Protein Dynamics in Cancer Drug Resistance: Mechanisms and Therapeutic Opportunities
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 1403
Editor
Interests: cell growth control; protein turnover; therapeutic strategy
Special Issue Information
Dear Colleagues,
This Special Issue focuses on how dynamic behaviors of proteins—including conformational changes, interactions, stability, localization, and regulatory modifications—contribute to cancer drug resistance. Cancer progression and therapeutic failure are deeply influenced by the dynamic behavior of proteins that govern cellular stress responses and survival. Drug resistance—whether intrinsic or acquired—emerges from coordinated proteomic adaptations involving altered protein turnover, stress-induced post-translational modifications, and the reorganization of biomolecular condensates.
Proteins such as efflux transporters, DNA-damage response factors, chaperones, and metabolic regulators collectively enable tumor cells to withstand chemotherapeutic pressure. Recent advances in artificial intelligence, structural biology, and chemical biology have accelerated the identification and characterization of these resistance-associated proteins, opening new avenues for the development of targeted therapies.
Dr. Slovénie Pyndiah
Guest Editor
Manuscript Submission Information
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Keywords
- drug resistance
- cancer proteome
- protein turnover
- post-translational modifications
- targeted therapy
- stress adaptation
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