The Role of Cannabinoids in Human Health and Disorder
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 773
Special Issue Editors
Interests: metabolic biochemistry; thyroid hormone analogs and metabolites; vitamin D analogs; drug design, synthesis and development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cannabinoid receptors, endocannabinoids, and the enzymes responsible for their biosynthesis and degradation constitute the endocannabinoid system (ECS). The ECS controls many basic biological processes, exerting its activity in the nervous system and in peripheral tissues, with direct involvement in synaptic plasticity and neuroprotection, pain control, stress response, reproduction, food intake and energy balance, immune response, and cancer progression.
As a result, ECS impairment has been reported in several diseases, and its modulation currently represents a possible therapeutic strategy for the treatment of numerous pathological conditions, including neurological diseases, mental and behavioral disorders, pain, inflammation, osteoporosis, cardiovascular disorders, obesity and cancer. Considering the importance of the ECS and the therapeutic potential of cannabinoids in this vast number of medical conditions, numerous ECS synthetic modulators have been developed over the past two decades, and several clinical studies are currently ongoing.
Prof. Dr. Grazia Chiellini
Dr. Beatrice Polini
Guest Editors
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Keywords
- cannabinoids
- cannabinoid receptors
- endocannabinoid system
- ECS synthetic modulators
- clinical trials
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