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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of Zinc Finger Proteins in Biological Processes and Diseases

edited by

Amelia Casamassimi

and Patrizia Gazzerro

submission deadline 30 Jan 2026 | 4 articles | Viewed by 7407 | Submission Open

Keywords: zinc finger domain; CTCF; PRDM family; nuclear receptors; human diseases; transcriptional regulation; epigenetic modifications

(This special issue belongs to the Section Molecular Biophysics)

Molecular Engineering in Dental Restorative and Regenerative Materials

edited by

Danijela Marović

submission deadline 30 Jan 2026 | 5 articles | Viewed by 7404 | Submission Open

Keywords: dental composites; ceramics; additive manufacturing; dental adhesives; bioactive; 3D printing; photopolymerization; curing devices; microstructure; degree of conversion; bulk-fill composites; lasers in dentistry; infrared spectroscopy; biocompatibility; bone regeneration; osseointegration; soft tissue regeneration

(This special issue belongs to the Section Materials Science)

High Fat Diet Metabolism and Diseases

edited by

Miguel Walter Fornés

and

Luís Fernando Barbisan

submission deadline 30 Jan 2026 | 6 articles | Viewed by 7341 | Submission Open

Keywords: diet; fat; high-fat diets; obesity; NAFLD; metabolism; reproductive system; lungs; pathology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Molecular Aspects of Colorectal Cancer

edited by

Christos K. Kontos

submission deadline 30 Jan 2026 | 3 articles | Viewed by 7114 | Submission Open

Keywords: colorectal adenocarcinoma; cancer pathobiology; molecular biomarkers; diagnosis and prognosis; prediction of therapy selection; therapeutic targets; RNA molecules; microRNA; long non-coding RNA; circular RNA

(This special issue belongs to the Section Molecular Oncology)

The Role of the IGF Axis in Disease, 4th Edition

edited by Claire M. Perks

submission deadline 30 Jan 2026 | 3 articles | Viewed by 6608 | Submission Open

Keywords: IGF axis; cancer; obesity; hallmarks of cancer

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms and Regulation in Blood-Brain Barrier

edited by Rajkumar Vutukuri

submission deadline 30 Jan 2026 | 1 articles | Viewed by 6579 | Submission Open

Keywords: blood brain barrier (BBB); tight junctions; NVU cell types; neurodegenerative diseases; neuro-inflammation

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Burn Wound Healing and Skin Regeneration: Innovations and Insights

edited by

H. Ibrahim Korkmaz

submission deadline 30 Jan 2026 | 2 articles | Viewed by 6575 | Submission Open

Keywords: burn wound healing; skin regeneration; novel biomaterials; wound dressings; regenerative therapies

(This special issue belongs to the Section Biochemistry)

Molecular Advances in Combinatorial Therapies for Spinal Cord Injury

edited by

Lingxiao Deng

submission deadline 30 Jan 2026 | 1 articles | Viewed by 6424 | Submission Open

Keywords: molecular; cellular; engineering; spinal cord injury

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Treatment Strategies for Head and Neck Cancer

edited by

Francesca Spirito

submission deadline 30 Jan 2026 | 1 articles | Viewed by 5736 | Submission Open

Keywords: head and neck cancer; drug resistance; cancer initiation; biomarker

(This special issue belongs to the Section Molecular Oncology)

Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease

edited by David Rohde

submission deadline 30 Jan 2026 | 5 articles | Viewed by 5634 | Submission Open

Keywords: myocardial infarction; heart failure; atherosclerosis; arterial hypertension; myocarditis; arrhythmia; inflammation; hematopoiesis; myelopoiesis; tissue macrophages; neutrophil biology; lymphocytes; endothelial cells; megakaryocytes; platelet biology; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Retinal Diseases: From Molecular Pathology to Therapies—2nd Edition

edited by

Peter Koulen

submission deadline 30 Jan 2026 | 3 articles | Viewed by 5617 | Submission Open

Keywords: diabetic retinopathy; age-related macular degeneration; neuroprotection; retina; diabetic macular edema; therapy development; pathophysiology; retinitis pigmentosa; aging; eye trauma; vitreous; macula; choroideremia; stargardt disease; cone– rod dystrophy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Toxic Liver Injury: Molecular, Mechanistic, and Medical Challenges 3.0

edited by

Rolf Teschke

submission deadline 30 Jan 2026 | 3 articles | Viewed by 5533 | Submission Open

Keywords: liver injury; nonalcoholic fatty liver disease; nonalcoholic steatonecrosis; nonalcoholic liver cirrhosis; hepatocellular carcinoma

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Photobiomodulation Therapy

edited by Maria Fernanda Setúbal Destro Rodrigues

submission deadline 30 Jan 2026 | 3 articles | Viewed by 5425 | Submission Open

Keywords: photobiomodulation; dosimetric parameters; human diseases; modulation of inflammation; photobiomodulation therapy; molecular mechanisms; preclinical and clinical studies; therapeutic applications of PBM

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Food Science and Molecular Nutrition

edited by

Hsinjung Ho

submission deadline 30 Jan 2026 | 1 articles | Viewed by 5213 | Submission Open

Keywords: food science; antioxidants; bioactive compounds; mitochondria; nutrigenomics; metabolomics

(This special issue belongs to the Section Biochemistry)

From Kidney Disease to Hypertension: Molecular Basis and Pathophysiology

edited by

Alexis A. Gonzalez

submission deadline 30 Jan 2026 | 3 articles | Viewed by 4941 | Submission Open

Keywords: renin-angiotensin-aldosterone system; endothelial cell dysfunction; systemic inflammation; hypertension; oxidative stress; vascular remodeling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Aspects of Forensic Toxicology

edited by

Angelo Montana

submission deadline 30 Jan 2026 | 1 articles | Viewed by 4700 | Submission Open

Keywords: forensic toxicology; molecular mechanism; toxicological biomarkers; post-mortem interval; in vitro; in vivo; and in silico models; new psychoactive substances (NPSs); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-tandem mass spectrometry (GC-MS/MS)

(This special issue belongs to the Section Molecular Toxicology)

Molecular Studies of Age-Related Diseases: Immunosenescence and Inflammaging

edited by

Lia Ginaldi

submission deadline 30 Jan 2026 | 2 articles | Viewed by 4594 | Submission Open

Keywords: aging; age-related; immunosenescence; immune system; inflammaging

(This special issue belongs to the Section Molecular Immunology)

New Insights into Autophagy and Retinal Degeneration

edited by

Francesco Fornai

submission deadline 30 Jan 2026 | 1 articles | Viewed by 4433 | Submission Open

Keywords: autophagy; retinal degeneration; retinal inflammation; oxidative stress; retinal alterations; age-related macular degeneration; retinal damage; inflammatory processes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Crustacean Aquaculture

edited by Tom Levy and

Tomer Ventura

submission deadline 30 Jan 2026 | 3 articles | Viewed by 4350 | Submission Open

Keywords: androgenic gland; aquaculture; crustaceans; disease management; gene silencing; genetic modification; monosex; selective breeding; sex reversal; yield improvement

(This special issue belongs to the Section Molecular Biology)

Unraveling Sugar Signaling: Insights into Plant Stress Responses

edited by

Claudia Uhde-Stone

submission deadline 30 Jan 2026 | 2 articles | Viewed by 4331 | Submission Open

Keywords: sugar signaling; glucose signaling; sucrose signaling; signal transduction pathways; plant response to stress; biotic stress; abiotic stress; plant physiology

(This special issue belongs to the Section Molecular Plant Sciences)

The Transcendental World of Plant Toxic Compounds

edited by

Helena Fernández

submission deadline 30 Jan 2026 | 2 articles | Viewed by 4221 | Submission Open

Keywords: alcaloids; biotic stress; defence; phenols; phytotoxins; secondary metabolism; terpenes

(This special issue belongs to the Section Molecular Plant Sciences)

Design, Synthesis and Applications of the Task-Specific Molecules

edited by

Ye Yuan

and

Yang Yang

submission deadline 30 Jan 2026 | 3 articles | Viewed by 3846 | Submission Open

Keywords: task-specific molecules; molecular design and synthesis; physical/chemical absorption; catalysis (including electrocatalysis; photocatalysis; etc.); mechanism on the molecular level; molecular dynamic simulations; optical materials; optoelectronic devices; photoelectric detection; semiconductors

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Latest Molecular Advances in Autophagy

edited by

Gloria Riitano

submission deadline 30 Jan 2026 | 2 articles | Viewed by 3519 | Submission Open

Keywords: autophagy; lipid rafts; Beclin 1; autoimmune diseases; cancer; clock genes; CLOCK

(This special issue belongs to the Section Molecular Biology)

New Insights into Hyaluronan in Human Medicine

edited by

Monica Salamone

submission deadline 30 Jan 2026 | 3 articles | Viewed by 3079 | Submission Open

Keywords: hyaluronan; regenerative medicine; inflammation; cancer therapy; metabolomics ; hyaluronidases; cell– matrix interaction; glucose metabolism; pathological processes

(This special issue belongs to the Section Biochemistry)

Dietary Components in the Brain–Gut Axis: Exploring Nutrigenetic and Microbiome Interactions

edited by

Piotr Dobrowolski

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2741 | Submission Open

Keywords: dietary components; carbohydrates; proteins; fats; fatty acids; vitamins; minerals; brain– gut axis; nutrigenetics; microbiome interactions; neurodegenerative disorders; metabolic pathways

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Glutamine Metabolism in Cancer

edited by

Andrew R. Green

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2635 | Submission Open

Keywords: glutamine metabolism; cancer; oncometabolism; cancer metabolism; metabolic reprogramming; personalised medicine; therapeutic resistance; drug targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Innovations in Synthetic Organic Chemistry

edited by Anand H. Shinde

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2497 | Submission Open

Keywords: organic synthesis; catalysis; material applications; bioactive molecules; active pharmaceutical ingredients; green chemistry

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms and Therapeutic Strategies to Overcome Drug Resistance in Cancer

edited by

Inamul Haque

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2313 | Submission Open

Keywords: drug resistance; cancer therapy; targeted therapy; nanotechnology; tumor microenvironment; signaling pathway; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

From Genes to Medicine: Exploring the Genetic and Biological Bases of Medicinal Plants

edited by Wajid Zaman

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2233 | Submission Open

Keywords: medicinal plants; genetic diversity; biosynthesis pathways; bioactive compounds; genomic technologies; plant breeding; biotechnology; CRISPR; phytochemistry; pharmacology; drug discovery; plant-based therapies

(This special issue belongs to the Section Molecular Biology)

Endothelial Function and Cardiovascular Disease: Molecular Advances and Challenges

edited by

Elena Grossini

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2220 | Submission Open

Keywords: endothelium; heart; protection; therapeutic strategies; vascular system; vesicles

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drug Development Breakthroughs: From Novel Antimicrobials to Targeted Cancer Drugs

edited by

Christos Papaneophytou

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2148 | Submission Open

Keywords: drug development; molecular science; small-molecule inhibitors; biopharmaceuticals; peptides; cancer therapy

(This special issue belongs to the Section Molecular Pharmacology)

Advanced Oxidation Processes for the Decontamination of Emerging Contaminants and Disinfection of Pathogenic Microorganisms

edited by

Chengdu Qi

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1934 | Submission Open

Keywords: advanced oxidation processes; emerging contaminants; pathogenic microorganisms; disinfection; hydroxyl radical; sulfate radical; organic radical

(This special issue belongs to the Section Molecular Microbiology)

Novel Biomarkers and Emerging Therapeutic Targets for Breast and Gynecologic Cancers

edited by

Hisham Bahmad

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1826 | Submission Open

Keywords: cancer; uterus; cervix; breast; ovary; endometrial cancer; ovarian cancer; cervical cancer; breast cancer; biomarkers; therapeutic target; personalized medicine; targeted therapy; molecular signatures; diagnosis; prognosis

(This special issue belongs to the Section Molecular Oncology)

Molecular Toxicity Research of Biological Venoms

edited by

Karla De Castro Figueiredo Bordon

and Suely Vilela Sampaio

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1805 | Submission Open

Keywords: neurotoxicity assays; insect models; electrophysiology; screening assays; ion channels; therapeutic molecules; animal venoms; antitumoral activity; enzyme activity; biotechnological application

(This special issue belongs to the Section Molecular Toxicology)

Metals and Metal Ions in Human Health, Diseases, and Environment

edited by

Agnieszka Scibior

and

Juan Llopis

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1793 | Submission Open

Keywords: metal toxicity; metal-based drugs; polyoxometalates; protein metalation; human health problems; diseases; in vitro/in vivo studies; human studies; environmental pollution

(This special issue belongs to the Section Molecular Biology)

Neuroblastoma: Molecular Pathology, Diagnostics and Therapeutics

edited by

Simona Dedoni

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1763 | Submission Open

Keywords: neuroblastoma; solid cancer; immature nerve cells; molecular mechanism; biomarker; tumor heterogeneity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cancer Immunotherapy Biomarkers

edited by Ilias P. Nikas,

Ioannis Pateras

and

Apostolos Zaravinos

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1704 | Submission Open

Keywords: tumor microenvironment; tumor immunology; cancer biomarkers; immunotherapy; immunohistochemistry; pathology; personalized medicine; omics technologies; prognosis and therapy; bioinformatics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Dynamics Simulations of Nanobubble for Different Applications

edited by

Ebrahim Kadivar

submission deadline 30 Jan 2026 | 2 articles | Viewed by 1702 | Submission Open

Keywords: cavitation bubble; nanobubble dynamics; hydrodynamic cavitation; molecular dynamics simulations; laser-induced cavitation bubble; cavitation exploitation

(This special issue belongs to the Section Molecular Nanoscience)

Plasma-Based Technologies for Food Safety and Health Enhancement

edited by

Ihn Han

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1639 | Submission Open

Keywords: plasma-based technologies; food safety; microbial pathogens; oxidative stability; nutrient preservation

(This special issue belongs to the Section Biochemistry)

Molecular Biological Determination of Physical Injury

edited by

Sorin Hostiuc

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1587 | Submission Open

Keywords: molecular markers; physical injury; micro-RNA; dating of traumatic injuries

(This special issue belongs to the Section Molecular Biology)

Unravelling Functional Biology in Retinal Dystrophies and Eye Disease

edited by

Luigi Donato

and

Simona Alibrandi

submission deadline 30 Jan 2026 | 1 articles | Viewed by 969 | Submission Open

Keywords: precision ophthalmology; inherited retinal diseases; functional genomics; multi-omics approaches; photoreceptor degeneration; retinal organoids and iPSC models; bioinformatics and systems biology; genotype– phenotype correlations; RNA therapeutics and gene editing; early and late biomarkers of retinal disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Biogenesis, Structure, Function and Division of Plastids

edited by

Xiaomin Liu

and Li'na Yin

submission deadline 30 Jan 2026 | Viewed by 905 | Submission Open

Keywords: plastid; chloroplast; chlorophyll; endosymbiotic cyanobacteria; photosynthesis; genetic engineering

(This special issue belongs to the Section Biochemistry)

Significance and Challenges of Plant-Derived Natural Compounds in Cancers

edited by Ba Vinh Le

submission deadline 30 Jan 2026 | 1 articles | Viewed by 852 | Submission Open

Keywords: metabolomic; bioactive compound; pharmacognosy; oriental medicine; drug discovery; pharmacology; anti-cancer; pharmacological effects

(This special issue belongs to the Section Bioactives and Nutraceuticals)

KRAS-Mutant Cancers: From Basic Biology to Clinical Translation

edited by

Mirela Sedic

Sérgia Velho

and Luka Bočkor

submission deadline 30 Jan 2026 | Viewed by 802 | Submission Open

Keywords: KRAS mutations; KRAS signalling; cancer; KRAS inhibitors; drug resistance; tumour microenvironment; cellular metabolism

(This special issue belongs to the Section Molecular Oncology)

Exosomes and Non-Coding RNA Research in Health and Disease—2nd Edition

edited by Stergios Boussios

submission deadline 30 Jan 2026 | 1 articles | Viewed by 794 | Submission Open

Keywords: exosomes; non-coding RNA; health; disease; intercellular communication; cancer; neurodegenerative disorders; cardiovascular diseases; immune regulation; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Advances in Aquatic Genetic Improvement

edited by Jun Qiang,

Yifan Tao

and Wenjing Tao

submission deadline 30 Jan 2026 | 1 articles | Viewed by 652 | Submission Open

Keywords: aquaculture genetic breeding; genomic selection; gene editing; disease-resistant breeding; multi-omics analysis; stress resistance enhancement; smart aquaculture; artificial intelligence

(This special issue belongs to the Section Molecular Genetics and Genomics)

Spectral Control of Stress Response in Plants

edited by

Gábor Kocsy

and Zsolt Gulyás

submission deadline 30 Jan 2026 | Viewed by 605 | Submission Open

Keywords: spectral control; stress response; light spectrum; photoreceptor; reactive oxygen; plant hormone; antioxidant; plant growth and development

(This special issue belongs to the Section Molecular Plant Sciences)

Mechanistic and Small Molecule Discoveries for Therapeutic Advances in Hypertrophic and Dilated Cardiomyopathies

edited by Osha Roopnarine

submission deadline 30 Jan 2026 | Viewed by 598 | Submission Open

Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathies; cardiomyopathies

(This special issue belongs to the Section Molecular Pharmacology)

Chemoinformatics and Bioinformatics Tools in Structure-Activity Modelling in Molecular Sciences: 3rd Edition

edited by

Bono Lučić

submission deadline 30 Jan 2026 | Viewed by 578 | Submission Open

Keywords: chemoinformatics tools and models; bioinformatics tools and models; structure– activity modeling; structure– property modeling; QSAR; QSPR; drug/structure identification in bioprospecting research; molecular docking; molecular interactions; protein– protein interactions; development of algorithms; databases and web servers; data mining in chemoinformatics and bioinformatics; structure representation and optimization; molecular descriptors; modeling of health and environmentally relevant endpoints (activities; properties); toxicity modeling and prediction; carcinogenicity modeling and prediction; computational methods in molecular sciences; model validation approaches; multivariate modeling; predictive modeling; descriptive modeling; continuous data modeling; classification data modeling; machine learning in molecular sciences; deep learning in molecular sciences; structure visualization tools

(This special issue belongs to the Section Molecular Informatics)

Protease and Carbonic Anhydrase Inhibitors: 3rd Edition

edited by

Alessio Nocentini

submission deadline 30 Jan 2026 | Viewed by 546 | Submission Open

Keywords: carbonic anhydrase; protease; inhibitor; antiviral drug; antitumor drug; drug design; serine protease; metalloprotease; aspartic protease

(This special issue belongs to the Section Biochemistry)

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