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The Role of Omics in Cancer Diagnosis and Treatment

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 1757

Special Issue Editor


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Guest Editor
Department of Biological Sciences, Michigan Technical University, Houghton, MI 49931, USA
Interests: cancer genetics and metabolism; mechanisms of cancer initiation and progression; functional genomics and bioinformatics; interactions of diet and nutrition with cancer

Special Issue Information

Dear Colleagues,

Cancer, as a complex and heterogeneous disease, presents numerous challenges in the management of its diagnosis and treatment. The advent of omics technologies—including genomics, transcriptomics, proteomics, metabolomics, and epigenomics—has revolutionized our understanding of cancer biology by identifying, characterizing, and quantifying the biomolecules and molecular processes in cancer cells. By integrating data across multiple omics platforms, researchers can uncover novel biomarkers, identify new therapeutic targets, elucidate mechanisms of drug resistance, and develop innovative treatment strategies. These advancements not only enhance the accuracy of cancer diagnosis but also pave the way for personalized treatment strategies tailored to each patient’s molecular profile.

This Special Issue, “The Role of Omics in Cancer Diagnosis and Treatment”, aims to compile both experimental and computational studies that demonstrate the transformative impact of omics technologies in human cancer. This Issue encompasses a wide range of topics, from identifying genetic mutations and epigenetic alterations to exploring proteomic and metabolomic profiles driving cancer progression, as well as developing algorithms for multiplatform data integration. Both original research articles and comprehensive reviews are welcome.

Dr. Xiaohu Tang
Guest Editor

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Keywords

  • cancer
  • heterogeneity
  • omics
  • biomarker
  • therapeutic targets
  • drug resistance
  • molecular profile
  • algorithm

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Published Papers (1 paper)

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Research

20 pages, 4089 KiB  
Article
Epigenetic and Cellular Reprogramming of Doxorubicin-Resistant MCF-7 Cells Treated with Curcumin
by Paola Poma, Salvatrice Rigogliuso, Manuela Labbozzetta, Aldo Nicosia, Salvatore Costa, Maria Antonietta Ragusa and Monica Notarbartolo
Int. J. Mol. Sci. 2024, 25(24), 13416; https://doi.org/10.3390/ijms252413416 - 14 Dec 2024
Viewed by 1212
Abstract
The MCF-7R breast cancer cell line, developed by treating the parental MCF-7 cells with increasing doses of doxorubicin, serves as a model for studying acquired multidrug resistance (MDR). MDR is a major challenge in cancer therapy, often driven by overexpression of the efflux [...] Read more.
The MCF-7R breast cancer cell line, developed by treating the parental MCF-7 cells with increasing doses of doxorubicin, serves as a model for studying acquired multidrug resistance (MDR). MDR is a major challenge in cancer therapy, often driven by overexpression of the efflux pump P-glycoprotein (P-gp) and epigenetic modifications. While many P-gp inhibitors show promise in vitro, their nonspecific effects on the efflux pump limit in vivo application. Curcumin, a natural compound with pleiotropic action, is a nontoxic P-gp inhibitor capable of modulating multiple pathways. To explore curcumin’s molecular effects on MCF-7R cells, we analyzed the expression of genes involved in DNA methylation and transcription regulation, including ABCB1/MDR1. Reduced representation bisulfite sequencing further unveiled key epigenetic changes induced by curcumin. Our findings indicate that curcumin treatment not only modulates critical cellular processes, such as ribosome biogenesis and cytoskeletal dynamics, but also reverses the resistant phenotype, toward that of sensitive cells. This study highlights curcumin’s potential as an adjuvant therapy to overcome chemoresistance, offering new avenues for pharmacological strategies targeting epigenetic regulation to re-sensitize resistant cancer cells. Full article
(This article belongs to the Special Issue The Role of Omics in Cancer Diagnosis and Treatment)
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