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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanism of Sympathetic Nerves in Cardiovascular Diseases and Cancer

edited by

Yutang Wang

submission deadline 30 Aug 2025 | Viewed by 489 | Submission Open

Keywords: sympathetic nerve activity; adrenergic receptors; renal denervation; heart disease; stroke; atherosclerosis; hypertension; diabetes; metabolic syndrome; cancer

(This special issue belongs to the Section Molecular Neurobiology)

Gastrointestinal Microbes: Implications for Health and Disease

edited by Suqin Hang

submission deadline 30 Aug 2025 | 1 articles | Viewed by 400 | Submission Open

Keywords: animal; gut; microbiota; gut hormone; nutrients

(This special issue belongs to the Section Molecular Microbiology)

Physics and Chemistry of Molecular Materials for Optoelectronic Applications

edited by

Aggelos Avramopoulos

submission deadline 30 Aug 2025 | Viewed by 375 | Submission Open

Keywords: polarization of matter; non-linear optics and non-linear optical phenomena; optical phenomena; quantum chemistry; density functional theory; physics and chemistry of molecular materials; molecular-based optoelectronics

(This special issue belongs to the Section Materials Science)

Role of Quorum Sensing in Plant Microbiome: Advances and Prospects

edited by

Clarisse Brígido

submission deadline 30 Aug 2025 | Viewed by 334 | Submission Open

Keywords: quorum sensing; quorum quenching; rhizosphere signaling; signaling molecules; N-Acyl-L-homoserine lactones; AHLs; microbiome; chemical molecules; sustainable agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Cytokines and Autoantibodies Against Cytokines in Health and Disease

edited by

Juan Bautista De Sanctis

submission deadline 30 Aug 2025 | Viewed by 307 | Submission Open

Keywords: cytokine; autoantibodies; cytokine therapy; cytokine inhibition

(This special issue belongs to the Section Molecular Immunology)

Latest Advances in Computational Drug Discovery

edited by

Sunil Gaikwad

submission deadline 30 Aug 2025 | Viewed by 248 | Submission Open

Keywords: design; synthesis; molecular docking; methodological reviews; novel docking approaches; ADME; toxicity; AI-driven molecular docking; molecular dynamics; bioisosteric replacement in drug design; rational drug design and synthesis; computational tools and algorithms; lead optimization and structure-based drug design; virtual screening of drug candidates; QSAR modelling; DFT

(This special issue belongs to the Section Molecular Pharmacology)

Recent Advances in Molecular Mechanisms and Targeted Therapies for Leukemia

edited by

Moo Kon Song

submission deadline 30 Aug 2025 | Viewed by 144 | Submission Open

Keywords: targeted therapy; acute myeloid leukemia; genetic mutations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cutting-Edge Research on Nanosensors

edited by

Giorgio Rispoli

submission deadline 30 Aug 2025 | Viewed by 142 | Submission Open

Keywords: nanostructure; microfabrication; nanoparticles; nanoscale; nanotechnology; nanomaterials; sensor response; sensitivity; miniaturization; analyte selectivity; smart materials; molecular recognition; sensing mechanism; real-time monitoring

(This special issue belongs to the Section Molecular Nanoscience)

Environmental Sensitivity Illnesses: Advances in Mechanisms and Molecular Signatures

edited by

Daniela Caccamo

submission deadline 30 Aug 2025 | Viewed by 141 | Submission Open

Keywords: electromagnetic hypersensitivity; multiple chemical sensitivity; fibromyalgia; chronic fatigue syndrome; chronic pain disorder; toxicant-induced loss of tolerance; total allergy syndrome; circulating biomarkers; genetic susceptibility factors; immune system alterations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research in Antioxidant Activity

edited by Demetrios Kouretas and

Fotios Tekos

submission deadline 30 Aug 2025 | Viewed by 136 | Submission Open

Keywords: xenobiotics; oxidative stress; free radicals; reactive oxygen species; reactive nitrogen species; antioxidants; glutathione; toxicology; redox metabolism; redox imbalance

(This special issue belongs to the Section Biochemistry)

Inflammation in Pregnancy and Childbirth

edited by

Małgorzata Szczuko

and Maciej Ziętek

submission deadline 30 Aug 2025 | Viewed by 133 | Submission Open

Keywords: pregnancy; labor; eicosanoid; chronic inflammation; cytokines; intestinal dysbiosis; mitogen-activated protein kinase; nuclear factor kappa-light-enhancer-activated B cell; maresins; resolvins and protectins

(This special issue belongs to the Section Molecular Immunology)

Application and Molecular Mechanisms of Microwaves for Materials Processing

edited by

Valentin Craciun

submission deadline 30 Aug 2025 | Viewed by 130 | Submission Open

Keywords: microwaves; non-ionizing radiation; molecular materials characterizations; molecular materials synthesis; microwave processing and engineering

(This special issue belongs to the Section Materials Science)

Molecular Insights into the Role of Exercise in Disease and Health, 2nd Edition

edited by

Brisamar Estébanez

, María José Cuevas-González and Chun-Jung Huang

submission deadline 30 Aug 2025 | Viewed by 127 | Submission Open

Keywords: physical activity; molecular mechanisms; disease prevention; metabolic health; cardiovascular diseases; neurodegenerative diseases; sarcopenia; immune function; healthy aging; epigenetics

(This special issue belongs to the Section Molecular Biology)

Artificial Intelligence and Computer-Aided Design: Molecular Simulation Technology in Exploring Bioactive Compounds for Health Promotion

edited by

Baojun Xu

submission deadline 30 Aug 2025 | Viewed by 125 | Submission Open

Keywords: molecular simulation; bioactive compounds; molecular docking; molecular dynamics; quantum mechanics; functional mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advancements in Novel Drug Delivery Systems for Gene and Drug Delivery

edited by

Rosamaria Pennisi

submission deadline 30 Aug 2025 | Viewed by 109 | Submission Open

Keywords: drug and gene delivery; novel drug delivery systems; nanoparticle-based delivery systems

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Endothelial Cell Injury and Repair

edited by

Eleni Gavriilaki

and

Panagiota Anyfanti

submission deadline 30 Aug 2025 | Viewed by 106 | Submission Open

Keywords: endothelial injury; endothelial repair; endotheliopathies; endothelial dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Plant–Microbe Interaction

edited by

Raja Ben-Laouane

and

Mohamed Ait-El-Mokhtar

submission deadline 30 Aug 2025 | Viewed by 103 | Submission Open

Keywords: biomarkers; molecular biotechnology; cell signalling; microbiota signaling; genetic editing of microbes; plant-microbe stress response; plant-microbe stress mitigation; plant-microbe underlying mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Lipoprotein in Cardiovascular Disease

edited by

Joan Carles Vallvé

submission deadline 30 Aug 2025 | Viewed by 97 | Submission Open

Keywords: lipoprotein; cardiovascular disease; atherosclerosis; lipid metabolism; HDL; LDL; VLDL; Lp(a); TRLs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Approaches for Tissue Repair and Tissue Regeneration

edited by Srinivas Madduri

submission deadline 30 Aug 2025 | Viewed by 88 | Submission Open

Keywords: injuries; tissue repair; tissue regeneration; tissue engineering; tissue bioengineering; bioactive biomaterial; cell and gene therapeutics; hydrogel; immune modulation

(This special issue belongs to the Section Molecular Biology)

Molecular Applications of Antioxidants and Anti-Inflammatory Activities of Natural Products

edited by

Vassilis Athanasiadis

submission deadline 30 Aug 2025 | Viewed by 85 | Submission Open

Keywords: antioxidants; anti-inflammatory agents; natural products; molecular mechanisms; oxidative stress; signaling pathways; inflammation; bioactive compounds; proteomics; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Computer-Aided Drug Design Strategies

edited by

Alexandre G. De Brevern

submission deadline 30 Aug 2025 | Viewed by 82 | Submission Open

Keywords: computer-aided drug design; artificial intelligence in drug discovery; molecular docking; molecular dynamics simulations; macromolecular systems; quantum mechanics/molecular mechanics (QM/MM); big data analytics in drug development; pharmacokinetics optimization; structure-based drug design (SBDD); ligand-based drug design; virtual screening techniques

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms and Treatment in Skin Cancer

edited by

Jànos Hunyadi

submission deadline 30 Aug 2025 | Viewed by 82 | Submission Open

Keywords: skin cancer; early detection; treatment; prevention; pathophysiology; vitamin-C; cell energetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Application of Large Language Models in Bioinformatics: Deep Exploration from Protein to Gene Networks

edited by Dukka B. Kc

submission deadline 30 Aug 2025 | Viewed by 82 | Submission Open

Keywords: large language models; protein language models; DNA language model; RNA language model; deep learning; bioinformatics; protein structure; sequence alignment; prediction of gene; protein function; gene networks

(This special issue belongs to the Section Molecular Informatics)

Molecular Research on Plant Breeding

edited by

Hélia Cardoso

, Sandra Correia and

Isaura Castro

submission deadline 30 Aug 2025 | Viewed by 81 | Submission Open

Keywords: plant breeding; proteomics; metabolomics; epigenomics; gene editing

(This special issue belongs to the Section Molecular Plant Sciences)

Heavy Metal Exposure on Health

edited by

Rosanna Mallamaci

submission deadline 30 Aug 2025 | Viewed by 81 | Submission Open

Keywords: heavy metals; toxic metal exposure; oxidative stress; mitochondrial dysfunction; epigenetic alterations; physiological and molecular pathways of cellular toxicology; biomarkers of toxicity; chelating agents; antioxidants; therapies or treatments

(This special issue belongs to the Section Molecular Toxicology)

Molecular Advances in Primary Colorectal Cancer and Liver Metastases

edited by Alexandros E. Giakoustidis

submission deadline 30 Aug 2025 | Viewed by 79 | Submission Open

Keywords: colorectal cancer; metastasis; treatment; management; screening; genetic alterations; epigenetic alterations; genomics; epigenomics; methylation; liver-directed therapy; radiation; immunotherapy; peritoneal carcinomatosis; monotherapy; chemotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Type 2 Diabetes and Its Complications: 2nd Edition

edited by

Anca Pantea Stoian

submission deadline 30 Aug 2025 | Viewed by 78 | Submission Open

Keywords: diabetes type 2; diabetes complications; pathophysiology of type 2 diabetes; new diabetes treatment; cardiovascular disease; stroke; peripheral artery disease; chronic kidney disease; retinopathy; neuropathy; non-alcoholic fatty liver disease in diabetes

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular and Cellular Research on Cardiac Repair and Regeneration

edited by

Francesca Pagano

and

Vittorio Picchio

submission deadline 30 Aug 2025 | Viewed by 78 | Submission Open

Keywords: cardiac repair; cardiomyocyte differentiation; cardiac fibroblast activation; cardiac fibrosis; cardiac tissue microenvironment; cardiac remodeling

(This special issue belongs to the Section Molecular Biology)

Melanoma: Molecular Mechanism and New Agents for Prevention and Therapy

edited by

M. Letizia Motti

submission deadline 30 Aug 2025 | Viewed by 76 | Submission Open

Keywords: melanoma; therapy resistance; melanoma microenvironment (MME); melanoma plasticity; epigenetic mechanism; predictive markers; prognostic markers; extracellular vesicles; molecular therapy; natural molecules

(This special issue belongs to the Section Molecular Oncology)

Molecular and Histological Approaches in Oral Tissue Regeneration and Diagnostics

edited by

Fabiana Nicita

submission deadline 30 Aug 2025 | Viewed by 74 | Submission Open

Keywords: dentistry; histological analysis; immunofluorescence; molecular pathogenesis; tissue

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cancer Biology and Epigenetic Modifications

edited by Tamer E. Fandy

submission deadline 30 Aug 2025 | Viewed by 74 | Submission Open

Keywords: epigenetics; DNA methylation; epigenetic modifiers; histone acetylation; histone methylation; miRNA; ncRNA; chrmoatin remodelling

(This special issue belongs to the Section Molecular Oncology)

Microbial Pathogens and Drug Resistance in the Environment

edited by

Mariusz Cycoń

submission deadline 30 Aug 2025 | Viewed by 74 | Submission Open

Keywords: antibiotics; peptides; chemotherapeutics; antimicrobial drugs; molecular mechanism of drug action

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms Behind Plant–Virus Interactions: Pathogenesis and Defense

edited by

Katarzyna Otulak-Kozieł

submission deadline 30 Aug 2025 | Viewed by 71 | Submission Open

Keywords: plant viruses; plant resistance; plant signaling; plant defense; biotic stress; plant– virus interactions; molecular mechanism

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights in Biomarkers of Autoimmune and Autoinflammatory Diseases: 2nd Edition

edited by

Mariapaola Marino

submission deadline 30 Aug 2025 | Viewed by 71 | Submission Open

Keywords: inflammaging; inflammasome; autoantibodies; free light chains; cytokines; receptor; signal transduction; innate immunity; adaptive immunity

(This special issue belongs to the Section Molecular Immunology)

Advancements in Pathogen Detection, Microdevice Technologies and AI-Driven Analysis

edited by

Younseong Song

submission deadline 30 Aug 2025 | Viewed by 70 | Submission Open

Keywords: pathogen detection; microfluidic; microdevice; AI analysis; virus; bacteria; point-of-care testing; infectious disease; nanotechnology

(This special issue belongs to the Section Molecular Biology)

Molecular Associations Between Adipose Tissue and Diseases

edited by

Roberto Cannataro

Erika Cione

and

Maria Cristina Caroleo

submission deadline 30 Aug 2025 | Viewed by 69 | Submission Open

Keywords: lipedema; adipose tissue; adipocyte; adipose organ; body fat; miRNA; ketogenic diet

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Electron or Ion Transport in Electrochemistry

edited by Simone Sanna

submission deadline 30 Aug 2025 | Viewed by 69 | Submission Open

Keywords: solid oxide fuel cells; mixed ionic and electronic conductors; perovskite; fluorite; hydrogen; CO2 reduction; water splitting; energy conversion and storage

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Transgenic Mouse Models in Human Disease Research in Epithelial Tissues: Insights and Advances

edited by

Manoocher Soleimani

and

Kamyar Zahedi

submission deadline 30 Aug 2025 | Viewed by 69 | Submission Open

Keywords: transgenic animals; kideny diseases; heart failure; cystic diseases

(This special issue belongs to the Section Molecular Biology)

Liquid Biopsies in Oncology—3rd Edition

edited by

Sandra V. Fernandez

and

Carmela Paolillo

submission deadline 30 Aug 2025 | Viewed by 68 | Submission Open

Keywords: precision oncology; personalized therapy; cancer biomarkers; liquid biopsy; biological fluids; circulating molecules; circulating tumor cells; CTCs; ctDNA; ctRNA; cell-free DNA; cfDNA; NGS; circulating miRNAs; exosomes; extracellular vesicles

(This special issue belongs to the Section Molecular Oncology)

Recent Progress in Biological and Molecular Mechanisms and Targeted Therapies of Leukemia

edited by Anna Sicuranza

submission deadline 30 Aug 2025 | Viewed by 65 | Submission Open

Keywords: leukemia-targeted therapies; AML; CML; venetoclax combination therapy; tyrosine kinase inhibitors (TKIs); hypomethylating agents; ALL; CLL; CAR-T cell therapy; monoclonal antibodies; immune checkpoint inhibitors; resistance mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Phytochemicals in Health and Disease: From Molecular Mechanisms to Evidence-Based Applications

edited by Olga Silva

submission deadline 30 Aug 2025 | Viewed by 65 | Submission Open

Keywords: phytochemicals; bioactive natural products; medicinal plants; chronic and inflammatory diseases; ethnopharmacology and phytotherapy

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Brain Plasticity

edited by

Beatrice Uguagliati

submission deadline 30 Aug 2025 | Viewed by 64 | Submission Open

Keywords: neurophysiology; neurobiology; synapses; synaptic plasticity; microglia; astrocytes; dendritic spines; neurodevelopment; neurodevelopmental disease; learning and memory; neuropharmacology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in the Genetics, Epidemiology and Management of Myopathies

edited by

Efthimios Dardiotis

and

Vasileios Siokas

submission deadline 30 Aug 2025 | Viewed by 64 | Submission Open

Keywords: myopathies; muscle disorders; muscle weakness; muscle pain; myalgia

(This special issue belongs to the Section Molecular Biology)

Molecular Advancements in Functional Materials

edited by

Joanna Karasiewicz

submission deadline 30 Aug 2025 | Viewed by 64 | Submission Open

Keywords: synthesis of specialty compounds; specialty compounds in functional materials; special applications: self-cleaning; anti-icing; self-healing; biocidal; etc.; properties; special-purpose functional materials

(This special issue belongs to the Section Materials Science)

Exosomes in the Processes of Tumorigenesis, Cancer Progression, Metastasis, and Treatment

edited by

Foteinos-Ioannis Dimitrakopoulos

submission deadline 30 Aug 2025 | Viewed by 61 | Submission Open

Keywords: exosomes; extracellular vesicles; metastasis; cancer; prognosis; prediction; biomarker; cancer treatment

(This special issue belongs to the Section Molecular Oncology)

The Toxicity of Bisphenol A and Its Analogs

edited by

Krystyna Makowska

submission deadline 30 Aug 2025 | Viewed by 61 | Submission Open

Keywords: bisphenols; endocrine disruptors; bisphenol A and analogs; toxicology

(This special issue belongs to the Section Molecular Toxicology)

Periodontal Disease: From Molecular Pathogenesis to Precision Diagnostics and Innovative Therapeutics

edited by

Elisabetta Ferrara

submission deadline 30 Aug 2025 | Viewed by 60 | Submission Open

Keywords: periodontitis; gingivitis; oral microbiome; host– pathogen interactions; periodontal immunology; systemic inflammation; salivary diagnostics; periodontal regeneration; precision dentistry; oral-systemic connections; inflammatory biomarkers; antimicrobial peptides; peri-implantitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

RNA-Based Regulation in Human Health and Disease

edited by

Alfredo Ciccodicola

and

Sudharshan Setra Janardhana Shetty

submission deadline 30 Aug 2025 | Viewed by 60 | Submission Open

Keywords: non-coding RNAs (ncRNAs); small nucleolar RNAs (snoRNAs); long non-coding RNAs (lncRNAs); microRNAs (miRNAs); piwi-interacting RNAs (piRNAs); circular RNAs (circRNAs); RNA modifications (m6A; pseudouridylation); RNA-protein interactions; post-transcriptional gene regulation; RNA interference (RNAi); antisense oligonucleotides (ASOs); RNA-binding proteins (RBPs); epitranscriptomics; RNA-based therapeutics; cancer-associated ncRNAs; neurodegenerative diseases and RNA regulation; cardiovascular RNA biology; metabolic disorders and RNA; ribosomal RNA modifications; RNA-targeted drug discovery

(This special issue belongs to the Section Molecular Genetics and Genomics)

Recent Advances in Osteoarthritis Pathways and Biomarker Research

edited by

Előd Ernő Nagy

submission deadline 30 Aug 2025 | Viewed by 60 | Submission Open

Keywords: osteoarthritis; low-grade inflammation; cartilage chondrocyte; synovial membrane; synovial fluid; subchondral bone; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Regenerative Medicine and Therapeutics

edited by Diana Torge

submission deadline 30 Aug 2025 | Viewed by 58 | Submission Open

Keywords: regenerative medicine; morphology; regenerative dentistry; biomaterials; scaffolds; organoids; tissue regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1901-1950 on page 39 of 69.

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