 | Submission Open

Keywords: kidney disease; molecular mechanism; precision medicine; translational nephrology; targeted molecular therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

DNA Methylation Dynamics Due to Environmental Factors and in Human Diseases

edited by

Naila Francis Paulo De Oliveira

and

José Maria Chagas Viana Filho

submission deadline 30 Apr 2027 | 3 articles | Viewed by 2469 | Submission Open

Keywords: inflammatory diseases; mental diseases; tumour diseases; epidrugs; exposure biomarkers; epigenetic drugs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Emerging Therapeutic Strategies and Immunometabolic Pathways in Cancer

edited by Medhi Wangpaichitr

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2419 | Submission Open

Keywords: immunotherapy; targeted therapy; tumor metabolism pathway; tumor microenvironment; immune checkpoint blockade; immune evasion; glucose/amino acids/lipid metabolism

(This special issue belongs to the Section Molecular Immunology)

Insights in Multiple Sclerosis (MS) and Neuroimmunology: 3rd Edition

edited by

Michael C. Levin

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2378 | Submission Open

Keywords: neurodegeneration; neuroimmunology; macrophage; T-cell; B-cell; antibody; neurons; oligodendrocytes; axon; axonal damage; cell death; multiple sclerosis

(This special issue belongs to the Section Molecular Immunology)

Advanced Functionalization of Biopolymers and Bio-Oligomers for Precision Therapeutics

edited by

Dayong Wang

submission deadline 30 Apr 2027 | 1 articles | Viewed by 2310 | Submission Open

Keywords: precision therapeutics; biopolymers; drug delivery; biopharmaceuticals; pharmacology

(This special issue belongs to the Section Materials Science)

Probiotics, Prebiotics, Synbiotics, and Gut Microbial Modulation in Intestinal Health and Disease

edited by Koji Yamamoto

submission deadline 30 Apr 2027 | 3 articles | Viewed by 2219 | Submission Open

Keywords: gut microbiota; probiotics; prebiotics; synbiotics; inter-organ network; intestinal barrier; microbial metabolites; immunoregulation; multi-omics; inflammatory bowel disease; microbiome-based therapy

(This special issue belongs to the Section Molecular Microbiology)

Functional Materials in Photocatalysis: From Design to Application

edited by

Miguel Díaz-Sánchez

submission deadline 30 Apr 2027 | 1 articles | Viewed by 2163 | Submission Open

Keywords: nanostructured materials ; photocatalysis ; catalysis ; green synthesis ; material design ; surface engineering

(This special issue belongs to the Section Materials Science)

Hydrogen Medicine: From Molecular Insights to Disease Intervention

edited by

Fei Xie

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2153 | Submission Open

Keywords: hydrogen medicine; molecular hydrogen; oxidative stress; inflammation; mitochondrial function; gasotransmitters; ischemia–reperfusion injury; clinical trials; signal transduction; bioinformatics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mathematical Computation and Modeling in Biology

edited by

Shinuk Kim

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2096 | Submission Open

Keywords: mathematical model; computational methods; systemic molecular interaction; machine learning; integrating molecular materials

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanism in Cardiac Remodeling

edited by Xianming Lin and

Xiaobo Wu

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1919 | Submission Open

Keywords: cardiomyopathy; cardiac arrhythmias; ion channel; calcium transient

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 2951-3000 on page 60 of 65.

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