Targeting Metabolism, Inflammation, and Oxidative Stress: Novel Therapeutic Approaches in Human Diseases

Dear Colleagues,

Modulating metabolism, inflammation, and oxidative stress is essential for managing various human diseases. Numerous recent studies have demonstrated strong links between cellular metabolism, inflammation, and oxidative stress, which contribute to the pathophysiology of conditions such as diabetes, aging, cardiovascular diseases, neurological disorders, and cancer. Strategies targeting these processes could offer therapeutic benefits. Specifically, dietary interventions, pharmacological agents, anti-inflammatory drugs, and lifestyle modifications like regular exercise and stress reduction can help control disease development and progression. Additionally, nutritional supplements, natural antioxidants, and phytochemicals that regulate various molecular signaling pathways may play crucial preventive roles in disease control. Emerging therapies, including gene editing, stem cell therapy, next-generation sequencing, regenerative medicine, and microbiome manipulation, show promise in modulating cellular metabolism, inflammatory responses, and oxidative stress for future treatments.

This Special Issue aims to provide an updated overview of the complex interplay between metabolic imbalance, chronic inflammation, and oxidative stress in the pathophysiology of human diseases. It invites contributions in the form of structural and computational studies, functional analyses, preclinical and clinical research, and comprehensive reviews, focusing on novel strategies targeting metabolism, inflammation, and oxidative stress to control various human pathologies.

Dr. Kota V. Ramana
Guest Editor

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