Pathogenesis of Pulmonary Arterial Hypertension: Differences in Molecular Mechanisms Between Neonatal and Adult Pulmonary Hypertension
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 41
Special Issue Editor
Interests: pulmonary arterial hypertension; newborn; cardiovascular perinatal transition; vascular remodeling; vascular reactivity; vascular inflammation
Special Issue Information
Dear Colleagues,
Pulmonary arterial hypertension (PAH) is a syndrome with multiple etiological agents. It is a pathology of great complexity as it progressively induces a sustained increase in pulmonary arterial pressure, often leading to right heart failure if left untreated. In addition, its etiological origins at different ages in humans are even more diverse; in the neonatal period, the pulmonary arteries show a decrease in the thickness of the inefficient arterial wall and increased vasoconstrictor reactivity, whereas in adults, the gradual thickening of the arterial wall is observed. Molecular research on PAH aims to unravel its underlying mechanisms and identify possible therapeutic targets.
Recent studies highlight the fundamental role of genetic mutations, epigenetic modifications, and variations within signaling pathways involved in PAH’s pathogenesis. Sex-associated changes may also significantly influence PAH by altering gene expression and promoting abnormal cell behavior and vascular remodeling.
Classical signaling pathways associated with vascular reactivity and remodeling are essential for maintaining vascular integrity and efficient function. The dysregulation of these pathways results in vasoconstriction and the proliferation of endothelial and smooth muscle cells, which are characteristic of PAH.
Topics of interest include similarities and differences between the neonatal and adult pathophysiology of PAH in terms of the following:
- Cellular and molecular mechanisms;
- The role of vascular reactivity mechanisms;
- The role of vascular remodeling mechanisms;
- The role of sex differences in the mechanisms involved.
Papers on potential new biomarkers and treatments based on molecular mechanisms are also welcome.
Dr. Germán Ebensperger
Guest Editor
Manuscript Submission Information
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Keywords
- pulmonary arterial hypertension
- newborn
- cardiovascular perinatal transition
- vascular remodeling
- vascular reactivity
- vascular inflammation
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