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Advancements in Pincer Ligand Chemistry

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Physical Chemistry and Chemical Physics".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 4651

Special Issue Editor

1. Natural Compounds and Organic Synthesis Department, MIGAL—Galilee Research Institute, Kiryat Shmona 11016, Israel
2. Biotechnology Department, Tel-Hai Academic College, Upper Galilee 9977, Qiryat Shemona 1220800, Israel
Interests: organic synthesis; biochemistry; microencapsulation; analytical chemistry

Special Issue Information

Dear Colleagues,

Pincer ligand complexes represent a versatile class of coordination compounds characterized by their unique tridentate ligands that bind to a central metal atom through three adjacent donor atoms. These ligands typically form robust, thermally stable metal–ligand bonds, creating a rigid, “pincer-like” structure. Pincer ligands’ structural rigidity and electronic properties confer high stability and reactivity to their metal complexes, making them valuable in various applications, including catalysis, materials science, and medicinal chemistry. In catalysis, pincer complexes are particularly notable for facilitating challenging transformations under mild conditions, including hydrogenation, dehydrogenation, and C-H activation reactions. The tunability of pincer ligands allows for the fine-tuning of electronic and steric properties, enabling precise control over the reactivity and selectivity of the metal center. As a result, pincer ligand complexes continue to be a focal point of research, driving advancements in fundamental coordination chemistry and applied chemical processes. To that end, this Special Issue of the International Journal of Molecular Sciences on Advancements in Pincer Ligand Chemistry will include original research papers and reviews on the latest developments in this field.

Dr. Sanaa Musa
Guest Editor

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Keywords

  • pincer ligands
  • metal complexes
  • tridentate ligands
  • catalysis
  • organometallic chemistry
  • homogenous catalysis
  • ligand tunability

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Published Papers (2 papers)

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Research

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15 pages, 4410 KiB  
Article
Synthesis, Structure, and Properties of a Copper(II) Binuclear Complex Based on Trifluoromethyl Containing Bis(pyrazolyl)hydrazone
by Olga G. Shakirova, Tatiana D. Morozova, Yulia S. Kudyakova, Denis N. Bazhin, Natalia V. Kuratieva, Lyubov S. Klyushova, Alexander N. Lavrov and Lyudmila G. Lavrenova
Int. J. Mol. Sci. 2024, 25(17), 9414; https://doi.org/10.3390/ijms25179414 - 30 Aug 2024
Cited by 1 | Viewed by 1280
Abstract
A new complex of copper(II) with methyl-5-(trifluoromethyl)pyrazol-3-yl-ketazine (H2L) was synthesized with the composition [Cu2L2]∙C2H5OH (1). Recrystallization of the sample from DMSO yielded a single crystal of the composition [Cu2L [...] Read more.
A new complex of copper(II) with methyl-5-(trifluoromethyl)pyrazol-3-yl-ketazine (H2L) was synthesized with the composition [Cu2L2]∙C2H5OH (1). Recrystallization of the sample from DMSO yielded a single crystal of the composition [Cu2L2((CH3)2SO)] (2). The coordination compounds were studied by single-crystal X-ray diffraction analysis, IR spectroscopy, and static magnetic susceptibility method. The data obtained indicate that the polydentate ligand is coordinated by both acyclic nitrogen and heterocyclic nitrogen atoms. The cytotoxic activity of the ligand and complex 1 was investigated on human cell lines MCF7 (breast adenocarcinoma), Hep2 (laryngeal carcinoma), A549 (lung carcinoma), HepG2 (hepatocellular carcinoma), and MRC5 (non-tumor lung fibroblasts). The complex was shown to have a pronounced dose-dependent cytotoxicity towards these cell lines with LC50 values in the range of 0.18–4.03 μM. Full article
(This article belongs to the Special Issue Advancements in Pincer Ligand Chemistry)
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Review

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30 pages, 6125 KiB  
Review
Advances in Chiral Pincer Complexes: Insights and Applications in Catalytic Asymmetric Reactions
by Sanaa Musa, Yuval Peretz and Gil Dinnar
Int. J. Mol. Sci. 2024, 25(19), 10344; https://doi.org/10.3390/ijms251910344 - 26 Sep 2024
Viewed by 1850
Abstract
Chiral pincer complexes, characterized by their rigid tridentate coordination framework, have emerged as powerful catalysts in asymmetric synthesis. This review provides a comprehensive overview of recent advancements in the development of chiral pincer-type ligands and their corresponding transition metal complexes. We highlight the [...] Read more.
Chiral pincer complexes, characterized by their rigid tridentate coordination framework, have emerged as powerful catalysts in asymmetric synthesis. This review provides a comprehensive overview of recent advancements in the development of chiral pincer-type ligands and their corresponding transition metal complexes. We highlight the latest progress in their application across a range of catalytic asymmetric reactions, including the (transfer) hydrogenation of polar and non-polar bonds, hydrophosphination, alkynylation, Friedel-Crafts reactions, enantioselective reductive cyclization of alkynyl-tethered cyclohexadienones, enantioselective hydrosilylation, as well as Aza–Morita–Baylis–Hillman reactions. The structural rigidity and tunability of chiral pincer complexes enable precise control over stereoselectivity, resulting in high enantioselectivity and efficiency in complex molecular transformations. As the field advances, innovations in ligand design and the exploration of new metal centers are expected to expand the scope and utility of these catalysts, bearing significant implications for the synthesis of enantioenriched compounds in pharmaceuticals, materials science, and beyond. Full article
(This article belongs to the Special Issue Advancements in Pincer Ligand Chemistry)
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