Current Research on Choroid Plexus

Dear Colleagues,

The choroid plexus has emerged as a central focus of contemporary neuroscience research due to its increasingly recognized roles in central nervous system physiology and pathology. Once regarded primarily as the producer of cerebrospinal fluid, the choroid plexus is now understood to be a dynamic and multifunctional interface.

Located within the ventricular system, the choroid plexuses are highly vascularized structures that form the blood–cerebrospinal fluid barrier, enabling continuous communication between the peripheral circulation and the central nervous system. Recent advances have highlighted their active participation in regulating immune cell trafficking, sensing inflammatory and metabolic signals, and coordinating protective responses to maintain neural integrity.

Emerging evidence further demonstrates that the choroid plexus possesses a robust intrinsic circadian clock capable of modulating several physiological processes, including cerebrospinal fluid dynamics and therapeutic distribution within the brain. In parallel, its role in chemical surveillance reinforces the concept of the choroid plexus as a sensitive sensor of alterations occurring in both the blood and cerebrospinal fluid compartments.

This Special Issue aims to provide a comprehensive and up-to-date overview of current advances in choroid plexus research, spanning molecular and cellular mechanisms, neuroimmune interactions, circadian regulation, aging, neurodevelopment, and translational approaches in neurological disease.

Dr. Telma Quintela
Guest Editor

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