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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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DNA Repair, Genome Stability and Diseases
edited by Melike Caglayan
submission deadline 30 Nov 2025 | Viewed by 198 | Submission Open
Keywords: DNA damage; DNA repair; genomic stability; targeted therapy; biomarkers
(This special issue belongs to the Section Molecular Genetics and Genomics)
Contemporary Perspective of Cardio-Kidney Metabolic Syndrome: From Prevention to Management
edited by Alberto Palazzuoli, and
submission deadline 30 Nov 2025 | Viewed by 195 | Submission Open
Keywords: cardiovascular risk factors; metabolic syndrome; chronic kidney disease; heart failure; endothelial dysfunction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genomics and Epigenetics of Stem Cell: An Update
edited by
submission deadline 30 Nov 2025 | Viewed by 184 | Submission Open
Keywords: stem cells; epigenetics; genomics; cell fate; self-renewal; differentiation; regenerative medicine; transcription factors
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Research on Autoimmune Diseases and Rheumatology
edited by
submission deadline 30 Nov 2025 | Viewed by 184 | Submission Open
Keywords: rheumatology; molecular immunology; autoimmune diseases; biomarkers; transcriptomics; proteomics; epigenetics; single-cell analysis; cytokine signaling; precision medicine; exosomes; microRNA; immune metabolism; fibroblast activation; translational research
(This special issue belongs to the Section Molecular Immunology)
Kidney Diseases: Molecular Research and Novel Therapies
edited by Niels Olsen Saraiva Camara
submission deadline 30 Nov 2025 | Viewed by 183 | Submission Open
Keywords: kidney disease; immunology and inflammation; zebrafish models; therapeutic targets; modern-era drivers of renal pathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring Recent Research on Natural Compounds: From Biosynthesis to Application
edited by
submission deadline 30 Nov 2025 | Viewed by 182 | Submission Open
Keywords: proteins like antibodies and enzymes; small molecules; plant extracts; biosynthesis; nanodelivery; drug discovery
(This special issue belongs to the Section Biochemistry)
Unraveling Bioactive Peptides: Structure, Function, and Applications
edited by
submission deadline 30 Nov 2025 | Viewed by 182 | Submission Open
Keywords: bioactive peptides; peptide structure– activity relationship; peptidomics; bioactivity assays; human health
(This special issue belongs to the Section Macromolecules)
Gynecologic Oncology: Tumor Microenvironment and Novel Therapeutics submission deadline 30 Nov 2025 | Viewed by 178 | Submission Open
Keywords: tumor microenvironment; peritoneal-cancer cell interactions; extracellular matrix; ascites; immune cells; cancer-associated fibroblasts; immunotherapy; novel therapeutic targets
(This special issue belongs to the Section Molecular Oncology)
Neuroinflammation: Emerging Insights and Advances in Drug Development submission deadline 30 Nov 2025 | Viewed by 178 | Submission Open
Keywords: neuroinflammation; drugs; neurodegenerative; Parkinson’ s disease; Alzheimer’ s disease; multiple scleroris; stroke
(This special issue belongs to the Section Molecular Neurobiology)
Infectious Diseases and Infection Models in Laboratory Animals
edited by and Fumio Ike
submission deadline 30 Nov 2025 | Viewed by 174 | Submission Open
Keywords: infection model; Infectious diseases in laboratory animals; bacterial infection; viral infection; parasitic infection; molecular diagnosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Rheumatoid Arthritis: From Molecular Mechanism to Emerging Therapeutic Target
edited by Elisa Gremese and Costantino Pitzalis
submission deadline 30 Nov 2025 | Viewed by 172 | Submission Open
Keywords: rheumatoid arthritis; molecular mechanisms; emerging therapeutic targets; precision medicine; synovial tissue
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Antimicrobial Nanoparticles: Mechanisms, Applications, and Future Directions submission deadline 30 Nov 2025 | Viewed by 170 | Submission Open
Keywords: antimicrobial activity; nanoparticles; biofilm nano-modulators; antibiotic resistence; wastewater treatment; preservative properties of nanoparticles
(This special issue belongs to the Section Molecular Microbiology)
Combined and Mixture Exposure Toxicology of Cancer
edited by and Quentin Felty
submission deadline 30 Nov 2025 | Viewed by 169 | Submission Open
Keywords: combined exposure; mixture exposure; toxicology of cancer; omics of cancer; AI in carcinogenesis; machine learning use in cancer; cancer biomarkers; pollutants of cancer; agrochemicals; endocrine-disruptive chemicals
(This special issue belongs to the Section Molecular Oncology)
Molecular Informatics and AI in Cancer Research
edited by and
submission deadline 30 Nov 2025 | Viewed by 169 | Submission Open
Keywords: molecular informatics; artificial intelligence (AI); cancer research; personalized medicine; high-throughput data; biomarkers; clinical applications; longitudinal data
(This special issue belongs to the Section Molecular Informatics)
Kidney Disease: Molecular Insights and Emerging Therapies
edited by
submission deadline 30 Nov 2025 | Viewed by 168 | Submission Open
Keywords: kidney disease; molecular mechanism; precision medicine; translational nephrology; targeted molecular therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Lipopolysaccharides submission deadline 30 Nov 2025 | Viewed by 166 | Submission Open
Keywords: LPS structural diversity; lipid A; amino arabinose and phosphoethanolamine; TLR4; antibiotic resistance; Lpt transport system; phospholipids and fatty acids; cell envelope stress; lipid A acyltransferases
(This special issue belongs to the Section Molecular Biology)
Brain Stroke Across the Lifespan: Mechanisms, Models, Translational Advances and Impacts Beyond the Brain
edited by
submission deadline 30 Nov 2025 | Viewed by 164 | Submission Open
Keywords: stroke; brain; cerebral injury; post-stroke recovery; systemic physiology; models; therapeutic strategies
(This special issue belongs to the Section Molecular Neurobiology)
Endometriosis: Current Trends and Research Developments submission deadline 30 Nov 2025 | Viewed by 164 | Submission Open
Keywords: endometriosis; molecular mechanisms; pathophysiology; hormonal regulation; immune response; epigenetics; inflammation; biomarkers; transcriptomics; therapeutic targets
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Stress Signaling and Horticultural Crops Quality Control
edited by and
submission deadline 30 Nov 2025 | Viewed by 164 | Submission Open
Keywords: stress tolerance; molecular mechanisms; quality traits; redox regulation; postharvest physiology; signal transduction
(This special issue belongs to the Section Molecular Plant Sciences)
Precision Medicine for Cancer-Associated Thrombosis: The Role of Biomarkers
edited by Darko Antic
submission deadline 30 Nov 2025 | Viewed by 163 | Submission Open
Keywords: biomarkers; precision medicine; cancer-associated thrombosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Modeling in Pharmaceutical Sciences
edited by
submission deadline 30 Nov 2025 | Viewed by 163 | Submission Open
Keywords: molecular modeling; computer-aided drug design; molecular docking; drug discovery; quantum chemistry; molecular dynamics simulations; virtual screening; computational pharmacology; pharmacy; in silico methods
(This special issue belongs to the Section Molecular Pharmacology)
Eukaryotic Cells Under Stress: Biochemical and Physiological Mechanisms of Resistance and Resilience submission deadline 30 Nov 2025 | Viewed by 162 | Submission Open
Keywords: cellular stress response; oxidative stress; bioactive compounds; ROS; DNA damage/repair; environmental stressors; molecular chaperones; antioxidant in human diseases
(This special issue belongs to the Section Molecular Biology)
Advances in Tau Protein Research submission deadline 30 Nov 2025 | Viewed by 161 | Submission Open
Keywords: tau biology; disease model systems; protein aggregation; tauopathies; neurodegeneration; Alzheimer’ s disase; seeded aggregation; amyloid filaments; tau propagation; antibodies; targeted protein degradation; tau therapeutics
(This special issue belongs to the Section Molecular Biology)
Predict to Treat: Prognostic and Predictive Biomarkers in Breast Cancer
edited by
submission deadline 30 Nov 2025 | Viewed by 161 | Submission Open
Keywords: breast cancer; predictive biomarkers; prognostic biomarkers; precision oncology; treatment resistance; gene expression; liquid biopsy; immune microenvironment; targeted therapy; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Horizons in Antiviral and Antibacterial Agent Discovery submission deadline 30 Nov 2025 | Viewed by 161 | Submission Open
Keywords: antimicrobial resistance; multidrug-resistant infections; new antimicrobial drug development; natural and synthetic an-timicrobial agents; drug repurposing
(This special issue belongs to the Section Molecular Microbiology)
Bioactive Small Molecules in Tissue Repair and Regeneration submission deadline 30 Nov 2025 | Viewed by 157 | Submission Open
Keywords: small molecules; organ and tissue regeneration; development; aging
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Diagnostics in Hereditary Hemolytic Anemias
edited by Joan-Lluís Vives-Corrons
submission deadline 30 Nov 2025 | Viewed by 157 | Submission Open
Keywords: anemia; red blood cell erythropoiesis; membranopathies  ; erythro enzymopathies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research on Antioxidant Activity
edited by Agnieszka Filipek
submission deadline 30 Nov 2025 | Viewed by 155 | Submission Open
Keywords: antioxidants; advanced mechanisms of action; signaling pathways; molecular mechanism; biologically active compounds
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Aspects of Diabetes and Its Complications
edited by
submission deadline 30 Nov 2025 | Viewed by 155 | Submission Open
Keywords: obesity; insulin resistance; type 2 diabetes; atherosclerosis; endothelial dysfunction; cardiovascular disease; peripheral artery disease; diabetic feet; diabetic micoangiopathy; diabetic neuropathy; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Breast Cancer and Molecular-Based Treatments
edited by
submission deadline 30 Nov 2025 | Viewed by 154 | Submission Open
Keywords: breast cancer; immunotherapy; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insight into Nematodes Management
edited by
submission deadline 30 Nov 2025 | Viewed by 152 | Submission Open
Keywords: biological control; micro-organisms; molecular identification; biodiversity; climatic changes; soil nema-todes; cultural practices; host plant resistance; anaerobic soil disinfection; biofumigation
(This special issue belongs to the Section Molecular Biology)
Metabolomics in Physiology and Disease: Advances and Perspectives
edited by
submission deadline 30 Nov 2025 | Viewed by 152 | Submission Open
Keywords: metabolomics; disease biomarkers; data integration; bioinformatics; mass spectrometry; personalized medicine
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Cellular Memory in Response to Environmental Conditions
edited by
submission deadline 30 Nov 2025 | Viewed by 150 | Submission Open
Keywords: cellular memory; cellular environment; embryonic development; epigenetics; transgenerational inheritance; mammals; DOHaD
(This special issue belongs to the Section Molecular Biology)
Non-Coding RNAs as Key Regulators in Human Disease Processes
edited by
submission deadline 30 Nov 2025 | Viewed by 150 | Submission Open
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; therapeutic targets; molecular mechanisms; RNA-based therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cellular and Molecular Mechanisms in Diabetes Therapies
edited by
submission deadline 30 Nov 2025 | Viewed by 150 | Submission Open
Keywords: diabetes; β -cells; insulin signaling; inflammation; metabolic pathways; molecular mechanisms; stem cell therapy; gene therapy; oxidative stress; microbiota; immune modulation; epigenetics; regenerative medicine; therapeutic targets
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Pathogenesis of Pulmonary Arterial Hypertension: Differences in Molecular Mechanisms Between Neonatal and Adult Pulmonary Hypertension
edited by Germán Ebensperger
submission deadline 30 Nov 2025 | Viewed by 148 | Submission Open
Keywords: pulmonary arterial hypertension; newborn; cardiovascular perinatal transition; vascular remodeling; vascular reactivity; vascular inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Mechanobiology of Regeneration
edited by and Timothy R. Deer
submission deadline 30 Nov 2025 | Viewed by 144 | Submission Open
Keywords: mechanotransduction; regeneration; stem cells; extracellular matrix; tissue repair
(This special issue belongs to the Section Molecular Biophysics)
Molecular Pathophysiology of Chronic Lung Diseases: Mechanisms and Therapeutics
edited by Gary C. Mouradian
submission deadline 30 Nov 2025 | Viewed by 144 | Submission Open
Keywords: chronic lung disease; vagal sensory neurons; inflammation; airway remodeling; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research in Alzheimer’s Disease: From Pathology to Therapy
edited by Sofía Yolanda Díaz Miranda
submission deadline 30 Nov 2025 | Viewed by 142 | Submission Open
Keywords: multifunctional compounds in Alzheimer’ s disease therapy; translational medicine in Alzheimer's disease; novel drug candidates for Alzheimer's disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Adhesion, Invasion, and Metastasis in Cancer Progression submission deadline 30 Nov 2025 | Viewed by 142 | Submission Open
Keywords: cancer metastasis; cellular adhesion; invasion and migration; noncoding RNAs; EMT; Wnt/β -catenin signalling; tumour microenvironment; biomarkers; AI-driven metastasis prediction
(This special issue belongs to the Section Molecular Oncology)
Advances in the Genetics and Precision Breeding of Tomato
edited by Younghoon Park
submission deadline 30 Nov 2025 | Viewed by 139 | Submission Open
Keywords: climate change; gene editing; genomic selection; flavor; functional compounds; molecular marker; omics; precision breeding; Solanum lycopersicum; tomato
(This special issue belongs to the Section Molecular Plant Sciences)
Antibiotics Science: Molecular Insights, Detection Strategies, Resistance Challenges and Interdisciplinary Applications
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 136 | Submission Open
Keywords: antibiotics; antibiotic molecular design and synthesis; antibiotic action mechanism; antibiotics resistance; environmental contamination; therapeutic monitoring; antibiotic sensing and detection; food and environmental safety
(This special issue belongs to the Section Molecular Microbiology)
Molecular Pathology and Treatment of Hepatocellular Carcinoma
edited by
submission deadline 30 Nov 2025 | Viewed by 135 | Submission Open
Keywords: hepatocellular carcinoma; cholangiocarcinoma; angiosarcoma; metastases; biomarkers; immunohistochemistry; genetics; clinical trial
(This special issue belongs to the Section Molecular Oncology)
Role of DNA Methylation Signatures in Genetic Disorders submission deadline 30 Nov 2025 | Viewed by 134 | Submission Open
Keywords: DNA methylation; genetic disorders; episignature; genomic medicine; differentially methylated regions
(This special issue belongs to the Section Molecular Genetics and Genomics)
Neurobiology and Psychopharmacology of Mood Disorders
edited by
submission deadline 30 Nov 2025 | Viewed by 134 | Submission Open
Keywords: mood disorders; psychopharmacology; neurobiology; molecular mechanisms; biomarkers; translational psychiatry; neuroinflammation; signal transduction; animal models; epigenetics
(This special issue belongs to the Section Molecular Neurobiology)
Omics Approach to Uncovering Signalling and Gene Regulation in Plants
edited by Xiang Li and Jingchun Shi
submission deadline 30 Nov 2025 | Viewed by 133 | Submission Open
Keywords: omics; plant signalling; gene regulation; bioinformatics
(This special issue belongs to the Section Molecular Plant Sciences)
Next-Gen Biomarkers for Cancer Immunotherapy
edited by
submission deadline 30 Nov 2025 | Viewed by 132 | Submission Open
Keywords: cancer biomarkers; immunotherapy; circulating tumor DNA; exosomes; tumor-specific microRNAs; sin-gle-cell sequencing; spatial transcriptomics; precision oncology
(This special issue belongs to the Section Molecular Immunology)
Structural, Optical and Electrical Properties of Metal Complexes
edited by and
submission deadline 30 Nov 2025 | Viewed by 132 | Submission Open
Keywords: metal complexes; transition metal (TM) complexes; TM-based materials; ligand field; electronic configuration; optical properties; density functional theory; time-dependent DFT; structure– property– function relationships
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Toxicity of Animal Venoms and the Components: Molecular Mechanisms of Action
edited by
submission deadline 30 Nov 2025 | Viewed by 132 | Submission Open
Keywords: venom toxicity; biochemical activity; toxin biology; cellular targets; peptide; protein; structure– function relationships
(This special issue belongs to the Section Molecular Biology)
New Pharmacological Insights on Natural Macromolecules and Natural Small Molecules: 2nd Edition
edited by
submission deadline 30 Nov 2025 | Viewed by 131 | Submission Open
Keywords: bioactive natural molecules; natural macromolecules; natural small molecules; drug delivery; inflammatoty diseases; neurodegenerative diseases; skin diseases; cancer; metabolic diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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