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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Natural Antioxidants—Sources, Characteristics, and Biological Activity
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1512 | Submission Open
Keywords: natural antioxidants; oxidative stress; reactive oxygen species; inflammation; free radicals; structure–activity relationship; nutraceuticals; synergistic effects; plant-derived compounds; drug discovery
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Application of Stem Cells in Regenerative Medicine submission deadline 31 Jan 2027 | 1 articles | Viewed by 1511 | Submission Open
Keywords: embryonic stem cells; induced pluripotent stem cells; adult stem cells; cancer stem cells; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring the Gut-Brain Axis: Mechanisms and Implications for Health and Disease
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1487 | Submission Open
Keywords: gut–brain axis; enteric nervous system; dysbiosis; gut microbiota; neuroinflammation; one health; microbiota–immune crosstalk; metabolic syndromes; cardiovascular diseases; neurodegenerative diseases; cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Thyroid Hormone Signaling: Mechanisms and Pathophysiological Implications
edited by and Horacio Eduardo Romeo
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1473 | Submission Open
Keywords: thyroid hormones; mitochondrial function; oxidative stress; redox signaling; metabolic disorders; immune modulation; cardiovascular pathology; neurodevelopment and aging; cancer progression
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Autophagy in Physiology and Pathophysiology: Recent Advances
edited by and Claudio Marcelo Fader
submission deadline 31 Jan 2027 | 2 articles | Viewed by 1435 | Submission Open
Keywords: macroautophagy; microautophagy; chaperone-mediated autophagy (CMA); autophagy-related genes (ATG); xenophagy; mitophagy; pexophagy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Atherosclerosis: From Molecular Biology to Therapeutic Perspective: 7th Edition submission deadline 31 Jan 2027 | 2 articles | Viewed by 1434 | Submission Open
Keywords: atherosclerosis; vascular smooth muscle cells; inflammation; endothelium; cell senescence; apoptosis; lipid metabolism; oxidative stress; nitric oxide; exosomes; vascular calcification; cytokines; growth factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Infectious Diseases and Infection Models in Laboratory Animals
edited by and Fumio Ike
submission deadline 31 Jan 2027 | 2 articles | Viewed by 1422 | Submission Open
Keywords: infection model; Infectious diseases in laboratory animals; bacterial infection; viral infection; parasitic infection; molecular diagnosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bridging Basic and Clinical Science: Shared Molecular and Metabolic Mechanisms in Preeclampsia, Gestational Diabetes and Gestational Weight Gain
edited by , Hector Borboa-Olivares, Verónica Zaga-Clavellina and
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1421 | Submission Open
Keywords: preeclampsia; gestational diabetes; gestational weight gain; metabolic mechanisms; molecular pathways; placental biology; maternal–fetal interface; biomarkers; insulin resistance; inflammation; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cancer, Chronic Disease and Health Equity: Translational Oncology in the Era of Multimorbidity and Systems Innovation
edited by , Kiven Erique Lukong and Marco Feligioni
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1409 | Submission Open
Keywords: molecular mechanisms in chronic diseases and cancer; cancer metabolism, inflammation, and systemic disease interactions; biomarker discovery in cancer and chronic diseases; biological mechanisms in cancer and chronic diseases; neuroimmune responses in cancer and chronic diseases; epigenetic events in cancer and chronic diseases; translational oncology and precision medicine; artificial intelligence and digital innovation in oncology and chronic disease care; cancer and cardiometabolic disease intersections; multimorbidity management strategies in oncology care; integrated screening, prevention, and survivorship models; implementation science in cancer and chronic disease care
(This special issue belongs to the Section Molecular Oncology)
Molecularly Engineered Nanomaterials for Energy Conversion, Storage, and AI-Driven Materials Discovery
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1389 | Submission Open
Keywords: molecular engineering; energy conversion and storage; hydrogen evolution reaction (HER); oxygen evolution reaction (OER); batteries and supercapacitors; optical properties; light-emitting diodes; AI-assisted materials design
(This special issue belongs to the Section Molecular Nanoscience)
Cancer Immunotherapy on Checkpoint Inhibitors: Future Directions
edited by
submission deadline 31 Jan 2027 | 2 articles | Viewed by 1355 | Submission Open
Keywords: immune checkpoint inhibitors (ICIs); PD-1/PD-L1 blockade; combination immunotherapy; immunotherapy resistance; tumor microenvironment (TME); predictive biomarkers; immune-related adverse events (irAEs); novel immune targets (LAG-3/TIM-3); personalized medicine; clinical trials
(This special issue belongs to the Section Molecular Oncology)
Research on Trace Elements in Nutrition and Health
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1315 | Submission Open
Keywords: trace elements; molecular mechanisms; micronutrients; supplementation; speciation analysis; biomarkers; health risk assessment
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Cardiovascular Disease: Pathophysiology, Diagnosis, and Therapy
edited by Masaru Tanaka
submission deadline 31 Jan 2027 | 2 articles | Viewed by 1272 | Submission Open
Keywords: cardiovascular disease; endothelial dysfunction; vascular remodeling; inflammation; immunothrombosis; biomarkers; extracellular vesicles; mitochondrial dysfunction; cellular senescence; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Cellular Functions of Tubulin in Neuronal Health and Disease
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1268 | Submission Open
Keywords: tubulin; microtubules; neurodegeneration; neuron; brain; neurodevelopment; motor proteins
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Parasitic Diseases
edited by Rajendranath Ramasawmy
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1261 | Submission Open
Keywords: parasites; molecular mechanisms; pathogenesis; genetics; symptomatics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Omics Approach to Uncovering Signalling and Gene Regulation in Plants
edited by Xiang Li and Jingchun Shi
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1249 | Submission Open
Keywords: omics; plant signalling; gene regulation; bioinformatics
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Biology of Gynecologic Health and Disease
edited by Marcin Bobiński
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1239 | Submission Open
Keywords: molecular biomarkers; gynecologic endocrinology; gynecologic oncology; hypothalamic–pituitary–ovarian axis; ovarian reserve and reproductive aging
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Discovery of Plant-Derived Compounds and Their Immunomodulatory Applications
edited by
submission deadline 31 Jan 2027 | 2 articles | Viewed by 1229 | Submission Open
Keywords: plant-derived compounds; immunomodulators; phytochemicals; immune signaling; natural products; autoimmune diseases; intestinal flora; in vitro evaluation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Chronic Lung Diseases submission deadline 31 Jan 2027 | 1 articles | Viewed by 1227 | Submission Open
Keywords: interstitial lung diseases; chronic respiratory diseases; genetic susceptibility; genomic; cytokine networks; metalloproteinases; inflammasome; inflammatory cytokines; telomere length
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Regulatory Mechanisms in Kidney Development and Function
edited by Gary F. Gerlach
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1190 | Submission Open
Keywords: drosophila nephrocyte; zebrafish pronephros; mesonephros; murine nephrogenesis; slit diaphragm; podocytes; junctions; tubule; mesenchymal-to-epithelia transition (MET); epithelial-to-mesenchymal transition (EMT); tubule segmentation; transcription factors; signaling pathways; foot processes; cytoskeleton; brush boarder; intercalated cells; renin angiotensin; diabetic kidney disease; podocytopathies; FSGS; minimal change disease; IgAN
(This special issue belongs to the Section Molecular Biology)
Roadmap of the Human Epigenome: Insights from RNAs
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1185 | Submission Open
Keywords: human epigenome; non-coding RNAs; RNA-mediated regulation; transcriptomics; diagnostics and therapeutic strategies
(This special issue belongs to the Section Molecular Genetics and Genomics)
Rheumatic Diseases: From Pathophysiology to Novel Therapeutic Approaches
edited by Namrata Singh
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1180 | Submission Open
Keywords: rheumatic diseases; disease mechanisms; treatment; long-term outcomes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Sphingolipids in Infections, Disorders and Diseases
edited by Elita Avota
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1170 | Submission Open
Keywords: sphingolipids; sphingolipid biosynthesis; sphingolipidoses; metabolic disorders; infections; lipidomics; sphingolipid targeting drugs
(This special issue belongs to the Section Biochemistry)
Unraveling Immunometabolism in Sepsis: From Cellular Reprogramming to Therapeutic Targets
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1160 | Submission Open
Keywords: sepsis; immunometabolism; metabolic reprogramming; cellular bioenergetics; innate and adaptive immunity; mitochondrial dysfunction; inflammatory signaling; metabolic biomarkers; therapeutic modulation; host–pathogen interactions
(This special issue belongs to the Section Molecular Immunology)
Chronic Stress, Neuroinflammation and Pain: Molecular Mechanisms, Biomarkers and Precision Therapies
edited by Nebojsa Knezevic and
submission deadline 31 Jan 2027 | Viewed by 1148 | Submission Open
Keywords: chronic stress; chronic pain; neuroinflammation; biomarkers; pain mechanisms; neuropathic pain; low back pain; neuroimmune interactions; precision medicine; personalized therapy; pain phenotyping; translational research; mental health; neurobiology; pain management; inflammatory pathways; stress biomarkers; central sensitization
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insight into Biomaterials for Tissue Engineering and Regenerative Medicine
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1112 | Submission Open
Keywords: biomaterials; tissue regeneration; regenerative medicine; bone regeneration; periodontal disease; morphology; tissue engineering
(This special issue belongs to the Section Molecular Biology)
mRNA Vaccines Against Viral Infectious Diseases: Progress and Prospects
edited by and Maria Teresa Maggiorella
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1111 | Submission Open
Keywords: viruses; mRNA vaccines; mRNA structure; mRNA platform technologies; lipid nanoparticle (LNP) delivery; immunization strategies; adjuvants; preclinical trials; clinical trials; germline-targeting; broadly neutralizing antibodies; humoral immune response; cellular immune response; host–vaccine interactions
(This special issue belongs to the Section Molecular Microbiology)
Emerging Topics in Polymeric Nanoparticles submission deadline 31 Jan 2027 | 1 articles | Viewed by 1080 | Submission Open
Keywords: polymeric nanoparticles; nanostructured materials; functional polymers; Janus particles; self-assembly; drug delivery; environmental remediation; microplastics; biodegradability; nanomedicine; green synthesis; adsorbents; life cycle assessment; surface functionalization; smart materials; biocompatibility; environmental impact; bioaccumulation; responsive polymers; hybrid nanomaterials
(This special issue belongs to the Section Macromolecules)
Current Molecular Advances in Apoptosis submission deadline 31 Jan 2027 | 1 articles | Viewed by 1072 | Submission Open
Keywords: apoptosis; glomerulonephritis; aging; caspase; endonuclease; DNA; cytokeratin
(This special issue belongs to the Section Biochemistry)
Novel Therapeutic Strategies and Targets in Rheumatoid Arthritis
edited by David Fox and
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1058 | Submission Open
Keywords: RA; synovium; FLS; synovial fluid; microbiome; autoimmunity; DMARD; joint inflammation; joint damage; nanoparticle
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Immune Responses, Viral Infection and Neurodegenerative Diseases
edited by and Barbara Hanson
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1044 | Submission Open
Keywords: immune response; innate immunity; viral neuropathogenesis; viral biomarker; AD; PD; neurodegenerative diseases
(This special issue belongs to the Section Molecular Immunology)
New Molecular Research on High-Fat Diet on Human Health and Disease submission deadline 31 Jan 2027 | 1 articles | Viewed by 1018 | Submission Open
Keywords: obesity; diet-induced obesity; antioxidants
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Early-Life Environmental Effects on Brain Development
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1008 | Submission Open
Keywords: early-life environment; brain development; neurodevelopmental programming; environmental exposures; developmental neurotoxicology; gene–environment interactions; maternal health; epigenetic regulation; neuroimmune interactions; endocrine disruption
(This special issue belongs to the Section Molecular Neurobiology)
Genome Editing and Biotechnology in Fruit Improvement
edited by Hongxia Miao
submission deadline 31 Jan 2027 | 1 articles | Viewed by 997 | Submission Open
Keywords: fruit improvement; horticultural crops; genome editing; biotechnology; molecular biology; plant genetics
(This special issue belongs to the Section Molecular Plant Sciences)
Computational Approaches in Biomedicine: Innovations and Insights
edited by
submission deadline 31 Jan 2027 | Viewed by 987 | Submission Open
Keywords: computational biomedicine; artificial intelligence; machine learning; omic technologies; system biology; medical imaging; structural biology; drug discovery
(This special issue belongs to the Section Molecular Informatics)
Advances in Anticancer Drug Discovery: Design, Synthesis and Molecular Insights
edited by
submission deadline 31 Jan 2027 | 2 articles | Viewed by 981 | Submission Open
Keywords: anticancer agents; drug design; drug synthesis; structure-activity relationship (SAR); target interactions; medicinal chemistry; lead optimization; targeted therapy; bioactive compounds
(This special issue belongs to the Section Molecular Pharmacology)
Vitamin D Metabolism and Molecular Signaling in Human Diseases
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 954 | Submission Open
Keywords: vitamin D; vitamin D metabolism; molecular signaling; genomic and non-genomic pathways; epigenetics; immune regulation; inflammation; metabolic disorders; autoimmune diseases; cancer biology; gut microbiota; genetic polymorphisms; precision medicine
(This special issue belongs to the Section Molecular Biology)
Alternative Splicing, Isoform Diversity, and Cell Function
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 946 | Submission Open
Keywords: alternative splicing; isoform diversity; RNA-binding proteins; splicing regulation; cellular stress response; proteomic complexity; splicing in disease; computational splicing analysis
(This special issue belongs to the Section Molecular Biology)
Molecular Horizons in Pain Therapeutics
edited by Alaa Abd-Elsayed
submission deadline 31 Jan 2027 | 1 articles | Viewed by 944 | Submission Open
Keywords: spinal cord stimulation; peripheral nerve stimulation; stem cell therapy; platelet-rich plasma (PRP) injections; chronic pain management; interventional pain procedure
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Green Gold: Microalgae as a Sustainable Source of Nutrients and Bioactive Compounds
edited by and Pilar Gómez-Cortés
submission deadline 31 Jan 2027 | 1 articles | Viewed by 919 | Submission Open
Keywords: microalgae; sustainable nutrition; bioactive compounds; functional foods; nutraceuticals; alternative proteins; phycochemistry; circular bioeconomy; biorefinery
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Retinal Degeneration: From Pathophysiology to Therapeutic Approaches—4th Edition
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 916 | Submission Open
Keywords: hereditary retinal disease; retinal inflammation; retinal gene augmentation, editing, optogenetics and splice modulation therapy; natural history studies of the retina; human iPSC-derived retinal organoids and retinal pigment epithelium; retinal iPSC-derived cell therapy; retinal pathology; pre- and clinical gene therapy; animal models for retinal dystrophy; retinal imaging; retina-on-a-chip
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Surfactants: Design, Synthesis and Properties
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 902 | Submission Open
Keywords: design and synthesis of surfactants; adsorption and aggregation properties of surfactants; behavior of surfactants at different interfaces; application of biosurfactants and specialist surfactants (industry, agriculture, medicine, pharmacy)
(This special issue belongs to the Section Materials Science)
Latest Advances in Targeted Molecular Therapies for Genetic Disease
edited by Viorica-Elena Rădoi
submission deadline 31 Jan 2027 | 1 articles | Viewed by 895 | Submission Open
Keywords: genetic diseases; precision medicine; gene editing; RNA-based therapeutics; genomic profiling; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research and Insights in Rapeseed Abiotic Stress
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 869 | Submission Open
Keywords: rapeseed (Brassica napus); abiotic stress; drought tolerance; salinity stress; heavy metal toxicity; molecular mechanisms; stress signaling; omics (transcriptomics, proteomics, metabolomics); molecular breeding; CRISPR-Cas9; stress-responsive genes; hormone cross-talk; epigenetic regulation; stress resilience
(This special issue belongs to the Section Molecular Plant Sciences)
Functional Materials for Biomedical Applications and Uses submission deadline 31 Jan 2027 | 1 articles | Viewed by 857 | Submission Open
Keywords: functional materials; nanomaterials; biomedical applications; molecular engineering
(This special issue belongs to the Section Materials Science)
Bioactive Small Molecules in Tissue Repair and Regeneration submission deadline 31 Jan 2027 | 1 articles | Viewed by 849 | Submission Open
Keywords: small molecules; organ and tissue regeneration; development; aging
(This special issue belongs to the Section Molecular Biology)
Supramolecular Liquid Crystal Compounds—from Molecular Design to Functional Materials
edited by
submission deadline 31 Jan 2027 | Viewed by 826 | Submission Open
Keywords: supramolecular; self-assembled; liquid crystal; hydrogen bonding
(This special issue belongs to the Section Materials Science)
Mesenchymal Stem Cell-Derived Extracellular Vesicles as Therapeutic Tools in Chronic Diseases
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 825 | Submission Open
Keywords: cell-free therapy; exosomes; immunomodulation; molecular mechanisms; regeneration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research Progress on Photosensitizers and Photodynamic Therapy
edited by
submission deadline 31 Jan 2027 | Viewed by 812 | Submission Open
Keywords: photodynamic therapy; photosensitizers; tumor microenvironment; nanotechnology; immunotherapy; targeted drug delivery; reactive oxygen species; hypoxia; combination therapy; molecular mechanisms
(This special issue belongs to the Section Biochemistry)
Vector–Pathogen–Host Interaction, Vaccines and Immunobiologicals
edited by Carlo José Freire Oliveira and
submission deadline 31 Jan 2027 | 1 articles | Viewed by 803 | Submission Open
Keywords: host–pathogen–vector interactions; active biomolecules; immunomodulation; vaccines; binding molecules; immunobiologicals
(This special issue belongs to the Section Molecular Immunology)
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