Recent Advances in the Application of NMR Spectroscopy to Study Structure and Dynamics of Proteins
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 431
Special Issue Editor
2. Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
Interests: biomolecular NMR spectroscopy; in-cell NMR; oncogenic proteins; neurodegenerative diseases; kinase; KRAS; structural biology; protein dynamics; protein allostery
Special Issue Information
Dear Colleagues,
Proteins are inherently dynamic biomolecules with motions spanning a large range in magnitude and timescale and it is well known that dynamics have important roles in the function of biomolecules. To better understand the structure–dynamics–function paradigm of proteins, information on their three-dimensional structure and description of their dynamics is required. Nuclear Magnetic Resonance (NMR) spectroscopy has emerged as a powerful and versatile tool for investigating biomolecular structure and dynamics. Investigating protein folding mechanisms, and protein–protein and protein–ligand interactions at atomic resolution can reveal the molecular mechanisms underlying various biological processes.
While most NMR-based structural biology approaches are mostly performed under in vitro conditions, the contribution of the intracellular environment to protein structure and dynamics is absent. This demands the in-depth investigation of proteins in living cells and in-cell NMR is an emerging technique to study the structure and dynamics of proteins in living cells at atomic resolution.
To this end, this Special Issue aims to provide a comprehensive overview of the latest advancements and applications of NMR in protein science, under both in vitro and in-cell conditions. We welcome original research, review articles, and short communications about different kinds and aspects of NMR studies for proteins and other biomolecules. Topics of interest include but are not limited to structure determination, protein dynamics, protein–ligand interactions, folding and misfolding, intrinsically disordered proteins (IDPs) and in-cell NMR. In this regard, I would be delighted if you would agree to contribute to this Special Issue either with an original research article, a short communication, or a review.
Dr. Harindranath Kadavath
Guest Editor
Manuscript Submission Information
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Keywords
- proteins
- dynamics
- NMR spectroscopy
- structure–dynamics–function
- protein folding
- protein–protein interactions
- in-cell NMR
- biomolecular structure
- intrinsically disordered proteins (IDPs)
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