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Molecular and Cellular Biology of Pregnancy Complications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 December 2025) | Viewed by 630

Special Issue Editors


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Guest Editor
Department of Obstetrics and Perinatology, Medical University of Lublin, 20-954 Lublin, Poland
Interests: pregnancy complications; gestational diabetes mellitus; adipokines; adiponectin; chemerin; lipocalin; apelin
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-954 Lublin, Poland
Interests: pregnancy complications; gestational diabetes mellitus; adipokines; adiponectin; chemerin; lipocalin; apelin

Special Issue Information

Dear Colleagues,

We are honored to present the Special Issue entitled “Molecular and Cellular Biology of Pregnancy Complications”. It aims to present high-quality scientific articles (original research articles or comprehensive/systematic review papers) presenting the latest achievements and research directions regarding the molecular and cellular biology of pregnancy complications.

Pregnancy is a unique period in which attention is focused simultaneously on two people, the mother and the developing baby. The health of the mother during pregnancy and the pre-pregnancy period is important for the proper development of the fetus and affects the further development of the child after birth.

Chronic diseases diagnosed before pregnancy, such as hypertension, diabetes, and autoimmune diseases, significantly increase the risk of complications observed during pregnancy, such as preterm birth, intraamniotic infection, preeclampsia, placental abnormalities, or hemorrhages. Other complications observed during pregnancy are not directly related to previously identified pre-pregnancy abnormalities. Despite ongoing research, the molecular and cellular processes leading to the development of many of these complications are not fully understood.

The remarkable development of neonatology, inextricably linked with perinatal medicine, provides a good start for future life, even in extremely premature babies or those born with diseases of intrauterine origin. The currently observed impressive progress in perinatal medicine in the field of basic sciences enables us to understand better the impact of maternal factors on the development of the fetus, and the development of clinical trials allows us to create the optimal conditions for development for the fetus through the prevention and treatment of diseases in the mother. Therefore, we also encourage authors to submit works concerning neonatological problems.

In the hope of creating a multidisciplinary platform for scientific exchange, we invite all researchers interested in maternal, fetal, and newborn health to share their research results and their own clinical experience.

Dr. Elżbieta Poniedziałek-Czajkowska
Dr. Radzisław Mierzyñski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • molecular biology of pregnancy complications
  • maternal pregnancy complications
  • neonatal pregnancy complications

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Published Papers (1 paper)

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Research

16 pages, 2237 KB  
Article
Altered AADAC Modulates Trophoblast Invasion and Suggests a Potential Angiogenic Regulatory Role in Severe Preeclampsia
by Hyo Jung An, Dae Hyun Song, Yu-min Kim, Hyen Chul Jo, Jong Chul Baek, Juseok Yang and Ji Eun Park
Int. J. Mol. Sci. 2026, 27(2), 1103; https://doi.org/10.3390/ijms27021103 - 22 Jan 2026
Viewed by 343
Abstract
Preeclampsia (PE) is a serious pregnancy complication characterized by hypertension and organ dysfunction. Its pathogenesis involves impaired trophoblast invasion and inadequate spiral artery remodeling; however, the underlying molecular mechanisms remain unclear. This study investigated the role of arylacetamide deacetylase (AADAC) in PE and [...] Read more.
Preeclampsia (PE) is a serious pregnancy complication characterized by hypertension and organ dysfunction. Its pathogenesis involves impaired trophoblast invasion and inadequate spiral artery remodeling; however, the underlying molecular mechanisms remain unclear. This study investigated the role of arylacetamide deacetylase (AADAC) in PE and its effects on trophoblast function by analyzing placental tissues from 30 patients with PE and 15 controls. Exploratory RNA sequencing was performed on pooled placental samples from six patients with severe PE and six controls, and AADAC expression was validated by semi-quantitative PCR and Western blotting. HTR8/SVneo cells were exposed to cobalt chloride (CoCl2) under hypoxia-mimicking conditions, and AADAC expression was manipulated by siRNA-mediated knockdown (KD) and overexpression (OE). RNA sequencing revealed increased AADAC expression in PE placentas (fold change > 2.0, raw p < 0.05). Although AADAC mRNA levels were elevated in PE tissues, protein levels were reduced. CoCl2 exposure was associated with increased expression of AADAC and hypoxia-inducible factor-1 alpha (HIF-1α). Under hypoxia-mimicking conditions, AADAC silencing was associated with increased trophoblast invasion and tube formation, whereas AADAC overexpression reduced tube formation without significantly affecting invasion. These findings suggest that dysregulated, hypoxia-responsive AADAC expression influences trophoblast invasive and angiogenic behavior in preeclampsia. Full article
(This article belongs to the Special Issue Molecular and Cellular Biology of Pregnancy Complications)
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