Current Research on Redox Homeostasis and Oxidative Stress in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 140
Special Issue Editor
Interests: free radical biology; redox signaling; medicine
Special Issue Information
Dear Colleagues,
Cellular function depends on a finely tuned balance between oxidant generation and antioxidant defence mechanisms. This dynamic equilibrium, known as redox homeostasis, integrates metabolic activity, mitochondrial function and signalling pathways that enable cells to adapt to environmental and physiological stress. Reactive oxygen and nitrogen species are involved in these regulatory processes by modulating signalling networks that control proliferation, differentiation, immune responses and cell survival. However, persistent disturbances in redox balance can shift these signalling mechanisms towards oxidative damage and pathological remodelling.
Increasing evidence highlights the role of redox imbalance in metabolic disorders, neurodegenerative and neuropsychiatric diseases, cardiovascular pathologies, cancer, endocrine regulation, immune dysfunction and ageing. Oxidative stress intersects with mitochondrial damage, chronic inflammation, altered proteostasis, epigenetic modifications and dysregulated cell death pathways, forming a complex disease network that necessitates therapeutic intervention. Despite extensive research, translating antioxidant strategies into consistent clinical benefit remains challenging, underscoring the need for deeper mechanistic insight and more precise redox-targeted approaches.
This Special Issue aims to provide a comprehensive and up-to-date overview of redox homeostasis and oxidative stress in health and disease. We welcome original research articles and reviews addressing the molecular mechanisms of redox regulation, redox-sensitive signalling pathways, disease-specific redox changes, biomarker development and innovative therapeutic approaches to correct imbalances and restore homeostasis.
Prof. Dr. Aleksandra Nikolić-Kokić
Guest Editor
Manuscript Submission Information
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Keywords
- reactive oxygen species
- reactive nitrogen species
- redox signalling
- antioxidant defence systems
- antioxidants
- ageing
- immunity
- metabolism disorder
- metabolomics
- degenerative diseases
- cardiovascular diseases
- cancer
- infectious diseases
- oxidative post-translational modifications
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