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Ocular Inflammation and Diseases: Infections, Pathogenesis, Drug Delivery and Treatments

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 1638

Special Issue Editor


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Guest Editor
Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Interests: retinal disease; retinal vascular disease; choroidal vascular disease; ocular surface disease; endophthalmitis; fungal endophthalmitis; Aspergillus; antifungal therapy; eye infections; drug resistance
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Special Issue Information

Dear Colleagues,

In recent years, significant attention has been given to the role of inflammation in ocular pathologies.

Inflammation constitutes a fundamental mechanism not only in ocular infections and uveitis but also in numerous other ocular conditions, ranging from ocular surface alterations to retinal diseases, where low-grade chronic inflammation plays a decisive part.

Delving into the role of inflammation in all ocular pathologies is of paramount importance as it allows us to gain a better understanding of the mechanisms of such pathologies, enabling us to improve their therapeutic management.

Therefore, this Special Issue aims to gather research that delves into the theme of inflammation in ocular diseases, with a particular focus on etiology, pathogenesis, diagnosis, and therapeutic management.

Dr. Francesco Petrillo
Guest Editor

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Keywords

  • eye inflammation
  • dry eye
  • diabetic retinopathy
  • age-related macular disease
  • pathogenesis
  • molecular/cellular mechanisms
  • DMLE
  • CNV
  • diabetic macular edema
  • drug design
  • drug delivery
  • uveitis
  • keratitis
  • scleritis
  • eye infection

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Published Papers (1 paper)

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Review

17 pages, 593 KiB  
Review
Atopic Dermatitis and Atopic Keratoconjunctivitis: New Insights in the Analyses of Microbiota and Probiotic Effect
by Francesco Petrillo, Annalisa Buonanno, Ludovica Fedi, Marilena Galdiero, Michele Reibaldi, Bruno Tamburini and Emilia Galdiero
Int. J. Mol. Sci. 2025, 26(4), 1463; https://doi.org/10.3390/ijms26041463 - 10 Feb 2025
Viewed by 1256
Abstract
Atopy is defined as a predisposition to hypersensitivity reactions against a range of antigens. It is characterized by the activation of CD4+ T helper type 2 (Th2) cells and an increased production of immunoglobulin E (IgE). The most common atopic conditions are atopic [...] Read more.
Atopy is defined as a predisposition to hypersensitivity reactions against a range of antigens. It is characterized by the activation of CD4+ T helper type 2 (Th2) cells and an increased production of immunoglobulin E (IgE). The most common atopic conditions are atopic dermatitis, asthma, allergic rhinitis, food allergies, and atopic ocular diseases. Atopic keratoconjunctivitis (AKC) is a chronic, bilateral inflammatory condition affecting the ocular surface, frequently occurring in conjunction with atopic dermatitis. It is not uncommon for patients to present with multiple conditions simultaneously or in a sequential manner. A comprehensive understanding of the underlying mechanisms of atopic diseases is essential for the effective clinical evaluation and treatment. Recent research has underscored the pivotal role of the microbiota in the pathogenesis of atopic dermatitis and atopic eye diseases, with alterations in microbial composition (dysbiosis) being linked to a spectrum of atopic conditions. Probiotics are currently being investigated as a potential treatment option for restoring microbial balance and alleviating disease symptoms. This review examines the relationship between atopic dermatitis, atopic keratoconjunctivitis, and the microbiota, evaluating the current evidence and exploring the potential of probiotics as a novel therapeutic approach. Full article
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