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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms and Pathways of Epithelial-Mesenchymal Transition

edited by

Noemi Monti

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1093 | Submission Open

Keywords: metastasis; fibrosis; tumor microenvironment; molecular pathways; EMT reversion

(This special issue belongs to the Section Molecular Biology)

Unraveling the Molecular Landscape of Primary Brain Tumors

edited by

Giuseppe Lombardi

, Francesco Pasqualetti and Tamara Ius

submission deadline 30 Nov 2026 | Viewed by 1089 | Submission Open

Keywords: primary brain tumors; molecular oncology; glioma; glioblastoma; biomarkers; targeted therapy; epigenetics; tumor microenvironment; genomic profiling; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Theoretical and Computational Chemistry: New Insights into Molecular Modeling and Design

edited by

Alejandro Morales-Bayuelo

and

Cleber Melo-Filho

submission deadline 30 Nov 2026 | 3 articles | Viewed by 1060 | Submission Open

Keywords: theoretical chemistry; computational chemistry; molecular modeling; quantum chemistry; density functional theory (DFT); molecular dynamics (MD); molecular structure prediction; reaction mechanism modeling

(This special issue belongs to the Section Molecular Informatics)

Molecular Advances in Zoonoses and Vector-Borne Diseases

edited by Ravi Durvasula

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1059 | Submission Open

Keywords: malaria; leishmaniasis; soil-transmitted helminths; one health; cryptosporidiosis; trypanosomiasis; mosquito-borne infections; arboviral diseases; paratransgenesis; drug discovery; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanisms of Genotoxicity Induced by Environmental Mutagens—Focus on Nanoparticles and Micro/Nanoplastics

edited by

Ricard Marcos

and Susana Pastor

submission deadline 30 Nov 2026 | 1 articles | Viewed by 987 | Submission Open

Keywords: genotoxicity; DNA damage; chromosome damage; DNA repair; comet assay; micronucleus assay; mechanisms; environmental pollutants; micro/nanoplastics; nanoparticles

(This special issue belongs to the Section Molecular Toxicology)

Radiofrequency on Human Health: A Molecular Perspective

edited by

Mariateresa Allocca

and Valentina Peluso

submission deadline 30 Nov 2026 | 1 articles | Viewed by 983 | Submission Open

Keywords: radiofrequency electromagnetic field; bioelectromagnetics; health effects; biological effects; molecular mechanisms; interaction mechanisms; electromagnetic risk assessment; biomedical application

(This special issue belongs to the Section Molecular Biophysics)

Molecular Regulation of Plant Tolerance to Saline, Alkali, and Combined Stresses

edited by

Lixin Li

and Yiming Zhang

submission deadline 30 Nov 2026 | 1 articles | Viewed by 967 | Submission Open

Keywords: saline–alkali stress; plant's environmental adaptation mechanisms; metabolism and secondary metabolism; signal transduction; plant–microorganism interaction; omics

(This special issue belongs to the Section Molecular Plant Sciences)

Microbial Enzymes: Molecular Structure and Mechanism

edited by Rui Ma

submission deadline 30 Nov 2026 | 2 articles | Viewed by 962 | Submission Open

Keywords: microbial enzymes; biocatalytic application; molecular enzymology

(This special issue belongs to the Section Molecular Biology)

Oral Stem Cells: Molecular Characteristics and the Applications in Regenerative Medicine

edited by

Emi Shimizu

and

Motoki Okamoto

submission deadline 30 Nov 2026 | Viewed by 942 | Submission Open

Keywords: oral stem cells; regenerative medicine; molecular mechanisms; stem cell therapy; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Adipose Tissue Dysfunction

edited by

Stefano Quarta

submission deadline 30 Nov 2026 | 1 articles | Viewed by 920 | Submission Open

Keywords: adipose tissue dysfunction; adipogenesis; immunometabolism and adipokines; mitochondrial dysfunction; extracellular vesicles; fibrosis and ECM remodeling; lipid metabolism; browning and beigeing; metabolic biomarkers and therapeutic targets; adipose-derived stem cells

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Insights into Allergic Asthma

edited by

Jose Antonio Cañas Mañas

submission deadline 30 Nov 2026 | 1 articles | Viewed by 883 | Submission Open

Keywords: allergic asthma; type 2 inflammation; airway remodeling; molecular endotypes; biomarkers; biologic therapies; immune regulation; microRNAs; extracellular vesicles; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nutrigenomics, Pharmacogenomics and Personalized Medicine: Integrating Omics Sciences, Advanced Diagnostics and Precision Health Strategies

edited by

Ana María Sifuentes Rincón

and

David Guillermo Pérez-Ishiwara

submission deadline 30 Nov 2026 | 1 articles | Viewed by 877 | Submission Open

Keywords: nutrigenomics and pharmacogenomics; presicion nutrition; individualized dietary interventions; personalized medicine; biomarkers; precision health devices

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Pharmacology and Biological Activities of Natural and Derivatives Bioactive Compounds

edited by

Rafał Hałasa

and

Katarzyna Turecka

submission deadline 30 Nov 2026 | 1 articles | Viewed by 875 | Submission Open

Keywords: molecular pharmacology; therapeutic potential; natural compounds; synthetic derivatives of natural compounds; biological activity; mechanism of action; molecular docking; anticancer; antimicrobial; pharmacokinetics; pharmacodynamics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Photodiagnosis and Photodynamic Therapy

edited by

Tomasz Kubrak

and

David Aebisher

submission deadline 30 Nov 2026 | Viewed by 859 | Submission Open

Keywords: photodiagnosis; photodynamic therapy; photosensitizers; natural photosensitizers; biomedical imaging; nanomedicine; targeted therapies; light as a therapeutic tool

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Neuropsychiatric Disorders

edited by Marina Mitrovic,

Gvozden Rosic

and

Dragica Selakovic

submission deadline 30 Nov 2026 | 1 articles | Viewed by 859 | Submission Open

Keywords: neurological disorders; psychiatric disorders; pathophysiological mechanisms; apoptosis; oxidative stress; inflammation; neurotransmitters; neurotrophins; pharmacotherapy; transcranial stimulation

(This special issue belongs to the Section Molecular Neurobiology)

Ferroptosis: Mechanisms and Roles in Diseases

edited by Yuquan Chen

submission deadline 30 Nov 2026 | 1 articles | Viewed by 842 | Submission Open

Keywords: ferroptosis; iron metabolism; lipid peroxidation; oxidative stress; endocrine diseases; metabolic disorders; environmental exposures; circadian rhythm; redox signaling; cell death

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Innovations in Functional Biomaterials for Biomedical Applications

edited by

Arpita Roy

submission deadline 30 Nov 2026 | 1 articles | Viewed by 834 | Submission Open

Keywords: functional biomaterials; molecular mechanisms; drug delivery systems; tissue engineering; biointerface interactions; smart/stimuli-responsive materials; molecular modeling and simulation; gene and protein expression; biomolecular characterization; regenerative medicine

(This special issue belongs to the Section Materials Science)

Emerging Technologies in Musculoskeletal Research: From Molecular Mechanisms to Translational Innovation

edited by

Javad Tavakoli

submission deadline 30 Nov 2026 | 1 articles | Viewed by 830 | Submission Open

Keywords: musculoskeletal tissue; cell mechanobiology; biofabrication; tissue regeneration; organ-on-a-chip; disease mechanism and screening; molecular and cellular diagnostics; AI and machine learning; omics technology; wearable technologies; implant technologies; biomarkers; predictive modelling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Interdisciplinary Molecular Design: Catalysis, Therapeutics, and Biomaterials

edited by

Zhiwei Yang

submission deadline 30 Nov 2026 | 1 articles | Viewed by 814 | Submission Open

Keywords: intelligent molecular design; computational catalysis; antibody and protein engineering; biomaterials design; molecular dynamics simulations; AI in drug discovery

(This special issue belongs to the Section Molecular Biophysics)

Functional Genomics and Computational Biology of Horticultural Plants

edited by

Claudio Pugliesi

submission deadline 30 Nov 2026 | 2 articles | Viewed by 795 | Submission Open

Keywords: transcriptomics; computational model; genome editing; GWAS; multi-omics; NGS technologies; MAS; genomic selection; mutagenesis; RNA-silencing

(This special issue belongs to the Section Molecular Plant Sciences)

Emerging Molecular Mechanisms and Therapeutic Targets in Neurodegenerative Diseases and Brain Cancers

edited by

Subramanian Thangaleela

submission deadline 30 Nov 2026 | 1 articles | Viewed by 786 | Submission Open

Keywords: neuroinflammation; mitochondrial dysfunction; oxidative stress; advanced glycation end products; brain cancers; tumor microenvironment; nutraceutical interventions; plant bioactive molecules; miRNA therapies; oncogenic signaling pathways; blood–brain barrier in brain cancer; immunotherapy

(This special issue belongs to the Section Molecular Neurobiology)

Mesenchymal Stem Cells: Evolving Concepts and Their Functions in Regeneration and Repair Processes

edited by Rodrigo Somoza

submission deadline 30 Nov 2026 | 2 articles | Viewed by 772 | Submission Open

Keywords: mesenchymal stem cells; medicinal signaling cells; pericytes; immunomodulation; paracrine signaling; regenerative medicine; perivascular niche; extracellular vesicles; allogeneic cell therapy

(This special issue belongs to the Section Molecular Biology)

Nanostructured Strategies for Bioactive Compounds

edited by

Karen Khachatryan

submission deadline 30 Nov 2026 | 1 articles | Viewed by 750 | Submission Open

Keywords: nanostructure-bioactive interaction; molecular encapsulation mechanisms; metallic nanoparticles (bioactivity); carbon-based nanocarriers; nano/microcapsule delivery systems; bioactive compound stabilisation; structure-activity relationships; molecular release kinetics

(This special issue belongs to the Section Molecular Biology)

Exploring Natural Products for Cancer

edited by Ana Carolina Gonçalves

submission deadline 30 Nov 2026 | Viewed by 746 | Submission Open

Keywords: natural products; plant-derived compounds; phenolic compounds; pharmacodynamics; pharma-cokinetics; antioxidant capacities; cancer; oxidative stress-related disorders; in vivo assays; in vitro assays; clinical assays; mechanisms of differentiation; tissue homeostasis

(This special issue belongs to the Section Molecular Oncology)

Spectroscopic Techniques in Molecular Sciences, 2nd Edition

edited by

Angela Staicu

submission deadline 30 Nov 2026 | 2 articles | Viewed by 733 | Submission Open

Keywords: spectroscopy; the structure, dynamics, interactions, and functions of molecules; chemical, biological, pharmaceutical, and materials systems

(This special issue belongs to the Section Biochemistry)

Zinc Signaling in Immunity

edited by

Lothar Rink

and

Inga Wessels

submission deadline 30 Nov 2026 | 1 articles | Viewed by 704 | Submission Open

Keywords: zinc signaling; zinc flux; zinc sparks; zinc wave; zinc transporter

(This special issue belongs to the Section Biochemistry)

Translational Advances in Melanoma Molecular Research

edited by

Marcela S. Villaverde

submission deadline 30 Nov 2026 | 1 articles | Viewed by 702 | Submission Open

Keywords: melanoma; molecular targets; resistance mechanism; future advances; metabolic reprogramming

(This special issue belongs to the Section Molecular Oncology)

Plant Viruses: Discovery and Genetic Diversity

edited by

Xifeng Wang

submission deadline 30 Nov 2026 | 1 articles | Viewed by 691 | Submission Open

Keywords: novel virus; discovery; high-throughput sequencing; diversity; population geneticss; evolutionary dynamic

(This special issue belongs to the Section Molecular Plant Sciences)

Effects of Natural Bioactive Compounds on Cellular Responses

edited by

Amélia M. Silva

submission deadline 30 Nov 2026 | Viewed by 687 | Submission Open

Keywords: cellular targets; cell proliferation; cell death mechanisms; cell signalling; cytokines; vitamins; phytochemicals; venoms; peptides; pharmacological effect

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms Underlying Plant Responses to Biotic and Abiotic Stress

edited by

Mohamed Ait-El-Mokhtar

and

Raja Ben-Laouane

submission deadline 30 Nov 2026 | 1 articles | Viewed by 685 | Submission Open

Keywords: plant stress responses; abiotic stress; biotic stress; signal transduction; multi-omics; epigenetic regulation; plant–microbe interactions; biostimulants; crop resilience

(This special issue belongs to the Section Molecular Plant Sciences)

Novel Diagnostic and Theragnostic Strategies in Brain Tumors

edited by Andrea Cimini and Laura Travascio

submission deadline 30 Nov 2026 | 1 articles | Viewed by 675 | Submission Open

Keywords: brain tumor; novel diagnostic and theragnostic approaches; neuro-oncology; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Bioactive Food Ingredients and Precision Nutrition: From Molecular Innovation to Clinical Relevance

edited by Lídia Pinheiro and

Célia Faustino

submission deadline 30 Nov 2026 | 1 articles | Viewed by 668 | Submission Open

Keywords: bioactive food ingredients; functional foods; nutraceuticals; precision nutrition; gut microbiota; delivery systems; omics technologies; AI in nutrition; personalized nutrition; immune modulation; neuroprotection

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Interaction Between Gut Microbiota and Food Bioactive Compounds

edited by

Abdul Mueed

submission deadline 30 Nov 2026 | 1 articles | Viewed by 612 | Submission Open

Keywords: gut microbiota; bioactive compounds; microbial metabolites; host–microbe interactions; molecular mechanisms; host signaling pathways; nutritional intervention; gut–diet–health axis; microbiota modulation; metagenomic/metatransxriptomics; prebiotics/probiotics/synbiotics; intestinal barrier function

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Pediatric Diseases: From Molecular Mechanisms to Novel Therapeutic Strategies—2nd Edition

edited by

Elena Tarca

submission deadline 30 Nov 2026 | 1 articles | Viewed by 607 | Submission Open

Keywords: congenital abnormalities; genetic disease; molecular mechanism; therapeutic agents; maternal and fetal medicine; pediatric diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Research on Skin Pigmentation and Photoaging

edited by Chang-Cheng Chang and

Tzong-Yuan Juang

submission deadline 30 Nov 2026 | Viewed by 596 | Submission Open

Keywords: skin pigmentation; melasma; photoaging; energy-based devices; skin rejuvenation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drug-Induced Toxicity and Its Role in Disease Progression and Therapeutic Outcomes

edited by

Eugenia Gallardo

and

Tiago Rosado

submission deadline 30 Nov 2026 | Viewed by 593 | Submission Open

Keywords: drug-induced toxicity; drug-drug interactions; drug delivery systems; toxicity; disease

(This special issue belongs to the Section Molecular Toxicology)

Biometallic Nanoparticles: Synthesis, Functionalization and Multidisciplinary Applications

edited by

Elvira Rozhina

submission deadline 30 Nov 2026 | 1 articles | Viewed by 590 | Submission Open

Keywords: biogenic nanomaterials; antibacterial agents; plant extracts; biogenic silver nanoparticles; biofilms; cytotoxicity

(This special issue belongs to the Section Molecular Nanoscience)

Transition-Metal-Based Nanoparticles: Synthesis, Properties and Applications

edited by Ramin Yousefi and

Sasan Rezaee

submission deadline 30 Nov 2026 | Viewed by 583 | Submission Open

Keywords: transition metal nanoparticles; synthesis; structure–property relationship; catalysis; photocatalysis; energy storage and conversion; biomedical applications; drug delivery; environmental remediation; plasmonics

(This special issue belongs to the Section Molecular Nanoscience)

Metabolic Diseases: From Molecular Mechanisms to Innovative Therapeutics

edited by

Aleksandra Szopa

and Anna D. Serefko

submission deadline 30 Nov 2026 | Viewed by 569 | Submission Open

Keywords: metabolic dysregulation; neuropsychiatric disorders; molecular crosstalk; neuroinflammation; mitochondrial dysfunction; neuroendocrine signaling; gut–brain axis; innovative therapeutic strategies; natural compounds; drug repurposing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Amyotrophic Lateral Sclerosis

edited by

Viviana Greco

submission deadline 30 Nov 2026 | Viewed by 566 | Submission Open

Keywords: amyotrophic lateral sclerosis; proteomics; protein aggregation; mitochondria; neurodegeneration; RNA metabolism; oxidative stress; neuroinflammation; systems biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuroinflammation: Emerging Insights and Advances in Drug Development

edited by

Guya Diletta Marconi

Francesca Diomede

Jacopo Pizzicannella

and Paolo Gugliemi

submission deadline 30 Nov 2026 | Viewed by 558 | Submission Open

Keywords: neuroinflammation; drugs; neurodegenerative; Parkinson’s disease; Alzheimer’s disease; multiple scleroris; stroke

(This special issue belongs to the Section Molecular Neurobiology)

Design, Synthesis and Development of Anticancer Drugs Targeting the Tumor Microenvironment

edited by

Yoshihiro Uto

submission deadline 30 Nov 2026 | 1 articles | Viewed by 558 | Submission Open

Keywords: anticancer drugs; tumor microenvironment; in vivo model; cancer-associated fibroblast; tumor-associated macrophage; tumor hypoxia; tumor endothelial cells

(This special issue belongs to the Section Molecular Oncology)

Current Research on Choroid Plexus

edited by

Telma Quintela

submission deadline 30 Nov 2026 | 1 articles | Viewed by 556 | Submission Open

Keywords: choroid plexus; blood–cerebrospinal fluid barrier; cerebrospinal fluid; neurological diseases; brain homeostasis

(This special issue belongs to the Section Molecular Neurobiology)

Chronic Kidney Disease: Underlying Molecular Mechanisms—2nd Edition

edited by

Luís Belo

and

Márcia Carvalho

submission deadline 30 Nov 2026 | 1 articles | Viewed by 545 | Submission Open

Keywords: chronic kidney disease; molecular mechanisms; toxicity mechanisms; inflammation; environmental factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cyclodextrins: Properties and Applications, 4th Edition

edited by

Miguel A. Esteso

and

Carmen M. Romero

submission deadline 30 Nov 2026 | 1 articles | Viewed by 543 | Submission Open

Keywords: cyclodextrins; controlled release systems; structure modification; thermodynamic properties; transport properties

(This special issue belongs to the Section Macromolecules)

Plant Reproductive Genetics and Genomics in Crop Breeding

edited by

Alejandro Garcia Ramirez

submission deadline 30 Nov 2026 | 1 articles | Viewed by 523 | Submission Open

Keywords: genetics; heredity; agronomy; maize breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Metabolomics in Functional Foods and Nutritional Health

edited by

Ahmed Mediani

and

Nurkhalida Kamal

submission deadline 30 Nov 2026 | 1 articles | Viewed by 521 | Submission Open

Keywords: metabolomics; functional foods; bioactive compounds; nutritional health; systems biology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Roles of Erythrocytes in Human Health and Disease: 4th Edition

edited by

Francesco Misiti

submission deadline 30 Nov 2026 | Viewed by 521 | Submission Open

Keywords: erythrocytes; red blood cells; red blood functions; vascular function; blood bank storage

(This special issue belongs to the Section Molecular Biology)

Kidney Disease: From Biomarkers, Molecular Mechanisms to Targeted Therapy

edited by

Rusu Crina Claudia

submission deadline 30 Nov 2026 | Viewed by 518 | Submission Open

Keywords: kidney disease; biomarkers; molecular mechanisms; precision nephrology; chronic kidney disease; acute kidney injury; renal fibrosis; omics technologies; targeted therapy; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Skeletal Muscle Aging: Mechanisms, Biomarkers, and Interventions

edited by

Ida Cariati

submission deadline 30 Nov 2026 | Viewed by 518 | Submission Open

Keywords: skeletal muscle aging; sarcopenia; muscle metabolism; mitochondrial dysfunction; inflammation; exercise adaptation; muscle adaptation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1601-1650 on page 33 of 63.

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