Role of Calprotectin in Human Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 June 2025 | Viewed by 1989
Special Issue Editors
Interests: anesthesiology; biomarkers; calprotectin; coagulation; cytokines; endotoxin; critical care medicine; inflammation; intensive care; intraosseous; leptin; point-of-care; SAPS3; sepsis; shock
Special Issues, Collections and Topics in MDPI journals
Interests: endotoxin; intensive care; acute kidney injury; glomerular filtration rate markers; kidney tubular damage markers; cardiovascular risk markers; neutrophil activation markers; calprotectin
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
You are invited to contribute research on calprotectin, a pleiotropic molecule released in both acute and chronic inflammation, is a heterodimer of two mammalian calcium-binding proteins and is released from the cytoplasm of neutrophil granulocytes upon their activation. Calprotectin (S100A9/S100A8) is a member of the S100 protein family. Calprotectin, as a proinflammatory factor of innate immunity, is related to the endogenous damage-associated molecular pattern (DAMP) molecule via Toll-like receptor 4 activation.
Determination of calprotectin is a valuable clinical biomarker of inflammation. In inflammatory gastro-intestinal diseases, colonoscopy and histopathologic evaluation of bowel biopsy specimens are usually regarded as the gold standards for diagnosis and management of such diseases. However, colonoscopy and colon biopsy are not only costly, but occasionally associated with complications. Since fecal calprotectin may serve as a potential surrogate marker for colonoscopy, several clinical studies have focused on this issue. Furthermore, calprotectin may serve as a biomarker of disease activity in rheumatoid arthritis. Plasma calprotectin seems to be a promising biomarker in respiratory infections, allowing more precise diagnosis and selective use of antibiotics compared to other biomarkers. In critically ill patients with bacterial infections, plasma calprotectin seems to be a useful biomarker. Based on these findings, a health economic analysis of the predictive use of plasma calprotectin indicates that this biomarker has cost-saving and life-saving impacts. Calprotectin may rapidly be analyzed turbidimetrically.
Dr. Mats B. Eriksson
Prof. Dr. Anders O. Larsson
Guest Editors
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Keywords
- acute phase reactants
- analysis
- bacterial infection
- biomarker
- calprotectin
- critical care
- inflammation
- turbidimetric
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