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Vascular, Oxidative and Inflammatory Dysregulation in Neurodegenerative Diseases: Current Status...
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Vascular, Oxidative and Inflammatory Dysregulation in Neurodegenerative Diseases: Current Status and Future Therapeutic Perspectives: 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 2327

Special Issue Editors

Dr. Melania Maria Serafini

E-Mail Website
Guest Editor
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy
Interests: nervous system; neurotoxicity; neurodegenerative diseases
Dr. Nicoletta Marchesi

E-Mail Website
Guest Editor
Department of Drug Sciences, University of Pavia, Pavia, Italy
Interests: neurodegenerative disease; pain; RNA-binding protein; diabetic retinopathy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

New reports from the World Health Organization (WHO) show that neurological disorders affect up to one billion people worldwide. Neurological disorders are medically defined as disorders that affect the brain and the nerves found throughout the human body and the spinal cord. Structural, biochemical, or electrical abnormalities in the brain, spinal cord, or other nerves can result in a range of symptoms. Some of the most common ones are epilepsy, Alzheimer’s and other dementias, strokes, migraine, multiple sclerosis, Parkinson’s disease, amyotrophic lateral sclerosis, polyneuropathies, neurological infections, brain tumors, traumatic conditions of the nervous system such as head injuries, and disorders caused by malnutrition or by an imbalance in the metabolism such as diabetes (i.e., diabetic retinopathy).

In this Special Issue for IJMS, we will focus on discovering and treating neurological disorders. New therapies in this area must improve the quality of life, symptoms, and treatment of the disease itself. Research papers, including in vitro and in vivo studies, and up-to-date review articles are welcome.

Dr. Melania Maria Serafini
Dr. Nicoletta Marchesi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Alzheimer’s disease
  • strokes
  • multiple sclerosis
  • amyotrophic lateral sclerosis
  • polyneuropathies
  • pain
  • diabetic retinopathy
  • neuroinflammation
  • dietary supplements
  • microbiome

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Published Papers (2 papers)

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Review

32 pages, 2656 KiB  
Review
Emerging Insights into Brain Inflammation: Stem-Cell-Based Approaches for Regenerative Medicine
by Marie Karam, Alba Ortega-Gascó and Daniel Tornero
Int. J. Mol. Sci. 2025, 26(7), 3275; https://doi.org/10.3390/ijms26073275 - 1 Apr 2025
Viewed by 767
Abstract
Neuroinflammation is a complex immune response triggered by brain injury or pathological stimuli, and is highly exacerbated in neurodegenerative diseases. It plays a dual role in the central nervous system, promoting repair in acute stages while aggravating disease progression by contributing to neuronal [...] Read more.
Neuroinflammation is a complex immune response triggered by brain injury or pathological stimuli, and is highly exacerbated in neurodegenerative diseases. It plays a dual role in the central nervous system, promoting repair in acute stages while aggravating disease progression by contributing to neuronal loss, synaptic dysfunction, and glial dysregulation in chronic phases. Inflammatory responses are mainly orchestrated by microglia and infiltrated monocytes, which, when dysregulated, not only harm existing neurons, but also impair the survival and differentiation of neural stem and progenitor cells in the affected brain regions. Modulating neuroinflammation is crucial for harnessing its protective functions while minimizing its detrimental effects. Current therapeutic strategies focus on fine-tuning inflammatory responses through pharmacological agents, bioactive molecules, and stem cell-based therapies. These approaches aim to restore immune homeostasis, support neuroprotection, and promote regeneration in various neurological disorders. However, animal models sometimes fail to reproduce human-specific inflammatory responses in the brain. In this context, stem-cell-derived models provide a powerful tool to study neuroinflammatory mechanisms in a patient-specific and physiologically relevant context. These models facilitate high-throughput screening, personalized medicine, and the development of targeted therapies while addressing the limitations of traditional animal models, paving the way for more targeted and effective treatments. Full article
(This article belongs to the Special Issue Vascular, Oxidative and Inflammatory Dysregulation in Neurodegenerative Diseases: Current Status and Future Therapeutic Perspectives: 2nd Edition)
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19 pages, 1537 KiB  
Review
Repulsive Guidance Molecule-A as a Therapeutic Target Across Neurological Disorders: An Update
by Vasilis-Spyridon Tseriotis, Andreas Liampas, Irene Zacharo Lazaridou, Sofia Karachrysafi, George D. Vavougios, Georgios M. Hadjigeorgiou, Theodora Papamitsou, Dimitrios Kouvelas, Marianthi Arnaoutoglou, Chryssa Pourzitaki and Theodoros Mavridis
Int. J. Mol. Sci. 2025, 26(7), 3221; https://doi.org/10.3390/ijms26073221 - 30 Mar 2025
Viewed by 898
Abstract
Repulsive guidance molecule-a (RGMa) has emerged as a significant therapeutic target in a variety of neurological disorders, including neurodegenerative diseases and acute conditions. This review comprehensively examines the multifaceted role of RGMa in central nervous system (CNS) pathologies such as Alzheimer’s disease, Parkinson’s [...] Read more.
Repulsive guidance molecule-a (RGMa) has emerged as a significant therapeutic target in a variety of neurological disorders, including neurodegenerative diseases and acute conditions. This review comprehensively examines the multifaceted role of RGMa in central nervous system (CNS) pathologies such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, neuromyelitis optica spectrum disorder, spinal cord injury, stroke, vascular dementia, auditory neuropathy, and epilepsy. The mechanisms through which RGMa contributes to neuroinflammation, neuronal degeneration, and impaired axonal regeneration are herein discussed. Evidence from preclinical studies associate RGMa overexpression with negative outcomes, such as increased neuroinflammation and synaptic loss, while RGMa inhibition, particularly the use of agents like elezanumab, has shown promise in enhancing neuronal survival and functional recovery. RGMa’s responses concerning immunomodulation and neurogenesis highlight its potential as a therapeutic avenue. We emphasize RGMa’s critical role in CNS pathology and its potential to pave the way for innovative treatment strategies in neurological disorders. While preclinical findings are encouraging so far, further clinical trials are needed to validate the safety and efficacy of RGMa-targeted therapies. Full article
(This article belongs to the Special Issue Vascular, Oxidative and Inflammatory Dysregulation in Neurodegenerative Diseases: Current Status and Future Therapeutic Perspectives: 2nd Edition)
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