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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Neurofibromatosis Type 1 and NF2-Related Schwannomatosis: Advances from Basic Research to Current Therapies

edited by

Bumjoon Park

and

Baehoon Kim

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3567 | Submission Open

Keywords: neurofibromatosis type 1 (NF1); neurofibromin; RAS/MAPK pathway; malignant peripheral nerve sheath tumor (MPNST); NF2-related schwannomatosis (NF2 syndrome); Merlin (Schwannomin); vestibular schwannoma; meningioma; ependymoma

(This special issue belongs to the Section Molecular Neurobiology)

Regulation of Brown Adipose Function

edited by

Stephen F. Vatner

and

Shinsuke Nirengi

submission deadline 31 Jan 2027 | 3 articles | Viewed by 3505 | Submission Open

Keywords: brown adipose tissue; metabolic disorders; thermogenesis; endocrine function; cellular signaling

(This special issue belongs to the Section Biochemistry)

Breakthroughs in Anti-Cancer Agents Discovery

edited by

Giulia Bononi

submission deadline 31 Jan 2027 | 3 articles | Viewed by 3382 | Submission Open

Keywords: medicinal chemistry; drug discovery; cancer; anti-cancer agents; synthesis; bioactive molecules; biological evaluation; computational drug discovery; artificial intelligence

(This special issue belongs to the Section Molecular Oncology)

Molecular Determinants of Neuromotor Control, Tremor, and Fatigue

edited by

Szymon Kulis

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3320 | Submission Open

Keywords: neuromuscular control; physiological tremor; muscle fatigue; sensorimotor integration; motor unit physiology; muscle oscillations; neuromuscular adaptation; excitation–contraction coupling; fatigue biomarkers; neurophysiology of movement

(This special issue belongs to the Section Molecular Neurobiology)

Analyzing the Molecular Mechanisms of Plant Disease Pathogenesis and Host Disease Resistance

edited by Zhibing Wu

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3307 | Submission Open

Keywords: pathogenicity mechanisms; plant–pathogen interactions; plant immunity; effector biology; resistance genes; multi-omics approaches; nanotechnology in plant protection

(This special issue belongs to the Section Molecular Plant Sciences)

Novel Biomarkers and Treatment Strategies for Parkinson’s Disease

edited by Aron Emmi

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3260 | Submission Open

Keywords: Parkinson’s Disease; alpha-synuclein; disease-modifying therapy; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Synthesis, Characterization and Applications of Advanced Polymer Materials

edited by Namil Kim

submission deadline 31 Jan 2027 | 3 articles | Viewed by 3210 | Submission Open

Keywords: synthesis methodologies; molecular architecture; functional polymers; characterization techniques; cutting-edge applications

(This special issue belongs to the Section Macromolecules)

Endocrine–Immune Crosstalk in Human Reproductive Health and Pathology

edited by

Juan Pablo Mackern-Oberti

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3168 | Submission Open

Keywords: T cells; B cells; autoimmune disease; reproduction; immunemodulation; inflammation; endocrinology; lactation

(This special issue belongs to the Section Molecular Immunology)

Computer-Aided Drug Discovery: Computational Chemistry and Cheminformatics

edited by

Daniel Glossman-Mitnik

submission deadline 31 Jan 2027 | 5 articles | Viewed by 3112 | Submission Open

Keywords: computer-aided drug discovery; computational chemistry; cheminformatics; conceptual density functional theory (CDFT); molecular docking; molecular dynamics simulations; QSAR/QSPR modeling; ADMET prediction; machine learning in drug design

(This special issue belongs to the Section Molecular Informatics)

Advanced Functional Materials for Catalysis and Storage

edited by

Kaixin Zhu

submission deadline 31 Jan 2027 | 1 articles | Viewed by 3101 | Submission Open

Keywords: functional materials; energy catalysis; small molecule conversion; energy storage

(This special issue belongs to the Section Materials Science)

Advances in Endoplasmic Reticulum Stress and Apoptosis—Second Edition

edited by

Orsolya Kapuy

and

Beáta Lizák

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3029 | Submission Open

Keywords: ER stress; apoptosis initiated by ER stress; cellular survival; redox homeostasis of ER; autophagy initiated by ER stress; cell death pathways initiated by ER stress

(This special issue belongs to the Section Biochemistry)

RNA in Biology and Medicine (2nd Edition)

edited by

Roberto Patarca

and William A. Haseltine

submission deadline 31 Jan 2027 | 3 articles | Viewed by 3024 | Submission Open

Keywords: noncoding RNAs; coding RNAs; RNA-based therapy; RNA vaccine; RNA structure; RNA function

(This special issue belongs to the Section Molecular Biology)

New Advances in Amyotrophic Lateral Sclerosis

edited by

Vacchiano Veria

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2989 | Submission Open

Keywords: genetics and epigenetics; biomarkers; nutrition and metabolism; TDP-43 pathology; advanced model of ALS

(This special issue belongs to the Section Molecular Neurobiology)

Protein Structure and Its Interactions

edited by

Dong Hae Shin

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2946 | Submission Open

Keywords: protein–protein interactions (PPIs); protein–ligand binding; molecular recognition; binding affinity and specificity; molecular interface analysis

(This special issue belongs to the Section Molecular Biology)

Molecular Perspectives in Lung Diseases: Pathogenesis, Diagnosis, and Treatment—2nd Edition

edited by

Elena Levantini

submission deadline 31 Jan 2027 | 3 articles | Viewed by 2918 | Submission Open

Keywords: lung cancer models; cancer stem cells; tumor microenvironment; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Treatment in Gastrointestinal Cancers

edited by

Dani Ran Castillo

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2914 | Submission Open

Keywords: gastrointestinal cancers; tumor microenvironment; immune regulation; biomarkers; therapeutic resistance; liquid biopsy; targeted therapy; immune checkpoint inhibitors; epigenetic regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recombinant Proteins and Antibody Engineering for Diagnostic and Treatment of Emerging Infectious Diseases

edited by

Gustavo Helguera

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2886 | Submission Open

Keywords: recombinant proteins; antibody engineering; monoclonal antibodies; hemorrhagic fevers; tuberculosis; emerging infectious diseases; neglected viruses; diagnostics; therapeutic antibodies

(This special issue belongs to the Section Molecular Immunology)

Systemic Lupus: Molecular Research, New Biomarkers and Novel Therapy

edited by

Juan Pablo Mackern-Oberti

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2822 | Submission Open

Keywords: lupus; biomarkers; autoimmunity; inflammation; therapy; treatment; endocrine; prolactin; stress; T cell and B cell activation; T cell and B cell proliferation; antigenic immunosuppression

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Electromagnetic Field Interactions with Biomolecules

edited by

Svetlana Jovanović

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2793 | Submission Open

Keywords: nonionizing electromagnetic fields; biomolecules; proteins; oxidative stress; Fe metabolism; amyloid-β peptide

(This special issue belongs to the Section Materials Science)

Cellular Memory in Response to Environmental Conditions

edited by

Satoshi Kishigami

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2717 | Submission Open

Keywords: cellular memory; cellular environment; embryonic development; epigenetics; transgenerational inheritance; mammals; DOHaD

(This special issue belongs to the Section Molecular Biology)

Multi-Target and Synergistic Therapeutic Strategies in Modern Drug Discovery

edited by

Vincenzo Piccolo

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2661 | Submission Open

Keywords: multi-target and synergistic therapeutic strategies; drug design; combination therapy; polypharmacology; drug re-purposing

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Modeling in Pharmaceutical Sciences

edited by

Maciej Spiegel

submission deadline 31 Jan 2027 | 3 articles | Viewed by 2637 | Submission Open

Keywords: molecular modeling; computer-aided drug design; molecular docking; drug discovery; quantum chemistry; molecular dynamics simulations; virtual screening; computational pharmacology; pharmacy; in silico methods

(This special issue belongs to the Section Molecular Pharmacology)

Current and Emerging Therapeutic Approaches for MASLD

edited by

Chrysoula Boutari

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2531 | Submission Open

Keywords: MASLD; MASH; GLP-1 agonists; anti-inflammatory agents; anti-obesity drugs; FGF-21

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Proteomics in Human Diseases and Infections: 2nd Edition

edited by

Mahamud Ur Rashid

submission deadline 31 Jan 2027 | 4 articles | Viewed by 2515 | Submission Open

Keywords: proteomics; human diseases; infections; biomarkers; therapeutic targets; disease pathogenesis; host–pathogen interactions; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Analysis on Effector and Regulatory Molecules in Renal Diseases

edited by

Takashi Oda

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2507 | Submission Open

Keywords: effector molecules; regulatory molecules; membrane attack complex (MAC); perforin; granzyme; immune complex; neutrophil extracellular traps (NETs); proteolytic enzymes; reactive oxygen species; infection-related glomerulonephritis (IRGN); nephritis-associated plasmin receptor (NAPlr); streptococcal pyrogenic exotoxin B (SPEB); adhesion molecules

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

In Silico Approaches to Unravelling Toxicity Mechanisms in Molecular Drugs

edited by

Yoshihiro Uesawa

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2494 | Submission Open

Keywords: cheminformatics; in silico analysis; QSAR; toxicity prediction; machine learning; toxicity mechanisms; omics data integration; toxicity biomarkers; artificial intelligence; adverse event database

(This special issue belongs to the Section Molecular Pharmacology)

Plants Redox Biology

edited by

Xin Li

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2483 | Submission Open

Keywords: plant–environment interaction; stress physiology; plant redox signaling; plant hormones; plant–pathogen interaction; reactive oxygen species (ROS); reactive nitrogen species (RNS); ascorbate; flavonoid; glutathione

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Protein Structure and Dynamics

edited by

Ki Hyun Nam

submission deadline 31 Jan 2027 | 3 articles | Viewed by 2440 | Submission Open

Keywords: experimental protein structure determination; structure–function relationships and mechanistic enzymology; molecular dynamics simulations; conformational dynamics, intrinsic disorder, and structural flexibility; protein–ligand and protein–protein interactions; AI-predicted structures with experimental and simulation data; methodological developments in structural and dynamic analysis.

(This special issue belongs to the Section Molecular Biophysics)

Molecular and Bioactive Properties of Novel and Functional Food Ingredients

edited by

Ewelina Zielińska

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2403 | Submission Open

Keywords: functional food; bioactive compounds; novel food; molecular properties; peptides; edible insects; metabolomics; health-promoting ingredients; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Molecular Ecology and Genomic Perspectives

edited by

Peng Zhao

submission deadline 31 Jan 2027 | 5 articles | Viewed by 2333 | Submission Open

Keywords: genome assembly and annotaion; genomic structure and function of plants; plant molecular ecology; genome prediction and GWAS; gene-editing technologies; transcriptomics and metabolomics; nuclear and organelle genomics

(This special issue belongs to the Section Molecular Plant Sciences)

Novel Advances in Ataxia-Telangiectasia

edited by David Coman

submission deadline 31 Jan 2027 | 3 articles | Viewed by 2330 | Submission Open

Keywords: ataxia-telangiectasia; ATM; metabolism; mitochondrial dysfunction; DNA repair; natural history; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Progression of Innate Immunity in Tuberculosis Infections

edited by

Octavio Miguel Rivero-Lezcano

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2297 | Submission Open

Keywords: macrophage; neutrophil; innate lymphoid cells; NK cells; mucosal associated invariant T (MAIT) cells; phagocytosis; trained innate immunity; collectins; autophagy; mucociliary clearance; NETosis

(This special issue belongs to the Section Molecular Immunology)

Structure and Function of Subcellular Organelle and Protein-Membrane Systems

edited by

Chikara Sato

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2286 | Submission Open

Keywords: immuno-electron microscopy; cell signaling; comparative anatomy; diagnosis; molecular recognition; molecular complexes; electro-chemistry; liquid-phase synthesis; metal sedimentation; membrane endoskeleton

(This special issue belongs to the Section Molecular Biophysics)

Unknown Pathogenesis of Musculoskeletal Diseases and Basic Sciences: The Role of New Technologies

edited by

Gianluigi Pasta

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2283 | Submission Open

Keywords: AI; musculoskeletal diseases; pathogenesis; basic sciences; molecular mechanisms; genetics; immunology; biomechanics; translational research; experimental models; tissue engineering

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biomarkers in Oral Pathology

edited by

Ioannis Astreidis

and Konstantinos Paraskevopoulos

submission deadline 31 Jan 2027 | 3 articles | Viewed by 2270 | Submission Open

Keywords: oral disease; oral pathology; oral cancer; biomarkers; molecular biomarkers; head and neck pathology; precision medicine; omics-based analysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cancer, Chronic Disease and Health Equity: Translational Oncology in the Era of Multimorbidity and Systems Innovation

edited by

Giorgio Malpeli

, Kiven Erique Lukong and Marco Feligioni

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2221 | Submission Open

Keywords: molecular mechanisms in chronic diseases and cancer; cancer metabolism, inflammation, and systemic disease interactions; biomarker discovery in cancer and chronic diseases; biological mechanisms in cancer and chronic diseases; neuroimmune responses in cancer and chronic diseases; epigenetic events in cancer and chronic diseases; translational oncology and precision medicine; artificial intelligence and digital innovation in oncology and chronic disease care; cancer and cardiometabolic disease intersections; multimorbidity management strategies in oncology care; integrated screening, prevention, and survivorship models; implementation science in cancer and chronic disease care

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Cellular Functions of Tubulin in Neuronal Health and Disease

edited by

Antonella Sferra

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2219 | Submission Open

Keywords: tubulin; microtubules; neurodegeneration; neuron; brain; neurodevelopment; motor proteins

(This special issue belongs to the Section Molecular Biology)

Heterocyclic Compounds: Molecular Modelling Studies and Pharmacological Investigation

edited by

Gabriella Guerrini

and

Maria P. Giovannoni

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2197 | Submission Open

Keywords: heterocycles; fused heteocycles; synthesis; small-molecules; natural product; drug design; biological studies; molecular modeling

(This special issue belongs to the Section Biochemistry)

Role of Glia in Human Health and Disease—2nd Edition

edited by

Daniele Lana

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2127 | Submission Open

Keywords: astrocytes; microglia; oligodendrocytes; Schwann cells; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Development of Responsive Nanoparticles for Cancer Therapy, 3rd Edition

edited by

Jordi Puiggalí

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2094 | Submission Open

Keywords: nanoparticles; liposomes; polymersomes; micelles; surface functionalization; cell targeting; stimuli-sensitivity; drug delivery; therapeutic applications; diagnostic applications; cancer treatment

(This special issue belongs to the Section Molecular Nanoscience)

Metabolic Features of Breast Cancer: From Understanding Heterogeneous Biology to Developing New Therapies

edited by

Lyudmila Bel'skaya

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2092 | Submission Open

Keywords: breast cancer; heterogeneity; metabolic processes; metabolites; proteins; gene expression; diagnosis; prognosis; treatment response

(This special issue belongs to the Section Molecular Oncology)

Plant Growth: Molecular Mechanisms

edited by

Zulfiqar Ali Sahito

and

Afsheen Zehra

submission deadline 31 Jan 2027 | 3 articles | Viewed by 2082 | Submission Open

Keywords: plant growth; hormonal crosstalk; epigenetics; CRISPR/Cas9 genome editing technologies; metabolomics; transcriptomics

(This special issue belongs to the Section Molecular Plant Sciences)

Chronic Stress, Neuroinflammation and Pain: Molecular Mechanisms, Biomarkers and Precision Therapies

edited by Nebojsa Knezevic and

Aleksandar Sič

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1956 | Submission Open

Keywords: chronic stress; chronic pain; neuroinflammation; biomarkers; pain mechanisms; neuropathic pain; low back pain; neuroimmune interactions; precision medicine; personalized therapy; pain phenotyping; translational research; mental health; neurobiology; pain management; inflammatory pathways; stress biomarkers; central sensitization

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Omics Approaches to Unravel Plant Responses to Habitat Stresses

edited by

Claudia Uhde-Stone

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1939 | Submission Open

Keywords: omics; multi-omics; high-throughput technologies; biotic stress; abiotic stress; environmental stress; crosstalk; translational biology; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

The Latest Research in Intestinal Inflammation and Immunity

edited by

Gabriela Fonseca-Camarillo

and

Jesús Yamamoto-Furusho

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1938 | Submission Open

Keywords: ulcerative colitis; mucins; inflammation; immunoregulation; T cells; B cells; Crohn’s disease; cytokines

(This special issue belongs to the Section Molecular Immunology)

DNA Damage and Repair Mechanisms in Cancer

edited by

Luigi Alfano

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1928 | Submission Open

Keywords: DNA damage response (DDR); genome instability ; synthethic lethality ; DNA repair

(This special issue belongs to the Section Molecular Oncology)

The Application of Stem Cells in Regenerative Medicine

edited by

Marina Gazdic Jankovic

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1863 | Submission Open

Keywords: embryonic stem cells; induced pluripotent stem cells; adult stem cells; cancer stem cells; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Thyroid Disorders: From Physiological Regulation to Targeted Cancer Therapy

edited by Lisa Thomasz

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1847 | Submission Open

Keywords: thyroid autoregulation; oxidative stress; iodide excess; sodium-iodide symporter (NIS); thyroid cancer; autoimmune thyroid disease; thyroid tumor microenvironment; dedifferentiation mechanisms; targeted therapies; radionuclide therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Genotypes and Experimental Advances in Xenotransplantation

edited by Konrad Fischer

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1827 | Submission Open

Keywords: xenotransplantation; genetic engineering; preclinical models; genetically modified donor organs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Targeted Therapy and Immunotherapy for Lung Cancer

edited by

Walid Shalata

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1816 | Submission Open

Keywords: lung cancer; small-cell lung cancer; non-small-cell lung cancer; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 1901-1950 on page 39 of 64.

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