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Molecular Mechanism in Cardiac Remodeling

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 384

Special Issue Editors


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Guest Editor
Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA
Interests: cardiomyopathy; ion channel; cardiac arrhythmias; intracellular calcium transient; pharmacology
Special Issues, Collections and Topics in MDPI journals
Fralin Biomedical Research Institute, Virginia Polytechnic Institute and State University, 2 Riverside Circle, Roanoke, VA 24016, USA
Interests: cardiac arrhythmias; electrical coupling; cardiopulmonary resuscitation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit your research to this IJMS Special Issue on the topic of “molecular mechanisms in cardiac remodeling”. Cardiac remodeling is a complex pathological process involving both electrical and structural remodeling of the heart, which are interrelated processes contributing to the risk of arrhythmias and the progression of heart failure. We encourage the submission of manuscripts that provide novel and mechanistic insights and offer a significant advancement of scientific understanding in this field.

This Special Issue aims to publish experimental, theoretical, and computational results in as much detail as possible to help facilitate the understanding of heart disease progression, development of new therapies, assessment of prognosis, and reversal of cardiac remodeling by drug or gene-/cell-based therapies.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  1. Cellular and molecular pathways of cardiac remodeling;
  2. Biomarker development to detect and predict remodeling;
  3. Pharmacology and precise medicine for cardiomyopathy;
  4. Computational modeling;
  5. Novel experimental models of cardiomyopathy.

Dr. Xianming Lin
Dr. Xiaobo Wu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiomyopathy
  • cardiac arrhythmias
  • ion channel
  • calcium transient

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Published Papers (1 paper)

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Review

18 pages, 777 KB  
Review
Immunometabolism in Cardiac Remodeling: Mechanisms and Therapeutic Perspectives
by Julia Nazaruk, Barbara Bilnik, Maciej Niewiadomski, Wojciech Pawlak and Piotr Gajewski
Int. J. Mol. Sci. 2026, 27(9), 3906; https://doi.org/10.3390/ijms27093906 - 28 Apr 2026
Abstract
Cardiovascular diseases remain the leading cause of mortality worldwide, and one of the key mechanisms driving the development of heart failure is pathological remodeling of the myocardium. This process involves complex structural, cellular, and metabolic alterations in which the immune system and its [...] Read more.
Cardiovascular diseases remain the leading cause of mortality worldwide, and one of the key mechanisms driving the development of heart failure is pathological remodeling of the myocardium. This process involves complex structural, cellular, and metabolic alterations in which the immune system and its interactions with cardiomyocytes and fibroblasts play a central role. The aim of this work was to present the current state of knowledge on immunometabolism in cardiac remodeling and to discuss its pathophysiological relevance and therapeutic potential. This review focuses on the metabolism of cardiac macrophages, highlighting the differences between the pro-inflammatory (M1) and reparative (M2) phenotypes and their impact on inflammation, fibrosis, and myocardial regeneration. The roles of major metabolic pathways, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and glutaminolysis, are discussed, as well as the importance of the NLRP3 inflammasome and efferocytosis in regulating the inflammatory response. Furthermore, the review briefly incorporates recent insights into neutrophil, T cell, and regulatory T cell (Treg) metabolism and their contributions to inflammation, repair, and fibrotic remodeling. Particular attention is also given to cardiac fibroblasts and their metabolic reprogramming during fibrosis, with emphasis on the pivotal role of transforming growth factor-β (TGF-β) signaling. The review further discusses the role of microRNAs as mediators of intercellular communication integrating immunological and metabolic signals. The work is complemented by a discussion of therapeutic perspectives, including modulation of macrophage metabolism, fibrogenic signaling pathways, mitochondrial function, and miRNA-based therapies. Immunometabolism emerges as a promising research field whose further exploration may contribute to the development of novel, more precise strategies for the treatment of cardiovascular diseases. Full article
(This article belongs to the Special Issue Molecular Mechanism in Cardiac Remodeling)
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