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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Microsatellite Instability (MSI) and Mismatch Repair Deficient (dMMR)-Related Diseases: From Detection Methods to Practice
edited by Federica Zito Marino
submission deadline 20 Aug 2025 | 1 articles | Viewed by 495 | Submission Open
Keywords: microsatellite instability (MSI); mismatch repair deficient (dMMR); immunotherapy; next-generation sequencing (NGS); immunohistochemistry (IHC); polymerase chain reaction (PCR); MSI-positive tumors
(This special issue belongs to the Section Molecular Biology)
Mechanistic and Small Molecule Discoveries for Therapeutic Advances in Hypertrophic and Dilated Cardiomyopathies
edited by Osha Roopnarine
submission deadline 20 Aug 2025 | Viewed by 488 | Submission Open
Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathies; cardiomyopathies
(This special issue belongs to the Section Molecular Pharmacology)
Revolutionizing Antifungal Therapeutics: From Understanding to Intervention submission deadline 20 Aug 2025 | Viewed by 484 | Submission Open
Keywords: fungi; antifungal; biofilm; Candida; Aspergillus; Trichoderma
(This special issue belongs to the Section Molecular Microbiology)
Physiological and Molecular Mechanisms of Abiotic Stresses in Crops submission deadline 20 Aug 2025 | Viewed by 480 | Submission Open
Keywords: abiotic stress; plant physiology; signaling pathways; plant molecular biology; resistance; crop yield and quality
(This special issue belongs to the Section Molecular Plant Sciences)
The Role of Genome in Cancer Therapy
edited by Yoav Smith and Hovav Nechushtan
submission deadline 20 Aug 2025 | Viewed by 444 | Submission Open
Keywords: genome analysis; molecular therapy; drug resistance; cancer genetic
(This special issue belongs to the Section Molecular Genetics and Genomics)
Mechanisms of Protein–Ligand Interactions in Therapies for Lifestyle Diseases and Their Complications
edited by Agnieszka Szkudlarek
submission deadline 20 Aug 2025 | Viewed by 443 | Submission Open
Keywords: chronic diseases and their complications; protein– ligand interactions; protein modifications; therapeutic efficacy; binding affinity; serum proteins; pharmaceutical applications; biomedical research
(This special issue belongs to the Section Molecular Biology)
Molecular Insights in Hepatic Disease and Hepatocellular Carcinoma
edited by and Jong-Young Choi
submission deadline 20 Aug 2025 | Viewed by 437 | Submission Open
Keywords: hepatology; viral hepatitis; liver cirrhosis; hepatocellular carcinoma; liver transplantation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Development Breakthroughs: From Novel Antimicrobials to Targeted Cancer Drugs submission deadline 20 Aug 2025 | Viewed by 432 | Submission Open
Keywords: drug development; molecular science; small-molecule inhibitors; biopharmaceuticals; peptides; cancer therapy
(This special issue belongs to the Section Molecular Pharmacology)
Recent Advances in the Application of NMR Spectroscopy to Study Structure and Dynamics of Proteins
edited by Harindranath Kadavath
submission deadline 20 Aug 2025 | Viewed by 430 | Submission Open
Keywords: proteins; dynamics; NMR spectroscopy; structure– dynamics– function; protein folding; protein– protein interactions; in-cell NMR; biomolecular structure; intrinsically disordered proteins (IDPs)
(This special issue belongs to the Section Molecular Biology)
Yeast Models in Genetic and Molecular Research
edited by
submission deadline 20 Aug 2025 | Viewed by 418 | Submission Open
Keywords: yeast; genome; epigenetics; chemogenomics; DNA repair
(This special issue belongs to the Section Molecular Biology)
Solanaceae Biology: From Genetics to Metabolism
edited by
submission deadline 20 Aug 2025 | Viewed by 380 | Submission Open
Keywords: Solanaceae; nightshade family; tomato; potato; tobacco; eggplant; genetics; metabolism; crop improvement; specialized metabolite
(This special issue belongs to the Section Molecular Plant Sciences)
Cellular Senescence as a Therapeutic Target in Cancer: Mechanisms, Challenges, and Therapeutic Opportunities
edited by
submission deadline 20 Aug 2025 | Viewed by 380 | Submission Open
Keywords: cellular senescence; cancer therapy; therapeutic targeting; senolytic drugs; senescence-associated secretory phenotype (SASP)
(This special issue belongs to the Section Molecular Oncology)
Interfaces for the Impact of Magnetic Pulses or EMF in Molecular Biology
edited by Richard H. W. Funk
submission deadline 20 Aug 2025 | Viewed by 374 | Submission Open
Keywords: electromagnetic treatment; magnetic pulses; biological interface; cell biology; molecular biology; signaling cascades; clinical treatment; monitoring; sensors
(This special issue belongs to the Section Molecular Biophysics)
Cellular Senescence and the Senescence-Associated Secretory Phenotype (SASP) in Age-Related Diseases
edited by Jordi Olloquequi
submission deadline 20 Aug 2025 | Viewed by 373 | Submission Open
Keywords: cellular senescence; senescence-associated secretory phenotype (SASP); age-related diseases; atherosclerosis; chronic obstructive pulmonary disease (COPD); type 2 diabetes mellitus (T2DM); non-alcoholic fatty liver disease (NAFLD); Alzheimer’ s disease (AD); inflammation; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into Autophagy and Retinal Degeneration
edited by
submission deadline 20 Aug 2025 | Viewed by 370 | Submission Open
Keywords: autophagy; retinal degeneration; retinal inflammation; oxidative stress; retinal alterations; age-related macular degeneration; retinal damage; inflammatory processes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cancer Immunotherapy Biomarkers
edited by Ilias P. Nikas, and
submission deadline 20 Aug 2025 | Viewed by 367 | Submission Open
Keywords: tumor microenvironment; tumor immunology; cancer biomarkers; immunotherapy; immunohistochemistry; pathology; personalized medicine; omics technologies; prognosis and therapy; bioinformatics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Aging: From Molecular Mechanisms and Pathophysiology to Novel Therapeutic Approaches (3rd Edition) submission deadline 20 Aug 2025 | 1 articles | Viewed by 366 | Submission Open
Keywords: human aging; molecular clock; aging genes; epigenetics; nutrigenomics; inflammaging; stem cells; telomeres; mitochondria; brain-gut axis; brain-muscle axis; gut microbiota; chronodisruption
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Neurodegeneration and Neuroprotection for Retinal and Optic Nerve Diseases
edited by
submission deadline 20 Aug 2025 | Viewed by 358 | Submission Open
Keywords: neuroprotection; neurodegeneration; neuronal cell death; regeneration; cell death and survival pathways; neurovascular unit; oxidative stress; inflammation; advanced glycation end products; ischemia; optic nerve injuries; glaucoma; optic neuritis; retinitis pigmentosa; diabetic retinopathy; age-related macular degeneration; retinal vein/artery occlusion; gene therapy; cell plantation; nutrients; neuroprotectants; drug delivery; translational research
(This special issue belongs to the Section Molecular Neurobiology)
Roles of Phytochemicals in Cancer Prevention and Therapeutics: 2nd Edition submission deadline 20 Aug 2025 | Viewed by 356 | Submission Open
Keywords: phytochemicals; cancer prevention; cancer therapeutics; oxidative stress; inflammation; energetic metabolism
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Exploring the Impact of the Biological Clock on Health and Disease
edited by
submission deadline 20 Aug 2025 | Viewed by 348 | Submission Open
Keywords: circadian rhythm; inflammation; oxidative stress; energy balance; metabolic syndrome; ageing; cancer; diabetes; obesity; entrainment; synchrony; melatonin
(This special issue belongs to the Section Molecular Biology)
Exploring Organic Compounds in Photodynamic Therapy: Synthesis, Mechanism of Action and Biological Potential submission deadline 20 Aug 2025 | Viewed by 344 | Submission Open
Keywords: organic photosensitizers; photodynamic therapy; synthetic strategies; mechanism of action; cancer cells; microorganisms
(This special issue belongs to the Section Biochemistry)
Experimental Models and Applications in Muscle Regeneration
edited by
submission deadline 20 Aug 2025 | Viewed by 341 | Submission Open
Keywords: stem cells; internal and external stimuli; scaffolds; signaling systems; muscle regeneration mechanisms
(This special issue belongs to the Section Molecular Biology)
Exploring the Role of Antioxidants in Supplements and Drug Responses
edited by
submission deadline 20 Aug 2025 | Viewed by 335 | Submission Open
Keywords: NSAIDs; glucocorticoids; vitamin E; antioxidants; oxidative stress; inflammation
(This special issue belongs to the Section Molecular Immunology)
Insights into Neurological and Psychiatric Diseases from Invertebrate Models submission deadline 20 Aug 2025 | Viewed by 334 | Submission Open
Keywords: disease model development; disease model validation; GWAS validation; ameliorative approaches; pharmacogenetics; pharmacoproteomics; disease mechanisms; suppressor/enhancer genetic screens; synthetic lethality screens; biomarker screens and validation
(This special issue belongs to the Section Molecular Neurobiology)
Advancements and Applications of Phyto-Nanotherapy in Targeted Disease Treatment submission deadline 20 Aug 2025 | Viewed by 329 | Submission Open
Keywords: phyto-nanotherapy; medicinal plants; nanoparticles; targeted drug delivery; phytochemicals; phytotherapy; green nanotechnology; chronic diseases; infectious diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Roles and Functions of Micronutrients in Gut Microbiota and Intestinal Inflammation
edited by
submission deadline 20 Aug 2025 | Viewed by 328 | Submission Open
Keywords: micronutrients; gut microbiota; intestinal inflammation; intestinal barrier; oxidative stress
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Role of Cannabinoids in Human Health and Disorder
edited by and Beatrice Polini
submission deadline 20 Aug 2025 | Viewed by 327 | Submission Open
Keywords: cannabinoids; cannabinoid receptors; endocannabinoid system; ECS synthetic modulators; clinical trials
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Nanomaterials in Immunology submission deadline 20 Aug 2025 | Viewed by 327 | Submission Open
Keywords: nanomaterials; immunology; nanoparticles; drug delivery; cancer immunotherapy; immune modulation; vaccine adjuvants; immunotoxicity; autoimmune diseases; biocompatibility; nanotechnology in immune diseases; nanostructures in tissue engineering; nanomedicine; diagnostic nanomaterials; immune cell interaction
(This special issue belongs to the Section Molecular Nanoscience)
Advance in Plant Abiotic Stress: 3rd Edition
edited by and
submission deadline 20 Aug 2025 | Viewed by 325 | Submission Open
Keywords: abiotic stress; cold; drought; salt; heat; nutrient deficiency; secondary metabolism; stress resistance; plant
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Biological Determination of Physical Injury
edited by
submission deadline 20 Aug 2025 | Viewed by 320 | Submission Open
Keywords: molecular markers; physical injury; micro-RNA; dating of traumatic injuries
(This special issue belongs to the Section Molecular Biology)
Advances in Heparin, Heparan Sulfate and Heparanase, 2nd Edition
edited by
submission deadline 20 Aug 2025 | Viewed by 311 | Submission Open
Keywords: allergy; angiogenesis; cancer metastasis; cellular trafficking; exosome; fibrosis; glycocalyx; glycosaminoglycans; heparan sulfate; heparanase; heparin; immune responses; inflammation; inbibitor development; sepsis/SIRS (systemic inflammatory response syndrome); sulfatase; viral infections
(This special issue belongs to the Section Macromolecules)
Gynecological Oncology: From Molecular Basis to Therapy
edited by and Lars Hanker
submission deadline 20 Aug 2025 | Viewed by 304 | Submission Open
Keywords: gynecological oncology; molecular basis; targeted therapy; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Exploring Mitochondria in Neurodegenerative Disorders: Unveiling Mechanisms and Therapeutic Strategies
edited by and Mohamad-Reza Aghanoori
submission deadline 20 Aug 2025 | Viewed by 291 | Submission Open
Keywords: neurodegenerative disorders; energy homeostasis and metabolism; mitochondrial dysfunction; mitochondrial dynamics; mitophagy and autophagy; synaptic function; axonal transport; oxidative stress; calcium homeostasis; treatments targeting mitochondria; mitochondrial biogenesis; neuroprotection; therapeutic strategies
(This special issue belongs to the Section Molecular Neurobiology)
Cellular and Molecular Mechanisms of Cardiovascular Repair
edited by
submission deadline 20 Aug 2025 | Viewed by 290 | Submission Open
Keywords: fibroblasts; injury repair; cardiac scar; extracellular matrix; fibrosis; angiogenesis; inflammation; cardioprotection
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Melatonin in Plants: 3rd Edition submission deadline 20 Aug 2025 | Viewed by 283 | Submission Open
Keywords: melatonin; phytomelatonin; plants; seed germination; seasonal and circadian rhythms; flowering; fruit ripening; plant immunity; abiotic stresses
(This special issue belongs to the Section Molecular Plant Sciences)
Nanotechnology in Drug Delivery: Applications and Perspectives
edited by Ádám Juhász
submission deadline 20 Aug 2025 | Viewed by 275 | Submission Open
Keywords: nanostructured materials; drug delivery; drug– carrier interactions; hydrogel; aerogels; associated colloids; surfactants; macromolecules; blood– brain barrier; controlled release
(This special issue belongs to the Section Molecular Nanoscience)
Artificial Intelligence in Human Disease: Current and Future Perspectives in Digital Medicine submission deadline 20 Aug 2025 | Viewed by 275 | Submission Open
Keywords: molecular genetics; artificial intelligence; pharmacogenomics; internet of things; molecular pathology; genomic medicine
(This special issue belongs to the Section Molecular Informatics)
Inflammation and Metabolic Response in Mitochondrial Diseases
edited by
submission deadline 20 Aug 2025 | Viewed by 275 | Submission Open
Keywords: mitochondrial diseases; mitochondria; mtDNA; metabolic remodeling; inflammation; immunity; cell death; neurodegenration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Fruit Crops Development
edited by
submission deadline 20 Aug 2025 | Viewed by 271 | Submission Open
Keywords: fruit crops; fruit tree; proteomics; genomics; metabolomics; biotic stress; abiotic stress
(This special issue belongs to the Section Molecular Plant Sciences)
Genetic Mechanisms of Neurological Disorders
edited by and Sara Duarte-Silva
submission deadline 20 Aug 2025 | Viewed by 268 | Submission Open
Keywords: neurodevelopmental disorders; neurodegenerative disorders; neuropsychiatric disorders; genetics; molecular biology; cellular models; animal models; pathogenesis; biomarkers; therapeutic targets; drug discovery; therapy  
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Insights in Nanomaterials and Electroactive Molecules—in Memory of Prof. Royce W. Murray
edited by
submission deadline 20 Aug 2025 | Viewed by 259 | Submission Open
Keywords: nanomaterials; organic electrochemistry; macromolecules and polymers; analytical chemistry
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Advances on Solubility and Diffusivity in Water-Based Systems and in Biological Media submission deadline 20 Aug 2025 | 1 articles | Viewed by 248 | Submission Open
Keywords: water solubility  ; water-solute interactions  ; solvation; hydrophobic and hydrophilic effects  ; improving water solubility and prediction  ; solution of chemicals in biological media  ; diffusivity  ; drug transport and bioavailability; chemicals diffusivity across biological barriers
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Signaling Pathways in Neuroinflammation or Neurodegenerative Disorders
edited by
submission deadline 20 Aug 2025 | Viewed by 245 | Submission Open
Keywords: inflammation; neuroinflammation; oxidative stress; neurodegenerative disorders; pathology; molecular pathways; dysregulation; mitochondrial dysfunction
(This special issue belongs to the Section Molecular Neurobiology)
Tumor Specific Immunotherapeutic Targets
edited by
submission deadline 20 Aug 2025 | Viewed by 231 | Submission Open
Keywords: immunotherapy; immunotherapeutics; tumour-specific antigens; immunotherapeutic targets; multi-omics approaches
(This special issue belongs to the Section Molecular Immunology)
New Insights into Hyaluronan in Human Medicine
edited by
submission deadline 20 Aug 2025 | Viewed by 211 | Submission Open
Keywords: hyaluronan; regenerative medicine; inflammation; cancer therapy; metabolomics  ; hyaluronidases; cell– matrix interaction; glucose metabolism; pathological processes
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms of Tumorigenesis of Human and Animal Stem Cells
edited by
submission deadline 20 Aug 2025 | Viewed by 210 | Submission Open
Keywords: malignancy; stem cells; safety; chromosal aberrations; animal; human; teratoma assay; in vitro assays
(This special issue belongs to the Section Molecular Oncology)
Advances in the Purinergic System
edited by Margarete Dulce Bagatini
submission deadline 20 Aug 2025 | Viewed by 209 | Submission Open
Keywords: purinergic system; receptors; ectonucleotidases; CD39; CD73; purinergic signaling
(This special issue belongs to the Section Biochemistry)
Modulation of the Immune System and Oxidative Stress in Liver Illnesses
edited by and Dan Ionuț Gheonea
submission deadline 20 Aug 2025 | Viewed by 204 | Submission Open
Keywords: oxidative stress; liver illnesses; immune system; inflammatory
(This special issue belongs to the Section Molecular Immunology)
Research Progress of Nanodrug Delivery System
edited by Kenta Morita
submission deadline 20 Aug 2025 | Viewed by 200 | Submission Open
Keywords: drug delivery; nanomaterials; nanomedicine; pharmacokinetics; theranostics; imaging; controlled release
(This special issue belongs to the Section Molecular Nanoscience)
Obesity and Cancer Risk: Molecular Mechanisms and Perspectives
edited by
submission deadline 20 Aug 2025 | Viewed by 194 | Submission Open
Keywords: epidemiology of obesity and cancer; experimental models of cancer in obesity; genetic and epigenetics of obesity and metabolic dysfunction associated cancer; tumor microenvironment; basis of metastatic spread of cancer in obesity; therapeutic modeling and targeting
(This special issue belongs to the Section Molecular Oncology)
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