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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Amyotrophic Lateral Sclerosis: From Molecular Basis to Therapies

edited by

Matteo Bordoni

submission deadline 20 Nov 2026 | 3 articles | Viewed by 7841 | Submission Open

Keywords: ALS; pathomechanisms; genetics; epigenetics; disease models; neuroinflammation; mithocondria; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Cancer Stem Cells

edited by

Ilze Štrumfa

and Inta Liepniece-Karele

submission deadline 20 Nov 2026 | 5 articles | Viewed by 6559 | Submission Open

Keywords: cancer stem cells; tumour microenvironment; pancreatic cancer; glioblastoma; gastric cancer; breast cancer; lung cancer; colorectal cancer; renal cancer; liver cancer; melanoma; leukemia; lymphoma

(This special issue belongs to the Section Molecular Oncology)

Bioactives from Natural Products

edited by

Antía González Pereira

submission deadline 20 Nov 2026 | 4 articles | Viewed by 6332 | Submission Open

Keywords: natural products; bioactive compounds; therapeutic potential; secondary metabolites; omics technologies; biotechnology; phytochemistry; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advancing Precision Medicine in Urological Cancers: Integrating Multi-Omics and Optimizing Therapeutic Approaches

edited by Magaly Martinez-Ferrer

submission deadline 20 Nov 2026 | 1 articles | Viewed by 6034 | Submission Open

Keywords: prostate cancer; proteomics; metabolomics; precision medicine; biomarker

(This special issue belongs to the Section Molecular Oncology)

Genomics, Genetics, and the Future of Fruit Improvement

edited by Zoe Hilioti

submission deadline 20 Nov 2026 | 4 articles | Viewed by 4883 | Submission Open

Keywords: fruit traits; genetics; genetic diversity; omics; new breeding techniques; fruit quality; shelf life

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Cancer Stem Cells

edited by

Sabrina Battista

submission deadline 20 Nov 2026 | 1 articles | Viewed by 3753 | Submission Open

Keywords: self-renewal; microenvironment; plasticity; epigenetics; epithelial-mesenchymal transition; heterogeneity; targeting; dormancy

(This special issue belongs to the Section Biochemistry)

Molecular Research on Dyslipidemia

edited by

Aleksandra Zeljkovic

and

Jelena Vekić

submission deadline 20 Nov 2026 | 2 articles | Viewed by 3640 | Submission Open

Keywords: dyslipidemia; chronic non-communicable diseases; dysregulation of lipid homeostasis; genetic and epigenetic regulation; lipidomics in personalized medicine; lipid biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomolecular Condensates and Their Role in Cellular Organization and Disease

edited by Anna Bratek-Skicki

submission deadline 20 Nov 2026 | 1 articles | Viewed by 3157 | Submission Open

Keywords: biocondensates; membrane-less organelles; liquid-liquid phase separation; protein aggregation; neurogenerative diseases

(This special issue belongs to the Section Molecular Biology)

Next-Generation Therapeutic Polymers: From Molecular Design to Dual Antibacterial/Antithrombotic Action

edited by

Piotr Dobrzynski

submission deadline 20 Nov 2026 | 2 articles | Viewed by 3146 | Submission Open

Keywords: antibacterial polymers; antifouling polymers; anticoagulant polymers; heparin-mimicking polymers; heparin-conjugated polymers; phosphorylcholine-based polymers; polymeric nitric oxide donors; polymers, loaded with silver ions, or antibiotics; antibacterial nano- and micro particles; anticoagulant layers

(This special issue belongs to the Section Materials Science)

Alzheimer’s Disease: Molecular Mechanisms and Novel Therapies

edited by Noah R. Johnson and

Chih Hung Lo

submission deadline 20 Nov 2026 | 3 articles | Viewed by 3005 | Submission Open

Keywords: intrinsically disordered proteins; apolipoproteins; neuroinflammation and neuroimmune; autolysosomal and mitochondrial functions; lipid metabolism; blood-brain barrier; biosensors; nanomedicine; high-throughput screening; therapeutic discovery

(This special issue belongs to the Section Molecular Neurobiology)

Allergic Reactions and Immune Factors

edited by

Liborija Lugovic-Mihic

submission deadline 20 Nov 2026 | 4 articles | Viewed by 2947 | Submission Open

Keywords: allergic reactions; immunity; immunological factors; hypersensitivity; antibody; cytokine; immune response; etiology; pathogenesis; clinical manifestations; diagnostic; therapy

(This special issue belongs to the Section Molecular Immunology)

Advancements in Novel Drug Delivery Systems for Gene and Drug Delivery

edited by

Rosamaria Pennisi

submission deadline 20 Nov 2026 | 2 articles | Viewed by 2670 | Submission Open

Keywords: drug and gene delivery; novel drug delivery systems; nanoparticle-based delivery systems

(This special issue belongs to the Section Molecular Biology)

Current Research on Colloidal Emulsions: Preparation and Applications

edited by Alexander Djerdjev

submission deadline 20 Nov 2026 | 2 articles | Viewed by 2606 | Submission Open

Keywords: emulsion formulation and stability; nano-, micro-, and high-internal-phase emulsions; drug delivery; aerogels; pickering emulsions; food emulsions; oil–water interface; surfactants; zeta potential at hydrophobic interfaces; advances in emulsion technology

(This special issue belongs to the Section Materials Science)

Current Research on Autophagy in Aging and Age Related Diseases

edited by

Tímea Sigmond

submission deadline 20 Nov 2026 | 2 articles | Viewed by 2297 | Submission Open

Keywords: autophagy; aging; molecular mechanisms; age related diseases; mitochondria

(This special issue belongs to the Section Biochemistry)

Recent Progress in Synthesis, Properties, and Applications of Polyoxometalates and Their Nanocrystals

edited by

Xiang Ma

and

Pengtao Ma

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1971 | Submission Open

Keywords: polyoxometalates; POMs; metal cluster compound; inorganic chemistry; nanocrystals

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

New Advances in Animal Reproduction

edited by Valdevane Rocha Araújo

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1958 | Submission Open

Keywords: folliculogenesis; oogenesis; oocyte maturation; follicle growth; preantral follicles; antral follicles; spermatogenesis; spermatozoa; bioengineering; scaffolds

(This special issue belongs to the Section Molecular Biology)

Plant Responses to Abiotic and Biotic Stresses: 2nd Editon

edited by

Longxing Tao

and

Tingting Chen

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1884 | Submission Open

Keywords: climate change and crop production; abiotic stress; biotic stress; plant resistance to abiotic and biotic stresses; molecular mechanism; physiological responses; plant hormones; carbohydrate metabolism and transport; molecular signaling; reactive oxygen species (ROS); calcium ions; photosynthesis; respiration; energy metabolism

(This special issue belongs to the Section Molecular Plant Sciences)

Responses of Plants to Abiotic and Biotic Stresses: Concepts and Mechanisms

edited by

Ning Liu

submission deadline 20 Nov 2026 | 2 articles | Viewed by 1847 | Submission Open

Keywords: plant stress tolerance; abiotic stresses; biotic stresses; molecular mechanisms; signal pathways; multi-omics technologies; epigenetic modifications; crop resilience

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Sepsis: Molecular and Biochemical Perspectives

edited by

Akrivi Chrysanthopoulou

submission deadline 20 Nov 2026 | 2 articles | Viewed by 1785 | Submission Open

Keywords: sepsis; outcome; molecular diagnosis; machine learning; biochemical biomarkers; targeted immunotherapy; personalized medicine; sepsis inflammatory endotypes

(This special issue belongs to the Section Biochemistry)

Marine Natural Products as a Source of Therapeutics—Recent Trends

edited by

Komal Anjum

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1600 | Submission Open

Keywords: marine natural products; marine-associated microbes; antimicrobial drug; antibiotics; marine-derived peptides; anti-inflammatory; molecular pharmacology; targeted therapies; extraction

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Dietary Polyphenols and Human Health

edited by

Chunmei Li

submission deadline 20 Nov 2026 | 2 articles | Viewed by 1463 | Submission Open

Keywords: natural polyphenols; health and disease; neurodegenerative diseases; gut microbiota; lowest effective dose; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Radiobiology: New Challenges and Advances

edited by

Lorenzo Manti

and

Pavel Bláha

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1458 | Submission Open

Keywords: strategies for overcoming cancer radioresistance and normal-tissue damage mitigation; combined approaches: BNCT, proton–boron capture therapy, radioimmunotherapy; emerging technologies and novel temporal regimes: FLASH RT mechanisms and radiobiology of laser-accelerated particles; radiobiology of new ions and of novel dose-delivery modalities in particle radiotherapy; limphopoenia in radiotherapy and biomarkers of radiation response; three-dimensional models; microdosimetry: standardising measurements; DNA damage/repair; tumour microenvironment: autophagy, ferroptosis, fibroblast activation protein; non-cancer effects and non-targeted effects

(This special issue belongs to the Section Molecular Biology)

Molecular Understanding Involved in Age-Related Diseases

edited by

David Della-Morte

and

Francesca Pacifici

submission deadline 20 Nov 2026 | 2 articles | Viewed by 1318 | Submission Open

Keywords: sirtuins; frailty; aging; age-related diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathogenesis and Treatment Approaches of Hematological Malignancies

edited by

Yosuke Minami

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1280 | Submission Open

Keywords: leukemia; lymphoma; minimal residual disease (MRD); cancer genomic profiling (CGP); molecular targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Biophysical Studies of Protein Structure-Function Relationships

edited by

Almerinda Di Venere

Giampiero Mei

and Velia Minicozzi

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1141 | Submission Open

Keywords: protein structure; molecular dynamics; computational modeling; drug discovery

(This special issue belongs to the Section Molecular Biophysics)

Metal-Organic Frameworks: Pioneering New Solutions for Biomedical Challenges

edited by

David Rodríguez-Lucena

and

Belén Begines

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1055 | Submission Open

Keywords: MOFs; biomedical advances; drug delivery; personalized medicine; biomedical imaging; bio-sensor; smart MOFs; nanomedicine; cancer therapy

(This special issue belongs to the Section Materials Science)

Molecular Insights into Pediatric Cancer: Advances in Hematopoietic Stem Cell Research

edited by

Paola Muggeo

submission deadline 20 Nov 2026 | 1 articles | Viewed by 955 | Submission Open

Keywords: bone marrow; microenvironment; precursor; hematopoietic stem cells; pediatric hematological malignancies

(This special issue belongs to the Section Molecular Oncology)

Human Meningioma: Recent Developments

edited by Jason P. Sheehan, Yuki Shinya and Stylianos Pikis

submission deadline 20 Nov 2026 | Viewed by 793 | Submission Open

Keywords: meningioma; molecular pathogenesis; genomic alteration; radiogenomics; tumor microenvironment; biomarkers; neurosurgery; radiosurgery; translational neuroscience; artificial intelligence

(This special issue belongs to the Section Molecular Oncology)

Molecules and Mechanisms of Oxidative Stress Relevant in the Pathophysiology of Diseases: 2nd Edition

edited by

Cinzia Signorini

submission deadline 20 Nov 2026 | 1 articles | Viewed by 696 | Submission Open

Keywords: redox-active iron; reactive oxygen species; antioxidants; oxidative damage; biomarkers; degenerative disease

(This special issue belongs to the Section Molecular Biology)

ErbB Family of Receptor Tyrosine Kinases in Cancer and Drug Therapy

edited by Ilaria Marrocco and

Donatella Romaniello

submission deadline 20 Nov 2026 | Viewed by 556 | Submission Open

Keywords: ErbB; RTKs; EGFR; HER2; HER3; cancer; targeted therapies; drug resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Involvement of the Ubiquitin Proteasome System in the Healthy and Diseased Heart

edited by

Ofer Binah

submission deadline 20 Nov 2026 | Viewed by 535 | Submission Open

Keywords: UPS; ubiquitin; proteasome; cardiac pathophysiology; coronary ischemia/reperfusion injury; heart failure; cardiomyopathies; E334K mutation; cMyBPC; electrophysiological dysfunction; hypertrophic cardiomyopathy; pharmacological targeting

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Regulation of Gene Expression in Cell Differentiation

edited by

Iole Robuffo

submission deadline 20 Nov 2026 | Viewed by 478 | Submission Open

Keywords: cell differentiation; gene expression regulation; signal transduction; autophagy; nutrigenomics; mechanobiology; longevity; aging mechanism; tumor progression; regenerative medicine; gene therapy; tissue remodeling

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research in Hepatic Amino Acid Catabolism

edited by Carolina Conter

submission deadline 20 Nov 2026 | Viewed by 475 | Submission Open

Keywords: amino acid catabolism; essential amino acids; non-essential amino acids; liver metabolism; urea cycle; gluconeogenesis; lipid metabolism; nutritional regulation; mTOR signaling; metabolic diseases

(This special issue belongs to the Section Biochemistry)

Bioactive Compounds in Foods: From Structural Profiling to Bioavailability and Health Benefits

edited by

Cong Wang

submission deadline 20 Nov 2026 | Viewed by 474 | Submission Open

Keywords: food bioactives; profiling; bioactive compounds; characterization; bioavailability; bioaccessibility; functionality; health-promoting benefits; structure/constituents–bioactivity relationship

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Olfactory Neurobiology, Adult Neurogenesis and Dopaminergic Neuron Research

edited by

Angela Pignatelli

submission deadline 20 Nov 2026 | 1 articles | Viewed by 457 | Submission Open

Keywords: olfaction; olfactory bulb; dopaminergic neurons; Parkinson’s disease; Alzheimer’s disease; adult neurogenesis; early biomarker; neurodegenerative disease; smell impairment; smell test

(This special issue belongs to the Section Molecular Neurobiology)

Tau Pathology Mechanisms and Therapeutic Interventions

edited by

Claudia Marino

submission deadline 20 Nov 2026 | Viewed by 414 | Submission Open

Keywords: tau; misfolding; neurodegeneration; Alzheimer’s disease; oligomer; tauopathies; therapies; hyperphorphorylation; frontotemporal lobe dementia; synapses; spreading

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Stress Resilience: Unveiling Mechanisms and Mitigation Strategies

edited by

Giuseppe Mannino

submission deadline 20 Nov 2026 | Viewed by 399 | Submission Open

Keywords: plant stress resilience; abiotic stress; biotic stress; stress signaling pathways; biostimulants; genetic and molecular mechanisms; crop improvement; GMO

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Cardiomyopathy

edited by

Selina Hein

submission deadline 20 Nov 2026 | Viewed by 389 | Submission Open

Keywords: cardiomyopathy; inflammation; molecular mechanisms; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drug Delivery for Human Diseases: From Basic Research to Clinical Applications

edited by

Kushagra Khanna

submission deadline 20 Nov 2026 | Viewed by 232 | Submission Open

Keywords: drug delivery systems; nanomedicine; targeted therapy; traditional medicine; translational pharmaceutical research

(This special issue belongs to the Section Molecular Pharmacology)

The Impact of the Exposome on Gut Health: Deciphering Molecular Mechanisms and Pathophysiological Pathways

edited by

Sylwia Smolińska

submission deadline 20 Nov 2026 | Viewed by 207 | Submission Open

Keywords: exposome (internal & external); molecular gastroenterology; intestinal barrier function; gut-microbiota-host crosstalk; environmental toxicology; signal transduction pathways; nutritional epigenomics; metabolic dysregulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapies of Colorectal Cancer: 5th Edition

edited by

Donatella Delle Cave

submission deadline 20 Nov 2026 | Viewed by 192 | Submission Open

Keywords: pancreatic cancer; metabolism; cellular plasticity; tumor microenvironment; target therapy

(This special issue belongs to the Section Molecular Oncology)

Latest Molecular Discoveries of Arthropod-Borne Viruses

edited by Henry Puerta-Guardo

submission deadline 20 Nov 2026 | Viewed by 184 | Submission Open

Keywords: arbovirus; whole genome sequencing; pathogenesis; transcriptomics; CRISPR-Cas9; in silico; antivirals; vaccines; diagnostics

(This special issue belongs to the Section Molecular Microbiology)

Role of MicroRNAs in Human Diseases: 2nd Edition

edited by

Lorenzo F. Sempere

submission deadline 25 Nov 2026 | 10 articles | Viewed by 20962 | Submission Open

Keywords: microRNAs, miRNAs, miRs; preclinical models; target interaction; regulatory networks; oncology; cancer biology; cardiovascular disease; neurodegenerative conditions; diagnostic applications; therapeutic development and clinical trials

(This special issue belongs to the Section Molecular Genetics and Genomics)

Novel Antiviral Agents: Challenges and Opportunities from Molecular Targeting to Validation

edited by

Luis Adrián De Jesús-González

and

Moises Leon-Juarez

submission deadline 25 Nov 2026 | 2 articles | Viewed by 896 | Submission Open

Keywords: antiviral agents; molecular targeting; virus–host interactions; drug repurposing; host-directed antivirals; combination therapy; antiviral resistance; translational virology

(This special issue belongs to the Section Molecular Pharmacology)

Nutrition and Cardiovascular Development, from Fetal Origins to Adulthood

edited by

Deanne H. Hryciw

submission deadline 25 Nov 2026 | Viewed by 338 | Submission Open

Keywords: fetal programming; developmental origins of health and disease; maternal nutrition; placental function; offspring; cardiovascular function; cardiometabolic risk; cardio renal development; essential fatty acids; linoleic acid

(This special issue belongs to the Section Molecular Biology)

Nanomaterial: Synthesis and Application

edited by

Hesam Kamyab

submission deadline 25 Nov 2026 | Viewed by 211 | Submission Open

Keywords: nanomaterials; green synthesis; surface functionalization; nanoparticle engineering; drug delivery systems; energy storage; catalysis; environmental remediation; biocompatibility; molecular nanotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Advanced 3D-Bioprinting for Next-Generation In Vitro Models: Molecular and Technological Perspectives

edited by

Alberto Portone

and

Laura Sercia

submission deadline 25 Nov 2026 | Viewed by 209 | Submission Open

Keywords: 3D bioprinting; in vitro models; biofabrication; bioinks; hydrogels; disease modeling; toxicology; drug screening; biomaterials; organ-on-a-chip

(This special issue belongs to the Section Macromolecules)

Mitochondrial Functions and Dynamics

edited by

Raffaella Isola

submission deadline 27 Nov 2026 | 4 articles | Viewed by 17018 | Submission Open

Keywords: bioenergetics; mitochondrial biogenesis; mitochondrial morphology; apoptosis; mitophagy; reactive oxygen species; calcium homeostasis; cardiovascular diseases; neurodegenerative diseases; in vitro, cellular, and animal models; myopathies; mitochondria and immune system

(This special issue belongs to the Section Molecular Biology)

Molecular Insight into Catalysis of Nanomaterials

edited by Dandan Liu

submission deadline 27 Nov 2026 | 3 articles | Viewed by 5378 | Submission Open

Keywords: nanomaterial catalyst; thermal catalysis; photocatalysis; electrocatalysis; DFT calculation

(This special issue belongs to the Section Molecular Nanoscience)

Mechanisms and Effects of Endocrine Disruptors and Environmental Contaminants on Human Health

edited by

Margarida Ferreira Lorigo

submission deadline 27 Nov 2026 | 3 articles | Viewed by 5243 | Submission Open

Keywords: environmental exposure; emerging compounds; human health; risk assessment; adverse outcome pathway; new approach methodologies; one health

(This special issue belongs to the Section Molecular Toxicology)

Displaying special issue 901-950 on page 19 of 64.

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