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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Stress-Related Disorders and Depression: From Molecular Basis to Therapy (3rd Edition) submission deadline 30 Sep 2026 | 2 articles | Viewed by 2239 | Submission Open
Keywords: psychobiology of stress; depression; posttraumatic stress disorder; anxiety disorders; animal models; biogenic monoamines; glucocorticoids; inflammation; antidepressant and anxiolytic drugs
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanism, Pathogenesis, and Precision Therapeutics in Thyroid Cancer
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 2189 | Submission Open
Keywords: thyroid cancer; molecular pathogenesis; driver mutations; tumor microenvironment; targeted therapy; resistance mechanisms; immunotherapy; precision oncology; liquid biopsy; prognostic biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Genetic and Epigenetic Alterations in Age-Related Diseases submission deadline 30 Sep 2026 | 1 articles | Viewed by 2107 | Submission Open
Keywords: genomics; epigenetic modifications; age-related pathologies; neurodegeneration; dysmetabolism; spatial omics; 3D genome; genetic variants; telomere length; mitochondrial DNA; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
Functional Materials in Photocatalysis: From Design to Application submission deadline 30 Sep 2026 | 1 articles | Viewed by 2075 | Submission Open
Keywords: nanostructured materials ; photocatalysis ; catalysis ; green synthesis ; material design ; surface engineering
(This special issue belongs to the Section Materials Science)
Biomarkers and Mechanisms Guiding Precision Therapy in Lung Cancer
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 2070 | Submission Open
Keywords: lung cancer; precision therapy; biomarkers; molecular mechanisms; treatment resistance; immunotherapy; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Cellular Mechanisms of Taste and Smell: From Physiology to Pathology
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 2067 | Submission Open
Keywords: taste; olfaction; taste/smell processing; chemosensory dysfunction; genetic variations; neurodegeneration; perireceptor space; sensory nutrition; hypogeusia and hyposmia
(This special issue belongs to the Section Molecular Biology)
Oral Squamous Cell Carcinoma: From Pathogenesis to Targeted Therapy submission deadline 30 Sep 2026 | 2 articles | Viewed by 2029 | Submission Open
Keywords: oral cancer; oral potentially malignant disorders; omics; oral squamous cell carcinoma; leukoplakia; biomarkers; tumor microenvironment; immunotherapy; target therapy; HPV; multidisciplinary team
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
State-of-the-Art Immunotherapy for Non-Small-Cell Lung Cancer
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 2005 | Submission Open
Keywords: immunotherapy; checkpoint inhibitors; vaccines; cellular therapies; predictive biomarkers; chemotherapy; angiogenesis inhibitors; radiotherapy; modulation microbiome
(This special issue belongs to the Section Molecular Oncology)
Breaking Barriers in Drug Discovery: Novel Methodologies and Mechanisms of Action
edited by Likun Gong, and Jing Chen
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1974 | Submission Open
Keywords: new approach methodologies (NAMs); in silico; in vitro; in vivo; in chemico; drug discovery; computational modeling; artificial intelligence (AI); high-throughput screening (HTS); high-throughput imaging (HTI); bioassay; omics; cell cultures; tissue engineering; organ engineering; therapeutic target; mechanism of drug action
(This special issue belongs to the Section Molecular Pharmacology)
Genetic and Molecular Markers in Prostate Cancer
edited by Thaidy Moreno-Rodriguez
submission deadline 30 Sep 2026 | 3 articles | Viewed by 1902 | Submission Open
Keywords: prostate cancer; genetic markers; androgen receptor signaling; molecular biomarkers; therapy resistance mechanisms; liquid biopsy; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Novel Natural Compound for Wound and Tissue Repair and Regeneration: 4th Edition
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1844 | Submission Open
Keywords: wound repair; tissue regeneration; natural compounds; phytochemicals; molecular mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanism in Cardiac Remodeling
edited by Xianming Lin and
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1826 | Submission Open
Keywords: cardiomyopathy; cardiac arrhythmias; ion channel; calcium transient
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Current Trends and Future Directions in Antimicrobial Peptide Research
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1824 | Submission Open
Keywords: antimicrobial peptides (AMPs); host defense; structure-function; antimicrobial agents; biomedical applications; antibiotic alternatives; antibiotic resistance
(This special issue belongs to the Section Molecular Biology)
Modeling Neurogenesis, Regeneration and Disease from Animal Models submission deadline 30 Sep 2026 | 2 articles | Viewed by 1801 | Submission Open
Keywords: neurogenesis; neural regeneration; animal models; neural stem cells; neurodevelopment; neurodegeneration; molecular mechanisms; disease modeling; nervous system repair, ultrastructure
(This special issue belongs to the Section Molecular Neurobiology)
Nanotechnology-Driven Insights into Plants: Mechanisms, Detection, and Sustainable Control
edited by
submission deadline 30 Sep 2026 | Viewed by 1721 | Submission Open
Keywords: nanotechnology; plant–pathogen interactions; plant immunity; nanoparticles; nano-enabled diagnostics; disease management; antimicrobial nanomaterials; nano-biocontrol; sustainable agriculture; phytopathology
(This special issue belongs to the Section Molecular Nanoscience)
Colorectal Cancer—Emerging Trends and Treatment Strategies
edited by Victor Strambu
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1710 | Submission Open
Keywords: innovative therapies; colorectal cancer; new therapeutic approach; synchronous tumors
(This special issue belongs to the Section Molecular Oncology)
Molecular Pathogenesis of Age-Related Ocular Diseases and Existing Therapies
edited by
submission deadline 30 Sep 2026 | 3 articles | Viewed by 1687 | Submission Open
Keywords: aging; senescence; diabetic retinopathy; glaucoma; age-related macular degeneration; ischemic retinal and optic nerve diseases; Werner syndrome; genetic disorders; inflammatory diseases; cataract; cellular dysfunction; cell death; axonal degeneration; vascular abnormalities; oxidative stress; inflammatory cytokines; senescence-associated secretory phenotype; autophagy; mitochondrial dysfunction; anti-aging; neuroprotection; regeneration; anti-inflammatory agents; nutrients; gene therapies; cell transplantation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Molecular Landscape of Endometrial and Ovarian Dysfunction in Polycystic Ovary Syndrome: Insights into Disease Mechanisms
edited by and
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1682 | Submission Open
Keywords: polycystic ovarian syndrome (PCOS); molecular mechanisms; endometrial dysfunction; ovarian dysfunction; pathophysiology; biomarkers; therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
In Honor of the 76th Birthday of Dr. Rachel Mata Essayag, a Distinguished Pioneer in Natural Products Research in Mexico
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1630 | Submission Open
Keywords: pharmacognosy; natural products; phytochemistry; diabetes, cancer; diarrhea; viral infections; bacterial infections; drug development; in vivo; ex vivo; in vitro; in silico
(This special issue belongs to the Section Molecular Pharmacology)
Microbiome–Epigenome Interactions in Early-Life Molecular Programming
edited by and Miljana Zivojin Jovandaric
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1629 | Submission Open
Keywords: early-life programming; microbiome–epigenome axis; DNA methylation; histone modification; microbial metabolites; non-coding RNAs; immune maturation; placental and postnatal development
(This special issue belongs to the Section Molecular Genetics and Genomics)
Protein Dynamics in Cancer Drug Resistance: Mechanisms and Therapeutic Opportunities
edited by Slovénie Pyndiah
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1521 | Submission Open
Keywords: drug resistance; cancer proteome; protein turnover; post-translational modifications; targeted therapy; stress adaptation
(This special issue belongs to the Section Molecular Oncology)
Integrative Omics Strategies for Biomarker Discovery and Mechanistic Insights into Disease
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1502 | Submission Open
Keywords: integrative omics; biomarker discovery; cancer signaling networks; drug resistance; phosphoproteomics; multi-omics integration; systems biology; translational research
(This special issue belongs to the Section Molecular Informatics)
Advances in Omics Approaches in Chronic Metabolic Diseases
edited by Ramos-López Omar
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1491 | Submission Open
Keywords: chronic metabolic diseases; obesity; diabetes; cardiovascular disease; fatty liver; genomics; epigenomics; metagenomics; metabolomics; proteomics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Research on Forensic Odontology, Legal Medicine, and Forensic Sciences submission deadline 30 Sep 2026 | 2 articles | Viewed by 1489 | Submission Open
Keywords: forensic odontology; legal medicine; forensic sciences; forensic genetics; human identification; criminal database; quality assurance; age assessment; sex estimation; ancestry; time of death
(This special issue belongs to the Section Molecular Biology)
Mechanisms of Tumor–Immune System Interactions
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1478 | Submission Open
Keywords: oncoimmunology; tumor–immune system interactions; tumor microenvironment; immune evasion; immunotherapy; antitumor immunity
(This special issue belongs to the Section Molecular Oncology)
New Insights in Translational Bioinformatics: 3rd Edition
edited by
submission deadline 30 Sep 2026 | 3 articles | Viewed by 1428 | Submission Open
Keywords: translational research; sequencing; single cell; spatial biology; treatment; diagnostics; machine learning; artificial intelligence; model; computational biology
(This special issue belongs to the Section Molecular Informatics)
Recent Advances in Nanotechnology for Biomedical Applications
edited by Sofía Municoy
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1419 | Submission Open
Keywords: nanotechnology; nanosensor; drug delivery; regenerative medicine
(This special issue belongs to the Section Molecular Nanoscience)
New Advances in Plant Disease Resistance submission deadline 30 Sep 2026 | 2 articles | Viewed by 1355 | Submission Open
Keywords: plant disease resistance; durable resistance; chromosome engineering; plant genomics; genome editing; molecular breeding; introgression; quantitative resistance; crop improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Pharmacological Research on Autoimmune Disease
edited by and Sandra Bertelli Ribeiro de Castro
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1346 | Submission Open
Keywords: autoimmune diseases; plant-derived formulations; drug repurposing strategies; nanostructured delivery systems; complementary therapies; inflammatory; immune system; gut–brain axis
(This special issue belongs to the Section Molecular Pharmacology)
Targeting Metabolism, Inflammation, and Oxidative Stress: Novel Therapeutic Approaches in Human Diseases
edited by Kota V. Ramana
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1341 | Submission Open
Keywords: metabolism ; inflammation ; oxidative stress ; diabetes ; aging ; cardiovascular diseases ; gene editing ; stem cell therapy ; next-generation sequencing ; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Inflammatory and Metabolic Biomarkers in Disease Prediction and Prognosis
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1328 | Submission Open
Keywords: inflammation; biomarkers; metabolic indices; triglyceride-glucose index; inflammatory ratios; risk stratification; prognosis; cardiovascular diseases; critical care; neuroinflammation; endocrine disorders; composite inflammatory scores; artificial intelligence; personalized medicine; clinical biochemistry
(This special issue belongs to the Section Biochemistry)
Human Papillomavirus and Cellular Pathways submission deadline 30 Sep 2026 | 1 articles | Viewed by 1289 | Submission Open
Keywords: human papillomavirus; HPV oncogenesis; E6 and E7 oncoproteins; cellular signaling pathways; viral integration; epigenetics; molecular biomarkers; host susceptibility; cervical cancer; targeted therapy
(This special issue belongs to the Section Molecular Microbiology)
Molecular Insights into Aquatic Animal Reproduction, Breeding Strategies and Genetic Improvement
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1257 | Submission Open
Keywords: reproductive biology; aquaculture genetics; fish breeding; genomic selection; marker-assisted selection; genome editing; hybridization; genetic improvement; molecular breeding; sustainable animal production
(This special issue belongs to the Section Molecular Biology)
Methodological Advances in Phytochemical Analysis submission deadline 30 Sep 2026 | 2 articles | Viewed by 1253 | Submission Open
Keywords: advanced phytochemical profiling; high-resolution mass spectrometry; green extraction methodologies; chemometric data processing; bioactive metabolite elucidation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Diagnostics and Therapeutic Advances in Hematology: From Mechanisms to Clinical Applications submission deadline 30 Sep 2026 | 1 articles | Viewed by 1231 | Submission Open
Keywords: hematology; molecular diagnostics; immunology; biomarkers; hematopoietic cell transplantation; bone marrow failure; hematologic malignancies; plasma cell disorders; translational research; therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Current Research on Redox Homeostasis and Oxidative Stress in Health and Disease submission deadline 30 Sep 2026 | 3 articles | Viewed by 1149 | Submission Open
Keywords: reactive oxygen species; reactive nitrogen species; redox signalling; antioxidant defence systems; antioxidants; ageing; immunity; metabolism disorder; metabolomics; degenerative diseases; cardiovascular diseases; cancer; infectious diseases; oxidative post-translational modifications
(This special issue belongs to the Section Biochemistry)
Advances in Beta Cells and Insulin Secretion submission deadline 30 Sep 2026 | 2 articles | Viewed by 1124 | Submission Open
Keywords: beta cell function; insulin secretion mechanisms; diabetes; glycemic control
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Neuroimmune Circuitry: Advances in Neuronal Regulation of Immunity
edited by
submission deadline 30 Sep 2026 | Viewed by 1115 | Submission Open
Keywords: neuroimmunology; neuronal circuits; molecular signaling; hypothalamus; autonomic regulation; neuropeptides; GPCR signaling; inflammation; cytokines; transcriptional regulation
(This special issue belongs to the Section Molecular Immunology)
Glial Cells in Brain and Eye: Emerging Mechanisms and Functions in Health and Disease
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1109 | Submission Open
Keywords: glial cells; brain & eye (retina); health & disease; neuronal regulation; therapeutic strategies; CNS; glia biology; cellular interactions
(This special issue belongs to the Section Molecular Biology)
Molecular and Cellular Mechanisms of Muscle Development and Remodelling submission deadline 30 Sep 2026 | 1 articles | Viewed by 1108 | Submission Open
Keywords: muscle plasticity; nutrient signaling; protein turnover; metabolic flexibility; bioenergetics; redox homeostasis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research on Porous Polymers for Advanced Separation and Analytical Applications
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1082 | Submission Open
Keywords: microporous polymers; molecular imprinting; ion imprinting; separation; porous surfaces; spectroscopy; chromatography
(This special issue belongs to the Section Macromolecules)
Recent Advances in Omics for Cancer Research
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1075 | Submission Open
Keywords: cancer; omics; genomics; transcriptomics; proteomics; metabolomics; multi-omics; biomarkers; precision oncology; systems biology
(This special issue belongs to the Section Molecular Oncology)
Computational Methods in Cancer Genomics and Molecular Oncology
edited by and Nicolas Carels
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1070 | Submission Open
Keywords: cancer genomics; computational biology; machine learning; precision oncology; multi-omics integration; molecular oncology; bioinformatics; tumor heterogeneity; biomarker discovery; single-cell sequencing
(This special issue belongs to the Section Molecular Genetics and Genomics)
Recent Advances in Benign Hematology
edited by Sirisha Kundrapu
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1048 | Submission Open
Keywords: molecular hematology; erythropoiesis; iron metabolism; complement cascade; coagulation pathways; genetic mutations; immune-mediated cytopenias; thrombotic microangiopathies; hematopoiesis; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease—2nd Edition
edited by David Rohde
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1033 | Submission Open
Keywords: myocardial infarction; heart failure; atherosclerosis; arterial hypertension; myocarditis; arrhythmia; inflammation; hematopoiesis; myelopoiesis; tissue macrophages; neutrophil biology; lymphocytes; endothelial cells; megakaryocytes; platelet biology; biomarkers
(This special issue belongs to the Section Molecular Immunology)
Molecular, Genetic, and Omics Approaches to Disorders in Bone–Inflammation Crosstalk submission deadline 30 Sep 2026 | 1 articles | Viewed by 1014 | Submission Open
Keywords: bone physiology; inflammatory; epigenetic regulation; molecular signaling pathways; cellular interactions
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
T Cell Immunity in Emerging Respiratory Viral Infections: Mechanisms, Dysregulation, and Therapeutic Targets
edited by Jian Zheng
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1000 | Submission Open
Keywords: T cell; coronavirus; immune memory; immunopathogenesis; aging
(This special issue belongs to the Section Molecular Immunology)
Cell Therapies: Cellular Mechanisms and Genetic Engineering
edited by Shirley O'Dea
submission deadline 30 Sep 2026 | 1 articles | Viewed by 967 | Submission Open
Keywords: cell engineering; advanced therapy medicinal products (ATMPs); cell fate control; translational cell therapy; next-generation cell therapy platforms; scalable cell manufacturing; personalized cell-based medicine; clinical translation; cell therapy delivery systems; bioprocessing of engineered cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Immunological Mechanisms Associated with Exercise submission deadline 30 Sep 2026 | 1 articles | Viewed by 924 | Submission Open
Keywords: signaling pathways; exercise training adaptation; exercise and mitochondrial health; skeletal muscle secretome; exercise and extracellular vesicles; myokines; exerkines; molecular immune responses to exercise
(This special issue belongs to the Section Molecular Biology)
Natural Bioactive Compounds: Molecular Mechanisms and Toxicological Evaluation
edited by and Irma Ares
submission deadline 30 Sep 2026 | 2 articles | Viewed by 923 | Submission Open
Keywords: natural bioactive compounds; toxicology and safety assessment; molecular mechanisms of action; redox and inflammatory signaling pathways; chemical diversity; nutraceuticals and functional foods; health benefits and bioactivity
(This special issue belongs to the Section Molecular Toxicology)
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