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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Intestinal Diseases and Gut Microbiota
edited by
submission deadline 20 Mar 2027 | 2 articles | Viewed by 5480 | Submission Open
Keywords: gut microbiota; dysbiosis; natural compounds; colorectal cancer; neurological diseases; autoimmune diseases; probiotics; gut-brain axis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Conventional Tree Breeding: Integrating Phenotypic Selection, Genetic Gain, and Sustainable Forest Management
edited by
submission deadline 20 Mar 2027 | 1 articles | Viewed by 3869 | Submission Open
Keywords: forest trees; genetic breeding; conventional tree breeding; forest management; forest tree varieties; modern molecular technology; genetic engineering
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Plant Protein and Enzyme Inhibitors
edited by Yan Zhang
submission deadline 20 Mar 2027 | Viewed by 642 | Submission Open
Keywords: plant proteins; active substances; bioactive compounds; enzyme inhibitors
(This special issue belongs to the Section Molecular Plant Sciences)
Application of Molecular Technology to Dental Treatment
edited by
submission deadline 20 Mar 2027 | Viewed by 343 | Submission Open
Keywords: biotechnology; implant material; titanium; zirconia; PEEK; in vitro; in vivo
(This special issue belongs to the Section Materials Science)
Hepatopancreatic and Intestine Diseases: From Molecular Basis to Therapy—Mitochondrial Insights submission deadline 20 Mar 2027 | Viewed by 234 | Submission Open
Keywords: hepatopancreatic diseases; intestine diseases; molecular basis therapy; pathogenesis; molecular pathways; pharmacological interventions; surgical techniques; immunotherapies; regenerative medicine approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Marine Toxins: Molecular and Biochemical Mechanisms of Marine and Freshwater Algal Toxins
edited by and Allisson Astuya-Villalón
submission deadline 20 Mar 2027 | Viewed by 72 | Submission Open
Keywords: harmful algal blooms (HABs); molecular toxicology; marine and freshwater toxins; cytotoxicity mechanisms; toxin–cell interactions; biochemical and structural biology; mechanistic omics; ichthyotoxicity; signal transduction; structure–activity relationships
(This special issue belongs to the Section Molecular Toxicology)
Cancer Metabolism as a Therapeutic Target: From Mechanisms to Therapies
edited by
submission deadline 25 Mar 2027 | Viewed by 35 | Submission Open
Keywords: metabolism; tumor microenvironment; tracing; molecular imaging; therapy; omics; drug response; cancer; immune populations
(This special issue belongs to the Section Molecular Oncology)
Biophysical Characterization and Molecular Engineering of Multidomain Proteins (4th Edition) submission deadline 26 Mar 2027 | 3 articles | Viewed by 3425 | Submission Open
Keywords: multidomain proteins; protein dynamics; domain interactions; allosteric regulation; protein engineering; SAXS; Cryo-EM; protein NMR; computational modeling; protein design
(This special issue belongs to the Section Molecular Biophysics)
Sustainable Material Development: From Molecular Insights to Functional Applications
edited by
submission deadline 26 Mar 2027 | Viewed by 446 | Submission Open
Keywords: sustainable materials; biodegradable polymers; green chemistry; functional materials; structure–property relationships; chemical modification; recycling and upcycling; circular economy; composites; analytical techniques
(This special issue belongs to the Section Materials Science)
Insights in Metabolomics: Chromatography and Mass Spectrometry Applications in Cancer Research submission deadline 30 Mar 2027 | 2 articles | Viewed by 3116 | Submission Open
Keywords: metabolomics; chromatography; mass spectrometry; molecular oncology; cancer pathways; precision medicine
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Novel Insights into Cardiac Diseases
edited by Kuo-Tzu Sung
submission deadline 30 Mar 2027 | 3 articles | Viewed by 2360 | Submission Open
Keywords: cardiovascular genetics; inherited cardiomyopathies; lysosomal storage disorders; precision medicine; translational cardiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Plant–Microbe Interactions in Biological Disease Control
edited by
submission deadline 30 Mar 2027 | Viewed by 384 | Submission Open
Keywords: plant–microbe interactions; microbial biocontrol; plant immunity; induced systemic resistance; microbial antagonism; secondary metabolites; functional genomics; multi-omics; rhizosphere microbiome; synthetic microbial communities
(This special issue belongs to the Section Molecular Plant Sciences)
Natural Products in Metabolic Diseases: From Molecular Target Discovery to Clinical Translation
edited by
submission deadline 30 Mar 2027 | 1 articles | Viewed by 232 | Submission Open
Keywords: metabolic diseases; natural products; molecular targets; network pharmacology; multi-omics and artificial intelligence; clinical translation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Cytokinin Biosynthesis, Metabolism, Signaling, and Action
edited by Martin Raspor
submission deadline 30 Mar 2027 | Viewed by 90 | Submission Open
Keywords: natural and synthetic cytokinins; isoprenoid cytokinins; aromatic cytokinins; diphenylurea-type cytokinins; cytokinin biosynthesis; cytokinin metabolism; histidine kinases; phosphotransfer; two-component signaling
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Vaccines: From Precision Molecular Platforms to Immune Remodeling
edited by Hong Jia
submission deadline 30 Mar 2027 | Viewed by 61 | Submission Open
Keywords: next-generation vaccines; mRNA; saRNA; circRNA; nanoparticle vaccines; structural vaccinology; emerging infectious diseases; cancer vaccines; neoantigens; tumor microenvironment; multi-omics; AI immunology
(This special issue belongs to the Section Molecular Immunology)
Regulatory Networks in Plant Development and Environmental Stress Response submission deadline 30 Mar 2027 | Viewed by 15 | Submission Open
Keywords: plant development; environmental stress; gene regulatory networks; transcriptional regulation; post-transcriptional regulation; transcription factors; signal transduction; hormone signaling; epigenetic regulation; genome-wide analysis
(This special issue belongs to the Section Molecular Plant Sciences)
Functional Genetics and Signaling Networks in Neurodevelopmental and Neuromuscular Disorders
edited by , Francesco Chemello and
submission deadline 30 Mar 2027 | Viewed by 8 | Submission Open
Keywords: zebrafish; neurodevelopment; neuromuscular disorders; functional genetics; gene editing; organoids; mammalian animal models; OMICs approaches; transgenesis; cell signaling
(This special issue belongs to the Section Molecular Neurobiology)
25th Anniversary of IJMS: Updates and Advances in Molecular Genetics and Genomics submission deadline 31 Mar 2027 | 32 articles | Viewed by 35132 | Submission Open
Keywords: molecular genetics; genomics; precision medicine; genetic diagnostics; gene therapy; next-generation sequencing (NGS); pharmacogenomics; epigenetics; forensic genomics; translational genomics; genome replication; gene expression; cell stress; cell cycle; cell signaling; macromolecular surveillance and turnover; molecular evolution
(This special issue belongs to the Section Molecular Genetics and Genomics)
25th Anniversary of IJMS: Updates and Advances in Molecular Informatics submission deadline 31 Mar 2027 | 14 articles | Viewed by 16882 | Submission Open
Keywords: AI-guided drug repurposing; virtual screening in personalized medicine; machine learning for toxicity prediction; network-based biomarkers in complex diseases; in silico pharmacokinetics and ADMET profiling; data-driven materials design; deep learning for molecular property prediction; AI-assisted nanomaterial synthesis; systems biology models for metabolic engineering
(This special issue belongs to the Section Molecular Informatics)
Plant Stress Biology
edited by
submission deadline 31 Mar 2027 | 11 articles | Viewed by 11231 | Submission Open
Keywords: abiotic stress; biotic stress; stress response mechanisms; oxidative stress; phytohormones signaling; stress tolerance
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Advances in Brain Cancers: Second Edition submission deadline 31 Mar 2027 | 1 articles | Viewed by 11230 | Submission Open
Keywords: brain tumors; malignant brain tumor; advanced cancer biology
(This special issue belongs to the Section Molecular Oncology)
Multifaceted Roles of Extracellular Vesicles in Cancer and Other Diseases submission deadline 31 Mar 2027 | 3 articles | Viewed by 8905 | Submission Open
Keywords: extracellular vesicles; exosomes; cancer diagnostics; non-invasive tests; liquid biopsy; cancer therapy; biomarker discovery; nanotechnology; EV engineering; drug delivery; neurodegenerative diseases; cardiovascular diseases; infectious diseases; autoimmune diseases; precision diagnostics
(This special issue belongs to the Section Molecular Oncology)
New Insights into the Mechanisms of Neurodegeneration and Regeneration: From Bench to Bedside
edited by Irina Ivanova Stoyanova
submission deadline 31 Mar 2027 | 4 articles | Viewed by 7789 | Submission Open
Keywords: neurodegeneration; neuroregeneration; molecular neurobiology; brain development; developmental brain disorders; synaptogenesis; synaptic plasticity; cognitive neuroscience; neurotrauma
(This special issue belongs to the Section Molecular Neurobiology)
Colorectal Cancer: Molecular and Cellular Basis
edited by Martina Lepore Signorile
submission deadline 31 Mar 2027 | 5 articles | Viewed by 7698 | Submission Open
Keywords: colorectal cancer; molecular and cellular biology; tumor initiation; tumor progression; metastasis
(This special issue belongs to the Section Molecular Oncology)
Molecular Genetics and Genomics of Neurodevelopmental Disorders submission deadline 31 Mar 2027 | 6 articles | Viewed by 6978 | Submission Open
Keywords: neurodevelopmental disorders; genetics; molecular biology; biomarkers; epigenetics; precision medicine; rare variants; common variants; artificial intelligence; machine learning
(This special issue belongs to the Section Molecular Genetics and Genomics)
Bioactive Natural Products: From Molecular Mechanisms to Biological Function submission deadline 31 Mar 2027 | 7 articles | Viewed by 6742 | Submission Open
Keywords: natural products; molecular mechanism; biological activities; drug discovery
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Advances on Solubility and Diffusivity in Water-Based Systems and in Biological Media submission deadline 31 Mar 2027 | 1 articles | Viewed by 6446 | Submission Open
Keywords: water solubility ; water-solute interactions ; solvation, hydrophobic and hydrophilic effects ; improving water solubility and prediction ; solution of chemicals in biological media ; diffusivity ; drug transport and bioavailability; chemicals diffusivity across biological barriers
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
The Application of an Electron Microscope in the Study of Cell Structure
edited by
submission deadline 31 Mar 2027 | 5 articles | Viewed by 5367 | Submission Open
Keywords: intracellular structure; organelles; cell surface structure; immuno-labeling
(This special issue belongs to the Section Molecular Biophysics)
SGLT2 Inhibitors and GLP/GIP/Glucagon Agonists: From Fundamental Mechanisms to Clinical Translation
edited by
submission deadline 31 Mar 2027 | 3 articles | Viewed by 5247 | Submission Open
Keywords: SGLT2 inhibitors; GLP-1 receptor agonists; GIP; glucagon; multi-agonists; cardiometabolic disease; renal protection; obesity; translational research
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Zebrafish as a Novel Model for Toxicological Research
edited by Leobardo Manuel Gómez-Oliván
submission deadline 31 Mar 2027 | 3 articles | Viewed by 5064 | Submission Open
Keywords: zebrafish; toxicological assessment; organic and inorganic contaminants; oxidative stress; developmental toxicity; neurotoxicity; reproductive toxicity; genotoxicity; alternative testing models; One Health
(This special issue belongs to the Section Molecular Toxicology)
Molecular Mechanisms and Therapeutic Strategies for Pregnancy Complications
edited by
submission deadline 31 Mar 2027 | 4 articles | Viewed by 4674 | Submission Open
Keywords: pregnancy complications; placenta diseases; molecular mechanisms; therapeutics; biomarkers; preeclampsia; gestational diabetes; intrauterine growth restriction; maternal-fetal exchange; inflammation mediators
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cell Proliferation and Differentiation in Cancer submission deadline 31 Mar 2027 | 2 articles | Viewed by 4216 | Submission Open
Keywords: cell signaling; cell transduction; transcriptional and post-transcriptional pathways; growth factors; second messengers; cell proliferation; cell differentiation; cell metabolism; cell death; cell invasion
(This special issue belongs to the Section Molecular Oncology)
Plant Breeding Strategies: Employment of Plant Adaptation Mechanisms to Biotic and Abiotic Stresses
edited by
submission deadline 31 Mar 2027 | 3 articles | Viewed by 3914 | Submission Open
Keywords: marker-assisted selection; molecular breeding; whole-transcriptome analysis; RNA sequencing; DNA sequencing; plant stress response
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Advances in Forensic Science: Integrating Innovation and Investigation
edited by
submission deadline 31 Mar 2027 | 1 articles | Viewed by 3861 | Submission Open
Keywords: DNA profiling; artificial intelligence; trace evidence analysis; immunohistochemical markers; molecular biology techniques; super-resolution microscopy; integrated forensic approach; new bioinformatics techniques; digital pathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Genetic and Epigenetic Research in Skin Diseases
edited by
submission deadline 31 Mar 2027 | 3 articles | Viewed by 3838 | Submission Open
Keywords: skin diseases; genodermatoses; psoriasis; atopic dermatitis; hidradenitis; suppurativa; epigenetic regulation; genome-wide association studies (GWAS); next-generation sequencing; translational dermatogenomics; Mendelian randomization; rare disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Physiology and Molecular Stress
edited by
submission deadline 31 Mar 2027 | 5 articles | Viewed by 3181 | Submission Open
Keywords: stress physiology; molecular stress responses; molecular biology; abiotic stress signaling; gene regulation; redox homeostasis; hormonal crosstalk; omics approaches; stress-adaptive mechanisms; epigenetic regulation; Abscisic Acid (ABA) signaling; antioxidant defense systems; photosynthetic regulation
(This special issue belongs to the Section Molecular Plant Sciences)
Hematopoietic Stem Cells: Molecular Insights into Homeostasis, Disease, and Aging
edited by Yoshikazu Matsuoka
submission deadline 31 Mar 2027 | 2 articles | Viewed by 3179 | Submission Open
Keywords: hematopoietic stem cells (HSCs); senescence; hematopoietic homeostasis; epigenetic drift; DNA damage responses; metabolic reprogramming; hematological disorders; inflammation; environmental stress
(This special issue belongs to the Section Molecular Biology)
Advances in Tau Protein Research submission deadline 31 Mar 2027 | 2 articles | Viewed by 3141 | Submission Open
Keywords: tau biology; disease model systems; protein aggregation; tauopathies; neurodegeneration; Alzheimer’s disase; seeded aggregation; amyloid filaments; tau propagation; antibodies; targeted protein degradation; tau therapeutics
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Medicinal Plants and Natural Products: Second Edition submission deadline 31 Mar 2027 | 2 articles | Viewed by 3122 | Submission Open
Keywords: medicinal plants; natural products; phytochemistry; bioactive substances; medicinal properties
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Coordination Chemistry: From Fundamental Principles to Multifunctional Applications
edited by
submission deadline 31 Mar 2027 | 4 articles | Viewed by 3109 | Submission Open
Keywords: coordination compounds; metal–ligand interactions; ligand design and synthesis; spectroscopic characterization; coordination geometry; molecular architecture; ion-association complexes; supramolecular chemistry; catalysis and activation mechanisms; functional materials; metal–organic frameworks; magnetism in coordination compounds; redox-active complexes; environmental and green chemistry applications; sensors and molecular devices; bioinorganic chemistry; medicinal coordination chemistry; theoretical and computational coordination chemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Pathophysiology of Chronic Lung Diseases: Mechanisms and Therapeutics
edited by Gary C. Mouradian
submission deadline 31 Mar 2027 | 1 articles | Viewed by 3013 | Submission Open
Keywords: chronic lung disease; vagal sensory neurons; inflammation; airway remodeling; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactivity and Mechanistic Insights of Plant-Derived Chemical Compounds
edited by
submission deadline 31 Mar 2027 | 2 articles | Viewed by 3010 | Submission Open
Keywords: plant-derived compounds; bioactivity; mechanism of action; phytochemicals; pharmacology; natural products; molecular targets; ethnopharmacology; drug discovery; translational research
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Oxidative Stress Unveiled: Mechanisms and Implications in Cardiac Pathologies
edited by and Vernat Exil
submission deadline 31 Mar 2027 | Viewed by 2974 | Submission Open
Keywords: reactive oxygen species (ROS); electron transport chain (ETC); mitochondrial permeability transition pore (mPTP); endothelial–cardiomyocyte–fibroblast crosstalk; metabolic adaptation; inflammation; cardiovascular disease (CVD)
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Molecular Life of Sperm: New Horizons in Male Infertility submission deadline 31 Mar 2027 | 2 articles | Viewed by 2866 | Submission Open
Keywords: human sperm; fertilization; infertility; biomarkers; genetics
(This special issue belongs to the Section Molecular Biology)
Computational and Multi-Omics Bioinformatics in Cancer Biology and Therapy Response
edited by
submission deadline 31 Mar 2027 | 3 articles | Viewed by 2852 | Submission Open
Keywords: cancer bioinformatics; multi‑omics integration; precision oncology; tumor heterogeneity; tumor microenvironment; therapy response; machine learning; deep learning; AI‑driven analysis; single‑cell multi‑omics; spatial omics; immunotherapy; tumor–immune interactions; network biology; pathway analysis; biomarker discovery; clinical outcome prediction; translational bioinformatics
(This special issue belongs to the Section Molecular Informatics)
New Advances in Protein Analysis in Disease
edited by
submission deadline 31 Mar 2027 | 4 articles | Viewed by 2793 | Submission Open
Keywords: proteomics; protein; profile; molecular mechanism; biomarker; therapeutical agent
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Upcycling Food Industry By-Products: Bioactive Ingredients for Nutrition and Health submission deadline 31 Mar 2027 | 1 articles | Viewed by 2730 | Submission Open
Keywords: bioactive compounds; food by-products; functional foods; molecular mechanisms; polyphenols; oxidative stress; inflammation; nutrigenomics; microbiome; prebiotics; postbiotics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Autoimmune Diseases: From Molecular Mechanisms to Therapeutic Innovations submission deadline 31 Mar 2027 | 2 articles | Viewed by 2587 | Submission Open
Keywords: autoimmunity; biological biomarkers; personalized therapies; biologics and JAK inhibitors; CAR-T cell therapy
(This special issue belongs to the Section Molecular Immunology)
Molecular Dialogues in the Tumor Microenvironment: Mechanisms, Methods and Therapeutic Implications submission deadline 31 Mar 2027 | 2 articles | Viewed by 2574 | Submission Open
Keywords: tumor microenvironment; blood vessels; immune cells; spatial transcriptomics; histology
(This special issue belongs to the Section Molecular Oncology)
Molecular Advances and Insights into Liver Diseases: Second Edition
edited by
submission deadline 31 Mar 2027 | 2 articles | Viewed by 2399 | Submission Open
Keywords: liver; hepatocellular carcinoma; cancer; hepatitis cirrhosis; encephalopathy; non-alcoholic fatty liver disease; autoimmune diseases; Wilson’s disease; fatty liver disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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