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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Advances in Blood Disorders

edited by

Tadej Pajič

submission deadline 30 Oct 2025 | 1 articles | Viewed by 1461 | Submission Open

Keywords: acquired and inherited blood disorders; diagnostic; prognostic and predictive biomarkers; molecular profiling; molecular monitoring; targeted therapy; leukaemia; lymphoma; disorders of haemostasis and thrombosis; genetic predisposition; germline pathogenic variants; molecular mechanisms; (epi)genomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Complications of Type 1 Diabetes in Pediatric Age: Early Biomarkers and New Insights into Diagnosis and Prevention Strategies

edited by

Enza Mozzillo

and Francesca Di Candia

submission deadline 30 Oct 2025 | 1 articles | Viewed by 989 | Submission Open

Keywords: pediatrics; endocrinology; diabetology; complications; type 1 diabetes; prevention; early biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancement of Understanding Alzheimer’s Disease Susceptibility and Novel Drug Targets

edited by Kunie Ando and Jean-Pierre Brion

submission deadline 30 Oct 2025 | Viewed by 829 | Submission Open

Keywords: Alzheimer’ s disease; neurodegenerative diseases; tau; amyloid; inflammation; disease modifying treatments; biomarkers; genetic variants; risk factors; mechanisms; protein– protein interactions; post-translational modifications

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Vascular Protection by Means of Nutraceuticals

edited by

Roberta Macri

submission deadline 30 Oct 2025 | 1 articles | Viewed by 630 | Submission Open

Keywords: cardiovascular disease; drugs; nutrients

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advances in Abiotic Stress Signaling in Plants: Focus on Atmospheric Stressors, 2nd Edition

edited by

Mateusz Labudda

submission deadline 30 Oct 2025 | 2 articles | Viewed by 624 | Submission Open

Keywords: abiotic stress; interactomics; gene expression regulation; kinases; oxidative stress; phytohormones; signaling; sugar sensing and signaling; transcription factors

(This special issue belongs to the Section Molecular Plant Sciences)

Horticultural Crop Improvement: A New Era for Plant Molecular Research: Fourth Edition

edited by

Bo Sun

submission deadline 30 Oct 2025 | 1 articles | Viewed by 424 | Submission Open

Keywords: horticultural plants; whole-genome resequencing; transcriptomics; proteomics; metabolomics; gene editing; gene regulation; growth and development; yield; quality; resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Research in Veterinary Drugs

edited by Jianyong Li

submission deadline 30 Oct 2025 | Viewed by 300 | Submission Open

Keywords: veterinary drug; target; chemical structure; mechanism; medicinal chemistry; toxicity; pharmacodynamics; pharmacokinetics; residues

(This special issue belongs to the Section Molecular Pharmacology)

Biomedical Polymer Materials: Design, Synthesis or Applications

edited by Lourdes Franco

submission deadline 30 Oct 2025 | Viewed by 271 | Submission Open

Keywords: biomedical polymeric materials; nanoparticles; drug delivery; smart materials; hydrogels; tissue regeneration; therapeutic applications; dendrimers; MOFs; micelles

(This special issue belongs to the Section Materials Science)

The Impact of Environmental Factors on Male Reproductive Development and Disorders

edited by

Gennaro Lettieri

submission deadline 30 Oct 2025 | Viewed by 270 | Submission Open

Keywords: spermatozoa; DNA; protamine; male reproductive health; pollution; endocrine disruption; heavy metals

(This special issue belongs to the Section Molecular Biology)

Molecular Biology of Extremophiles: Recent Advances

edited by

Paulina Corral

submission deadline 30 Oct 2025 | Viewed by 160 | Submission Open

Keywords: extremophiles; multi-omics approaches; secondary metabolites; bioactive compounds; genome mining; phylogeny and evolution; bioprospecting

(This special issue belongs to the Section Molecular Biology)

Advances in Brassica Crop Metabolism and Genetics (Second Edition)

edited by

Bo Sun

and

Honghao Lv

submission deadline 30 Oct 2025 | Viewed by 103 | Submission Open

Keywords: brassica crop; genomics; transcriptomics; proteomics; metabolomics; gene editing; metabolite synthesis and regulation; phylogeny and taxonomy; physiological traits; biotic/abiotic stresses; biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Bioactive Compounds in Cancers: Second Edition

edited by

Patrícia M. A. Silva

Hassan Bousbaa

and

Honorina Cidade

submission deadline 30 Oct 2025 | Viewed by 73 | Submission Open

Keywords: anticancer strategies; bioactive compounds; natural products; synthetic products; medicinal chemistry; drug repurposing; drug delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Liver Diseases: Causes, Molecular Mechanism and Treatment/Prevention

edited by

Munish Puri

submission deadline 30 Oct 2025 | Viewed by 63 | Submission Open

Keywords: liver diseases; pathophysiology; molecular mechanisms; genetics and epigenetics; non-alcoholic fatty liver disease (NAFLD); hepatitis; liver injury and repair; gene therapy; pharmacological interventions; treatment and prevention; gut– liver axis; spleen– liver axis; alcoholic liver disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of miRNAs in Healthy Lungs and Chronic Lung Diseases

edited by Victor Ruiz

submission deadline 30 Oct 2025 | Viewed by 63 | Submission Open

Keywords: miRNA; DROSHA; DICER; DGCR8; ADAR; pulmonary fibrosis; COPD; asthma; lung neoplasm

(This special issue belongs to the Section Molecular Biology)

New Insights into Environmental Stresses and Plants: Second Edition

edited by

Zhou Li

submission deadline 30 Oct 2025 | Viewed by 62 | Submission Open

Keywords: abiotic stress; biotic stress; adaptation; gene function; omics; metabolic regulation; stress signal; molecular mechanism

(This special issue belongs to the Section Molecular Plant Sciences)

Venom Research

edited by Juliana Pavan Zuliani

submission deadline 30 Oct 2025 | Viewed by 52 | Submission Open

Keywords: venoms; toxins; biological activities; therapeutic potential; molecular mechanism; venomous animals; pharmacological effects

(This special issue belongs to the Section Molecular Toxicology)

Ion Transporters and Channels

edited by

Yoshinori Marunaka

submission deadline 30 Oct 2025 | Viewed by 41 | Submission Open

Keywords: ion transporter; ion channel; proton; interstitial fluid pH; Na+ channels; K+ channels; Cl− channels; ENaC; CALHM

(This special issue belongs to the Section Biochemistry)

Modern Chromatography: A Multi-Faceted Approach to the Analysis of Biological Samples

edited by Lucyna Konieczna

submission deadline 30 Oct 2025 | Viewed by 40 | Submission Open

Keywords: modern chromatography; biological sample analysis; biomarker discovery; sample preparation techniques; separation science; quantitative analysis; method validation; microextraction methods; analytical sensitivity

(This special issue belongs to the Section Biochemistry)

Recent Progress in Hypertension Research

edited by

Massimo Volpe

submission deadline 30 Oct 2025 | Viewed by 38 | Submission Open

Keywords: hypertension; organ damage; biomarker; genetics diagnosis; renin– angiotensin– aldosterone system; natriuretic peptides; hypertension therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

mRNA/miRNAs Network in Diabetes and Its Complications

edited by

Daniela Lixandru

submission deadline 30 Oct 2025 | Viewed by 38 | Submission Open

Keywords: RNA/miRNAs; exosomes; regenerative medicine; translational medicine; adipose tissue biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathogenesis and New Treatment in Non-Small Cell Lung Cancer

edited by

Eleonora Vecchio

submission deadline 30 Oct 2025 | Viewed by 31 | Submission Open

Keywords: non-small cell lung cancer; drug resistance; survival pathway; cell death pathway; innovative therapies

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Laser and Photodynamic Therapy

edited by Rafał Wiench and Aleksandra Kawczyk-Krupka

submission deadline 30 Oct 2025 | Viewed by 29 | Submission Open

Keywords: laser therapy; photodynamic therapy; photosensitizers; drug delivery; biomedical imaging; nanotechnology; combination therapies; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Dysfunctional Neural Circuits and Impairments in Brain Function, 2nd Edition

edited by

Takashi Tominaga

submission deadline 30 Oct 2025 | Viewed by 28 | Submission Open

Keywords: neural circuits; dysfunctional circuits; neuropsychiatric disorders; optical recording; voltage-sensitive dyes; genetically encoded optical indicators; local brain activity; whole-brain activity; cognitive impairments; behavioral test

(This special issue belongs to the Section Molecular Neurobiology)

Synthesis and Application of Natural and Inspired-Natural Products

edited by Mauro de Nisco

submission deadline 30 Oct 2025 | Viewed by 28 | Submission Open

Keywords: natural products; natural substances; derivative; synthesis; application

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cellular and Molecular Mechanisms in Inflammatory Bowel Disease

edited by Michael Bording-Jorgensen

submission deadline 30 Oct 2025 | Viewed by 26 | Submission Open

Keywords: IBD; cytokines; microbiome; Crohn’ s disease; ulcerative colitis; dysbiosis; mucosal immunity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Translational Research in Antiviral and Vaccine Development

edited by

Gabriel Pires De Souza

submission deadline 30 Oct 2025 | Viewed by 26 | Submission Open

Keywords: antiviral drug discovery; vaccines development; translational research; viral resistance; host-targeted therapies; therapeutic platforms; antiviral screening; virology; vaccinology; emerging viruses

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurodegenerative Disease: Genetic Bases and Pathogenetic Mechanism

edited by Emanuele Panza

submission deadline 30 Oct 2025 | Viewed by 23 | Submission Open

Keywords: neurodegenerative diseases; molecular and cellular pathways; pathogenetic mechanisms

(This special issue belongs to the Section Molecular Neurobiology)

Role of Immune Cells in Cancers

edited by Helga Maria Schmetzer

submission deadline 30 Oct 2025 | Viewed by 22 | Submission Open

Keywords: cancer; immune monitoring; immune escape; immune activation

(This special issue belongs to the Section Molecular Oncology)

Progress in the Application of Nanoparticles Against Lung Infection/Inflammation

edited by

Eder Lilia Romero

submission deadline 30 Oct 2025 | Viewed by 22 | Submission Open

Keywords: nanoparticulate material; lung; infection; inflammation; antitumoral activity

(This special issue belongs to the Section Molecular Nanoscience)

New Insights into the Biochemistry and Molecular Genetics of Diatoms

edited by

Bettina Scholz

submission deadline 30 Oct 2025 | Viewed by 20 | Submission Open

Keywords: diatom; environmental stress response; frustule biosynthesis; microalgal biotechnology; ecological interactions

(This special issue belongs to the Section Biochemistry)

Emerging Biological and Molecular Targets in Schizophrenia

edited by Jacopo Sapienza

submission deadline 30 Oct 2025 | Viewed by 16 | Submission Open

Keywords: schizophrenia; cognition; negative symptoms; synapses; kynurenine pathway; TAAR1; psychedelics; new treatments

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research and Insights into Acute Kidney Injury

edited by

Paolo Monardo

submission deadline 30 Oct 2025 | Viewed by 16 | Submission Open

Keywords: acute kidney injury; renal biomarkers; renal replacement therapy; sepsis; hemofilters; AKI-CKD transition

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cardiovascular Effects of Newer Glucose-Lowering Therapies: Molecular Mechanisms and Therapeutic Targets

edited by

Paschalis Karakasis

and

Dimitrios Patoulias

submission deadline 30 Oct 2025 | Viewed by 16 | Submission Open

Keywords: sodium-glucose cotransporter 2 (SGLT2) inhibitors; glucagon-like peptide-1 receptor agonists (GLP-1RAs); dual incretin receptor; cardiovascular protection; vascular signaling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism and Innovative Therapeutic Approaches in Gliomas: Translating Bench to Bedside

edited by Fabio Cofano and

Diego Garbossa

submission deadline 30 Oct 2025 | Viewed by 15 | Submission Open

Keywords: glioma; low-grade glioma; high-grade glioma; glioblastoma; tumor microenvironment; therapeutic resistance; molecular biomarkers; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Basis and Treatment of Skin Diseases and Their Associated Complications (2nd Edition)

edited by

Maria Maisto

submission deadline 30 Oct 2025 | Viewed by 8 | Submission Open

Keywords: diagnosis; biomarkers; imaging; histopathology; cutaneous comorbidities complication; therapy; management; clinical Trials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Extracellular Vesicles: Advances in Multi-Omics

edited by

Leo Kei Iwai

submission deadline 30 Oct 2025 | Viewed by 8 | Submission Open

Keywords: extracellular vesicles; omics; mass spectrometry; molecular targets; biomarker

(This special issue belongs to the Section Molecular Biology)

Antimicrobial and Antiviral Peptides: 2nd Edition

edited by

Tecla Ciociola

submission deadline 30 Oct 2025 | Viewed by 8 | Submission Open

Keywords: antimicrobial peptides; antiviral peptides; peptide mining; molecular mechanism of biological activity; structure– activity relationship; molecular targets; in silico design; in vivo models; peptide delivery strategies; biomedical applications

(This special issue belongs to the Section Biochemistry)

Recent Advances in Neurofibromatosis Type 1: From Molecular Insights to Novel Therapies

edited by László Szabó and

Márta Medvecz

submission deadline 30 Oct 2025 | Viewed by 7 | Submission Open

Keywords: neurofibromatosis type 1; genotype– phenotype analyses; molecular pathogenesis; next-generation sequencing (NGS); molecular targeted therapy; MEK inhibitors; imaging studies

(This special issue belongs to the Section Molecular Neurobiology)

Nanocomposite Fibers: Current Status and Applications

edited by

Mourad Krifa

submission deadline 30 Oct 2025 | Viewed by 5 | Submission Open

Keywords: advanced fibrous and particulate materials; nano-enhanced textiles; natural fiber utilization; fiber quality; textile processing

(This special issue belongs to the Section Molecular Nanoscience)

Recent Advances in Dementia with Lewy Bodies and Alzheimer’s Disease

edited by

Kurt A. Jellinger

submission deadline 30 Oct 2025 | Viewed by 4 | Submission Open

Keywords: dementia with Lewy bodies; Alzheimer’ s disease; dementing disorders in advanced age

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Research on Bioactive Natural Products: 2nd Edition

edited by

Alexandros Tsoupras

submission deadline 30 Oct 2025 | Viewed by 4 | Submission Open

Keywords: chronic disorders; bioactives; natural sources; sustainable sources; biomolecular; structure– activity relationship; synergism; health promoting; bio-functional; products; supplements; nutraceuticals; drugs

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advances in Antimicrobial Nanoparticles

edited by

Lide Arana

and Ianire Mate

submission deadline 30 Oct 2025 | Viewed by 3 | Submission Open

Keywords: antimicrobial nanoparticles; resistant pathogens; antimicrobial resistance; lipid nanoparticles; biomimetic nanostructures; combined therapy; antimicrobial strategies

(This special issue belongs to the Section Molecular Nanoscience)

Interplay Between Blood Cells and Cytokines

edited by

Mats B. Eriksson

and

Anders O. Larsson

submission deadline 30 Oct 2025 | Viewed by 3 | Submission Open

Keywords: blood cells; communication; cytokine; erythrocyte; immunology; inflammation; interplay; leucocyte; platelet; network

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Actin Cytoskeleton in Health and Disease

edited by

Malgorzata Kloc

submission deadline 30 Oct 2025 | Viewed by 2 | Submission Open

Keywords: actin; nuclear actin; virus; bacterium; organelle positioning; cell polarity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Molecular Research on Photocatalytic Applications

edited by Hassan Ait Ahsaine

submission deadline 30 Oct 2025 | Viewed by 1 | Submission Open

Keywords: photocatalysis; photocatalytic degradation; molecular catalysts; photocatalysts; functional materials

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Effects of the Environmental Conditions on Bacterial Growth and Functions

edited by

Fernanda Abreu

submission deadline 30 Oct 2025 | Viewed by 1 | Submission Open

Keywords: bacterial growth; growth conditions; gene expression; bioproducts; biofilm; resistance; population dynamics

(This special issue belongs to the Section Molecular Microbiology)

Rare Diseases Associated with Short Stature: Genetics, Pathogenesis and Therapy

edited by

Michal Ordak

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3942 | Submission Open

Keywords: skeletal disorders; dwarfism; skeletal dysplasias; short stature; biomarkers; mutations; rare disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Review Papers in Molecular Neurobiology 2025

edited by Hyo Eun Moon

submission deadline 31 Oct 2025 | 4 articles | Viewed by 2673 | Submission Open

Keywords: neurobiology; neurochemistry; neurology; neuropathology; neurophysiology; neuropharmacology.; neurogenetics; neuro-oncology; aging neuroscience; neurotrauma; neurogenesis; neurotransmitter; neuroinflammation; neuroendocrine tumor; neurodegenerative diseases; neuroscience; molecular and cellular neuroscience; cognitive neuroscience; computational neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Dietary Compounds in Cancer Management

edited by

Maria Magdalena Mocanu

and

Alexandru Filippi

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2102 | Submission Open

Keywords: dietary compounds; cancer prevention; cancer therapy; signaling pathways; heterogeneity; multidrug resistance; cancer stem cells; genetic modifications in cancer; cancer and inflammation; viral infection in cancer; tumor microenvironment

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Editorial Board Members’ Collection Series in Diet in the Prevention and Treatment of Non-Communicable Disease

edited by