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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Endothelial Cells in Health and Disease

edited by

Alessia Ricci

and

Amelia Cataldi

submission deadline 30 Sep 2026 | 5 articles | Viewed by 8858 | Submission Open

Keywords: endothelial cells; vascular homeostasis; tissue homeostasis; endothelial cell biology; endothelial cells dysfunction; oxidative stress; redox signaling; aging; endothelial regulation of tissue repair

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms Driving Liver Disease: From Cellular Stress to Therapeutic Targets

edited by

Konstantinos Arvanitakis

submission deadline 30 Sep 2026 | 4 articles | Viewed by 7985 | Submission Open

Keywords: liver disease; molecular mechanisms; hepatocellular stress; fibrosis; non-coding RNAs; metabolism; MASLD; liver fibrosis; hepatocellular carcinoma; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bone Development and Regeneration—4th Edition

edited by

Kazuo Yudoh

submission deadline 30 Sep 2026 | 4 articles | Viewed by 7924 | Submission Open

Keywords: osteoblast; osteocyte; osteoclast; mesenchymal stem cell; cell differentiation; epigenetics; omics; integrative analysis; biomaterials

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Biomarkers in Cancer and Metabolic Diseases

edited by

José Antonio Morales-González

and

Angel Morales-González

submission deadline 30 Sep 2026 | 4 articles | Viewed by 7344 | Submission Open

Keywords: biomarkers; cancer; metabolic disease; diagnosis; prognosis; treatment

(This special issue belongs to the Section Molecular Biology)

Oxidative-Stress in Human Health and Diseases

edited by

Ramoji Kosuru

submission deadline 30 Sep 2026 | 2 articles | Viewed by 7255 | Submission Open

Keywords: oxidative stress; ROS; redox signaling; metabolic adaptation; oxidative homeostasis; endothelial dysfunction

(This special issue belongs to the Section Biochemistry)

Advances in Pathogenesis and Treatment of Skin Cancer (2nd Edition)

edited by

Enrica Flori

Giorgia Cardinali

and

Vittoria Maresca

submission deadline 30 Sep 2026 | 3 articles | Viewed by 7106 | Submission Open

Keywords: melanoma; squamous cell carcinoma; basal cell carcinoma; tumor microenvironment; epithelial–mesenchymal transition (EMT) process; ultraviolet radiation; oxidative stress; bioactive modulators; signal transduction pathways

(This special issue belongs to the Section Molecular Oncology)

Natural Products in Drug Discovery and Development: 2nd Edition

edited by Tian-Le Gao

submission deadline 30 Sep 2026 | 8 articles | Viewed by 6833 | Submission Open

Keywords: natural product components; traditional medicine; biological entropy reduction; aromatic drugs; essential oils; gut microbiota modulation; probiotics; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Melatonin Biology and Signaling

edited by Walter Manucha

submission deadline 30 Sep 2026 | 3 articles | Viewed by 6707 | Submission Open

Keywords: melatonin signaling; mitochondrial homeostasis; redox dyshomeostasis; oxidative stress and Inflammation; MT1/MT2 receptors; epigenetic regulation; cytoprotection; translational pharmacology; nanoformulations and drug delivery; lipid rafts and biomolecular condensates

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Interaction Between Cell and Virus, 3rd Edition

edited by

Masahiro Fujimuro

submission deadline 30 Sep 2026 | 6 articles | Viewed by 6276 | Submission Open

Keywords: viral replication; gene expression; lytic infection; viral structure; viral assembly; cell signaling pathway; post-translational modification; immune evasion; viral tumorigenesis; antiviral medication

(This special issue belongs to the Section Molecular Microbiology)

Erythrocyte Cell Death: Molecular Insights

edited by

Anton Tkachenko

submission deadline 30 Sep 2026 | 4 articles | Viewed by 6003 | Submission Open

Keywords: cell death signaling; eryptosis; erythrocyte senescence; erythrocytes; necroptosis; regulated cell death

(This special issue belongs to the Section Molecular Biology)

Advancing Liver Health: State of the Art and Recent Research Advances

edited by

Chase Wehrle

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5694 | Submission Open

Keywords: liver; liver cancer and malignancy; liver transplantation; inflammation and immunity; liver health and ageing; molecular genomics; cellular senescence; metabolic dysfunction-associated liver disease; cirrhosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innate Immunity: New Insights into Genetic and Signaling Networks

edited by

Styliani Sarrou

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5521 | Submission Open

Keywords: innate immunity; innate immune response; signaling pathways; genetic variations

(This special issue belongs to the Section Molecular Immunology)

Genetic, Functional and Therapeutic Aspects of Procoagulant and Anticoagulant Factors (Third Edition)

edited by

Rima Dardik

and

Tami Livnat

submission deadline 30 Sep 2026 | 4 articles | Viewed by 5430 | Submission Open

Keywords: procoagulant factors; anticoagulant factors; hemostasis; inflammation; genetics; therapeutics; cell signaling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

DNA Damage and Repair: Current Research

edited by

Mahara A. Valverde Ramírez

and Emilio Rojas

submission deadline 30 Sep 2026 | 8 articles | Viewed by 5404 | Submission Open

Keywords: DNA damage; DNA repair; endogenous compounds; exogenous compounds; therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Bioactivity and Molecular Mechanisms of Natural Products

edited by

Jingya Ruan

submission deadline 30 Sep 2026 | 7 articles | Viewed by 5354 | Submission Open

Keywords: natural products; bioactivity; molecular mechanisms; anti-inflammatory; anticancer; multi-omics; target identification; structure–activity relationship (SAR)

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exploring Molecular Properties Through Molecular Modeling

edited by

Emili Besalu

submission deadline 30 Sep 2026 | 7 articles | Viewed by 5219 | Submission Open

Keywords: molecular modeling; molecular properties; structure–activity relationships; QSAR; prediction; drug design; materials science; virtual screening; in-silico synthesis; computational chemistry; cheminformatics

(This special issue belongs to the Section Molecular Informatics)

Lipid Peroxidation and Protein Carbonylation in Human Diseases

edited by

Galina Nikolova

submission deadline 30 Sep 2026 | 1 articles | Viewed by 4774 | Submission Open

Keywords: free radicals; lipid peroxidation; protein carbonylation; apoptosis; autophagy; ferroptosis; antioxidant enzymes

(This special issue belongs to the Section Biochemistry)

Cardiomyocytes Among Physiology and Pathophysiology: Molecular Insights and Therapeutic Implications

edited by Rosetta Ragusa and

Chiara Caselli

submission deadline 30 Sep 2026 | 3 articles | Viewed by 4718 | Submission Open

Keywords: sarcomere; metabolic stress; epigenetic mechanisms; exercise; aging

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Epilepsy: From Molecular Physiology to Pathology

edited by Paolo Mainardi

submission deadline 30 Sep 2026 | 3 articles | Viewed by 4559 | Submission Open

Keywords: epilepsy; molecular pathology; disease; therapeutic strategies; celluar advance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Research on Optoelectronic Materials

edited by

Meysam Tayebi

submission deadline 30 Sep 2026 | 1 articles | Viewed by 3701 | Submission Open

Keywords: photoelectrochemistry; optoelectronic materials; perovskite materials; semiconductor interfaces; molecular-level catalysis; solar fuel conversion; nanostructured materials; light-harvesting systems

(This special issue belongs to the Section Materials Science)

Biomarkers in Oncology

edited by

Beatriz da Costa Aguiar Alves

submission deadline 30 Sep 2026 | 4 articles | Viewed by 3666 | Submission Open

Keywords: cancer biomarkers; precision oncology; liquid biopsy; circulating tumor DNA; molecular diagnostics; multiomics; translational research; personalized medicine; prognostic and predictive markers

(This special issue belongs to the Section Molecular Oncology)

Molecular Biology of Hypoxia: 2nd Edition

edited by Yuji Arai

submission deadline 30 Sep 2026 | 4 articles | Viewed by 3452 | Submission Open

Keywords: hypoxia; HIFs; normoxic environment

(This special issue belongs to the Section Molecular Biology)

Dynamics of Fascia: Cellular, Molecular, and Biochemical Mechanisms

edited by

Caterina Fede

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3428 | Submission Open

Keywords: fascia; homeostasis and pathology; extracellular matrix remodeling; fibroblast signaling; chronic pain; fibrosis and inflammation; hormonal regulation

(This special issue belongs to the Section Biochemistry)

Current Trends in Gut Microbiota and Food Bioactive Compounds

edited by Uyory Choe

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3407 | Submission Open

Keywords: gut microbiota; food bioactive compounds; polyphenols; microbial metabolism; functional foods; nutritional biochemistry; microbiome; bioavailability; metabolomics; dietary phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Phytochemical Insights and Green Extraction Strategies for Bioactive Natural Compounds

edited by

Ana M. L. Seca

and

Gonçalo Pereira da Rosa

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3395 | Submission Open

Keywords: plant and algal bioactive metabolites; phytochemistry; green extraction techniques; natural sustainable solvents (NADES); structural elucidation of natural molecules; molecular characterization

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exploring UV-Induced Disease: Insights into Mechanisms and Innovative Strategies for Prevention and Therapy

edited by Hui Xu and

Ying Huang

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2973 | Submission Open

Keywords: ultraviolet radiation; skin; DNA damage; DNA repair; immunosuppression; inflammatory disease; autoimmune disease; melanoma; non-melanoma skin cancers; genetic susceptibility; chemopre-vention; tumor immunotherapy; skin organoids for UV study; new animal models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biosynthesis and Regulatory Mechanism of Secondary Metabolites in Medicinal Plants: 3rd Edition

edited by

Shanfa Lu

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2794 | Submission Open

Keywords: biosynthetic pathway; epigenetic regulation; high-throughput sequencing; medicinal plant; metabolic engineering; omics; regulatory mechanism; secondary metabolite; synthetic biology; transcription factor

(This special issue belongs to the Section Molecular Plant Sciences)

Extracellular Vesicles in Cancer and Tumor Microenvironment

edited by Celeste Caruso Bavisotto,

Alessandra Maria Vitale

and

Giuseppa D’Amico

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2757 | Submission Open

Keywords: EVs; cancer; tumor cell-derived EVs (TCdEVs); tumor microenvironment (TME); tumor-associated antigens (TAAs)

(This special issue belongs to the Section Molecular Oncology)

Abnormal Production and Structure of Hemoglobin Molecules

edited by Maria Dimopoulou

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2431 | Submission Open

Keywords: hemoglobin; hemoglobinopathies; thalassemias; sickle cell disease; structural hemoglobin variants; alpha globin; beta globin; globin chain genes; unstable hemoglobins; oxygen affinity

(This special issue belongs to the Section Biochemistry)

Advancements and Applications of Phyto-Nanotherapy in Targeted Disease Treatment

edited by

Adewale Fadaka

and

Nicole Remaliah Samantha Sibuyi

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2390 | Submission Open

Keywords: phyto-nanotherapy; medicinal plants; nanoparticles; targeted drug delivery; phytochemicals; phytotherapy; green nanotechnology; chronic diseases; infectious diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuroblastoma: Advances in Molecular Pathogenesis and Therapy

edited by Paola Fadda and

Simona Dedoni

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2218 | Submission Open

Keywords: neuroblastoma; molecular pathogenesis; MYCN; ALK; epigenetics; non-coding RNAs; tumor microenvironment; immunotherapy; targeted therapy; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Stress-Related Disorders and Depression: From Molecular Basis to Therapy (3rd Edition)

edited by

Irena Nalepa

and

Agnieszka Zelek-Molik

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2211 | Submission Open

Keywords: psychobiology of stress; depression; posttraumatic stress disorder; anxiety disorders; animal models; biogenic monoamines; glucocorticoids; inflammation; antidepressant and anxiolytic drugs

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanism, Pathogenesis, and Precision Therapeutics in Thyroid Cancer

edited by

Laura Sterian Ward

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2175 | Submission Open

Keywords: thyroid cancer; molecular pathogenesis; driver mutations; tumor microenvironment; targeted therapy; resistance mechanisms; immunotherapy; precision oncology; liquid biopsy; prognostic biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Genetic and Epigenetic Alterations in Age-Related Diseases

edited by

Valerio Caputo

and

Andrea Latini

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2086 | Submission Open

Keywords: genomics; epigenetic modifications; age-related pathologies; neurodegeneration; dysmetabolism; spatial omics; 3D genome; genetic variants; telomere length; mitochondrial DNA; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Functional Materials in Photocatalysis: From Design to Application

edited by

Miguel Díaz-Sánchez

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2065 | Submission Open

Keywords: nanostructured materials ; photocatalysis ; catalysis ; green synthesis ; material design ; surface engineering

(This special issue belongs to the Section Materials Science)

Molecular and Cellular Mechanisms of Taste and Smell: From Physiology to Pathology

edited by

Mariano Mastinu

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2043 | Submission Open

Keywords: taste; olfaction; taste/smell processing; chemosensory dysfunction; genetic variations; neurodegeneration; perireceptor space; sensory nutrition; hypogeusia and hyposmia

(This special issue belongs to the Section Molecular Biology)

Biomarkers and Mechanisms Guiding Precision Therapy in Lung Cancer

edited by

Jun Hyeok Lim

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2028 | Submission Open

Keywords: lung cancer; precision therapy; biomarkers; molecular mechanisms; treatment resistance; immunotherapy; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oral Squamous Cell Carcinoma: From Pathogenesis to Targeted Therapy

edited by

Giuseppina Campisi

and

Vito Carlo Alberto Caponio

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1989 | Submission Open

Keywords: oral cancer; oral potentially malignant disorders; omics; oral squamous cell carcinoma; leukoplakia; biomarkers; tumor microenvironment; immunotherapy; target therapy; HPV; multidisciplinary team

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

State-of-the-Art Immunotherapy for Non-Small-Cell Lung Cancer

edited by

Haris Charalambous

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1954 | Submission Open

Keywords: immunotherapy; checkpoint inhibitors; vaccines; cellular therapies; predictive biomarkers; chemotherapy; angiogenesis inhibitors; radiotherapy; modulation microbiome

(This special issue belongs to the Section Molecular Oncology)

Breaking Barriers in Drug Discovery: Novel Methodologies and Mechanisms of Action

edited by Likun Gong,

Qiuping Qin

and Jing Chen

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1953 | Submission Open

Keywords: new approach methodologies (NAMs); in silico; in vitro; in vivo; in chemico; drug discovery; computational modeling; artificial intelligence (AI); high-throughput screening (HTS); high-throughput imaging (HTI); bioassay; omics; cell cultures; tissue engineering; organ engineering; therapeutic target; mechanism of drug action

(This special issue belongs to the Section Molecular Pharmacology)

Novel Natural Compound for Wound and Tissue Repair and Regeneration: 4th Edition

edited by

Elia Ranzato

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1838 | Submission Open

Keywords: wound repair; tissue regeneration; natural compounds; phytochemicals; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Current Trends and Future Directions in Antimicrobial Peptide Research

edited by

Sara Elsa Aita

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1818 | Submission Open

Keywords: antimicrobial peptides (AMPs); host defense; structure-function; antimicrobial agents; biomedical applications; antibiotic alternatives; antibiotic resistance

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanism in Cardiac Remodeling

edited by Xianming Lin and

Xiaobo Wu

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1808 | Submission Open

Keywords: cardiomyopathy; cardiac arrhythmias; ion channel; calcium transient

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Modeling Neurogenesis, Regeneration and Disease from Animal Models

edited by

Kamel Mhalhel

Giuseppe Montalbano

and

Sepand Rastegar

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1739 | Submission Open

Keywords: neurogenesis; neural regeneration; animal models; neural stem cells; neurodevelopment; neurodegeneration; molecular mechanisms; disease modeling; nervous system repair, ultrastructure

(This special issue belongs to the Section Molecular Neurobiology)

Genetic and Molecular Markers in Prostate Cancer

edited by Thaidy Moreno-Rodriguez

submission deadline 30 Sep 2026 | 3 articles | Viewed by 1738 | Submission Open

Keywords: prostate cancer; genetic markers; androgen receptor signaling; molecular biomarkers; therapy resistance mechanisms; liquid biopsy; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Nanotechnology-Driven Insights into Plants: Mechanisms, Detection, and Sustainable Control

edited by

Ezzeldin Ibrahim

submission deadline 30 Sep 2026 | Viewed by 1714 | Submission Open

Keywords: nanotechnology; plant–pathogen interactions; plant immunity; nanoparticles; nano-enabled diagnostics; disease management; antimicrobial nanomaterials; nano-biocontrol; sustainable agriculture; phytopathology

(This special issue belongs to the Section Molecular Nanoscience)

Colorectal Cancer—Emerging Trends and Treatment Strategies

edited by Victor Strambu

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1687 | Submission Open

Keywords: innovative therapies; colorectal cancer; new therapeutic approach; synchronous tumors

(This special issue belongs to the Section Molecular Oncology)

The Molecular Landscape of Endometrial and Ovarian Dysfunction in Polycystic Ovary Syndrome: Insights into Disease Mechanisms

edited by

Saad Amer

and

Raheela N. Khan

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1674 | Submission Open

Keywords: polycystic ovarian syndrome (PCOS); molecular mechanisms; endometrial dysfunction; ovarian dysfunction; pathophysiology; biomarkers; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Infectious and Immunoinflammatory Mechanisms of Alzheimer's Disease

edited by Hiroshi Nakanishi

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1660 | Submission Open

Keywords: Alzheimer's Disease; amyloid; neuroinflammation

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Pathogenesis of Age-Related Ocular Diseases and Existing Therapies

edited by

Toshiyuki Oshitari

submission deadline 30 Sep 2026 | 3 articles | Viewed by 1608 | Submission Open

Keywords: aging; senescence; diabetic retinopathy; glaucoma; age-related macular degeneration; ischemic retinal and optic nerve diseases; Werner syndrome; genetic disorders; inflammatory diseases; cataract; cellular dysfunction; cell death; axonal degeneration; vascular abnormalities; oxidative stress; inflammatory cytokines; senescence-associated secretory phenotype; autophagy; mitochondrial dysfunction; anti-aging; neuroprotection; regeneration; anti-inflammatory agents; nutrients; gene therapies; cell transplantation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 451-500 on page 10 of 61.

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