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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Circumventing Resistance to Channel-Targeting Insecticides: A Challenge for Global Health and Food Security

edited by

Bruno Lapied

and David Barry Sattelle

submission deadline 20 Oct 2026 | 2 articles | Viewed by 4170 | Submission Open

Keywords: pest insects and resistance; resistance in insect vectors of human and livestock diseases; mechanisms of resistance; circumventing resistance; ion channels and resistance; integrated approaches to resistance management; alternating insecticide classes; minimizing risk to beneficial insects; novel control strategies

(This special issue belongs to the Section Molecular Biology)

Advances in Plant Molecular Breeding and Molecular Diagnostics

edited by

Jiří Sedlák

submission deadline 20 Oct 2026 | 4 articles | Viewed by 4132 | Submission Open

Keywords: plant molecular breeding; molecular diagnostics; pathogen detection; disease symptomatology; genetic resources, genetic diversity; phenology; genotype–phenotype integration; genome editing; omics; bioinformatics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Abiotic Stress in Plants, 2nd Edition

edited by

Xiujun Zhang

submission deadline 20 Oct 2026 | 5 articles | Viewed by 4000 | Submission Open

Keywords: abiotic stress; ROS; redox; antioxidants; phytohormones; ethylene; plant stress eco-physiology

(This special issue belongs to the Section Molecular Plant Sciences)

Gene Function, Molecular Mechanisms, and Crop Breeding

edited by Hongwei Lu

submission deadline 20 Oct 2026 | 2 articles | Viewed by 3864 | Submission Open

Keywords: molecular biology; gene function; molecular mechanism; crop breeding; molecular biology; agronomic traits; gene discovery; genomics; bioinfomatics; gene regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Immunity in Neurodegenerative Diseases: Systemic Immune Imbalance, Neuroinflammation, and Beyond—2nd Edition

edited by

Ivana Munitic

submission deadline 20 Oct 2026 | 3 articles | Viewed by 3798 | Submission Open

Keywords: neurodegeneration; CNS immunosurveillance; neuroinflammation; neuroimmune axis; glia; T cells; phagocytosis; immunomodulation; autoimmunity; immunodeficiency

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Next-Generation Sequencing for Aging and Cancer Research

edited by Hyunsoo Kim

submission deadline 20 Oct 2026 | 3 articles | Viewed by 3175 | Submission Open

Keywords: next-generation sequencing; aging; cancer genomics; cellular senescence; single-cell sequencing; epigenomics; transcriptomics; tumor evolution; biomarkers; precision medicine

(This special issue belongs to the Section Molecular Informatics)

Molecular Advances in Brain Plasticity

edited by

Beatrice Uguagliati

submission deadline 20 Oct 2026 | 2 articles | Viewed by 3008 | Submission Open

Keywords: neurophysiology; neurobiology; synapses; synaptic plasticity; microglia; astrocytes; dendritic spines; neurodevelopment; neurodevelopmental disease; learning and memory; neuropharmacology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolomics as a Window into Human Disease Mechanisms

edited by

Paolo Iadarola

submission deadline 20 Oct 2026 | 3 articles | Viewed by 2624 | Submission Open

Keywords: biomarker discovery; metabolomics; disease mechanisms

(This special issue belongs to the Section Molecular Informatics)

Purine Signaling as a Therapeutic Target in Human Diseases

edited by

Aránzazu Mediero

submission deadline 20 Oct 2026 | 2 articles | Viewed by 2557 | Submission Open

Keywords: disease; adenosine; ATP; receptors; transporters; therapeutics; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

Bioactive Compounds: Innovative Technologies for Extraction, Synthesis, and Functional Evaluation

edited by

Parisa Abbasi Parizad

submission deadline 20 Oct 2026 | 3 articles | Viewed by 2510 | Submission Open

Keywords: bioactive compounds; extraction; synthesis; functional evaluation; molecular aspects; mechanism of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Skin Cancer: Molecular Drivers, Biomarkers, Non-Invasive Diagnostics and Therapeutic Strategies

edited by

Federico Venturi

Emi Dika

and Giulia Veronesi

submission deadline 20 Oct 2026 | 3 articles | Viewed by 2462 | Submission Open

Keywords: melanoma; skin cancers; immunotherapy; targeted therapy; liquid biopsy; non-invasive diagnostics techniques; miRNA; genomic

(This special issue belongs to the Section Molecular Oncology)

Neurodegenerative Disease: From Molecular Basis to Therapy, 5th Edition

edited by

Claudia Ricci

submission deadline 20 Oct 2026 | 2 articles | Viewed by 2275 | Submission Open

Keywords: neurodegenerative diseases; molecular biology; neurogenetics; pathogenesis; therapy; personalized medicine

(This special issue belongs to the Section Molecular Neurobiology)

Antibacterial and Antioxidant Effects of Plant-Sourced Compounds: 2nd Edition

edited by Johana Rondevaldova

submission deadline 20 Oct 2026 | 2 articles | Viewed by 2135 | Submission Open

Keywords: antibacterial effect; antioxidants; medicinal plants; anti-infective agents; phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Fiber Plants: Genetics and Genomics, Molecular Mechanisms and Potential Applications—Novel Materials, Functional Foods and Beyond

edited by

Jian Zhang

and

Michael Deyholos

submission deadline 20 Oct 2026 | 1 articles | Viewed by 2103 | Submission Open

Keywords: fiber plant; genetics; genomics; bioactive products; natural fibers; fatty acids; medical products; environmental and ecological effects of fiber plants

(This special issue belongs to the Section Molecular Plant Sciences)

Novel Immunotherapies for Reshaping the Tumor Immune Microenvironment

edited by

Alessandro Canella

submission deadline 20 Oct 2026 | 1 articles | Viewed by 2100 | Submission Open

Keywords: TIME; TME; immunosuppression; inflammation; immune cells; immunotherapy; cancer immune evasion

(This special issue belongs to the Section Molecular Oncology)

Exploring Molecular Insights in Oral Health and Disease

edited by

Iulia-Ioana Stanescu-Spinu

and

Tudor Claudiu Spînu

submission deadline 20 Oct 2026 | 3 articles | Viewed by 2082 | Submission Open

Keywords: oral health; saliva; oral diseases; molecular insights; molecular targets; oral cavity physiology; wound healing; oral microbiome; oral biocompatibility; material interactions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Nephrotoxicity: From Environmental Toxins to Therapeutic Agents

edited by

Chih-Kang Chiang

submission deadline 20 Oct 2026 | 2 articles | Viewed by 2027 | Submission Open

Keywords: pesticides; emerging pollutants; environmental toxicants; therapeutic strategies; nephrology; toxicology; public health

(This special issue belongs to the Section Molecular Toxicology)

Pharmacological Approaches in Inflammation, Aging, and Cardiovascular Diseases

edited by

Omer Dzemali

and

Era Gorica

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1990 | Submission Open

Keywords: inflammation; aging; cardiovascular diseases; approaches; translational research; therapeutic targets

(This special issue belongs to the Section Molecular Pharmacology)

The Role of Micronutrients in Cancer Prevention

edited by Jacek Baj

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1978 | Submission Open

Keywords: micronutrient; metallomics; metallomic analysis; nutrient; ICP-MS; ICP-OES; prevention; carcinogenesis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exosomes in the Processes of Tumorigenesis, Cancer Progression, Metastasis, and Treatment

edited by

Foteinos-Ioannis Dimitrakopoulos

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1808 | Submission Open

Keywords: exosomes; extracellular vesicles; metastasis; cancer; prognosis; prediction; biomarker; cancer treatment

(This special issue belongs to the Section Molecular Oncology)

Advanced Research in Cancer Pharmacotherapy

edited by

Yavuz Silig

submission deadline 20 Oct 2026 | 3 articles | Viewed by 1758 | Submission Open

Keywords: cancer pharmacotherapy; molecular oncology; biomarker discovery; tumour microenvironment; signalling pathways; drug resistance; multi-omics; translational research; targeted therapy; preclinical models

(This special issue belongs to the Section Molecular Oncology)

Investigating Gut Axes: Pathophysiological Functions and Therapeutic Strategies

edited by

Alessio Ardizzone

and

Sarah Adriana Scuderi

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1757 | Submission Open

Keywords: gut–brain axis; gut–heart axis; gut–liver axis; neurological diseases; cancer; novel and alternative therapies; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Molecular Research in Colitis

edited by

Pablo García-Miranda

and

María Vázquez-Carretero

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1718 | Submission Open

Keywords: colitis; inflammatory bowel disease (IBD); gut-brain axis; intestinal barrier; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Medicinal Fungi and Plants: From Bioactive Compounds to Therapeutic Mechanisms

edited by

Jasmina Glamočlija

and

Ana Ćirić

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1709 | Submission Open

Keywords: medicinal fungi; medicinal plants; molecular mechanisms; bioactive compounds; metabolomics; phytochemistry; natural products; network pharmacology; molecular docking; functional foods; therapeutic development

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Regulation and Mechanisms of Nitric Oxide in Endothelial Cells and Beyond

edited by

Roberto Berra-Romani

and

Francesco Moccia

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1696 | Submission Open

Keywords: nitric oxide (NO); endothelial cells; endothelial nitric oxide synthase (eNOS); vascular homeostasis; vasodilation; endothelial dysfunction; molecular signaling; vascular diseases; reactive oxygen species (ROS); nitric oxide regulation

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Cerebrovascular Diseases

edited by

Mariagiovanna Cantone

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1640 | Submission Open

Keywords: cerebrovascular diseases; stroke; vascular dementia; molecular mechanisms; biomarkers; omics; therapeutic targets; translational medicine

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Surfactant Systems: Thermodynamics, Molecular Interactions, and Applications

edited by

Mihalj Poša

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1588 | Submission Open

Keywords: micelles; mixed micelles; thermodynamic functions of micellization; micellar solubilization; enthalpy–entropy compensation; boundary surface; Langmuir isotherm; theoretical models

(This special issue belongs to the Section Biochemistry)

Plant Responses to Environmental Stresses: Physiological and Molecular Mechanisms

edited by

Viviana Maresca

and

Alessia Postiglione

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1548 | Submission Open

Keywords: plant stress; abiotic stress; biotic stress; oxidative stress; antioxidant enzymes; reactive oxygen species (ROS); phytoremediation; biomonitoring; secondary metabolites; molecular mechanisms; omics approaches; bryophytes; heavy metals; plant–microbe interactions

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Dietary Fibre, Nutrition in Gastrointestinal Diseases

edited by

Sara Jarmakiewicz-Czaja

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1475 | Submission Open

Keywords: dietary fibre; gut microbiome; gastrointestinal disease; inflammatory bowel disease; nutrients; nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Relationships Between Diabetic Retinal Neuropathies and Vascular Pathologies in Diabetic Retinopathy

edited by

Steven Abcouwer

and David A. Antonetti

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1441 | Submission Open

Keywords: retinal neurons; retinal vasculature; diabetic retinopathy; diabetic macular edema (DME); neurovascular coupling; neurovascular unit (NVU); diabetic vascular pathology; diabetic retinal neuropathy; diabetic retinal neurodegeneration; retinal thinning in diabetes; photoreceptor pathology in diabetes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional (Pharmaco) Genomics and Genetics in Atrial Fibrillation Associated with Sudden Cardiac Death Syndromes

edited by

Hector Barajas-Martinez

and

Anthony Ashton

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1428 | Submission Open

Keywords: atrial fibrillation; sudden cardiac death syndromes; channelopathies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms and Pathophysiology of Nerve Regeneration

edited by Fabian Szepanowski and Mark Stettner

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1398 | Submission Open

Keywords: nerve injury; nerve inflammation; autoimmune neuropathies; immune-mediated neuropathies; polyneuropathies; peripheral neuroinflammation; nerve regeneration; Schwann cell; Schwann cell differentiation; repair Schwann cell

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Rheumatic Diseases and Rheumatoid Arthritis

edited by

Ilaria Mormile

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1350 | Submission Open

Keywords: rheumatoid arthritis; systemic lupus erythematous; systemic sclerosis; Sjögren’s syndrome; psoriatic arthritis; rare autoimmune rheumatic diseases; vasculitis; biological therapies

(This special issue belongs to the Section Molecular Immunology)

Advances in Drug Discovery: Emerging Radiotracers and Small Molecule Inhibitors for Cancer and Neurological Disorders

edited by

Ramya Tokala

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1347 | Submission Open

Keywords: radiotracers; cytotoxic agents; drug discovery; molecular imaging; cancer therapy; neurological disorders; radiochemistry; medicinal chemistry; theranostics; drug development; molecular diagnostics

(This special issue belongs to the Section Molecular Pharmacology)

Advanced Composite Materials: Innovative Molecular Design, Cross-Scale Materials Characterization and Integrated Engineering Applications

edited by

Zhengzhi Mu

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1344 | Submission Open

Keywords: composite materials; molecular design; cross-scale characterization; advanced synthesis; integrated applications

(This special issue belongs to the Section Materials Science)

Design, Synthesis, Application and Mechanism of Functional Polymers

edited by Jingyuan Liu

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1341 | Submission Open

Keywords: functional polymers; polymer synthesis; structure–property relationship; molecular mode of actions; interfacial interaction; molecular design; smart materials; functional coatings; biomedical applications; energy storage

(This special issue belongs to the Section Materials Science)

The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation: 4th Edition

edited by

Ralf Kircheis

and

Oliver Planz

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1281 | Submission Open

Keywords: toll-like receptors (TLR); pathogen associated molecular patterns (PAMPs); sepsis; bacterial infections; viral infections; Myd88; TRIF; NF-kappaB; COVID-19; coagulopathies

(This special issue belongs to the Section Molecular Immunology)

Polymer Biocomposites: Synthesis, Applications and End-Life

edited by

Maria Chiara Mistretta

and

Manuela Ceraulo

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1206 | Submission Open

Keywords: polymer biocomposites; biodegradable polymers; molecular design and synthesis; functional modifications; biodegradation

(This special issue belongs to the Section Materials Science)

Lung Cancer: Molecular Basis and Treatment Strategies

edited by

Hamada A.A. Noreldeen

submission deadline 20 Oct 2026 | Viewed by 1137 | Submission Open

Keywords: adenocarcinoma; oncogenic drivers; precision oncology; signal transduction; tumor microenvironment; targeted therapy; resistance mechanisms; epigenetics; biomarker discovery; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Neural Stem Cells as Tools for Therapies: Challenges and Future Perspectives

edited by

Daniele Bottai

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1048 | Submission Open

Keywords: spinal cord injury; spinal muscular atrophy; amyotrophic lateral sclerosis; neurological diseases; neural stem cell differentiation; cellular models; transplantation; trophic factor release

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Cell Adhesion

edited by

Surajit Bhattacharjya

submission deadline 20 Oct 2026 | Viewed by 1012 | Submission Open

Keywords: cell adhesion; cell–cell communication; structures; drug discovery; integrins; cadherins; selectins

(This special issue belongs to the Section Molecular Biophysics)

Amyloid-β: An Antimicrobial Defense Peptide

edited by

Anna Lia Asti

submission deadline 20 Oct 2026 | 1 articles | Viewed by 929 | Submission Open

Keywords: amyloid (Aß); aggregation prone regions (ARPs); lipopolysaccharide (LPS); amphipathic molecules; LL-37 peptide; neurodegeneration; aggregation inhibition; Alzheimer's disease (AD)

(This special issue belongs to the Section Molecular Biology)

Advanced Research in Crops: From Physiology to Breeding

edited by

Guang Chen

and Edyta Zdunek-Zastocka

submission deadline 20 Oct 2026 | 1 articles | Viewed by 872 | Submission Open

Keywords: crops; stress; cultivation measures; molecular mechanisms; breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Therapeutic Strategies for Oral Mucosal Diseases: From Radiotherapy-Induced Damage to Other Pathologies

edited by

Fernanda Gonçalves Salum

submission deadline 20 Oct 2026 | 1 articles | Viewed by 799 | Submission Open

Keywords: oral mucosal diseases; drug-induced oral lesions; radiotherapy- and chemotherapy-induced oral disorders; targeted therapy- and immunotherapy-induced stomatitis; oxidative stress and inflammation; oral microbiome and immunity; nanomedicine and biomaterials; photobiomodulation and photodynamic therapy; oral potentially malignant disorders; oral oncology; immune modulation; tissue regeneration and repair; translational research; investigational therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Electrochemical Detection: A Molecular-Level Perspective

edited by Katarzyna Fendrych and

Joanna Smajdor-Baran

submission deadline 20 Oct 2026 | 1 articles | Viewed by 766 | Submission Open

Keywords: electrochemical detection; molecular sensing; biosensors; nanostructured electrodes; biomolecular interactions; electroanalytical chemistry; molecular electrochemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

The Plant Phenotyping and Phenomics for Breeding

edited by

Jaeil Lyu

submission deadline 20 Oct 2026 | Viewed by 760 | Submission Open

Keywords: plant phenomics; high-throughput phenotyping (HTP); genotype–phenotype association; non-invasive imag-ing; functional genomics; environmental interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Immunotherapy for Cancer: From Molecular Basis to Novel Biomarkers and Therapeutic Targets—2nd Edition

edited by

Laura Conti

and

Valentina Audrito

submission deadline 20 Oct 2026 | 1 articles | Viewed by 753 | Submission Open

Keywords: tumor microenvironment; immune suppression; metabolic and molecular mechanisms of resistance to therapy; tumor immune escape; immunotherapy; immune checkpoint inhibitors; cancer vaccination; tumor-infiltrating cells; biomarkers; tumor antigens; cancer metabolism

(This special issue belongs to the Section Molecular Oncology)

Mitochondrial Disorders: From Molecular Mechanisms to New Therapies

edited by

Yury Ladilov

and

Muhammad Aslam

submission deadline 20 Oct 2026 | Viewed by 696 | Submission Open

Keywords: mitochondrial disorders; mitochondrial dysfunction; molecular mechanisms; targeted therapeutic approaches; mitochondrial biology regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Activation of the Blood–Brain Barrier and Neurological Dysfunction: 2nd Edition

edited by

Monique F. Stins

submission deadline 20 Oct 2026 | 1 articles | Viewed by 650 | Submission Open

Keywords: blood–brain barrier; neuro-infectious diseases; microbes; traumatic brain injury; Alzheimer’s disease; Parkinson’s disease; schizophrenia; cerebral vasculature; vascular heterogeneity; white matter; gray matter; therapeutic delivery; opening the BBB; neuro vascular unit

(This special issue belongs to the Section Molecular Neurobiology)

Advances in the Nanoparticles-Based Drug Delivery in Cancer Therapy

edited by

André F. Moreira

submission deadline 20 Oct 2026 | Viewed by 628 | Submission Open

Keywords: nanoparticle-based drug delivery; stimuli responsive; cancer targeting; theragnostic nanoparticles; protein corona; combinatorial drug therapies; tumor penetration; cancer cells uptake

(This special issue belongs to the Section Molecular Nanoscience)

Displaying special issue 701-750 on page 15 of 63.

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