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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Microbiome and Immunology in Gynecologic Diseases submission deadline 20 Jun 2025 | 1 articles | Viewed by 2431 | Submission Open
Keywords: microbiome; immunology; gynecological diseases; cancer; PCOS; hormones; infertility
(This special issue belongs to the Section Molecular Immunology)
Plant Phenolic Accumulation and Application in Human Diseases submission deadline 20 Jun 2025 | 2 articles | Viewed by 2389 | Submission Open
Keywords: antioxidant effects; anticancer/antiproliferative activity; anti-inflammatory activity; antimicrobial effects bioactive polyphenols; chemical identification of plant compounds; chemistry and mechanisms of action; health beneficial effect; medicinal plant; molecular targets; natural products; phytochemicals; structure– activity relationship
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Regulation Mechanisms of Tumor Progression: State-of-the-Art and Future Perspectives
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 2384 | Submission Open
Keywords: tumor progression; metastasis; invasion; molecular mechanisms; tumorigenesis
(This special issue belongs to the Section Molecular Oncology)
Modern Analytical Strategies for Foodomics: From Nutritional Value to Food Security submission deadline 20 Jun 2025 | 3 articles | Viewed by 2366 | Submission Open
Keywords: food adulteration; food authenticity; mass spectrometry; spectroscopic techniques; method development
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Bioactive Compounds in Cancer, Inflammation and Related Diseases: 2nd Edition
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 2355 | Submission Open
Keywords: oxidative disorders; inflammatory disorders; molecular signaling; bioactive compounds; cytokine
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Vascular, Oxidative and Inflammatory Dysregulation in Neurodegenerative Diseases: Current Status and Future Therapeutic Perspectives: 2nd Edition
edited by Melania Maria Serafini and
submission deadline 20 Jun 2025 | 2 articles | Viewed by 2321 | Submission Open
Keywords: Alzheimer’ s disease; strokes; multiple sclerosis; amyotrophic lateral sclerosis; polyneuropathies; pain; diabetic retinopathy; neuroinflammation; dietary supplements; microbiome
(This special issue belongs to the Section Molecular Neurobiology)
Nutrients in Plants: Friend or Foe?
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 2259 | Submission Open
Keywords: plant nutrient; essential elements; beneficial elements; plant growth; plant development; cellu-lar mechanism; molecular mechanism; hyperaccumulation; hypertolerance; new-type fertilizer
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Biological Insights and Targeted Therapies for Sarcomas submission deadline 20 Jun 2025 | 1 articles | Viewed by 2211 | Submission Open
Keywords: sarcoma; therapeutic target; preclinical models; molecular target
(This special issue belongs to the Section Molecular Oncology)
Cellular and Molecular Mechanisms in Lung Health and Disease
edited by
submission deadline 20 Jun 2025 | 2 articles | Viewed by 2204 | Submission Open
Keywords: lung disease; asthma; chronic obstructive pulmonary disease; fibrosis; inflammation; sarcoidosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Self-Assembled Protein-, Polymer-, and Surfactant-Based Nanostructured Materials and Their Potential Applications
edited by
submission deadline 20 Jun 2025 | 2 articles | Viewed by 2185 | Submission Open
Keywords: self-assembly; bioinspired; biomimetics; nanostructures; protein; polymer; surfactant
(This special issue belongs to the Section Molecular Nanoscience)
Mitochondrial Biology and Human Diseases submission deadline 20 Jun 2025 | 2 articles | Viewed by 2169 | Submission Open
Keywords: mitochondria; mitochondrial gene expression; bioenergetics; mitochondriopathies; human diseases
(This special issue belongs to the Section Molecular Biology)
Biocatalysis of Compounds for Pharmaceutical and Biomedical Applications
edited by
submission deadline 20 Jun 2025 | 2 articles | Viewed by 2143 | Submission Open
Keywords: biocatalysis; biomedical application; biotechnology; compounds for pharmacy; compounds for biomedicine; enantiomers; enzyme activity; enzyme engineering; enzyme immobilization; kinetic resolution; pharmaceutical application; supports materials
(This special issue belongs to the Section Molecular Pharmacology)
Lipid Peroxidation and Protein Carbonylation in Human Diseases
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 2118 | Submission Open
Keywords: free radicals; lipid peroxidation; protein carbonylation; apoptosis; autophagy; ferroptosis; antioxidant enzymes
(This special issue belongs to the Section Biochemistry)
The Multiple Faces of Non-small Cell Lung Cancer: Targeted Therapies and Recent Developments
edited by Angelo Delmonte and Alberto Verlicchi
submission deadline 20 Jun 2025 | 1 articles | Viewed by 2117 | Submission Open
Keywords: non-small cell lung cancer; tyrosine-kinase inhibitors; next generation sequencing; immunoconjugates; targeted therapies 
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Therapeutic Targets for Pain Regulation
edited by
submission deadline 20 Jun 2025 | 2 articles | Viewed by 2115 | Submission Open
Keywords: acute and chronic pain; osteoarthritis; nerve growth factor; molecular mechanism of chronic pain
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Biology of Tumor Cells: Present and Future submission deadline 20 Jun 2025 | 1 articles | Viewed by 2087 | Submission Open
Keywords: molecular immunology of cancer; ubiquitin-proteasome system in cancer; microRNA in cancer; extracellular matrix in cancer; metalloproteinases; cancer stem cells; ROS; molecular prognosis and diagnosis of cancer; cancer epigenetics
(This special issue belongs to the Section Molecular Oncology)
Data Science in Cancer Genomics and Precision Medicine: 2nd Edition submission deadline 20 Jun 2025 | 1 articles | Viewed by 2077 | Submission Open
Keywords: cancer genomics; big data; tumor immunology; translational oncology; precision medicine; next-generation sequencing; omics; cancer genomic datasets
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Biomarkers in Cancers: Advances and Challenges, 2nd Edition submission deadline 20 Jun 2025 | 2 articles | Viewed by 2054 | Submission Open
Keywords: cancer; cancer staging; diagnostic tools; novel biomarkers; proteomics; molecular markers; metabolic profiling; prognostic value
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Artificial Intelligence in Cancer Treatment: Molecular Perspective
edited by Andra Valentina Krauze
submission deadline 20 Jun 2025 | 1 articles | Viewed by 2045 | Submission Open
Keywords: cancer treatment; artificial intelligence; machine learning; precision medicine; molecular insights
(This special issue belongs to the Section Molecular Informatics)
Epigenetic Modifications in Cancer: Mechanisms, Diagnostics and Therapeutic Implications
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 2039 | Submission Open
Keywords: cancer; epigenetic; next-generation sequencing; epigenome mapping; DNA methylation; histone modifications; non-coding RNA involvement; chromatin remodeling
(This special issue belongs to the Section Molecular Genetics and Genomics)
Glutamine Metabolism in Cancer
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1947 | Submission Open
Keywords: glutamine metabolism; cancer; oncometabolism; cancer metabolism; metabolic reprogramming; personalised medicine; therapeutic resistance; drug targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Anti-Cancer Drugs: Natural Products, Synthetic Compounds and Potential Pharmacological Effects and Applications
edited by Kaiqun Ren and Hui Zou
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1946 | Submission Open
Keywords: cancer; natural product; synthetic compounds; mechanism; structural modification; pharmacological action
(This special issue belongs to the Section Molecular Pharmacology)
The Role of Extracellular Matrix in Cancer submission deadline 20 Jun 2025 | 1 articles | Viewed by 1935 | Submission Open
Keywords: extracellular matrix; cancer; collagen; integrins; metastasis
(This special issue belongs to the Section Molecular Oncology)
Research and Innovations in Green Monomers and Macromolecular Materials submission deadline 20 Jun 2025 | 1 articles | Viewed by 1911 | Submission Open
Keywords: green monomers and macromolecular material for a sustainable future; current barriers and future needs of green macromolecular materials; latest breakthroughs and approaches in molecular sciences; bio-based and/or biodegradable polymers based on natural; renewable; and synthetic polymers; synthesis; design; characterization; and development of innovative; technologically advanced; adaptable; and multifunctional green polymers in chemistry; biology; and medicine; relationships between structure; properties; functions; and performance of green polymers; sustainability; recycling; and environmental issues of green macromolecular materials; commercial applications: concepts; methodologies; and tools; 3D printing for personalized consumer products
(This special issue belongs to the Section Materials Science)
Targeting Non-coding RNAs for the Development of Cancer Therapeutic Approaches submission deadline 20 Jun 2025 | 1 articles | Viewed by 1904 | Submission Open
Keywords: cancer; short/long non-coding RNAs; therapy; diagnosis; tumor markers; mechanism of action
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research in Bone and Soft Tissue Tumors
edited by
submission deadline 20 Jun 2025 | 2 articles | Viewed by 1886 | Submission Open
Keywords: sarcoma; therapeutic target; metastasis; anticancer agent; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Innate Immunity: New Insights into Genetic and Signaling Networks
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1874 | Submission Open
Keywords: innate immunity; innate immune response; signaling pathways; genetic variations
(This special issue belongs to the Section Molecular Immunology)
New Aspects of Bioenergetics in Cancer
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1858 | Submission Open
Keywords: cancer metabolism; bioenergetics; mitochondria; redox
(This special issue belongs to the Section Molecular Oncology)
Molecular Research on Kidney Disease/Renal Dysfunction
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1840 | Submission Open
Keywords: kidney disease/renal dysfunction; hypoxia-inducible factor-prolyl hydroxylase (HIF-PHD) inhibitors; renal anemia; chronic renal faikure
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Role of Calprotectin in Human Health and Disease submission deadline 20 Jun 2025 | 1 articles | Viewed by 1834 | Submission Open
Keywords: acute phase reactants; analysis; bacterial infection; biomarker; calprotectin; critical care; inflammation; turbidimetric
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nonalcoholic Liver Disease: Mechanisms, Prevention, and Treatment submission deadline 20 Jun 2025 | 1 articles | Viewed by 1825 | Submission Open
Keywords: MAFLD; MASH; metabolic syndrome; steatosis; lipid droplets; SNPs; GWAS; therapeutc target; fatty liver; steatohepatitis; HCC; EpigEnetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Effect of Plant Bioactives and Their Constituents on Human Cell Activity
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1794 | Submission Open
Keywords: oriental prescriptions; herbal extracts; natural compounds; inflammation; cancer; immune; thrombosis; biological activity
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Cell Apoptosis in Cancers: Regulation Factors
edited by Shabnam Malik
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1770 | Submission Open
Keywords: apoptosis; regulation factors; cell death; cancer; treatment
(This special issue belongs to the Section Molecular Oncology)
The Role of Omics in Cancer Diagnosis and Treatment
edited by Xiaohu Tang
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1756 | Submission Open
Keywords: cancer; heterogeneity; omics; biomarker; therapeutic targets; drug resistance; molecular profile; algorithm
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights into Autoimmune Diseases submission deadline 20 Jun 2025 | 1 articles | Viewed by 1739 | Submission Open
Keywords: autoimmune diseases; autoantibodies; biomarkers; immuno-inflammatory diseases; molecular pathways; translational research; molecular pathobiology; targeted therapy
(This special issue belongs to the Section Molecular Immunology)
Role of NRF2 Pathway in Chronic Diseases submission deadline 20 Jun 2025 | 1 articles | Viewed by 1739 | Submission Open
Keywords: chronic diseases; NRF2; oxidative stress; inflammation; neurodegenerative diseases; cardiovascular disease; autoimmune diseases; chronic kidney diseases; liver disease
(This special issue belongs to the Section Biochemistry)
Molecular Cages: Design, Synthesis, and Applications submission deadline 20 Jun 2025 | 1 articles | Viewed by 1732 | Submission Open
Keywords: molecular cages; supramolecular chemistry; synthetic chemistry; self-assembly; molecular design; host– guest chemistry; biological applications
(This special issue belongs to the Section Macromolecules)
New Trends and Challenges in Chronic Diseases
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1725 | Submission Open
Keywords: chronic diseases; ER stress; oxidative stress; immune regulation; new pathways of pathogenesis; cancer development
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Emerging Trends in Antimicrobial Biomaterials
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1723 | Submission Open
Keywords: antimicrobial agents; chemical modification; polymer engineering; polymer synthesis; surface functionalization; immobilization of antimicrobial agents; new drug delivery systems; microbicides; infection control
(This special issue belongs to the Section Materials Science)
Ocular Inflammation and Diseases: Infections, Pathogenesis, Drug Delivery and Treatments
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1692 | Submission Open
Keywords: eye inflammation; dry eye; diabetic retinopathy; age-related macular disease; pathogenesis; molecular/cellular mechanisms; DMLE; CNV; diabetic macular edema; drug design; drug delivery; uveitis; keratitis; scleritis; eye infection
(This special issue belongs to the Section Molecular Immunology)
Inflammatory Bowel Diseases: Molecular Mechanism and Therapeutics
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1573 | Submission Open
Keywords: inflammatory bowel disease; IBD; ulcerative colitis; Crohn’ s disease; animal models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Radiopharmaceuticals and Radiotherapy
edited by Feifei An
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1567 | Submission Open
Keywords: positron emission tomography; single photon emission computed tomography; boron neutron capture therapy; alfa-particle; radiopharmaceutical; radiotherapy; radiosensitizer; Cu-67; Lu-177; I-131; Ac-225; Pb-212; At-211  
(This special issue belongs to the Section Molecular Pharmacology)
Interactions between Plants and Nematodes
edited by Qian Liu
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1566 | Submission Open
Keywords: plant nematodes; hosts; interaction; effectors; giant cells; syncytia
(This special issue belongs to the Section Molecular Plant Sciences)
Protein Networks and Their Signaling submission deadline 20 Jun 2025 | 1 articles | Viewed by 1550 | Submission Open
Keywords: protein-protein interaction; chromatin/nucleosome; signaling; protein structure; drug design
(This special issue belongs to the Section Molecular Biology)
Anticancer and Chemopreventive Activity of Natural Products and Its Derivatives
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1544 | Submission Open
Keywords: coumarins; coumarin derivatives; anticancer activity; chemopreventive activity; therapy adjuvant; mechanism of action; in vitro and in vivo studies; molecular research; metabolic pathway; phytochemicals; natural products; apoptosis; bioactivity assessment; chemical composition; therapeutic targets
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Immune Mechanisms and Biomarkers in Systemic Lupus Erythematosus—Second Edition
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1512 | Submission Open
Keywords: systemic lupus erythematosus; lupus nephritis; neuropsychiatric lupus; autoimmunity; biomarkers; B lymphocyte; interferons
(This special issue belongs to the Section Molecular Immunology)
Microbiome Modulation Through Probiotics: Molecular Insights and Therapeutic Applications
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1509 | Submission Open
Keywords: live bacterial cells; prebiotic agents; synbiotic formulations; probiotic formulations; microbial dysbiosis; inflammation; oxidative stress; host– microbe interactions
(This special issue belongs to the Section Molecular Microbiology)
Breakthroughs in Cardiac Tissue Remodeling: From Mechanisms to Therapeutics
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1483 | Submission Open
Keywords: myocardial infarction; heart failure; adverse remodeling; cardiac fibrosis; cardiomyopathy; cardiotoxicity; ventricular remodeling; cardiac dysfunction; biomarkers; cardiac regeneration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Diagnosis and Latest Treatment for Gastric Cancer
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1458 | Submission Open
Keywords: gastric cancer; biomarkers; genetics; epigenetics; immunotherapy; molecular diagnostics; personalized medicine; predisposition; risk factors
(This special issue belongs to the Section Molecular Oncology)
Nanomedicine in Gene Therapy and Immunotherapy
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1446 | Submission Open
Keywords: nanomedicine; drug delivery; gene delivery; genome editing; immunotherapy
(This special issue belongs to the Section Molecular Immunology)
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