Plant Phenolic Accumulation and Application in Human Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: 20 June 2025 | Viewed by 2310
Special Issue Editor
Interests: natural compounds; phytochemistry; plant in vitro culture; polyphenols; methods of determination of antioxidant activity; phytotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress and inflammation play important roles in the pathogenesis of various diseases. Redox balance and rebalance are essential for maintaining cellular physiological function and adaptation against oxidative stress. In this regard, plants rich in bioactive compounds such as polyphenols, which have broad health benefits for humans, deserve attention. Polyphenols are secondary metabolites recognized as one of the largest classes of plant constituents. Their health-protective effects are mainly due to their antioxidant and anti-inflammatory activities, which play a role in protecting against oxidative stress and related diseases. Natural products based on polyphenolic compounds can be used in supplementary treatment or serve as sources for the development of new therapeutic agents. Studies have indicated that a diet rich in polyphenols reduces the risk of various diseases, such as cancer, obesity, diabetes, cardiovascular diseases, and aging-related disorders. Although many natural bioactive products have already been isolated and investigated, nature remains an endless source of medicinal drugs awaiting discovery.
The aim of this Special Issue is to collect reviews and original articles addressing the current knowledge of the multifaceted roles of polyphenols in offering health benefits. It is dedicated to recent research that explores the acquisition, identification, and utilization of these bioactive compounds. For many polyphenolic compounds, there is a lack of knowledge regarding their molecular targets; therefore, special emphasis is given to insights into the molecular action mechanisms supporting the pharmacological properties of the identified phytochemicals and their structure–activity relationships.
Complex extracts and herbal mixtures without clearly identified ingredients will not be considered.
Dr. Izabela Grzegorczyk-Karolak
Guest Editor
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Keywords
- antioxidant effects
- anticancer/antiproliferative activity
- anti-inflammatory activity
- antimicrobial effects bioactive polyphenols
- chemical identification of plant compounds
- chemistry and mechanisms of action
- health beneficial effect
- medicinal plant
- molecular targets
- natural products
- phytochemicals
- structure–activity relationship
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