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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Autoimmune Diseases: From Pathogenesis to Treatment and Prognostic Markers

edited by Alessandra Bettiol

submission deadline 20 Feb 2026 | 8 articles | Viewed by 14676 | Submission Open

Keywords: autoimmune diseases; inflammation; immunity; pathogenesis; immunosuppressants; biologics; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Recent Molecular Trends and Prospects in Kidney Diseases

edited by

Federico Greco

and

Carlo A. Mallio

submission deadline 20 Feb 2026 | 6 articles | Viewed by 14498 | Submission Open

Keywords: nephrology; molecular biology; renal disease; genomic research; kidney molecular pathways; biomarkers in renal disease; transcriptomics of renal dysfunction; omics approaches in kidney research; molecular diagnostics for renal diseases; pharmacogenomics in kidney treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Omics: Sensing, Signaling, Regulation and Homeostasis

edited by

Margherita-Gabriella De Biasi

submission deadline 20 Feb 2026 | 6 articles | Viewed by 14112 | Submission Open

Keywords: plant homeostasis; omics; transcriptomics; metabolomics; proteomics; genomics; ionomics; environmental stress; regulatory mechanisms; metabolic processes; systems biology

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Therapeutic Strategies in Allergic Diseases

edited by

Sylwia Smolińska

submission deadline 20 Feb 2026 | 6 articles | Viewed by 13601 | Submission Open

Keywords: molecular allergy diagnostics; allergen identification; allergen neutralization/elimination strategies; allergen immunotherapy; impact of pollution on allergies; new allergens; cross-reactivity; unexpected allergen sources

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Inflammatory Bowel Diseases: Molecular Mechanism and Therapeutics

edited by

Woon Kyu Lee

submission deadline 20 Feb 2026 | 4 articles | Viewed by 12970 | Submission Open

Keywords: inflammatory bowel disease; IBD; ulcerative colitis; Crohn’ s disease; animal models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondrial Function in Health and Diseases

edited by Sally P. Wheatley

submission deadline 20 Feb 2026 | 5 articles | Viewed by 12767 | Submission Open

Keywords: mitochondria; metabolism; lipid; ATP; respiration; calcium; iron; inheritance; apoptosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Organoids and Organs-on-Chip for Medical Research

edited by

Miguel Hueso

submission deadline 20 Feb 2026 | 4 articles | Viewed by 12476 | Submission Open

Keywords: organoids; organs-on-chip; tissue engineering; disease modeling; biomarkers; molecular pathways; nanotechnology; preclinical models; artificial organs; artificial intelligence; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genomics and Proteomics of Cancer

edited by

Raffaella Lazzarini

submission deadline 20 Feb 2026 | 6 articles | Viewed by 12066 | Submission Open

Keywords: cancer; carcinogenesis; genetic; epigenetic modification; protein expression; protein phosphorylation; proteomic

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Bioactive Nutrients Promoting Health Through Gut Microbiota: 3rd Edition

edited by

Baojun Xu

and

Matteo Bordiga

submission deadline 20 Feb 2026 | 3 articles | Viewed by 11896 | Submission Open

Keywords: phytochemicals; complex carbohydrates; gut microbiota; prebiotics; probiotics; inflammation; molecular mechanisms; human health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Antioxidants as Regulators of Metabolic Pathways: Potential and Therapeutic Strategies

edited by Halina Tkaczenko and

Natalia Kurhaluk

submission deadline 20 Feb 2026 | 2 articles | Viewed by 11868 | Submission Open

Keywords: antioxidants; metabolic pathways; oxidative stress; cellular homeostasis; redox signaling; energy metabolism; lipid metabolism; therapeutic strategies; chronic diseases

(This special issue belongs to the Section Molecular Biology)

Anti-Cancer, Anti-Inflammatory, and Antioxidation Active Substances: 3rd Edition

edited by

Ming-Ju Hsieh

submission deadline 20 Feb 2026 | 12 articles | Viewed by 11789 | Submission Open

Keywords: anti-inflammatory; anti-cancer; antioxidants; antiproliferative; antiviral; antibacterial; antibodies; molecular mechanism; chemoresistance; molecular biology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Natural Products from Plants: Association with Human Health and Therapeutic Benefits

edited by

Andrey Marchev

and

Nikolina Mihaylova

submission deadline 20 Feb 2026 | 6 articles | Viewed by 11512 | Submission Open

Keywords: botanical products; phytochemicals; bio/pharmacological compounds; cellular and molecular targets; molecular and physiological mechanism; human health; disease prevention and treatment; inflammatory diseases; age-related disorders; chronic and (auto)immune diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Drug-Induced Modulation and Immunotherapy of Leukemia

edited by Helga Maria Schmetzer

submission deadline 20 Feb 2026 | 3 articles | Viewed by 11419 | Submission Open

Keywords: leukemia; dendritic cells; immunotherapy; immune modulation

(This special issue belongs to the Section Molecular Immunology)

New Insights into Aquaporins: 2nd Edition

edited by

Graça Soveral

and

Inês Vieira Da Silva

submission deadline 20 Feb 2026 | 5 articles | Viewed by 11313 | Submission Open

Keywords: aquaporin; membrane channel; regulation; pathophysiology; drug target

(This special issue belongs to the Section Molecular Biology)

New Molecular Mechanisms in the Development of Brain Tumors and Metastases

edited by

Raffaele Addeo

Michele Caraglia

and

Marianna Abate

submission deadline 20 Feb 2026 | 4 articles | Viewed by 10234 | Submission Open

Keywords: brain tumor; brain metastasis; blood– brain barrier; target therapy; cancer molecular biology; brain tumor microenvironment; molecular biomarkers

(This special issue belongs to the Section Molecular Oncology)

Chronic Rhinosinusitis: Aetiology, Immunology and Treatment, 3rd Edition

edited by

Seung-Heon Shin

submission deadline 20 Feb 2026 | 3 articles | Viewed by 9937 | Submission Open

Keywords: innate immunity; adaptive immunity; protease; cytokine; inflammation; epithelial cells; fibroblasts; eosinophils; lymphocytes; biologics

(This special issue belongs to the Section Molecular Immunology)

The Biochemistry, Molecular and Cell Biology Beyond Flowers

edited by

Isabel Marques

submission deadline 20 Feb 2026 | 3 articles | Viewed by 9916 | Submission Open

Keywords: flowers; homeotic genes; MADSBox; molecular expression; pollination; stress; transcription factors

(This special issue belongs to the Section Molecular Plant Sciences)

Machine Learning and Bioinformatics in Human Health and Disease: 2nd Edition

edited by

Andreas Leiherer

submission deadline 20 Feb 2026 | 5 articles | Viewed by 9655 | Submission Open

Keywords: machine learning; bioinformatics; deep learning; multi-omics approaches; genetic risk factors; drug interactions; precision medicine; neurodegenerative diseases; disease diagnosis; epidemic prediction

(This special issue belongs to the Section Molecular Informatics)

Heterocyclic Compounds: Synthesis, Design, and Biological Activity

edited by

Josef Jampilek

submission deadline 20 Feb 2026 | 8 articles | Viewed by 8989 | Submission Open

Keywords: heterocycles; bioactive molecules and materials; pharmacophore; design; targeting; computer studies; synthesis and analysis; natural compounds; carbohydrates; physicochemical properties; biological screening

(This special issue belongs to the Section Biochemistry)

Advances in Insulin Resistance Research: 2nd Edition

edited by

Byungyong Ahn

submission deadline 20 Feb 2026 | 2 articles | Viewed by 8693 | Submission Open

Keywords: insulin resistance; obesity; metabolic diseases; diabetes; metabolism; inflammation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Insights in Antibody Therapy

edited by

Loredana Frasca

submission deadline 20 Feb 2026 | 3 articles | Viewed by 8579 | Submission Open

Keywords: biological therapy; antibody therapy; non-communicable diseases; infectious diseases; chronic disease

(This special issue belongs to the Section Molecular Immunology)

Immunotherapy Versus Immune Modulation of Leukemia

edited by Helga Maria Schmetzer

submission deadline 20 Feb 2026 | 5 articles | Viewed by 8321 | Submission Open

Keywords: leukemia; immunotherapy; immune modulation; antileukemic; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Neurodegenerative Diseases: From Molecular Mechanisms to Pathophysiology (Second Edition)

edited by

Anne Vejux

submission deadline 20 Feb 2026 | 2 articles | Viewed by 8143 | Submission Open

Keywords: neurodegenerative diseases; molecular mechanisms; physiology; cell death; autophagy; oxidative stress; inflammation; genetic factors; diet; cognitive functions; exosomes; blood– brain barrier; immunity

(This special issue belongs to the Section Molecular Neurobiology)

Role of MicroRNAs in Human Diseases: 2nd Edition

edited by

Lorenzo F. Sempere

submission deadline 20 Feb 2026 | 7 articles | Viewed by 7809 | Submission Open

Keywords: microRNAs; miRNAs; miRs; preclinical models; target interaction; regulatory networks; oncology; cancer biology; cardiovascular disease; neurodegenerative conditions; diagnostic applications; therapeutic development and clinical trials

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in the Genetics, Epidemiology and Management of Myopathies

edited by

Efthimios Dardiotis

and

Vasileios Siokas

submission deadline 20 Feb 2026 | 1 articles | Viewed by 7516 | Submission Open

Keywords: myopathies; muscle disorders; muscle weakness; muscle pain; myalgia

(This special issue belongs to the Section Molecular Biology)

New Advances in Bioactive Compounds in Health and Disease

edited by

Luís Silva

submission deadline 20 Feb 2026 | 3 articles | Viewed by 7324 | Submission Open

Keywords: phenolic compounds; bioactive compounds; health-promoting properties; human diseases; chronic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Biocatalysis of Compounds for Pharmaceutical and Biomedical Applications

edited by

Tomasz Siodmiak

submission deadline 20 Feb 2026 | 3 articles | Viewed by 7308 | Submission Open

Keywords: biocatalysis; biomedical application; biotechnology; compounds for pharmacy; compounds for biomedicine; enantiomers; enzyme activity; enzyme engineering; enzyme immobilization; kinetic resolution; pharmaceutical application; supports materials

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Studies in Aging, 2nd Edition

edited by

Rosa Mancinelli

submission deadline 20 Feb 2026 | 4 articles | Viewed by 7230 | Submission Open

Keywords: senescence; active aging; sarcopenia; osteoporosis; oxidative stress; brain aging; cardiovascular aging

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genes and Human Diseases: 3rd Edition

edited by

Mikhail I. Churnosov

submission deadline 20 Feb 2026 | 6 articles | Viewed by 7184 | Submission Open

Keywords: genes; human diseases; genetic-epidemiological studies; genetic factors; susceptibility

(This special issue belongs to the Section Molecular Genetics and Genomics)

In Silico Methods of Assessing the Therapeutic Potential of Natural Substances

edited by

Radosław Zajdel

and

Anna Merecz-Sadowska

submission deadline 20 Feb 2026 | 4 articles | Viewed by 7181 | Submission Open

Keywords: in silico screening; natural products; molecular docking; computational drug discovery; QSAR modeling; molecular dynamics simulations; natural compounds; drug-target interactions; virtual screening; structure-activity relationships; computational chemistry; cheminformatics; ADMET prediction; bioinformatics; phytochemicals; machine learning in drug discovery; computer-aided drug design; pharmacophore modeling; natural therapeutics; computational pharmacology

(This special issue belongs to the Section Molecular Informatics)

Health-Promoting Effects of Medicinal and Edible Plants and Their Molecular Mechanism

edited by

Baojun Xu

and

Matteo Bordiga

submission deadline 20 Feb 2026 | 4 articles | Viewed by 7052 | Submission Open

Keywords: medicinal plants; edible plants; health-promoting effect; molecular mechanism; phytochemicals; diseases; curing targets; signaling pathway

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Tea Tree Metabolism and Genetics

edited by Xiaoling Sun

submission deadline 20 Feb 2026 | 4 articles | Viewed by 7040 | Submission Open

Keywords: tea tree; secondary metabolite; genetic transformation; genetic breeding; tea germplasm improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Role of Diet and Nutrition in Metabolic Diseases

edited by

Fernando Guerrero-Romero

submission deadline 20 Feb 2026 | 3 articles | Viewed by 6997 | Submission Open

Keywords: nutrients; biomarkers; molecular targets; pahodiagnosis; treatment

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Cytokines and Autoantibodies Against Cytokines in Health and Disease

edited by

Juan Bautista De Sanctis

submission deadline 20 Feb 2026 | 1 articles | Viewed by 6828 | Submission Open

Keywords: cytokine; autoantibodies; cytokine therapy; cytokine inhibition

(This special issue belongs to the Section Molecular Immunology)

Peripheral Neuropathies: Molecular Research and Novel Therapy—2nd Edition

edited by

Zhidong Zhou

submission deadline 20 Feb 2026 | 2 articles | Viewed by 6516 | Submission Open

Keywords: axonal degeneration; demyelination; schwann cells; dorsal root ganglia; diabetic neuropathy; chemotherapy-induced peripheral neuropathies; immune-mediated neuropathies; immune checkpoint inhibitors; charcot-marie-tooth disease; autonomic neuropathies

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms, Pathophysiology and Therapeutic Strategies of Chronic Obstructive Pulmonary Disease (COPD)

edited by

Shih-feng Liu

submission deadline 20 Feb 2026 | 3 articles | Viewed by 6502 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); pathophysiology; novel therapeutic approaches; biomarkers; pulmonary rehabilitation; inflammation; oxidative stress; genetic factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Fish Genomics and Developmental Biology, 2nd Edition

edited by

Elena Sarropoulou

and

Jorge Fernandes

submission deadline 20 Feb 2026 | 5 articles | Viewed by 6452 | Submission Open

Keywords: development; teleost; gene regulation; comparative genomics; genomics; aquaculture; transcriptomics; gene expression; environment; genomes; population genomics; selective breeding; biomarker

(This special issue belongs to the Section Molecular Biology)

Exploring Novel Molecular, Metabolic and Cellular Mechanisms for Developing New Therapeutic Targets Against Childhood Cancers, 2nd Edition

edited by

Alessandro Fanzani

and

Silvia Codenotti

submission deadline 20 Feb 2026 | 3 articles | Viewed by 6213 | Submission Open

Keywords: childhood cancers; rhabdomyosarcoma; leukemias; lymphomas; central nervous system tumors; sarcomas of bone and soft tissue; neuroblastoma; retinoblastoma; rhabdoid tumors; rare cancers; genomic alterations; molecular drivers; tissue microenvironment; development of drugs; therapies

(This special issue belongs to the Section Molecular Oncology)

Progression of Multiple Sclerosis: Environmental Factors, Genetics, Therapeutics and Immunopathogenesis

edited by Alberto Gajofatto

submission deadline 20 Feb 2026 | 4 articles | Viewed by 6175 | Submission Open

Keywords: multiple sclerosis; disability progression; neurodegeneration; pathogenesis; immunology; risk factor; environment; genetics; treatment

(This special issue belongs to the Section Molecular Neurobiology)

Embryonic Development and Differentiation: 2nd Edition

edited by

László Márk

submission deadline 20 Feb 2026 | 3 articles | Viewed by 6158 | Submission Open

Keywords: blastocyte; embryogenesis; endometrium; implantation; in vitro fertilization (IFV); ICSI; oocyte; pregnancy; seminal plasma; sperm

(This special issue belongs to the Section Molecular Biology)

Food-Derived Bioactive Peptides

edited by

Fidel Toldrá

and

Leticia Mora

submission deadline 20 Feb 2026 | 3 articles | Viewed by 6060 | Submission Open

Keywords: peptides identification; peptides characterization; functional foods; biological activity; peptidomics; proteomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Endothelial Dysfunction and Its Related Cardiometabolic Disorders: From Mechanisms to Targeted Therapies

edited by

Nacci Carmela

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5971 | Submission Open

Keywords: endothelial dysfunction; endothelial activation; endothelial nitric oxide synthase; cardiometabolic disease; vascular inflammation; chemokines; adipocytokines; atherosclerosis; diabetes; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Plant and Insect Interactions (Second Edition)

edited by

Yonggen Lou

and Xiaoling Sun

submission deadline 20 Feb 2026 | 5 articles | Viewed by 5966 | Submission Open

Keywords: plant defense responses; elicitors; effectors; defense-related signaling; insect– plant interactions; tritrophic interactions; detoxification; defensive compounds; defensive genes

(This special issue belongs to the Section Molecular Plant Sciences)

Hearing Loss: Recent Progress in Molecular Genomics

edited by

Chen-Chi Wu

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5741 | Submission Open

Keywords: hearing loss; high-throughput sequencing; prognostic analyses; translational medicine; gene therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Computer-Aided Drug Design Strategies

edited by

Alexandre G. De Brevern

submission deadline 20 Feb 2026 | 2 articles | Viewed by 5691 | Submission Open

Keywords: computer-aided drug design; artificial intelligence in drug discovery; molecular docking; molecular dynamics simulations; macromolecular systems; quantum mechanics/molecular mechanics (QM/MM); big data analytics in drug development; pharmacokinetics optimization; structure-based drug design (SBDD); ligand-based drug design; virtual screening techniques

(This special issue belongs to the Section Molecular Informatics)

Identification of Novel Biomarkers Towards Improved Diagnosis and Management of Peripheral Vascular Diseases

edited by

Daniel P. Zalewski

submission deadline 20 Feb 2026 | 4 articles | Viewed by 5660 | Submission Open

Keywords: vascular pathophysiology; peripheral atherosclerosis; aneurysm; venous disorders; congenital vascular malformations; molecular biomarkers; diagnostic biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research of Cancer Metabolism and Biomarkers

edited by

Mario Cioce

submission deadline 20 Feb 2026 | 2 articles | Viewed by 5612 | Submission Open

Keywords: metabolic reprogramming; tumor microenvironment (TME); resistance; metabolic modulator; multidisciplinary omics approach; cancer metabolism; biomarkers; cancer stem cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathology and Treatment of Spinal Cord Injury

edited by James Hong

submission deadline 20 Feb 2026 | 1 articles | Viewed by 5324 | Submission Open

Keywords: spinal cord injury; neuroinflammation; gene targets; neural regeneration; synaptic plasticity; molecular pathways; biomarkers; oxidative stress; apoptosis; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Gut Microbiota and Nutrition in Human Health (2nd Edition)

edited by

Sunmin Park

submission deadline 20 Feb 2026 | 1 articles | Viewed by 5316 | Submission Open

Keywords: microbiome; gut; brain; obesity; diabetes; inflammation; liver; nutrition; probiotic; prebiotic

(This special issue belongs to the Section Molecular Microbiology)

Circulating Non-Coding RNAs as Diagnostic and Prognostic Markers of Human Diseases: 3rd Edition

edited by

Kyriacos N. Felekkis

and

Christos Papaneophytou

submission deadline 20 Feb 2026 | 6 articles | Viewed by 5216 | Submission Open

Keywords: miRNA; gene expression regulation; diagnosis; prognosis; therapy; biomarkers

(This special issue belongs to the Section Biochemistry)

Displaying special issue 1601-1650 on page 33 of 69.

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