Mitochondrial Biology and Human Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 June 2025 | Viewed by 2086
Special Issue Editors
Interests: mitochondria; mitochondrial biogenesis; mtDNA gene expression; mitoribosome
Special Issues, Collections and Topics in MDPI journals
Interests: mitochondrial biogenesis; mtDNA replication; mtDNA transcription; OXPHOS
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The impact of mitochondrial function in the context of cellular physiology is getting increasingly significant. Besides the most recognized role in the generation of cellular ATP by oxidative phosphorylation, mitochondria perform a wide variety of tasks ranging from the biosynthesis of essential molecules (amino acids, lipids, heme, etc.) to calcium homeostasis, cellular signalling, quality control, and programmed cell death. Moreover, these organelles own a genome functionally synchronized with the nuclear DNA. Replication, transcription, translation, and respiratory chain complex assembly are among the molecular processes occurring within mitochondria and mediating their functions in the cellular framework.
Elucidating the molecular mechanisms that underlie mitochondrial activity has therapeutic significance. Mitochondria crucially contribute to the development of various pathologies, including primary and secondary mitochondrial diseases that are clinically heterogeneous and can exhibit symptoms of varying severity. Additionally, mitochondria are implicated in the progression of numerous other health conditions such as cancer, respiratory illnesses, cardiac and vascular diseases, metabolic disorders, diabetes, neurodegenerative diseases, autism, and many more.
Our Special Issue aims to bring together high-quality research and review articles covering the aforementioned aspects of mitochondrial physiology and their link, whether direct or indirect, with human diseases.
Dr. Francesco Bruni
Dr. Paola Loguercio Polosa
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- mitochondria
- mitochondrial gene expression
- bioenergetics
- mitochondriopathies
- human diseases
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