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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advancements in Genomic Technologies for Molecular Safety Assessment

edited by

Eric Blomme

submission deadline 30 Dec 2025 | Viewed by 571 | Submission Open

Keywords: gene expression; safety assessment; genomic technologies; genomic tools; molecular toxicology; toxicity; predictive safety assessments; proteomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research on Pathophysiology of Multiple Sclerosis and Neuroinflammation

edited by

Fabrizio Michetti

submission deadline 30 Dec 2025 | Viewed by 495 | Submission Open

Keywords: multiple sclerosis (MS); autoimmune diseases; encephalomyelitis; neuroinflammation; central nervous system (CNS); autoimmunity and neurodegeneration; molecular basis of immune mechanisms

(This special issue belongs to the Section Molecular Neurobiology)

Metal-Based Compounds: Molecular Mechanisms of Pharmacological Action and Toxicity

edited by

Danijela Z. Krstić

submission deadline 30 Dec 2025 | Viewed by 488 | Submission Open

Keywords: metal elements and ions; metal complexes; metal nanoclusters; pharmacology andpharmacokinetics; in vitro toxicity; in vivo toxicity; toxicity biomarkers; enzymes as pharmacological and toxicity targets; toxicity mechanisms; metallodrugs

(This special issue belongs to the Section Molecular Toxicology)

Brain Ischemia: From Molecular Mechanisms to Innovative Therapies

edited by

Ryszard Pluta

submission deadline 30 Dec 2025 | Viewed by 366 | Submission Open

Keywords: ischemic neurodegeneration; focal brain ischemia; global brain ischemia; perinatal asphyxia; ischemic stroke; traumatic brain injury; apnea; neuroinflammation; proteins; genes; genes involved in neurodegeneration; glia-to-neurons genetic conversion; dementia; Alzheimer’s disease; genetic conversion of ischemia to Alzheimer's disease; new therapeutic approaches; biomarkers

(This special issue belongs to the Section Molecular Biology)

Advances in Regenerative Medicine, Organ Bioengineering and Transplantation

edited by

Dorota Latek

submission deadline 30 Dec 2025 | Viewed by 360 | Submission Open

Keywords: regenerative medicine; organ bioengineering; transplantation; allografting; stem cells; drug discovery; immunosuppression; xenotransplantation; organogenesis; biomaterials

(This special issue belongs to the Section Molecular Immunology)

Molecular Insight into Antimicrobial Resistance

edited by

Dan-Alexandru Țoc

and

Carmen Costache

submission deadline 30 Dec 2025 | Viewed by 358 | Submission Open

Keywords: antimicrobial resistance; MRSA; ESBL-producing bacteria; carbapenem-resistant enterobacterales (CRE); vancomycin-resistant enterococci (VRE); linezolid resistance; novel antibiotic combinations; resistance mechanisms; horizontal gene transfer; molecular epidemiology

(This special issue belongs to the Section Molecular Pharmacology)

Electromagnetic Field Interactions with Biomolecules

edited by Samina Masood

submission deadline 30 Dec 2025 | Viewed by 358 | Submission Open

Keywords: magnetic field; biomolecules; medicine; drug delivery; protective methods; disease control

(This special issue belongs to the Section Biochemistry)

Neuroimmune Regulation of Acute and Chronic Pain

edited by Karen M. Wagner

submission deadline 30 Dec 2025 | Viewed by 316 | Submission Open

Keywords: acute pain; chronic pain; central sensitization; neuroinflammation; neuroimmunity; neurovascular coupling; cytokines; chemokines; catacholamines; stress

(This special issue belongs to the Section Molecular Neurobiology)

Skin Cancer: A Focus from Pathophysiology to Novel Therapeutic Strategies

edited by

Piotr Sobolewski

submission deadline 30 Dec 2025 | Viewed by 256 | Submission Open

Keywords: skin cancer; melanoma; keratinocyte carcinoma; pathophysiology; biomarkers; immunotherapy; targeted therapy; nanomedicine; resistance; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Role of Mitochondria in Neurodegenerative Diseases

edited by Małgorzata Wojtkowska

submission deadline 30 Dec 2025 | Viewed by 247 | Submission Open

Keywords: mitochondria; ccfDNA; Parkinson’ s disease’ Alzheimer’ s disease

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Obesity Research: Metabolic Pathways and Pathophysiological Factors

edited by Aleksandra Stefanović

submission deadline 30 Dec 2025 | Viewed by 239 | Submission Open

Keywords: obesity; inflammation; oxidative stress; obesity-related diseases; adypocitokines

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Basis for Sustainable Management of Migratory Insects

edited by

Xingfu Jiang

submission deadline 30 Dec 2025 | Viewed by 226 | Submission Open

Keywords: migrant insects; molecular basis of population growth; migration and reproduction; migration and immunity; migration and diapause; migration and orientation; molecular regulation of migration

(This special issue belongs to the Section Molecular Biology)

Role of Immune and Inflammatory Cells in Pulmonary Diseases

edited by Remo C. Russo

submission deadline 30 Dec 2025 | Viewed by 203 | Submission Open

Keywords: idiopathic pulmonary fibrosis (IPF); pulmonary immunology; precision medicine; single-cell RNA sequencing (scRNA-seq); spatial transcriptomics sequencing; animal model of pulmonary fibrosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Immune-Modulating Therapies and Cutting-Edge Technologies for Immune-Related Diseases

edited by

Xingxing Fan

submission deadline 30 Dec 2025 | Viewed by 202 | Submission Open

Keywords: immune heomostasis; immune related diseases; small molecules; cell therapy; bacteria and virus; antibodies

(This special issue belongs to the Section Molecular Immunology)

Synthesis, Characterization and Applications of Advanced Polymer Materials

edited by Namil Kim

submission deadline 30 Dec 2025 | Viewed by 184 | Submission Open

Keywords: synthesis methodologies; molecular architecture; functional polymers; characterization techniques; cutting-edge applications

(This special issue belongs to the Section Macromolecules)

Machine Learning in Disease Diagnosis and Treatment: 2nd Edition

edited by

Makrina Karaglani

submission deadline 30 Dec 2025 | Viewed by 175 | Submission Open

Keywords: machine learning; diagnosis; treatment; algorithm; predictive; artificial intelligence

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Immunotherapy in Cancer

edited by Magdalena Król

submission deadline 30 Dec 2025 | Viewed by 172 | Submission Open

Keywords: cancer immunotherapy; tumor microenvironment; immune checkpoint inhibitors; monoclonal antibodies; cytokine signaling; tumor immune evasion; metabolic regulation in cancer; cell-based therapies

(This special issue belongs to the Section Molecular Immunology)

Epigenetic Regulation in Cell Development, Differentiation and Cell Fate

edited by Gang Ren

submission deadline 30 Dec 2025 | Viewed by 157 | Submission Open

Keywords: 3D genome; myogenesis; transgenerational inheritance; enhancer– promoter interaction; histone modification; epigenetic variation; complex traits

(This special issue belongs to the Section Molecular Genetics and Genomics)

Telocytes: Unraveling Their Roles in Health and Disease

edited by

Sanda Cretoiu

submission deadline 30 Dec 2025 | Viewed by 155 | Submission Open

Keywords: telocytes; telopodes; intercellular communication; stem cell niche; extracellular vesicles; regenerative medicine; tissue remodelling; stromal cells

(This special issue belongs to the Section Molecular Biology)

Cellular Physiology and Aging: Membrane Dynamics, Intracellular Environment and Signaling Pathways

edited by

Alessia Remigante

Rossana Morabito

and Sara Spinelli

submission deadline 30 Dec 2025 | Viewed by 153 | Submission Open

Keywords: aging; oxidative stress; ion channels; antioxidant molecules; membrane transport systems; redox signaling; cellular senescence; inflammation; intracellular signaling pathways; mitochondrial dysfunction; bioactive compounds; cell physiology; homeostasis; longevity; age-related diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Research in RNA–Protein Networks

edited by Hidenori Tani

submission deadline 30 Dec 2025 | Viewed by 145 | Submission Open

Keywords: machine learning; bioinformatics; ribonucleoprotein; RNA– protein complex; alternative splicing; RNA stability; RNA localization

(This special issue belongs to the Section Molecular Biology)

Cellular Mechanisms of Pulmonary Arterial Hypertension

edited by

David P Marciano

and Saurabh Aggarwal

submission deadline 30 Dec 2025 | Viewed by 142 | Submission Open

Keywords: pulmonary arterial hypertension (PAH); pulmonary vascular remodeling; endothelial cells; endothelial dysfunction; smooth muscle cells; hyperplasia; pericytes; fibroblasts; monocytes; macrophage; neutrophil; mechanotransduction; oxidative stress; cytokines; extracellular vesicles; extracellular matrix; epigenetics; metabolism; biomarkers; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Products in Immune Regulation

edited by

Wansu Park

submission deadline 30 Dec 2025 | Viewed by 140 | Submission Open

Keywords: natural products; immune responses; immunomodulatory therapies

(This special issue belongs to the Section Molecular Immunology)

Molecular and Cellular Biology of Pregnancy Complications

edited by Elżbieta Poniedziałek-Czajkowska and Radzisław Mierzyñski

submission deadline 30 Dec 2025 | Viewed by 136 | Submission Open

Keywords: molecular biology of pregnancy complications; maternal pregnancy complications; neonatal pregnancy complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Evolutionary Drivers and Adaptive Mechanisms in Algal Organellar Genomes

edited by

Feng Liu

submission deadline 30 Dec 2025 | Viewed by 132 | Submission Open

Keywords: organellar genome of algae; molecular evolution; secondary structure of intron; evolutionary driving force; horizontal gene transfer

(This special issue belongs to the Section Molecular Plant Sciences)

Role of Microorganisms and Their Metabolites in Agriculture, Food and the Environment: 3rd Edition

edited by

Barbara Sokolowska

submission deadline 30 Dec 2025 | Viewed by 125 | Submission Open

Keywords: fermentation; biopreservation; biocontrol; biodegradation; bioremediation; bioaugmentation; omic-technologies

(This special issue belongs to the Section Molecular Microbiology)

New Breakthroughs in Molecular Diagnostic Tools for Human Diseases, 2nd Edition

edited by

Vittorio Fineschi

submission deadline 30 Dec 2025 | Viewed by 118 | Submission Open

Keywords: molecular pathology; molecular diagnostics; genetics; epigenetics; proteomics; immunohistochemistry; thrombo-embolic disease; sudden cardiac death; the molecular pathology of traumatic injuries; hypoxic– ischemic brain damage; the experimental models of injury and diseases; the targeted therapy of injuries and diseases; drug abuse; histological diagnosis; the epigenetics of organs injuries; miRNA and the prognosis of diseases; novel approaches and proofs of principle in therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolic Crossroads in Cardiac Pathophysiology

edited by

Robert J. Chilton

submission deadline 30 Dec 2025 | Viewed by 114 | Submission Open

Keywords: cardiometabolic disease; cardiac metabolism; heart failure; mitochondrial dysfunction; insulin resistance; cardiometabolic therapies; metabolomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Biomarkers and New Therapeutic Options in Neoplastic Diseases

edited by

Maurizio Martini

submission deadline 30 Dec 2025 | Viewed by 106 | Submission Open

Keywords: biomarkers; neoplastic diseases; molecular targets; targeted therapy; precision oncology; signaling pathways; cancer diagnostics; therapeutic options; drug resistance; molecular profiling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Diet in Lipid and Lipoprotein Metabolism

edited by

Kyung-Hyun Cho

submission deadline 30 Dec 2025 | Viewed by 98 | Submission Open

Keywords: dyslipidemia; hypertension; diabetes; dementia

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Predictive, Prognostic Biomarkers and Therapeutic Targets of Breast Cancer: Second Edition

edited by Antonella Ciabattoni and Fabiana Gregucci

submission deadline 30 Dec 2025 | Viewed by 96 | Submission Open

Keywords: radiotherapy; breast cancer; stereotactic body radiotherapy; brain radiosurgery; target therapy; immunotherapy; tailored systemic therapy

(This special issue belongs to the Section Molecular Oncology)

The Unresolved Molecular Bases of Major Histocompatibility Complex (MHC) Function with Transplantation and Diseases Linkage

edited by Antonio Arnaiz-Villena

submission deadline 30 Dec 2025 | Viewed by 80 | Submission Open

Keywords: HLA; disease; autoimmunity; immune deficiency; MHC phylogeny; HLA pharmacogenomics; immune modulatory MHC and HLA genes (G; E; F); transplantation; hemochromatosis; MHC/HLA epithelial interaction; MHC evolution; MHC phylogenetics; Vertebrate MHC; Amimal MHC; Veterinary

(This special issue belongs to the Section Molecular Immunology)

Research on the Key Role of Ubiquitination in Signaling and Cancer

edited by

Bo Zhao

submission deadline 30 Dec 2025 | Viewed by 69 | Submission Open

Keywords: ubiquitin; ubiquitination; E3 ligase; deubiquitinating enzymes; protein degradation; mutations; cancer progression; signal transduction; drug development

(This special issue belongs to the Section Molecular Oncology)

Effects of Bioactive Compounds in Oxidative Stress and Inflammation

edited by

Paul-Mihai Boarescu

and

Raluca Maria Pop

submission deadline 31 Dec 2025 | 9 articles | Viewed by 28607 | Submission Open

Keywords: natural products; antioxidant effects; anti-inflammatory effects; molecular targets; health beneficial effect; bioactive compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Schizophrenia: From Molecular Mechanism to Therapy

edited by

Yael Abreu-Villaça

submission deadline 31 Dec 2025 | 7 articles | Viewed by 22145 | Submission Open

Keywords: schizophrenia; neurodevelopmental disorders; therapeutic approaches; drug of abuse; mental disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biological Research on Plant Bioactive Compounds

edited by

Adriana Trifan

and

Simon Vlad Luca

submission deadline 31 Dec 2025 | 9 articles | Viewed by 16795 | Submission Open

Keywords: plant bioactive compounds; extraction and analysis of plant bioactive compounds; bioactivity and pharmacokinetics of plant compounds; natural products and modern diseases; plant bioactive compounds and by-products; discovery and development of natural plant drugs

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Research Progress of Metabolomics in Health and Disease

edited by

Maria Assunta Acquavia

submission deadline 31 Dec 2025 | 10 articles | Viewed by 15853 | Submission Open

Keywords: metabolomics; health; diseases; target metabolites; mass spectrometry; hyphenated techniques

(This special issue belongs to the Section Molecular Biology)

The Role of Lipids in Health and Diseases

edited by

Yutang Wang

submission deadline 31 Dec 2025 | 5 articles | Viewed by 15250 | Submission Open

Keywords: lipids; triglycerides; phospholipids; cholesterol; sphingolipids; steroids; fatty acids; lipid metabolism

(This special issue belongs to the Section Biochemistry)

Phyto-Functional Nanomaterials: Synthesis, Characterization and Application

edited by

Maria G. P. M. S. Neves

Carla Isabel Madeira dos Santos

and

Nuno M. M. Moura

submission deadline 31 Dec 2025 | 8 articles | Viewed by 14307 | Submission Open

Keywords: phyto-functional nanomaterials; green synthesis; hydrogen generation; pollutant degradation/removal; fine chemistry; photoinactivation; cancer; microorganisms

(This special issue belongs to the Section Molecular Nanoscience)

Natural Products in Drug Discovery and Development

edited by Tian-Le Gao

submission deadline 31 Dec 2025 | 10 articles | Viewed by 13663 | Submission Open

Keywords: natural product components; traditional medicine; biological entropy reduction; aromatic drugs; essential oils; gut microbiota modulation; probiotics; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Editorial Board Members’ Collection Series: Cancer Metastasis

edited by

Carlos Cabañas

and

Sung-Hoon Kim

submission deadline 31 Dec 2025 | 5 articles | Viewed by 13631 | Submission Open

Keywords: biomarkers; liquid biopsy; premetastatic niche; angiogenesis; immune evasion and suppression; genetic and epigenetic determinants; chemoresistance; extracellular vesicles

(This special issue belongs to the Section Molecular Oncology)

The Impact of Natural Bioactive Compounds on Human Health and Disease

edited by

Yeong-geun Lee

submission deadline 31 Dec 2025 | 6 articles | Viewed by 12579 | Submission Open

Keywords: natural product chemistry; nuclear magnetic resonance; structural elucidation; herbal drug

(This special issue belongs to the Section Molecular Pharmacology)

Abiotic Stress Tolerance and Genetic Diversity in Plants, 2nd Edition

edited by

Andrés J. Cortés

submission deadline 31 Dec 2025 | 6 articles | Viewed by 9932 | Submission Open

Keywords: biodiversity; molecular breeding; comparative genomics; abiotic stress adaptation; genetic mapping; predictive breeding; genomic prediction; assisted gene flow; plant breeding; restoration ecology; conservation genetics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research in Bamboo, Tree, Grass, and Other Forest Products

edited by

Huayu Sun

submission deadline 31 Dec 2025 | 8 articles | Viewed by 9212 | Submission Open

Keywords: bamboo; tree; grass; molecular biology; gene function

(This special issue belongs to the Section Molecular Plant Sciences)

25th Anniversary of IJMS: Updates and Advances in Molecular Neurobiology

edited by

Kiminobu Sugaya

submission deadline 31 Dec 2025 | 6 articles | Viewed by 8979 | Submission Open

Keywords: molecular neurobiology; neural signaling and gene regulation; synaptic plasticity; neurodevelopment; neurodegeneration; neuroregeneration; neuroinflammation; epigenetics in neuroscience; non-coding RNAs; protein misfolding and aggregation; exosomes and extracellular vesicles; stem cells and neural repair; biomarkers of neurological disease; translational neuroscience; neuropharmacology; brain omics (genomics; proteomics; transcriptomics); neuronal-glial interactions; mitochondrial dysfunction in the nervous system

(This special issue belongs to the Section Molecular Neurobiology)

25th Anniversary of IJMS: Updates and Advances in Molecular Oncology

edited by

Peter J. K. Kuppen

submission deadline 31 Dec 2025 | 9 articles | Viewed by 8147 | Submission Open

Keywords: molecular oncology; cancer epigenetics; tumour heterogeneity; tumour microenvironment; precision oncology; liquid biopsy; cancer immunotherapy

(This special issue belongs to the Section Molecular Oncology)

25th Anniversary of IJMS: Advances in Molecular Endocrinology and Metabolism

edited by

José L. Quiles

submission deadline 31 Dec 2025 | 5 articles | Viewed by 7963 | Submission Open

Keywords: molecular endocrinology; metabolic diseases; hormonal regulation; systems biology; precision medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Coordination Complexes: From Molecular Design to Functional Applications

edited by

Sanaa Musa

submission deadline 31 Dec 2025 | 2 articles | Viewed by 7653 | Submission Open

Keywords: coordination complexes; organometallic complexes; functional materials; metal– ligand interactions; homogenous catalysis; sensing; magnetic materials; ligand tunability

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

25th Anniversary of IJMS: Updates and Advances in Macromolecules

edited by

Haiyang Gao

Salah-Eddine Stiriba

and

Zhongzhou Chen

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6224 | Submission Open

Keywords: macromolecules; monomers; lipids; peptides; proteins; carbohydrates; polysaccharides; nucleic acids; modification; functionalization; structure– property relationship

(This special issue belongs to the Section Macromolecules)

Recent Progress in Metabolic Diseases

edited by

Dariusz Chlubek

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5509 | Submission Open

Keywords: metabolic diseases; enzymes related to metabolic disorders; inborn errors of metabolism; inherited single-gene anomalies; molecular diagnostics in metabolic disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 851-900 on page 18 of 69.

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