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Nanomaterials in Immunology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 744

Special Issue Editor


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Guest Editor
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, RO-011061 Bucharest, Romania
Interests: synthesis and characterization of nanobiomaterials; polymers; pharmaceutical nanotechnology; drug delivery; anti-biofilm surfaces; nanomodified surfaces; natural products
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Special Issue Information

Dear Colleagues,

Nanomaterials have emerged as powerful tools in biomedical research, especially in the field of immunology. Their unique properties—such as their small size, high surface area, and the ability to be engineered for specific functions—make them ideal for applications in immune-related therapies. These materials offer new opportunities for improving the delivery of drugs, enhancing the effectiveness of vaccines, and developing treatments for diseases that involve the immune system.

This Special Issue, titled "Nanomaterials in Immunology", aims to highlight recent advances in this rapidly growing area of research. We invite you to submit your work, whether it be original research or reviews, that explores how nanomaterials can be used to interact with, modulate, or enhance the immune response. Studies that examine the safety and biocompatibility of these materials, as well as their potential for clinical applications, are particularly welcome.

Topics of interest include, but are not limited to, the following:

  • Nanomaterials as adjuvants in vaccines;
  • Immunotoxicity and safety assessment of nanomaterials;
  • Nanoparticle-mediated drug delivery for autoimmune diseases;
  • Nanomaterials in cancer immunotherapy;
  • Role of nanomaterials in immunomodulation;
  • Interaction of nanomaterials with immune cells (T cells, B cells, macrophages, and dendritic cells);
  • Nanotechnology in allergy treatments;
  • Nanomaterials for enhancing antiviral and antibacterial immunity;
  • Biocompatibility and biodegradability of nanomaterials in immunological applications;
  • Nanostructures in tissue engineering and immunoregeneration;
  • Use of nanomaterials in diagnostic tools for immune diseases.

We look forward to receiving your valuable contributions that will advance our understanding of how nanomaterials can revolutionize immunology and related biomedical fields.

Prof. Dr. Alexandru Mihai Grumezescu
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • nanomaterials
  • immunology
  • nanoparticles
  • drug delivery
  • cancer immunotherapy
  • immune modulation
  • vaccine adjuvants
  • immunotoxicity
  • autoimmune diseases
  • biocompatibility
  • nanotechnology in immune diseases
  • nanostructures in tissue engineering
  • nanomedicine
  • diagnostic nanomaterials
  • immune cell interaction

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Published Papers (1 paper)

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Research

29 pages, 5997 KiB  
Article
DMPC-Based Liposomal Vesicles for Encapsulation and Controlled Release of NMN and Matrigel in Sarcopenia Therapy
by Alfred Najm, Alexandra Cătălina Bîrcă, Adelina-Gabriela Niculescu, Adina Alberts, Alexandru Mihai Grumezescu, Bianca Gălățeanu, Bogdan Ștefan Vasile, Mircea Beuran, Bogdan Severus Gaspar, Claudiu Ștefan Turculeț and Ariana Hudiță
Int. J. Mol. Sci. 2025, 26(12), 5594; https://doi.org/10.3390/ijms26125594 - 11 Jun 2025
Viewed by 328
Abstract
Accurate diagnosis of diseases in patients is crucial, particularly in older individuals, where the focus is often placed primarily on advanced age and its associated symptoms. However, advancements in technology and research have revealed that certain diseases traditionally linked to aging can also [...] Read more.
Accurate diagnosis of diseases in patients is crucial, particularly in older individuals, where the focus is often placed primarily on advanced age and its associated symptoms. However, advancements in technology and research have revealed that certain diseases traditionally linked to aging can also manifest in younger populations, demonstrating similar bodily changes. One such condition is sarcopenia, a degenerative disease of skeletal muscle that arises from various pathological processes affecting the tissues. In this study, we developed a liposomal formulation based on 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), in which both nicotinamide mononucleotide (NMN) and Matrigel (Mgel) were co-encapsulated, each playing a distinct role in the management of sarcopenia. NMN is known to stimulate the increase of NAD+ levels, while Matrigel enhances the activity of satellite cells, thereby facilitating muscle fiber regeneration and stabilizing protein levels. Results from the DLS, SEM, and TEM analyses revealed significant differences attributed to the type of therapeutic agent used and the synthesis parameters. Additionally, the drug release profile underscored the complementary nature and significance of selecting the appropriate active substances for effective treatment strategies. The in vitro investigations aimed to assess the potential of DMPC lipid vesicles loaded with NMN, either alone or in combination with Matrigel, to counteract sarcopenia-associated oxidative stress and mitochondrial dysfunction. The results showed that both NMN-based formulations reduced oxidative damage, preserved mitochondrial function, and maintained cytoskeletal integrity in a hydrogen peroxide-induced model of sarcopenia. Importantly, the formulation containing both NMN and Matrigel demonstrated superior protective effects, suggesting a synergistic role of the extracellular matrix components in enhancing muscle cell resilience. These findings support the use of DMPC-based delivery systems as promising candidates for sarcopenia therapy and warrant further investigation into their mechanisms of action in preventing muscle cell degeneration. Full article
(This article belongs to the Special Issue Nanomaterials in Immunology)
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