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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Insights into Genetic and Epigenetic Alterations in Age-Related Diseases submission deadline 30 Sep 2026 | 1 articles | Viewed by 2118 | Submission Open
Keywords: genomics; epigenetic modifications; age-related pathologies; neurodegeneration; dysmetabolism; spatial omics; 3D genome; genetic variants; telomere length; mitochondrial DNA; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
Functional Materials in Photocatalysis: From Design to Application submission deadline 30 Sep 2026 | 1 articles | Viewed by 2094 | Submission Open
Keywords: nanostructured materials ; photocatalysis ; catalysis ; green synthesis ; material design ; surface engineering
(This special issue belongs to the Section Materials Science)
Biomarkers and Mechanisms Guiding Precision Therapy in Lung Cancer
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 2092 | Submission Open
Keywords: lung cancer; precision therapy; biomarkers; molecular mechanisms; treatment resistance; immunotherapy; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Cellular Mechanisms of Taste and Smell: From Physiology to Pathology
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 2084 | Submission Open
Keywords: taste; olfaction; taste/smell processing; chemosensory dysfunction; genetic variations; neurodegeneration; perireceptor space; sensory nutrition; hypogeusia and hyposmia
(This special issue belongs to the Section Molecular Biology)
Oral Squamous Cell Carcinoma: From Pathogenesis to Targeted Therapy submission deadline 30 Sep 2026 | 2 articles | Viewed by 2056 | Submission Open
Keywords: oral cancer; oral potentially malignant disorders; omics; oral squamous cell carcinoma; leukoplakia; biomarkers; tumor microenvironment; immunotherapy; target therapy; HPV; multidisciplinary team
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
State-of-the-Art Immunotherapy for Non-Small-Cell Lung Cancer
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 2041 | Submission Open
Keywords: immunotherapy; checkpoint inhibitors; vaccines; cellular therapies; predictive biomarkers; chemotherapy; angiogenesis inhibitors; radiotherapy; modulation microbiome
(This special issue belongs to the Section Molecular Oncology)
Breaking Barriers in Drug Discovery: Novel Methodologies and Mechanisms of Action
edited by Likun Gong, and Jing Chen
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1989 | Submission Open
Keywords: new approach methodologies (NAMs); in silico; in vitro; in vivo; in chemico; drug discovery; computational modeling; artificial intelligence (AI); high-throughput screening (HTS); high-throughput imaging (HTI); bioassay; omics; cell cultures; tissue engineering; organ engineering; therapeutic target; mechanism of drug action
(This special issue belongs to the Section Molecular Pharmacology)
Genetic and Molecular Markers in Prostate Cancer
edited by Thaidy Moreno-Rodriguez
submission deadline 30 Sep 2026 | 3 articles | Viewed by 1988 | Submission Open
Keywords: prostate cancer; genetic markers; androgen receptor signaling; molecular biomarkers; therapy resistance mechanisms; liquid biopsy; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Novel Natural Compound for Wound and Tissue Repair and Regeneration: 4th Edition
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1851 | Submission Open
Keywords: wound repair; tissue regeneration; natural compounds; phytochemicals; molecular mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanism in Cardiac Remodeling
edited by Xianming Lin and
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1840 | Submission Open
Keywords: cardiomyopathy; cardiac arrhythmias; ion channel; calcium transient
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Modeling Neurogenesis, Regeneration and Disease from Animal Models submission deadline 30 Sep 2026 | 2 articles | Viewed by 1836 | Submission Open
Keywords: neurogenesis; neural regeneration; animal models; neural stem cells; neurodevelopment; neurodegeneration; molecular mechanisms; disease modeling; nervous system repair, ultrastructure
(This special issue belongs to the Section Molecular Neurobiology)
Current Trends and Future Directions in Antimicrobial Peptide Research
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1831 | Submission Open
Keywords: antimicrobial peptides (AMPs); host defense; structure-function; antimicrobial agents; biomedical applications; antibiotic alternatives; antibiotic resistance
(This special issue belongs to the Section Molecular Biology)
Molecular Pathogenesis of Age-Related Ocular Diseases and Existing Therapies
edited by
submission deadline 30 Sep 2026 | 3 articles | Viewed by 1748 | Submission Open
Keywords: aging; senescence; diabetic retinopathy; glaucoma; age-related macular degeneration; ischemic retinal and optic nerve diseases; Werner syndrome; genetic disorders; inflammatory diseases; cataract; cellular dysfunction; cell death; axonal degeneration; vascular abnormalities; oxidative stress; inflammatory cytokines; senescence-associated secretory phenotype; autophagy; mitochondrial dysfunction; anti-aging; neuroprotection; regeneration; anti-inflammatory agents; nutrients; gene therapies; cell transplantation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Colorectal Cancer—Emerging Trends and Treatment Strategies
edited by Victor Strambu
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1723 | Submission Open
Keywords: innovative therapies; colorectal cancer; new therapeutic approach; synchronous tumors
(This special issue belongs to the Section Molecular Oncology)
Nanotechnology-Driven Insights into Plants: Mechanisms, Detection, and Sustainable Control
edited by
submission deadline 30 Sep 2026 | Viewed by 1721 | Submission Open
Keywords: nanotechnology; plant–pathogen interactions; plant immunity; nanoparticles; nano-enabled diagnostics; disease management; antimicrobial nanomaterials; nano-biocontrol; sustainable agriculture; phytopathology
(This special issue belongs to the Section Molecular Nanoscience)
The Molecular Landscape of Endometrial and Ovarian Dysfunction in Polycystic Ovary Syndrome: Insights into Disease Mechanisms
edited by and
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1690 | Submission Open
Keywords: polycystic ovarian syndrome (PCOS); molecular mechanisms; endometrial dysfunction; ovarian dysfunction; pathophysiology; biomarkers; therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
In Honor of the 76th Birthday of Dr. Rachel Mata Essayag, a Distinguished Pioneer in Natural Products Research in Mexico
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1665 | Submission Open
Keywords: pharmacognosy; natural products; phytochemistry; diabetes, cancer; diarrhea; viral infections; bacterial infections; drug development; in vivo; ex vivo; in vitro; in silico
(This special issue belongs to the Section Molecular Pharmacology)
Microbiome–Epigenome Interactions in Early-Life Molecular Programming
edited by and Miljana Zivojin Jovandaric
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1657 | Submission Open
Keywords: early-life programming; microbiome–epigenome axis; DNA methylation; histone modification; microbial metabolites; non-coding RNAs; immune maturation; placental and postnatal development
(This special issue belongs to the Section Molecular Genetics and Genomics)
Protein Dynamics in Cancer Drug Resistance: Mechanisms and Therapeutic Opportunities
edited by Slovénie Pyndiah
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1527 | Submission Open
Keywords: drug resistance; cancer proteome; protein turnover; post-translational modifications; targeted therapy; stress adaptation
(This special issue belongs to the Section Molecular Oncology)
Molecular Research on Forensic Odontology, Legal Medicine, and Forensic Sciences submission deadline 30 Sep 2026 | 2 articles | Viewed by 1508 | Submission Open
Keywords: forensic odontology; legal medicine; forensic sciences; forensic genetics; human identification; criminal database; quality assurance; age assessment; sex estimation; ancestry; time of death
(This special issue belongs to the Section Molecular Biology)
Advances in Omics Approaches in Chronic Metabolic Diseases
edited by Ramos-López Omar
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1506 | Submission Open
Keywords: chronic metabolic diseases; obesity; diabetes; cardiovascular disease; fatty liver; genomics; epigenomics; metagenomics; metabolomics; proteomics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Mechanisms of Tumor–Immune System Interactions
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1506 | Submission Open
Keywords: oncoimmunology; tumor–immune system interactions; tumor microenvironment; immune evasion; immunotherapy; antitumor immunity
(This special issue belongs to the Section Molecular Oncology)
Integrative Omics Strategies for Biomarker Discovery and Mechanistic Insights into Disease
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1505 | Submission Open
Keywords: integrative omics; biomarker discovery; cancer signaling networks; drug resistance; phosphoproteomics; multi-omics integration; systems biology; translational research
(This special issue belongs to the Section Molecular Informatics)
New Insights in Translational Bioinformatics: 3rd Edition
edited by
submission deadline 30 Sep 2026 | 3 articles | Viewed by 1460 | Submission Open
Keywords: translational research; sequencing; single cell; spatial biology; treatment; diagnostics; machine learning; artificial intelligence; model; computational biology
(This special issue belongs to the Section Molecular Informatics)
Recent Advances in Nanotechnology for Biomedical Applications
edited by Sofía Municoy
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1436 | Submission Open
Keywords: nanotechnology; nanosensor; drug delivery; regenerative medicine
(This special issue belongs to the Section Molecular Nanoscience)
New Advances in Plant Disease Resistance submission deadline 30 Sep 2026 | 2 articles | Viewed by 1399 | Submission Open
Keywords: plant disease resistance; durable resistance; chromosome engineering; plant genomics; genome editing; molecular breeding; introgression; quantitative resistance; crop improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Targeting Metabolism, Inflammation, and Oxidative Stress: Novel Therapeutic Approaches in Human Diseases
edited by Kota V. Ramana
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1394 | Submission Open
Keywords: metabolism ; inflammation ; oxidative stress ; diabetes ; aging ; cardiovascular diseases ; gene editing ; stem cell therapy ; next-generation sequencing ; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pharmacological Research on Autoimmune Disease
edited by and Sandra Bertelli Ribeiro de Castro
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1375 | Submission Open
Keywords: autoimmune diseases; plant-derived formulations; drug repurposing strategies; nanostructured delivery systems; complementary therapies; inflammatory; immune system; gut–brain axis
(This special issue belongs to the Section Molecular Pharmacology)
Inflammatory and Metabolic Biomarkers in Disease Prediction and Prognosis
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1343 | Submission Open
Keywords: inflammation; biomarkers; metabolic indices; triglyceride-glucose index; inflammatory ratios; risk stratification; prognosis; cardiovascular diseases; critical care; neuroinflammation; endocrine disorders; composite inflammatory scores; artificial intelligence; personalized medicine; clinical biochemistry
(This special issue belongs to the Section Biochemistry)
Human Papillomavirus and Cellular Pathways submission deadline 30 Sep 2026 | 1 articles | Viewed by 1302 | Submission Open
Keywords: human papillomavirus; HPV oncogenesis; E6 and E7 oncoproteins; cellular signaling pathways; viral integration; epigenetics; molecular biomarkers; host susceptibility; cervical cancer; targeted therapy
(This special issue belongs to the Section Molecular Microbiology)
Methodological Advances in Phytochemical Analysis submission deadline 30 Sep 2026 | 2 articles | Viewed by 1274 | Submission Open
Keywords: advanced phytochemical profiling; high-resolution mass spectrometry; green extraction methodologies; chemometric data processing; bioactive metabolite elucidation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Insights into Aquatic Animal Reproduction, Breeding Strategies and Genetic Improvement
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1269 | Submission Open
Keywords: reproductive biology; aquaculture genetics; fish breeding; genomic selection; marker-assisted selection; genome editing; hybridization; genetic improvement; molecular breeding; sustainable animal production
(This special issue belongs to the Section Molecular Biology)
Molecular Diagnostics and Therapeutic Advances in Hematology: From Mechanisms to Clinical Applications submission deadline 30 Sep 2026 | 1 articles | Viewed by 1251 | Submission Open
Keywords: hematology; molecular diagnostics; immunology; biomarkers; hematopoietic cell transplantation; bone marrow failure; hematologic malignancies; plasma cell disorders; translational research; therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Beta Cells and Insulin Secretion submission deadline 30 Sep 2026 | 2 articles | Viewed by 1247 | Submission Open
Keywords: beta cell function; insulin secretion mechanisms; diabetes; glycemic control
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Current Research on Redox Homeostasis and Oxidative Stress in Health and Disease submission deadline 30 Sep 2026 | 3 articles | Viewed by 1212 | Submission Open
Keywords: reactive oxygen species; reactive nitrogen species; redox signalling; antioxidant defence systems; antioxidants; ageing; immunity; metabolism disorder; metabolomics; degenerative diseases; cardiovascular diseases; cancer; infectious diseases; oxidative post-translational modifications
(This special issue belongs to the Section Biochemistry)
Neuroimmune Circuitry: Advances in Neuronal Regulation of Immunity
edited by
submission deadline 30 Sep 2026 | Viewed by 1133 | Submission Open
Keywords: neuroimmunology; neuronal circuits; molecular signaling; hypothalamus; autonomic regulation; neuropeptides; GPCR signaling; inflammation; cytokines; transcriptional regulation
(This special issue belongs to the Section Molecular Immunology)
Molecular and Cellular Mechanisms of Muscle Development and Remodelling submission deadline 30 Sep 2026 | 1 articles | Viewed by 1126 | Submission Open
Keywords: muscle plasticity; nutrient signaling; protein turnover; metabolic flexibility; bioenergetics; redox homeostasis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Glial Cells in Brain and Eye: Emerging Mechanisms and Functions in Health and Disease
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1119 | Submission Open
Keywords: glial cells; brain & eye (retina); health & disease; neuronal regulation; therapeutic strategies; CNS; glia biology; cellular interactions
(This special issue belongs to the Section Molecular Biology)
Molecular Research on Porous Polymers for Advanced Separation and Analytical Applications
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1099 | Submission Open
Keywords: microporous polymers; molecular imprinting; ion imprinting; separation; porous surfaces; spectroscopy; chromatography
(This special issue belongs to the Section Macromolecules)
Recent Advances in Omics for Cancer Research
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1097 | Submission Open
Keywords: cancer; omics; genomics; transcriptomics; proteomics; metabolomics; multi-omics; biomarkers; precision oncology; systems biology
(This special issue belongs to the Section Molecular Oncology)
Computational Methods in Cancer Genomics and Molecular Oncology
edited by and Nicolas Carels
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1083 | Submission Open
Keywords: cancer genomics; computational biology; machine learning; precision oncology; multi-omics integration; molecular oncology; bioinformatics; tumor heterogeneity; biomarker discovery; single-cell sequencing
(This special issue belongs to the Section Molecular Genetics and Genomics)
Recent Advances in Benign Hematology
edited by Sirisha Kundrapu
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1066 | Submission Open
Keywords: molecular hematology; erythropoiesis; iron metabolism; complement cascade; coagulation pathways; genetic mutations; immune-mediated cytopenias; thrombotic microangiopathies; hematopoiesis; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease—2nd Edition
edited by David Rohde
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1050 | Submission Open
Keywords: myocardial infarction; heart failure; atherosclerosis; arterial hypertension; myocarditis; arrhythmia; inflammation; hematopoiesis; myelopoiesis; tissue macrophages; neutrophil biology; lymphocytes; endothelial cells; megakaryocytes; platelet biology; biomarkers
(This special issue belongs to the Section Molecular Immunology)
Natural Bioactive Compounds: Molecular Mechanisms and Toxicological Evaluation
edited by and Irma Ares
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1041 | Submission Open
Keywords: natural bioactive compounds; toxicology and safety assessment; molecular mechanisms of action; redox and inflammatory signaling pathways; chemical diversity; nutraceuticals and functional foods; health benefits and bioactivity
(This special issue belongs to the Section Molecular Toxicology)
Molecular, Genetic, and Omics Approaches to Disorders in Bone–Inflammation Crosstalk submission deadline 30 Sep 2026 | 1 articles | Viewed by 1023 | Submission Open
Keywords: bone physiology; inflammatory; epigenetic regulation; molecular signaling pathways; cellular interactions
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
T Cell Immunity in Emerging Respiratory Viral Infections: Mechanisms, Dysregulation, and Therapeutic Targets
edited by Jian Zheng
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1008 | Submission Open
Keywords: T cell; coronavirus; immune memory; immunopathogenesis; aging
(This special issue belongs to the Section Molecular Immunology)
Molecular and Immunological Mechanisms Associated with Exercise submission deadline 30 Sep 2026 | 1 articles | Viewed by 985 | Submission Open
Keywords: signaling pathways; exercise training adaptation; exercise and mitochondrial health; skeletal muscle secretome; exercise and extracellular vesicles; myokines; exerkines; molecular immune responses to exercise
(This special issue belongs to the Section Molecular Biology)
Cell Therapies: Cellular Mechanisms and Genetic Engineering
edited by Shirley O'Dea
submission deadline 30 Sep 2026 | 1 articles | Viewed by 984 | Submission Open
Keywords: cell engineering; advanced therapy medicinal products (ATMPs); cell fate control; translational cell therapy; next-generation cell therapy platforms; scalable cell manufacturing; personalized cell-based medicine; clinical translation; cell therapy delivery systems; bioprocessing of engineered cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
MicroRNAs in Cancer: Molecular Mechanisms and Regulatory Networks submission deadline 30 Sep 2026 | 2 articles | Viewed by 912 | Submission Open
Keywords: microRNAs; cancer; non-coding RNAs; gene regulation; tumor microenvironment; transcriptomics; cancer signaling
(This special issue belongs to the Section Molecular Biology)
Carbon-Based Nanomaterials: From Synthesis and Functionalization to Biomedical Applications
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 901 | Submission Open
Keywords: carbon-based nanomaterials; graphene; graphene oxide; carbon nanotubes; fullerenes; carbon quantum dots; surface functionalization; nano– bio interface; drug and gene delivery; cancer nanotherapeutics
(This special issue belongs to the Section Materials Science)
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