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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Molecular Biology on Mycobacteria: 2nd Edition
edited by
submission deadline 20 Jul 2026 | 2 articles | Viewed by 2648 | Submission Open
Keywords: genus Mycobacterium; non-tuberculous mycobacteria; Mycobacterium tuberculosis; Mycobacterium leprae; molecular diagnosis; molecular surveillance methodologies; molecular resistance prediction
(This special issue belongs to the Section Molecular Microbiology)
Recent Advances in Gastrointestinal Cancer, 3rd Edition
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 2417 | Submission Open
Keywords: gastrointestinal cancer; chemotherapeutic agents; innovative therapies; human nutrition; nutrigenomics; nutrition and immunity epigenetics; cytotoxicity; apoptosis
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Sjögren's Syndrome, 4th Edition submission deadline 20 Jul 2026 | 2 articles | Viewed by 2383 | Submission Open
Keywords: autoimmunity; sjö gren’ s syndrome; autoantibodies; salivary gland; lacrimal gland; dry eyes/mouth
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Horticultural Crop Improvement: A New Era for Plant Molecular Research: Fourth Edition
edited by
submission deadline 20 Jul 2026 | 2 articles | Viewed by 2170 | Submission Open
Keywords: horticultural plants; whole-genome resequencing; transcriptomics; proteomics; metabolomics; gene editing; gene regulation; growth and development; yield; quality; resistance
(This special issue belongs to the Section Molecular Plant Sciences)
Bioactive Compounds in Neurodegenerative Diseases
edited by
submission deadline 20 Jul 2026 | 2 articles | Viewed by 2151 | Submission Open
Keywords: bioactive compounds; neurodegenerative diseases; neuroinflammation; oxidative stress
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Advances in Forensic Science: Integrating Innovation and Investigation
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 1877 | Submission Open
Keywords: DNA profiling; artificial intelligence; trace evidence analysis; immunohistochemical markers; molecular biology techniques; super-resolution microscopy; integrated forensic approach; new bioinformatics techniques; digital pathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Supplements and Drug-Based Strategies in Neonatal and Paediatric Health submission deadline 20 Jul 2026 | 1 articles | Viewed by 1804 | Submission Open
Keywords: neonatal pharmacology; paediatric supplements; nutraceuticals in early life; microbiota– host interactions; infectious diseases in children; neurodevelopmental disorders; drug– nutrient interactions; dosing and delivery routes; molecular paediatrics; critical analysis of paediatric interventions
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Insights into the Pathogenesis, Molecular Landscape and Therapeutics of Triple-Negative Breast Cancer
edited by Rebecca Chin
submission deadline 20 Jul 2026 | 3 articles | Viewed by 1757 | Submission Open
Keywords: breast cancer; cancer stemness; therapeutic resistance; brain metastasis; epigenetic mechanisms; chromatin remodeling; multi-omics approaches; high-throughput screening; patient-derived organoids
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms Governing Lipid Metabolism in Health and Disease submission deadline 20 Jul 2026 | 2 articles | Viewed by 1632 | Submission Open
Keywords: lipidomics; lipid biomarkers; lipid metabolism; cardiovascular disease; cardiometabolic diseases; non-alcoholic fatty liver disease; diabetes; lipoproteins; NMR spectroscopy; mass spectrometry
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Tuberculosis: Host Immunity, Diagnosis and Treatment submission deadline 20 Jul 2026 | 1 articles | Viewed by 1568 | Submission Open
Keywords: tuberculosis; immune response; diagnosis; treatment; antibiotics; resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
In Silico Approaches to Unravelling Toxicity Mechanisms in Molecular Drugs
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 1371 | Submission Open
Keywords: cheminformatics; in silico analysis; QSAR; toxicity prediction; machine learning; toxicity mechanisms; omics data integration; toxicity biomarkers; artificial intelligence; adverse event database
(This special issue belongs to the Section Molecular Pharmacology)
Computational Approaches in Drug Discovery and Design: From Molecular Modeling to Translational Applications submission deadline 20 Jul 2026 | 2 articles | Viewed by 1336 | Submission Open
Keywords: computational drug discovery; molecular modeling; AI-driven drug design; molecular dynamics simulations; quantum chemistry; structure-based drug design; machine learning in pharmacology; virtual screening and docking; ADMET prediction; personalized medicine modeling
(This special issue belongs to the Section Molecular Informatics)
Recent Nanotechnology in Drug Delivery
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 1333 | Submission Open
Keywords: smart nanoparticles; hybrid nanomaterial; functionalization; drug targeting; liposome; cubosome; polypeptide; polymers; biomolecules; cancer; vaccine; antimicrobial; antiparasite; antioxidant; immunomodulatory; genetic therapy; nanomedicine
(This special issue belongs to the Section Molecular Nanoscience)
Pathogenesis and Treatments of Head and Neck Cancer: 2nd Edition
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 1314 | Submission Open
Keywords: HNSCC; premalignant changes; tumor microenvironment; molecular biomarkers; targeted therapy; oral tumorigenesis; molecular pathogenesis; tumor biology; tumor immunology
(This special issue belongs to the Section Molecular Oncology)
Nanoparticle-Based Biosensors and Their Applications
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 1233 | Submission Open
Keywords: biosensors; metal nanoparticles (MNPs); synthesis methods; molecular spectroscopy characteristics; molecular medicine; molecular biology
(This special issue belongs to the Section Molecular Nanoscience)
Circulating Tumor Cells in Oncology: From Liquid Biopsy to Clinical Decision-Making submission deadline 20 Jul 2026 | 1 articles | Viewed by 1194 | Submission Open
Keywords: circulating tumor cells (CTCs); liquid biopsy; cancer biomarkers; precision oncology; metastasis; cancer diagnostics; cancer prognosis; CTC enrichment; CTC isolation techniques; single-cell analysis; tumor microenvironment; CTC culture; immune surveillance; blood-based biomarkers; molecular profiling; CTC-derived cell lines; treatment resistance; personalized cancer therapy; cell reprogramming; anti-tumor immunity
(This special issue belongs to the Section Molecular Oncology)
25th Anniversary of IJMS: Updates and Advances in Molecular Biophysics submission deadline 20 Jul 2026 | 1 articles | Viewed by 1079 | Submission Open
Keywords: biomolecular interactions; biomolecular NMR; biophysics; chaperones; computational modeling; computer simulations; crystal thermodynamics; DNA structure and dynamics; drug– receptor interactions; enzymology; fluorescence imaging; genome structure; inter-molecular interactions; intrinsically disordered proteins; ion channels; macromolecular crystallography; macromolecular structure and dynamics; membrane dynamics; microcalorimetry; molecular dynamics; molecular imprinting; molecular mechanics; molecular modeling; molecular simulations; molecular modeling; molecular structure; molecular recognition; nucleic acid– protein interactions; post-translational modifications; protein design; protein– DNA interactions; protein engineering; protein– ligand binding; protein– membrane interactions; protein structure and folding; RNA structure; single-molecule techniques; spectroscopic techniques; statistical mechanics; structure– function relationships; structure prediction; thermodynamics; transient kinetic techniques; transmembrane proteins; x-ray crystallography
(This special issue belongs to the Section Molecular Biophysics)
Skin Cancer: A Focus from Pathophysiology to Novel Therapeutic Strategies
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 692 | Submission Open
Keywords: skin cancer; melanoma; keratinocyte carcinoma; pathophysiology; biomarkers; immunotherapy; targeted therapy; nanomedicine; resistance; precision oncology
(This special issue belongs to the Section Molecular Oncology)
G Protein-Coupled Receptors: Signaling, Regulation and Therapeutic Opportunities, 2nd Edition
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 679 | Submission Open
Keywords: GPCR; cell signaling; small-molecule drugs; biased signaling; endosomal signaling; post-translational modification; GPCR internalization; phosphorylation barcode
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Pathophysiology of Chronic Lung Diseases: Mechanisms and Therapeutics
edited by Gary C. Mouradian
submission deadline 20 Jul 2026 | 1 articles | Viewed by 644 | Submission Open
Keywords: chronic lung disease; vagal sensory neurons; inflammation; airway remodeling; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biological Pathways and Nutraceutical Compounds in Genetic Disease Treatment
edited by
submission deadline 20 Jul 2026 | Viewed by 536 | Submission Open
Keywords: micronutrients; supplements; functional foods; inherited disease; microbiome; RNA expression; protein expression; signaling pathways; DNA methylation; animal models; cell lines; clinical trials
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Nucleic Acid Aptamers in Molecular Medicine
edited by
submission deadline 20 Jul 2026 | Viewed by 421 | Submission Open
Keywords: aptamers; SELEX; targeted therapy; drug delivery; diagnosis; biomarker discovery
(This special issue belongs to the Section Molecular Biology)
Neuronal Differentiation: From Pathology to Therapeutic Strategies
edited by
submission deadline 20 Jul 2026 | Viewed by 372 | Submission Open
Keywords: neuronal differentiation; molecular mechanisms of neurodifferentiation; neurodegenerative diseases; ischemic stroke; spinal cord and brain injury; neural tissue recovery; regeneration therapy; stem cells
(This special issue belongs to the Section Molecular Neurobiology)
Advanced Strategies for Melanoma Immunotherapy submission deadline 20 Jul 2026 | Viewed by 287 | Submission Open
Keywords: melanoma immunotherapy; immune Checkpoint Inhibitors; combination therapies; biomarkers; tumor microenvironment
(This special issue belongs to the Section Molecular Immunology)
Biomaterials for Bone Treatment, Replacement and Regeneration: Focus on Regeneration and Inflammation
edited by
submission deadline 20 Jul 2026 | Viewed by 246 | Submission Open
Keywords: biomaterials  ; bone substitute  ; inflammation  ; foreign body response  ; bone regeneration
(This special issue belongs to the Section Materials Science)
Advancing Mental Disorder Therapies: Drug Repositioning and Translational Insights from Animal Models
edited by Claudia Bregonzio and Mariela Fernanda Pérez
submission deadline 20 Jul 2026 | Viewed by 231 | Submission Open
Keywords: anxiety; depression; Parkinson's disease; Alzheimer; schizophrenia; neurotransmitter imbalance; novel treatments; new pharmacological targets; preclinical studies
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights in Medical Microbiology and Infectious Diseases: The Role of Artificial Intelligence and Machine Learning
edited by
submission deadline 20 Jul 2026 | Viewed by 229 | Submission Open
Keywords: molecular diagnostics; pathogen genomics; antimicrobial resistance; host– pathogen interaction; infectious diseases surveillance; artificial intelligence; machine learning
(This special issue belongs to the Section Molecular Informatics)
Non-Coding RNAs as Key Regulators in Human Disease Processes
edited by
submission deadline 20 Jul 2026 | Viewed by 193 | Submission Open
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; therapeutic targets; molecular mechanisms; RNA-based therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Adhesion, Invasion, and Metastasis in Cancer Progression submission deadline 20 Jul 2026 | Viewed by 188 | Submission Open
Keywords: cancer metastasis; cellular adhesion; invasion and migration; noncoding RNAs; EMT; Wnt/β -catenin signalling; tumour microenvironment; biomarkers; AI-driven metastasis prediction
(This special issue belongs to the Section Molecular Oncology)
Bioactive Small Molecules in Tissue Repair and Regeneration submission deadline 20 Jul 2026 | Viewed by 185 | Submission Open
Keywords: small molecules; organ and tissue regeneration; development; aging
(This special issue belongs to the Section Molecular Biology)
Endocrine–Immune Crosstalk in Human Reproductive Health and Pathology
edited by Juan Pablo Mackern-Oberti
submission deadline 20 Jul 2026 | 1 articles | Viewed by 182 | Submission Open
Keywords: T cells; B cells; autoimmune disease; reproduction; immunemodulation; inflammation; endocrinology; lactation
(This special issue belongs to the Section Molecular Immunology)
Molecular Insight into Nematodes Management
edited by
submission deadline 20 Jul 2026 | Viewed by 176 | Submission Open
Keywords: biological control; micro-organisms; molecular identification; biodiversity; climatic changes; soil nema-todes; cultural practices; host plant resistance; anaerobic soil disinfection; biofumigation
(This special issue belongs to the Section Molecular Biology)
From Biology to Biomechanics: Molecular Advances in Orthodontic Remodeling and Acceleration submission deadline 20 Jul 2026 | 1 articles | Viewed by 164 | Submission Open
Keywords: orthodontic tooth movement; bone remodeling; root resorption; molecular mechanisms; inflammatory response; corticotomy-assisted orthodontics; biomechanics; periodontal ligament; cellular signaling; accelerated orthodontic treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Molecular Mechanisms of Human Papillomavirus Family (HPV) Induced Oncogenesis, 2nd Edition
edited by
submission deadline 20 Jul 2026 | Viewed by 157 | Submission Open
Keywords: human papillomavirus (HPV); oncogenesis; mechanism; diagnosis; classification; etiology; pathophysiology; biochemistry; genetics; molecular biology; epidemiology; cervical cancer; oropharyngeal cancer; oncology
(This special issue belongs to the Section Molecular Oncology)
Natural Product-Inspired Anticancer Drug Development
edited by
submission deadline 20 Jul 2026 | Viewed by 156 | Submission Open
Keywords: anticancer; antiproliferative; cytotoxic; natural product; drug development; semi-synthesis; total synthesis; structure– activity relationship; computational simulation; enzyme inhibition
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Role of DNA Methylation Signatures in Genetic Disorders submission deadline 20 Jul 2026 | Viewed by 156 | Submission Open
Keywords: DNA methylation; genetic disorders; episignature; genomic medicine; differentially methylated regions
(This special issue belongs to the Section Molecular Genetics and Genomics)
Recent Molecular Research on Photocatalytic Applications
edited by Hassan Ait Ahsaine
submission deadline 20 Jul 2026 | Viewed by 144 | Submission Open
Keywords: photocatalysis; photocatalytic degradation; molecular catalysts; photocatalysts; functional materials
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Characterization of Immune and Inflammatory Tumor Microenvironment on Canine, Feline and Human Species
edited by
submission deadline 20 Jul 2026 | Viewed by 135 | Submission Open
Keywords: inflammation; tumor microenvironment; cancer biomarkers; comparative pathology; cancer epidemiology; cancer risk factors; molecular diagnostics; proteomics; treatment response; targeted therapy; immunotherapy; translation cancer research
(This special issue belongs to the Section Molecular Oncology)
Regenerative Medicine for Tendon: Harnessing Stem Cell Potential submission deadline 20 Jul 2026 | Viewed by 132 | Submission Open
Keywords: stem cells; endogenic differentiation; three-dimensional in vitro tendon models; immunomodulation; biomimetic scaffolds; in vivo tendon models; dynamic cultures
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Chronic Airway Diseases: Molecular Basis and Advanced Therapeutics
edited by
submission deadline 20 Jul 2026 | Viewed by 129 | Submission Open
Keywords: chronic airway diseases; asthma; chronic obstructive pulmonary disease (COPD); cystic fibrosis; bronchiectasis; pulmonary fibrosis; airway remodeling; cytokines; inflammation; immune dysregulation; mucociliary clearance; microbiome; epithelial– mesenchymal transition (EMT); molecular mechanisms; biomarkers; proteases; protease inhibitors; precision medicine; targeted therapeutics; RNA-based and gene therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Rhizospheric Microbial Interactions
edited by
submission deadline 20 Jul 2026 | Viewed by 124 | Submission Open
Keywords: plant– microorganism interactions; rhizosphere community; secretory systems; secondary metabolites; volatile compounds
(This special issue belongs to the Section Molecular Microbiology)
Obesity and Obesity-Associated Co-Morbidities: From Mechanisms to Mechanism-Based Therapies
edited by
submission deadline 20 Jul 2026 | Viewed by 118 | Submission Open
Keywords: obesity; adipose tissue inflammation; microbiota; oxidative stress; gene expression regulation; metabolism; obesity-associated co-morbidities; non-communicable disease; cancer; mechanism-based therapy
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Bioactive Natural Compounds in the Prevention and Treatment of Human and Veterinary Diseases submission deadline 20 Jul 2026 | Viewed by 93 | Submission Open
Keywords: bioactive natural substances; nutraceuticals; drug discovery; drug resistance; inflammation; antioxidant; health promotion; prevention; treatment; synergistic effect; molecular mechanism; computational analysis; repurposed molecules
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Phytochemicals in Cancer Therapy: From Preclinical Studies to Clinical Practice
edited by Mounir Tilaoui
submission deadline 20 Jul 2026 | Viewed by 30 | Submission Open
Keywords: phytochemicals; cancer therapy; molecular mechanisms; signaling pathways; programmed cell death; tumor microenvironment; drug resistance; preclinical models; clinical translation; adjuvant therapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Docking Method and Application
edited by
submission deadline 20 Jul 2026 | Viewed by 26 | Submission Open
Keywords: drug discovery; docking scores; docking poses; traditional methods of drug discovery; ligand-based virtual screening (LBVS); structure-based virtual screening (SBVS); machine learning (ML)
(This special issue belongs to the Section Molecular Informatics)
Molecular Mechanisms of Chronic Lung Diseases submission deadline 25 Jul 2026 | Viewed by 185 | Submission Open
Keywords: interstitial lung diseases; chronic respiratory diseases; genetic susceptibility; genomic; cytokine networks; metalloproteinases; inflammasome; inflammatory cytokines; telomere length
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Evolving Landscape of Cardiovascular Pathophysiology
edited by
submission deadline 25 Jul 2026 | Viewed by 86 | Submission Open
Keywords: biomarker discovery in cardiovascular pathophysiology; precision diagnostics-novel contrast agents combined with PET/CT; MRI; machine learning/AI and clinical implementations in cardiology; cardio-metabolic disease; inflammation and immunity in cardiovascular diseases; mechanisms of non-coding RNAs and microRNAs in cardiac diseases; translational research in large animals bridging the rodent re-search with human pathophysiology; targeted therapies- genetic therapies/gene editing approach (CRISPR); stem cell therapies; and therapeutic mRNA and siRNA-based approaches
(This special issue belongs to the Section Biochemistry)
Neurodegenerative Diseases: Molecular Mechanisms and Therapies, 4th Edition submission deadline 25 Jul 2026 | Viewed by 32 | Submission Open
Keywords: neurodegeneration; neurodegenerative diseases; protein aggregation; pathogenesis; therapy; mitochondria; neuroinflammation; oxidative stress; cell therapy; clinical trial
(This special issue belongs to the Section Molecular Neurobiology)
Neurobiology Linking Alcohol Addiction to Psychiatry Symptoms submission deadline 30 Jul 2026 | Viewed by 138 | Submission Open
Keywords: alcohol use disorder (AUD); psychiatry; neurobiology; biomarkers; translational
(This special issue belongs to the Section Molecular Neurobiology)
Cancer Drug Resistance and Therapeutic Targets submission deadline 30 Jul 2026 | Viewed by 136 | Submission Open
Keywords: drug resistance; therapeutic targets; efflux transporters’ oncogenic signaling pathways; tumor microenvironment; dna damage/repair; personalized therapies
(This special issue belongs to the Section Molecular Oncology)
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