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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Treatment Strategies for Head and Neck Cancer
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 5784 | Submission Open
Keywords: head and neck cancer; drug resistance; cancer initiation; biomarker
(This special issue belongs to the Section Molecular Oncology)
Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease
edited by David Rohde
submission deadline 30 Jan 2026 | 5 articles | Viewed by 5749 | Submission Open
Keywords: myocardial infarction; heart failure; atherosclerosis; arterial hypertension; myocarditis; arrhythmia; inflammation; hematopoiesis; myelopoiesis; tissue macrophages; neutrophil biology; lymphocytes; endothelial cells; megakaryocytes; platelet biology; biomarkers
(This special issue belongs to the Section Molecular Immunology)
Retinal Diseases: From Molecular Pathology to Therapies—2nd Edition
edited by
submission deadline 30 Jan 2026 | 3 articles | Viewed by 5662 | Submission Open
Keywords: diabetic retinopathy; age-related macular degeneration; neuroprotection; retina; diabetic macular edema; therapy development; pathophysiology; retinitis pigmentosa; aging; eye trauma; vitreous; macula; choroideremia; stargardt disease; cone– rod dystrophy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Toxic Liver Injury: Molecular, Mechanistic, and Medical Challenges 3.0
edited by
submission deadline 30 Jan 2026 | 3 articles | Viewed by 5583 | Submission Open
Keywords: liver injury; nonalcoholic fatty liver disease; nonalcoholic steatonecrosis; nonalcoholic liver cirrhosis; hepatocellular carcinoma
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in Photobiomodulation Therapy
edited by Maria Fernanda Setúbal Destro Rodrigues
submission deadline 30 Jan 2026 | 3 articles | Viewed by 5581 | Submission Open
Keywords: photobiomodulation; dosimetric parameters; human diseases; modulation of inflammation; photobiomodulation therapy; molecular mechanisms; preclinical and clinical studies; therapeutic applications of PBM
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Food Science and Molecular Nutrition
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 5234 | Submission Open
Keywords: food science; antioxidants; bioactive compounds; mitochondria; nutrigenomics; metabolomics
(This special issue belongs to the Section Biochemistry)
From Kidney Disease to Hypertension: Molecular Basis and Pathophysiology
edited by
submission deadline 30 Jan 2026 | 3 articles | Viewed by 4996 | Submission Open
Keywords: renin-angiotensin-aldosterone system; endothelial cell dysfunction; systemic inflammation; hypertension; oxidative stress; vascular remodeling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Aspects of Forensic Toxicology
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 4734 | Submission Open
Keywords: forensic toxicology; molecular mechanism; toxicological biomarkers; post-mortem interval; in vitro; in vivo; and in silico models; new psychoactive substances (NPSs); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-tandem mass spectrometry (GC-MS/MS)
(This special issue belongs to the Section Molecular Toxicology)
Molecular Studies of Age-Related Diseases: Immunosenescence and Inflammaging
edited by
submission deadline 30 Jan 2026 | 2 articles | Viewed by 4684 | Submission Open
Keywords: aging; age-related; immunosenescence; immune system; inflammaging
(This special issue belongs to the Section Molecular Immunology)
New Insights into Autophagy and Retinal Degeneration
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 4466 | Submission Open
Keywords: autophagy; retinal degeneration; retinal inflammation; oxidative stress; retinal alterations; age-related macular degeneration; retinal damage; inflammatory processes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Crustacean Aquaculture
edited by Tom Levy and
submission deadline 30 Jan 2026 | 3 articles | Viewed by 4396 | Submission Open
Keywords: androgenic gland; aquaculture; crustaceans; disease management; gene silencing; genetic modification; monosex; selective breeding; sex reversal; yield improvement
(This special issue belongs to the Section Molecular Biology)
Unraveling Sugar Signaling: Insights into Plant Stress Responses
edited by
submission deadline 30 Jan 2026 | 2 articles | Viewed by 4346 | Submission Open
Keywords: sugar signaling; glucose signaling; sucrose signaling; signal transduction pathways; plant response to stress; biotic stress; abiotic stress; plant physiology
(This special issue belongs to the Section Molecular Plant Sciences)
The Transcendental World of Plant Toxic Compounds
edited by
submission deadline 30 Jan 2026 | 2 articles | Viewed by 4251 | Submission Open
Keywords: alcaloids; biotic stress; defence; phenols; phytotoxins; secondary metabolism; terpenes
(This special issue belongs to the Section Molecular Plant Sciences)
Design, Synthesis and Applications of the Task-Specific Molecules
edited by and
submission deadline 30 Jan 2026 | 3 articles | Viewed by 3874 | Submission Open
Keywords: task-specific molecules; molecular design and synthesis; physical/chemical absorption; catalysis (including electrocatalysis; photocatalysis; etc.); mechanism on the molecular level; molecular dynamic simulations; optical materials; optoelectronic devices; photoelectric detection; semiconductors
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Latest Molecular Advances in Autophagy
edited by
submission deadline 30 Jan 2026 | 2 articles | Viewed by 3564 | Submission Open
Keywords: autophagy; lipid rafts; Beclin 1; autoimmune diseases; cancer; clock genes; CLOCK
(This special issue belongs to the Section Molecular Biology)
New Insights into Hyaluronan in Human Medicine
edited by
submission deadline 30 Jan 2026 | 3 articles | Viewed by 3152 | Submission Open
Keywords: hyaluronan; regenerative medicine; inflammation; cancer therapy; metabolomics  ; hyaluronidases; cell– matrix interaction; glucose metabolism; pathological processes
(This special issue belongs to the Section Biochemistry)
Dietary Components in the Brain–Gut Axis: Exploring Nutrigenetic and Microbiome Interactions
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 2751 | Submission Open
Keywords: dietary components; carbohydrates; proteins; fats; fatty acids; vitamins; minerals; brain– gut axis; nutrigenetics; microbiome interactions; neurodegenerative disorders; metabolic pathways
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Glutamine Metabolism in Cancer
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 2643 | Submission Open
Keywords: glutamine metabolism; cancer; oncometabolism; cancer metabolism; metabolic reprogramming; personalised medicine; therapeutic resistance; drug targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Innovations in Synthetic Organic Chemistry
edited by Anand H. Shinde
submission deadline 30 Jan 2026 | 1 articles | Viewed by 2511 | Submission Open
Keywords: organic synthesis; catalysis; material applications; bioactive molecules; active pharmaceutical ingredients; green chemistry
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms and Therapeutic Strategies to Overcome Drug Resistance in Cancer
edited by
submission deadline 30 Jan 2026 | 2 articles | Viewed by 2337 | Submission Open
Keywords: drug resistance; cancer therapy; targeted therapy; nanotechnology; tumor microenvironment; signaling pathway; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
From Genes to Medicine: Exploring the Genetic and Biological Bases of Medicinal Plants
edited by Wajid Zaman
submission deadline 30 Jan 2026 | 2 articles | Viewed by 2287 | Submission Open
Keywords: medicinal plants; genetic diversity; biosynthesis pathways; bioactive compounds; genomic technologies; plant breeding; biotechnology; CRISPR; phytochemistry; pharmacology; drug discovery; plant-based therapies
(This special issue belongs to the Section Molecular Biology)
Endothelial Function and Cardiovascular Disease: Molecular Advances and Challenges
edited by
submission deadline 30 Jan 2026 | 2 articles | Viewed by 2243 | Submission Open
Keywords: endothelium; heart; protection; therapeutic strategies; vascular system; vesicles
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Development Breakthroughs: From Novel Antimicrobials to Targeted Cancer Drugs submission deadline 30 Jan 2026 | 2 articles | Viewed by 2203 | Submission Open
Keywords: drug development; molecular science; small-molecule inhibitors; biopharmaceuticals; peptides; cancer therapy
(This special issue belongs to the Section Molecular Pharmacology)
Advanced Oxidation Processes for the Decontamination of Emerging Contaminants and Disinfection of Pathogenic Microorganisms
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 1944 | Submission Open
Keywords: advanced oxidation processes; emerging contaminants; pathogenic microorganisms; disinfection; hydroxyl radical; sulfate radical; organic radical
(This special issue belongs to the Section Molecular Microbiology)
Metals and Metal Ions in Human Health, Diseases, and Environment submission deadline 30 Jan 2026 | 1 articles | Viewed by 1904 | Submission Open
Keywords: metal toxicity; metal-based drugs; polyoxometalates; protein metalation; human health problems; diseases; in vitro/in vivo studies; human studies; environmental pollution
(This special issue belongs to the Section Molecular Biology)
Novel Biomarkers and Emerging Therapeutic Targets for Breast and Gynecologic Cancers
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 1869 | Submission Open
Keywords: cancer; uterus; cervix; breast; ovary; endometrial cancer; ovarian cancer; cervical cancer; breast cancer; biomarkers; therapeutic target; personalized medicine; targeted therapy; molecular signatures; diagnosis; prognosis
(This special issue belongs to the Section Molecular Oncology)
Molecular Toxicity Research of Biological Venoms
edited by and Suely Vilela Sampaio
submission deadline 30 Jan 2026 | 1 articles | Viewed by 1811 | Submission Open
Keywords: neurotoxicity assays; insect models; electrophysiology; screening assays; ion channels; therapeutic molecules; animal venoms; antitumoral activity; enzyme activity; biotechnological application
(This special issue belongs to the Section Molecular Toxicology)
Neuroblastoma: Molecular Pathology, Diagnostics and Therapeutics
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 1791 | Submission Open
Keywords: neuroblastoma; solid cancer; immature nerve cells; molecular mechanism; biomarker; tumor heterogeneity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Dynamics Simulations of Nanobubble for Different Applications
edited by
submission deadline 30 Jan 2026 | 2 articles | Viewed by 1729 | Submission Open
Keywords: cavitation bubble; nanobubble dynamics; hydrodynamic cavitation; molecular dynamics simulations; laser-induced cavitation bubble; cavitation exploitation
(This special issue belongs to the Section Molecular Nanoscience)
Cancer Immunotherapy Biomarkers
edited by Ilias P. Nikas, and
submission deadline 30 Jan 2026 | 1 articles | Viewed by 1717 | Submission Open
Keywords: tumor microenvironment; tumor immunology; cancer biomarkers; immunotherapy; immunohistochemistry; pathology; personalized medicine; omics technologies; prognosis and therapy; bioinformatics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plasma-Based Technologies for Food Safety and Health Enhancement
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 1671 | Submission Open
Keywords: plasma-based technologies; food safety; microbial pathogens; oxidative stability; nutrient preservation
(This special issue belongs to the Section Biochemistry)
Molecular Biological Determination of Physical Injury
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 1604 | Submission Open
Keywords: molecular markers; physical injury; micro-RNA; dating of traumatic injuries
(This special issue belongs to the Section Molecular Biology)
Unravelling Functional Biology in Retinal Dystrophies and Eye Disease submission deadline 30 Jan 2026 | 1 articles | Viewed by 985 | Submission Open
Keywords: precision ophthalmology; inherited retinal diseases; functional genomics; multi-omics approaches; photoreceptor degeneration; retinal organoids and iPSC models; bioinformatics and systems biology; genotype– phenotype correlations; RNA therapeutics and gene editing; early and late biomarkers of retinal disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Biogenesis, Structure, Function and Division of Plastids
edited by and Li'na Yin
submission deadline 30 Jan 2026 | Viewed by 908 | Submission Open
Keywords: plastid; chloroplast; chlorophyll; endosymbiotic cyanobacteria; photosynthesis; genetic engineering
(This special issue belongs to the Section Biochemistry)
Significance and Challenges of Plant-Derived Natural Compounds in Cancers
edited by Ba Vinh Le
submission deadline 30 Jan 2026 | 1 articles | Viewed by 868 | Submission Open
Keywords: metabolomic; bioactive compound; pharmacognosy; oriental medicine; drug discovery; pharmacology; anti-cancer; pharmacological effects
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Exosomes and Non-Coding RNA Research in Health and Disease—2nd Edition
edited by Stergios Boussios
submission deadline 30 Jan 2026 | 1 articles | Viewed by 817 | Submission Open
Keywords: exosomes; non-coding RNA; health; disease; intercellular communication; cancer; neurodegenerative disorders; cardiovascular diseases; immune regulation; therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
KRAS-Mutant Cancers: From Basic Biology to Clinical Translation
edited by , and Luka Bočkor
submission deadline 30 Jan 2026 | Viewed by 802 | Submission Open
Keywords: KRAS mutations; KRAS signalling; cancer; KRAS inhibitors; drug resistance; tumour microenvironment; cellular metabolism
(This special issue belongs to the Section Molecular Oncology)
Latest Advances in Aquatic Genetic Improvement
edited by Jun Qiang, and Wenjing Tao
submission deadline 30 Jan 2026 | 1 articles | Viewed by 665 | Submission Open
Keywords: aquaculture genetic breeding; genomic selection; gene editing; disease-resistant breeding; multi-omics analysis; stress resistance enhancement; smart aquaculture; artificial intelligence
(This special issue belongs to the Section Molecular Genetics and Genomics)
Spectral Control of Stress Response in Plants
edited by and Zsolt Gulyás
submission deadline 30 Jan 2026 | Viewed by 606 | Submission Open
Keywords: spectral control; stress response; light spectrum; photoreceptor; reactive oxygen; plant hormone; antioxidant; plant growth and development  
(This special issue belongs to the Section Molecular Plant Sciences)
Mechanistic and Small Molecule Discoveries for Therapeutic Advances in Hypertrophic and Dilated Cardiomyopathies
edited by Osha Roopnarine
submission deadline 30 Jan 2026 | Viewed by 598 | Submission Open
Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathies; cardiomyopathies
(This special issue belongs to the Section Molecular Pharmacology)
Chemoinformatics and Bioinformatics Tools in Structure-Activity Modelling in Molecular Sciences: 3rd Edition
edited by
submission deadline 30 Jan 2026 | Viewed by 578 | Submission Open
Keywords: chemoinformatics tools and models; bioinformatics tools and models; structure– activity modeling; structure– property modeling; QSAR; QSPR; drug/structure identification in bioprospecting research; molecular docking; molecular interactions; protein– protein interactions; development of algorithms; databases and web servers; data mining in chemoinformatics and bioinformatics; structure representation and optimization; molecular descriptors; modeling of health and environmentally relevant endpoints (activities; properties); toxicity modeling and prediction; carcinogenicity modeling and prediction; computational methods in molecular sciences; model validation approaches; multivariate modeling; predictive modeling; descriptive modeling; continuous data modeling; classification data modeling; machine learning in molecular sciences; deep learning in molecular sciences; structure visualization tools
(This special issue belongs to the Section Molecular Informatics)
Protease and Carbonic Anhydrase Inhibitors: 3rd Edition
edited by
submission deadline 30 Jan 2026 | Viewed by 546 | Submission Open
Keywords: carbonic anhydrase; protease; inhibitor; antiviral drug; antitumor drug; drug design; serine protease; metalloprotease; aspartic protease
(This special issue belongs to the Section Biochemistry)
Experimental Models and Applications in Muscle Regeneration
edited by
submission deadline 30 Jan 2026 | Viewed by 539 | Submission Open
Keywords: stem cells; internal and external stimuli; scaffolds; signaling systems; muscle regeneration mechanisms
(This special issue belongs to the Section Molecular Biology)
Hepatocellular Carcinoma: From Pathophysiology to Innovative Therapeutic Approaches
edited by Andrea Martini
submission deadline 30 Jan 2026 | Viewed by 526 | Submission Open
Keywords: liver carcinogenesis; tumor microenvironment; immune surveillance; fibrogenesis; inflammation
(This special issue belongs to the Section Molecular Oncology)
Epigenetics of Metabolic Diseases
edited by
submission deadline 30 Jan 2026 | Viewed by 497 | Submission Open
Keywords: epigenetics; metabolic diseases; DNA methylation; histone modifications; non-coding RNAs; obesity; diabetes; metabolic syndrome
(This special issue belongs to the Section Molecular Genetics and Genomics)
Recent Advances in Molecular and Cellular Approaches to Tuberculosis Pathogenesis, Treatment and Prevention
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 485 | Submission Open
Keywords: tuberculosis (TB); animal models of mycobacterium infections; molecular pathogenesis; host-directed therapy (HDT); nanoparticle drug delivery; vaccine development; cellular immunology; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Insights into Neurological and Psychiatric Diseases from Invertebrate Models submission deadline 30 Jan 2026 | Viewed by 476 | Submission Open
Keywords: disease model development; disease model validation; GWAS validation; ameliorative approaches; pharmacogenetics; pharmacoproteomics; disease mechanisms; suppressor/enhancer genetic screens; synthetic lethality screens; biomarker screens and validation
(This special issue belongs to the Section Molecular Neurobiology)
Autoimmune and Inflammatory Diseases: Latest Advances and Prospects
edited by
submission deadline 30 Jan 2026 | Viewed by 471 | Submission Open
Keywords: autoimmunity; autoimmune disease; inflammation; inflammatory disease; cellular pathways; molecular mechanisms; pathogenesis; therapy
(This special issue belongs to the Section Molecular Immunology)
Molecular Research and Insights into Anti-Cancer Vaccines
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 443 | Submission Open
Keywords: anti-cancer vaccines; tumor antigens; molecular mechanisms; immunotherapy; molecular oncology
(This special issue belongs to the Section Molecular Oncology)
Molecular Dialogues in the Tumor Microenvironment: Mechanisms, Methods and Therapeutic Implications submission deadline 30 Jan 2026 | 1 articles | Viewed by 421 | Submission Open
Keywords: tumor microenvironment; blood vessels; immune cells; spatial transcriptomics; histology
(This special issue belongs to the Section Molecular Oncology)
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