Cell Therapies: Cellular Mechanisms and Genetic Engineering

Dear Colleagues,

Cell therapies are transforming medicine by harnessing living cells to repair, replace or regenerate damaged tissues and organs, including advanced cancer treatments such as CAR-T cell therapy. This versatile approach spans fields from oncology to autoimmune disease to regenerative medicine and understanding its molecular foundations is essential to maximizing impact.

We are pleased to invite you to contribute an article to this Special Issue in which we will explore key cellular mechanisms underlying the therapeutic effects of cell therapy products and the role of genetic engineering as an enabler.

This Special Issue aims to bring together articles that discuss themes such as cell functionality, differentiation, exhaustion, toxicity and manufacturing, as well as how these factors influence therapeutic performance and safety. We also welcome contributions addressing gene-editing strategies and engineering approaches used to enhance the efficacy, persistence, targeting and clinical outcomes of cell-based therapies.

Research areas may include (but are not limited to) the following: engineering cell therapies for improved clinical outcomes; cellular mechanisms to clinical impact; controlling cell fate; next-generation cell therapy platforms; scalable manufacturing of engineered cell products; personalization in cell-based medicine; manufacturing challenges in advanced therapy medicinal products; and delivery strategies for effective cell therapies

I look forward to receiving your contributions.

Dr. Shirley O'Dea
Guest Editor

Manuscript Submission Information

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