Molecular Insights into Autoimmune Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 20 June 2025 | Viewed by 1758
Special Issue Editors
Interests: biomaterials; nanomaterials; regenerative medicine; vitamin D; extracellular matrix; inflammatory and rheumatic diseases; cardiovascular diseases; translational research
Special Issues, Collections and Topics in MDPI journals
Interests: multiple sclerosis; autoimmune diseases; anti-rheumatic drug therapy; osteoporosis; hypovitaminosis D; chronic inflammatory demyelinating polyneuropathy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autoimmune diseases are clinical entities characterized by etherogeneous clinical manifestation, the pathogenesis of which relies on environmental and genetic determinants that determine the loss of immunological tolerance, finally leading to a dysregulated immune response. One relevant feature of these conditions is the production of autoantibodies directed against self antigens. These pathological autoantibodies, which are the hallmark of autoimmune diseases, are known to be involved in disease pathogensesis in different ways, as they can directly damage the host tissues or induce an aberrant activation of the intracellular signaling pathways. Autoimmune diseases have no predefined targets but can affect a wide range of human tissues, such as the skin, the muscles, the nerves, the joints, and the endocrine glands. In all cases, autoantibody production eventually results in tissue damage and severe inflammation. Due to the sustained inflamatory response that accompanies tissue damage, the most conventional therapeutic approach is represented by anti-inflammatory drugs. However, it is worth noting that in the last decades, many targeted therapies, such as non conventional diesease modifying drugs and biologics, have started to emerge.
The aim of this Special Issue is to collect updated information about the molecular mechanisms involved in autoimmune disease pathophysiology. Moreover, contributions dealing with the identification and validation of novel biomarkers as well as new therapeutic targets are welcome. Last but not least, reports focused on the molecular basis of available or experimental therapeutic approaches are encouraged. To reach this goal, we encourage the submission of both comprehensive reviews and original articles offering original insights into the molecular aspects of autoimmune disease pathophysiology and treatment.
Dr. Manuela Rizzi
Dr. Pier Paolo Sainaghi
Guest Editors
Manuscript Submission Information
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Keywords
- autoimmune diseases
- autoantibodies
- biomarkers
- immuno-inflammatory diseases
- molecular pathways
- translational research
- molecular pathobiology
- targeted therapy
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