The Molecular Landscape of Endometrial and Ovarian Dysfunction in Polycystic Ovary Syndrome: Insights into Disease Mechanisms
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 March 2026
Special Issue Editors
Interests: reproductive medicine; reproductive biology; ovarian pathophysiology; polycystic ovary syndrome (PCOS)
Special Issues, Collections and Topics in MDPI journals
Interests: ovarian physiology; reproductive physiology; metabolomics; ion channels; pregnancy disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Polycystic ovarian syndrome (PCOS) is the most common ovarian endocrinopathy affecting women of reproductive age. The syndrome is recognised as a heterogeneous disorder that affects reproductive, metabolic, and endocrine functions. While much research over the last two decades has focused on the hormonal and metabolic aspects, increasing attention is now being directed towards the underlying molecular and cellular mechanisms of endometrial and ovarian dysfunction in PCOS. These dysfunctions contribute not only to reproductive disorders but also to the broader health risks associated with PCOS, including metabolic and cardiovascular diseases as well as gynaecological cancers.
This Special Issue aims to highlight recent advances in our understanding of the intricate molecular pathways, regulation, and signalling networks that drive tissue-specific alterations in PCOS. By bringing together original research articles and comprehensive reviews, the Issue seeks to provide new perspectives on the pathophysiology of PCOS, identify potential biomarkers for diagnosis and prognosis, and explore novel therapeutic strategies targeting the molecular underpinnings of reproductive dysfunction.
Prof. Dr. Saad Amer
Prof. Dr. Raheela N. Khan
Guest Editors
Manuscript Submission Information
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Keywords
- Polycystic Ovarian Syndrome (PCOS)
- Molecular Mechanisms
- Endometrial Dysfunction
- Ovarian Dysfunction
- Pathophysiology
- Biomarkers
- Therapeutic Strategies
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