Signaling Pathways in Neuroinflammation or Neurodegenerative Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (20 February 2026) | Viewed by 1892
Special Issue Editor
Interests: oxidative stress; nutrition; cell physiology; animal model; inflammation; molecular pathways
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Research into neurodegenerative illnesses, such as Huntington's, Parkinson's, and Alzheimer's disease and amyotrophic lateral sclerosis, has revealed that inflammation plays a critical role in the process of neurodegeneration in addition to being a symptom of it. Protein aggregates, a prevalent pathogenic feature in neurodegeneration, can trigger neuroinflammation, exacerbating both the neurodegenerative process and the protein aggregates. In fact, inflammation occurs even before the aggregation of proteins. For instance. certain susceptible populations may experience protein deposition as a result of neuroinflammation brought on by genetic differences in CNS cells or by peripheral immune cells. Though they are still far from being fully understood, a variety of CNS cells and a number of signaling pathways have been implicated in the etiology of neurodegeneration. This Special Issue aims to provide a thorough overview of the variables influencing neuroinflammation and the main inflammatory signaling pathways implicated in the pathophysiology of neurodegenerative illnesses. In vitro and in vivo investigations are welcome as well as clinical studies that provide compelling scientific evidence for the effectiveness of novel molecular mechanisms limiting the onset of neurodegenerative disorders.
Dr. Marika Cordaro
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- inflammation
- neuroinflammation
- oxidative stress
- neurodegenerative disorders
- pathology
- molecular pathways
- dysregulation
- mitochondrial dysfunction
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
