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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Pharmacological Insights on Natural Macromolecules and Natural Small Molecules: 2nd Edition

edited by

Dong-Sung Lee

submission deadline 30 Nov 2025 | Viewed by 131 | Submission Open

Keywords: bioactive natural molecules; natural macromolecules; natural small molecules; drug delivery; inflammatoty diseases; neurodegenerative diseases; skin diseases; cancer; metabolic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Metabolites under Environmental Stress: Mechanisms, Responses and Adaptation Strategies

edited by

Alfosea-Simón Marina

submission deadline 30 Nov 2025 | Viewed by 130 | Submission Open

Keywords: omics; biosynthesis; defense; stress; adaptation; metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Cancer-Associated Stromal Cells

edited by Krisztián Németh and Balazs Mayer

submission deadline 30 Nov 2025 | Viewed by 129 | Submission Open

Keywords: cancer; microenvironment; tumor-associated stromal cells; cancer-associated fibroblast; mesenchymal stem cell; tumor-associated adipocyte; pericyte; cancer immunology; angiogenesis; metastasis; targeted cancer therapy; checkpoint inhibitor; CAR T cells; immunotherapy; signal transduction; small molecules

(This special issue belongs to the Section Molecular Oncology)

Computational Cancer Genomics and Molecular Profile in Breast Cancer

edited by Daniel Guimarães Tiezzi and

Stefano Maria Pagnotta

submission deadline 30 Nov 2025 | Viewed by 129 | Submission Open

Keywords: breast cancer; computational biology; genomics; molecular biology

(This special issue belongs to the Section Molecular Informatics)

Molecular Advances in Gynecologic Cancer, 2nd Edition

edited by

Alicja Forma

submission deadline 30 Nov 2025 | Viewed by 128 | Submission Open

Keywords: ovarian cancer; uterine cancer; cervical cancer; vaginal cancer; vulvar cancer

(This special issue belongs to the Section Molecular Oncology)

Signal Transduction Pathways: From Molecular Mechanisms to Therapeutic Targets

edited by

Boratkó Anita

submission deadline 30 Nov 2025 | Viewed by 127 | Submission Open

Keywords: signal transduction; molecular mechanism; cell signaling; disease pathways; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Molecular Pathology and Treatment of Oral Diseases

edited by

Paolo Boffano

submission deadline 30 Nov 2025 | Viewed by 127 | Submission Open

Keywords: odontogenic tumor; odontogenic cyst; oral pathology; oral cancer; molecular

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Cell Signaling Targets and Mechanism for Effective Individualized Therapies

edited by Kazuyuki Matsushita

submission deadline 30 Nov 2025 | Viewed by 125 | Submission Open

Keywords: novel cell signaling targets; individualized therapies; addiction signal pathway; diagnosis and treatment; cancer; neurodegenerative diseases; cell development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Gene Regulation in Endocrine Disease, 2nd Edition

edited by

Alberto Falchetti

submission deadline 30 Nov 2025 | Viewed by 124 | Submission Open

Keywords: gene regulation; endocrine disease; endocrinology; diabetes mellitus; thyroid disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Current Treatment Models in Hepatocellular Carcinomas

edited by

Michał P. Wasilewicz

submission deadline 30 Nov 2025 | Viewed by 123 | Submission Open

Keywords: hepatocellular carcinoma (HCC); liver tumors; liver cancer; molecular mechanisms; systemic therapies; immunochemotherapy; immunotherapy; adjuvant therapy; neoadjuvant therapy; hepatocellular carcinoma microenvironment; liver resection/liver transplantation in HCC; microwave ablation (MWA); transarterial chemoembolisation (TACE)

(This special issue belongs to the Section Molecular Oncology)

The Role of Natural Products in the Treatment and Prevention of Human Diseases

edited by

Jae-Hyun Kim

submission deadline 30 Nov 2025 | Viewed by 122 | Submission Open

Keywords: natural products; bone metabolism; sarcopenia; osteoporosis; herbal medicine; osteo-sarcopenic obesity; bone– muscle crosstalk; low-molecular-weight compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Natural Product-Inspired Anticancer Drug Development

edited by

Erzsébet Mernyák

submission deadline 30 Nov 2025 | Viewed by 122 | Submission Open

Keywords: anticancer; antiproliferative; cytotoxic; natural product; drug development; semi-synthesis; total synthesis; structure– activity relationship; computational simulation; enzyme inhibition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Nutrition in Neurodegenerative Diseases: Molecular Perspectives

edited by

Vittorio Emanuele Bianchi

submission deadline 30 Nov 2025 | Viewed by 121 | Submission Open

Keywords: nutrition; neurodegenerative disease; phenols; B vitamins; alpha-tocotrienol; dietary factors; intestinal microbiota; central nervous system

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Serotonin

edited by Joachim Neumann

submission deadline 30 Nov 2025 | Viewed by 121 | Submission Open

Keywords: serotonin; serotonin receptors; migraine; depression; hypertension; heart failure; arrhythmias

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Translational Infectious Diseases Research

edited by

Carlo Acierno

submission deadline 30 Nov 2025 | Viewed by 120 | Submission Open

Keywords: translational medicine; molecular pathogenesis; host– pathogen interaction; antimicrobial resistance; immune evasion; microbiome and infection; biomarkers; multi-omics approaches; infectious disease models; personalized infectious disease therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Studies of DNA Strand Exchange

edited by

Masayuki Takahashi

submission deadline 30 Nov 2025 | Viewed by 119 | Submission Open

Keywords: DNA strand exchange; homologous recombination: RecA-family recombinases; drug resistance: drug development against recombinases; evolution

(This special issue belongs to the Section Molecular Biophysics)

Nanobiotechnology: Breaking Barriers in Phytomedicine

edited by

Maria Aparecida Medeiros Maciel

submission deadline 30 Nov 2025 | Viewed by 116 | Submission Open

Keywords: nanotechnology; nanobiotechnology; phytocompounds; phytochemistry; natural products

(This special issue belongs to the Section Molecular Nanoscience)

Ion Regulation in Human Pathophysiology

edited by

Lars Kaestner

submission deadline 30 Nov 2025 | Viewed by 115 | Submission Open

Keywords: ion channels; ion gradients; membrane potential; action potential; ion pumps; uniporter; co-transporter; patch-clamp; ion flux; concentration gradient; ion stores; physiological processes; pathophysiological processes

(This special issue belongs to the Section Molecular Biology)

Roles of Phytochemicals in Molecular Signaling Networks

edited by

Jui-Hung Yen

submission deadline 30 Nov 2025 | Viewed by 112 | Submission Open

Keywords: phytochemicals; molecular signaling pathways; inflammation; apoptosis; chronic diseases; cancer; cardiovascular diseases; structure– activity relationships

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advancements in Cardiovascular Health Research: Investigating Novel Biomaterials, Cellular Responses, and Therapeutic

edited by Magdalena Wawrzyńska

submission deadline 30 Nov 2025 | Viewed by 111 | Submission Open

Keywords: cardiovascular biomaterials; nanomaterials; surface coatings; drug delivery systems; polymers; biocompatibility; hemocompatibility; molecular response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Product Therapies in Cancer

edited by

Domenica Mangieri

submission deadline 30 Nov 2025 | Viewed by 110 | Submission Open

Keywords: natural compounds; phytochemicals; flavonoids; alkaloids; metastasis; epithelial– mesenchymal transition; cancer cell invasion; cell cycle; programmed cell death; signaling pathways

(This special issue belongs to the Section Molecular Pharmacology)

Wired for Change: Neurotransmitter Plasticity and Circuit Dynamics in Health and Disease

edited by Alessandra Porcu

submission deadline 30 Nov 2025 | Viewed by 110 | Submission Open

Keywords: neurotransmitter; behavioral neuroscience; neuropsychiatric disorders; neurological disorders; neuroplasticity; neuronal circuit

(This special issue belongs to the Section Molecular Neurobiology)

Viral Infections: Molecular, Cellular, and Systems Perspectives

edited by Arnaldo Caruso and

Francesca Caccuri

submission deadline 30 Nov 2025 | Viewed by 109 | Submission Open

Keywords: virus– host interaction; epidemiology; evolution; innate immunity; computational modeling

(This special issue belongs to the Section Molecular Microbiology)

Immunity and Autoimmunity in Cardiovascular and Respiratory Diseases

edited by

Mizanur Rahman

submission deadline 30 Nov 2025 | Viewed by 108 | Submission Open

Keywords: cardiovascular diseases; respiratory diseases; autoimmune diseases; T cell; B cell; lipid mediators; autoantibodies; genetic variants; mucin

(This special issue belongs to the Section Molecular Immunology)

Advances in Targeted Therapies and Immunometabolic Pathways in Cancer

edited by Medhi Wangpaichitr

submission deadline 30 Nov 2025 | Viewed by 106 | Submission Open

Keywords: immunotherapy; targeted therapy; tumor metabolism pathway; tumor microenvironment; immune checkpoint blockade; immune evasion; glucose/amino acids/lipid metabolism

(This special issue belongs to the Section Molecular Immunology)

New Strategy on Diagnosis and Treatment of Meningioma and Glioma

edited by

Giuseppe Lombardi

submission deadline 30 Nov 2025 | Viewed by 101 | Submission Open

Keywords: meningiomas; gliomas; molecular characterization; biomarker discovery; targeted therapy; neuroimaging; artificial intelligence

(This special issue belongs to the Section Molecular Oncology)

Deciphering Allergies—Structural and Immunological Characterization of Allergenic Proteins and Immunomodulatory Agents: 2nd Edition

edited by

Marija Gavrović-Jankulović

submission deadline 30 Nov 2025 | Viewed by 95 | Submission Open

Keywords: allergen; allergenicity; IgE; innate immunity; exposome; cross-reactivity; B cell epitopes; T cell epitopes; in silico prediction

(This special issue belongs to the Section Molecular Immunology)

Artificial Intelligence and Data Science for the Discovery of Anticancer Targets and Decision Support

edited by

Soumia Ziti

submission deadline 30 Nov 2025 | Viewed by 94 | Submission Open

Keywords: artificial intelligence in oncology; data science and decision support in cancer therapy; target discovery and biomarker identification; machine learning and multi-omics integration; predictive modeling in precision medicine

(This special issue belongs to the Section Molecular Informatics)

Structure and Function of Subcellular Organelle and Protein-Membrane Systems

edited by

Chikara Sato

submission deadline 30 Nov 2025 | Viewed by 94 | Submission Open

Keywords: immuno-electron microscopy; cell signaling; comparative anatomy; diagnosis; molecular recognition; molecular complexes; electro-chemistry; liquid-phase synthesis; metal sedimentation; membrane endoskeleton

(This special issue belongs to the Section Molecular Biophysics)

Molecular Insights into Microbial Adaptations to Marine Plastics

edited by

Matan Oren

submission deadline 30 Nov 2025 | Viewed by 94 | Submission Open

Keywords: plastisphere; marine plastic debris; microbial colonization; biofilms; microbial adaptation; community assembly; quorum sesing; plastic biodegradation; biogeochemical cycling; antibiotic resistance genes; marine microbial ecology; metagenomics; microbe– plastic interactions; microbial succession

(This special issue belongs to the Section Molecular Microbiology)

Intestinal Immune System and Anti-Inflammatory Pathways

edited by

Moira Paroni

submission deadline 30 Nov 2025 | Viewed by 91 | Submission Open

Keywords: immune checkpoints; mucosal immunity; gut homeostasis; microbiota-driven inflammation; targeted immunotherapy; im-munomodulatory compounds

(This special issue belongs to the Section Molecular Immunology)

Signaling in Cells Proliferating in Two- and Three-Dimensional Cultures

edited by Hedwig Sutterluety-Fall

submission deadline 30 Nov 2025 | Viewed by 91 | Submission Open

Keywords: proliferation; signaling; two-dimensional; three-dimensional; cell culturing; in vitro; growth factors

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanism and Therapeutics in Human Cancer

edited by

Rachel Bar-Shavit

submission deadline 30 Nov 2025 | Viewed by 87 | Submission Open

Keywords: oncogenes; Wnt/b-catenin; G-protein-coupled receptors (GPCR); translational means; cancer stem cells; ubiquitination and deubiquitinating in cancer

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into Rhizospheric Microbial Interactions

edited by

Jelena Lozo

submission deadline 30 Nov 2025 | Viewed by 80 | Submission Open

Keywords: plant– microorganism interactions; rhizosphere community; secretory systems; secondary metabolites; volatile compounds

(This special issue belongs to the Section Molecular Microbiology)

Monovalent Ion-Exchange Membranes for Various Applications

edited by Noor ul Afsar

submission deadline 30 Nov 2025 | Viewed by 79 | Submission Open

Keywords: molecular design; ion-exchange membranes; membrane-based separations; energy and resource recovery

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Host DNA Damage Responses in Virus Propagation and Human Disease

edited by Nimrat Chatterjee

submission deadline 30 Nov 2025 | Viewed by 76 | Submission Open

Keywords: DNA repair; DNA viruses; RNA viruses; translesion synthesis; cancer

(This special issue belongs to the Section Molecular Microbiology)

Novel Molecular Pathways in Oncology, 3rd Edition

edited by

Giovanna Casili

submission deadline 1 Dec 2025 | 10 articles | Viewed by 10472 | Submission Open

Keywords: molecular pathway involved in tumorigenesis; cancer therapy; targeted therapy; anticancer drugs; brain cancer; oral cancer; gastrointestinal cancer

(This special issue belongs to the Section Molecular Oncology)

Gene Editing for Cereal Crops

edited by

Ke Wang

submission deadline 1 Dec 2025 | 1 articles | Viewed by 1438 | Submission Open

Keywords: gene-editing techniques; novel germplasm; quality; nutrition; agronomic traits

(This special issue belongs to the Section Molecular Plant Sciences)

The Current Landscape of Microglia-Glioma Research: From Basic Science to Therapeutic Potential

edited by

Manuel Benedikt Graeber

submission deadline 1 Dec 2025 | Viewed by 430 | Submission Open

Keywords: microglia; glioma; tumor associated macrophages; immunosuppression; epigenetics

(This special issue belongs to the Section Molecular Neurobiology)

Long-COVID and Its Complications

edited by

Alexey Sarapultsev

submission deadline 4 Dec 2025 | 9 articles | Viewed by 35281 | Submission Open

Keywords: acquired immune deficiency; auto-immunity; blood– brain barrier dysfunction; complication; COVID-19; gut microbiome; hypothalamic– pituitary– adrenal axis; immune dysfunction; long COVID; multisystem dysfunction; neurological complications; SARS-CoV-2; systemic inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biology of Oral Cancer

edited by Rafał Pęksa

submission deadline 10 Dec 2025 | 1 articles | Viewed by 1002 | Submission Open

Keywords: oral cancer; molecular mechanisms; biomarkers; tumor microenvironment; therapy resistance; precision medicine; carcinogenesis; oral squamous cell carcinoma; epigenetics; microbiome; immunotherapy; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Biophysical Characterization and Molecular Engineering of Multidomain Proteins (4th Edition)

edited by

Koichi Kato

and

Takayuki Uchihashi

submission deadline 10 Dec 2025 | Viewed by 98 | Submission Open

Keywords: multidomain proteins; protein dynamics; domain interactions; allosteric regulation; protein engineering; SAXS; Cryo-EM; protein NMR; computational modeling; protein design

(This special issue belongs to the Section Molecular Biophysics)

Molecular Mechanisms of Obesity and Metabolic Diseases

edited by

Liliya Mihaylova

submission deadline 15 Dec 2025 | 7 articles | Viewed by 22080 | Submission Open

Keywords: molecular pharmacology; molecular mechanisms; obesity; metabolic diseases; metabolic syndrome; type 2 diabetes; atherosclerosis; cardio-metabolic disorders; non-alcoholic fatty liver disease (NAFLD)

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Pathogenesis and Molecular Therapy of Brain Tumor

edited by

Theo Kraus

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1123 | Submission Open

Keywords: brain tumor; glioma; glioblastoma; astrocytoma; oligodendroglioma; epigenetics; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Unveiling Mental Disorders: Molecular Mechanisms and Innovative Therapies

edited by Blerida Banushi

submission deadline 20 Dec 2025 | 7 articles | Viewed by 41937 | Submission Open

Keywords: molecular psychiatry; epigenetics; neurobiology; gene– environment interactions; neuroplasticity; psychopharmacology; neuromodulation; personalized medicine; neuroinflammation

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Retinal Diseases: 2nd Edition

edited by Minzhong Yu

submission deadline 20 Dec 2025 | 9 articles | Viewed by 28279 | Submission Open

Keywords: retina; optic nerve; ocular disorder; retinal disease; genetic mutation; aging; drug side effects; novel mutations/biomarkers; signaling pathways; spectral domain optical coherence tomography; stem cell; gene therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Responses to Biotic and Abiotic Stresses

edited by

Shu Yuan

submission deadline 20 Dec 2025 | 20 articles | Viewed by 24359 | Submission Open

Keywords: plant enzymes and metabolites; abiotic stress; stress response; phytohormones; secondary metabolism; gene regulation network; developmental and environmental adaptation; microbial interactions; biotic stress; pathogen response

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Reproductive Physiology and Endocrinology

edited by

Kamil Gill

submission deadline 20 Dec 2025 | 12 articles | Viewed by 24012 | Submission Open

Keywords: reproductive; endocrinology; reproductive hormones; embryology; molecular research; IVF; obesity

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

High-Density Lipoproteins in Health and Disease

edited by

Ilaria Zanotti

submission deadline 20 Dec 2025 | 7 articles | Viewed by 23903 | Submission Open

Keywords: omics; protein; lipid; cardiovascular; neurodegenerative disease; inflammation; preclinical studies; therapy

(This special issue belongs to the Section Molecular Biology)

Exosomes and Extracellular Vesicles in Health and Diseases: 3rd Edition

edited by

Manuela Zavatti

and

Francesca Beretti

submission deadline 20 Dec 2025 | 8 articles | Viewed by 21686 | Submission Open

Keywords: exosome; extracellular vesicles; network signals; biomarkers; pathological conditions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 451-500 on page 10 of 69.

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