Insights into Neurological and Psychiatric Diseases from Invertebrate Models
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 331
Special Issue Editor
Interests: mechanisms of associative and nonassciative learning and memory; Drosophila and mouse models of intelectual disability; neurological and psychiatric conditions
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The plethora of data produced by the -omic and GWAS studies of neurological and psychiatric disease patients needs experimental validation and mechanistic investigation. This includes, but is not limited to, determination of the potential effects of GWAS-identified polymorphisms on the expression of proximal gene(s) and linking these effects to disease manifestations. Changes in gene expression levels or the abundance of proteins or molecular interactions identified by various -omics approaches have to be tested experimentally and placed in the context of disease manifestations. Moreover, the genetic underpinnings of numerous neurological and psychiatric conditions still remain unclear and in need of a versatile genetic model to expediently test predictions and hypotheses stemming from patient genomic data. Over a century of invertebrate research resulted in powerful invertebrate, with Drosophila melanogaster and Caenorhabditis elegans acting as leading genetic models that offer unsurpassed genetic and molecular tools, expedience, and a rich and expandable repertoire of behaviors that can be used or adapted to model specific aspects and manifestations of neurological and psychiatric conditions.
This Special Issue aims to host experimental research contributions and reviews on the development and use of invertebrate models of neurological and psychiatric conditions, validation of GWAS hits and -omics linkages, genetic and molecular explorations of disease mechanisms, and potential ameliorative approaches.
Prof. Dr. Efthimios M. C. Skoulakis
Guest Editor
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Keywords
- disease model development
- disease model validation
- GWAS validation
- ameliorative approaches
- pharmacogenetics
- pharmacoproteomics
- disease mechanisms
- suppressor/enhancer genetic screens
- synthetic lethality screens
- biomarker screens and validation
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