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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Insights into Serotonin
edited by Joachim Neumann
submission deadline 30 Nov 2025 | Viewed by 122 | Submission Open
Keywords: serotonin; serotonin receptors; migraine; depression; hypertension; heart failure; arrhythmias
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Translational Infectious Diseases Research
edited by
submission deadline 30 Nov 2025 | Viewed by 122 | Submission Open
Keywords: translational medicine; molecular pathogenesis; host– pathogen interaction; antimicrobial resistance; immune evasion; microbiome and infection; biomarkers; multi-omics approaches; infectious disease models; personalized infectious disease therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Studies of DNA Strand Exchange
edited by
submission deadline 30 Nov 2025 | Viewed by 119 | Submission Open
Keywords: DNA strand exchange; homologous recombination: RecA-family recombinases; drug resistance: drug development against recombinases; evolution
(This special issue belongs to the Section Molecular Biophysics)
Nanobiotechnology: Breaking Barriers in Phytomedicine submission deadline 30 Nov 2025 | Viewed by 118 | Submission Open
Keywords: nanotechnology; nanobiotechnology; phytocompounds; phytochemistry; natural products
(This special issue belongs to the Section Molecular Nanoscience)
Ion Regulation in Human Pathophysiology
edited by
submission deadline 30 Nov 2025 | Viewed by 116 | Submission Open
Keywords: ion channels; ion gradients; membrane potential; action potential; ion pumps; uniporter; co-transporter; patch-clamp; ion flux; concentration gradient; ion stores; physiological processes; pathophysiological processes
(This special issue belongs to the Section Molecular Biology)
Roles of Phytochemicals in Molecular Signaling Networks
edited by
submission deadline 30 Nov 2025 | Viewed by 112 | Submission Open
Keywords: phytochemicals; molecular signaling pathways; inflammation; apoptosis; chronic diseases; cancer; cardiovascular diseases; structure– activity relationships
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Natural Product Therapies in Cancer
edited by
submission deadline 30 Nov 2025 | Viewed by 111 | Submission Open
Keywords: natural compounds; phytochemicals; flavonoids; alkaloids; metastasis; epithelial– mesenchymal transition; cancer cell invasion; cell cycle; programmed cell death; signaling pathways
(This special issue belongs to the Section Molecular Pharmacology)
Advancements in Cardiovascular Health Research: Investigating Novel Biomaterials, Cellular Responses, and Therapeutic
edited by Magdalena Wawrzyńska
submission deadline 30 Nov 2025 | Viewed by 111 | Submission Open
Keywords: cardiovascular biomaterials; nanomaterials; surface coatings; drug delivery systems; polymers; biocompatibility; hemocompatibility; molecular response
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Viral Infections: Molecular, Cellular, and Systems Perspectives
edited by Arnaldo Caruso and
submission deadline 30 Nov 2025 | Viewed by 110 | Submission Open
Keywords: virus– host interaction; epidemiology; evolution; innate immunity; computational modeling
(This special issue belongs to the Section Molecular Microbiology)
Immunity and Autoimmunity in Cardiovascular and Respiratory Diseases
edited by
submission deadline 30 Nov 2025 | Viewed by 108 | Submission Open
Keywords: cardiovascular diseases; respiratory diseases; autoimmune diseases; T cell; B cell; lipid mediators; autoantibodies; genetic variants; mucin
(This special issue belongs to the Section Molecular Immunology)
Advances in Targeted Therapies and Immunometabolic Pathways in Cancer
edited by Medhi Wangpaichitr
submission deadline 30 Nov 2025 | Viewed by 106 | Submission Open
Keywords: immunotherapy; targeted therapy; tumor metabolism pathway; tumor microenvironment; immune checkpoint blockade; immune evasion; glucose/amino acids/lipid metabolism
(This special issue belongs to the Section Molecular Immunology)
New Strategy on Diagnosis and Treatment of Meningioma and Glioma
edited by
submission deadline 30 Nov 2025 | Viewed by 102 | Submission Open
Keywords: meningiomas; gliomas; molecular characterization; biomarker discovery; targeted therapy; neuroimaging; artificial intelligence
(This special issue belongs to the Section Molecular Oncology)
Deciphering Allergies—Structural and Immunological Characterization of Allergenic Proteins and Immunomodulatory Agents: 2nd Edition submission deadline 30 Nov 2025 | Viewed by 96 | Submission Open
Keywords: allergen; allergenicity; IgE; innate immunity; exposome; cross-reactivity; B cell epitopes; T cell epitopes; in silico prediction
(This special issue belongs to the Section Molecular Immunology)
Signaling in Cells Proliferating in Two- and Three-Dimensional Cultures
edited by Hedwig Sutterluety-Fall
submission deadline 30 Nov 2025 | Viewed by 96 | Submission Open
Keywords: proliferation; signaling; two-dimensional; three-dimensional; cell culturing; in vitro; growth factors
(This special issue belongs to the Section Molecular Biology)
Structure and Function of Subcellular Organelle and Protein-Membrane Systems
edited by
submission deadline 30 Nov 2025 | Viewed by 96 | Submission Open
Keywords: immuno-electron microscopy; cell signaling; comparative anatomy; diagnosis; molecular recognition; molecular complexes; electro-chemistry; liquid-phase synthesis; metal sedimentation; membrane endoskeleton
(This special issue belongs to the Section Molecular Biophysics)
Artificial Intelligence and Data Science for the Discovery of Anticancer Targets and Decision Support
edited by
submission deadline 30 Nov 2025 | Viewed by 95 | Submission Open
Keywords: artificial intelligence in oncology; data science and decision support in cancer therapy; target discovery and biomarker identification; machine learning and multi-omics integration; predictive modeling in precision medicine
(This special issue belongs to the Section Molecular Informatics)
Molecular Insights into Microbial Adaptations to Marine Plastics
edited by
submission deadline 30 Nov 2025 | Viewed by 94 | Submission Open
Keywords: plastisphere; marine plastic debris; microbial colonization; biofilms; microbial adaptation; community assembly; quorum sesing; plastic biodegradation; biogeochemical cycling; antibiotic resistance genes; marine microbial ecology; metagenomics; microbe– plastic interactions; microbial succession
(This special issue belongs to the Section Molecular Microbiology)
Intestinal Immune System and Anti-Inflammatory Pathways
edited by
submission deadline 30 Nov 2025 | Viewed by 93 | Submission Open
Keywords: immune checkpoints; mucosal immunity; gut homeostasis; microbiota-driven inflammation; targeted immunotherapy; im-munomodulatory compounds
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanism and Therapeutics in Human Cancer
edited by
submission deadline 30 Nov 2025 | Viewed by 87 | Submission Open
Keywords: oncogenes; Wnt/b-catenin; G-protein-coupled receptors (GPCR); translational means; cancer stem cells; ubiquitination and deubiquitinating in cancer
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights into Rhizospheric Microbial Interactions
edited by
submission deadline 30 Nov 2025 | Viewed by 80 | Submission Open
Keywords: plant– microorganism interactions; rhizosphere community; secretory systems; secondary metabolites; volatile compounds
(This special issue belongs to the Section Molecular Microbiology)
Monovalent Ion-Exchange Membranes for Various Applications
edited by Noor ul Afsar
submission deadline 30 Nov 2025 | Viewed by 79 | Submission Open
Keywords: molecular design; ion-exchange membranes; membrane-based separations; energy and resource recovery
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Host DNA Damage Responses in Virus Propagation and Human Disease
edited by Nimrat Chatterjee
submission deadline 30 Nov 2025 | Viewed by 76 | Submission Open
Keywords: DNA repair; DNA viruses; RNA viruses; translesion synthesis; cancer
(This special issue belongs to the Section Molecular Microbiology)
Novel Molecular Pathways in Oncology, 3rd Edition
edited by
submission deadline 1 Dec 2025 | 10 articles | Viewed by 10667 | Submission Open
Keywords: molecular pathway involved in tumorigenesis; cancer therapy; targeted therapy; anticancer drugs; brain cancer; oral cancer; gastrointestinal cancer
(This special issue belongs to the Section Molecular Oncology)
Gene Editing for Cereal Crops
edited by
submission deadline 1 Dec 2025 | 1 articles | Viewed by 1484 | Submission Open
Keywords: gene-editing techniques; novel germplasm; quality; nutrition; agronomic traits
(This special issue belongs to the Section Molecular Plant Sciences)
The Current Landscape of Microglia-Glioma Research: From Basic Science to Therapeutic Potential submission deadline 1 Dec 2025 | Viewed by 431 | Submission Open
Keywords: microglia; glioma; tumor associated macrophages; immunosuppression; epigenetics
(This special issue belongs to the Section Molecular Neurobiology)
Long-COVID and Its Complications
edited by
submission deadline 4 Dec 2025 | 9 articles | Viewed by 35515 | Submission Open
Keywords: acquired immune deficiency; auto-immunity; blood– brain barrier dysfunction; complication; COVID-19; gut microbiome; hypothalamic– pituitary– adrenal axis; immune dysfunction; long COVID; multisystem dysfunction; neurological complications; SARS-CoV-2; systemic inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biology of Oral Cancer
edited by Rafał Pęksa
submission deadline 10 Dec 2025 | 1 articles | Viewed by 1010 | Submission Open
Keywords: oral cancer; molecular mechanisms; biomarkers; tumor microenvironment; therapy resistance; precision medicine; carcinogenesis; oral squamous cell carcinoma; epigenetics; microbiome; immunotherapy; liquid biopsy
(This special issue belongs to the Section Molecular Oncology)
Biophysical Characterization and Molecular Engineering of Multidomain Proteins (4th Edition) submission deadline 10 Dec 2025 | Viewed by 99 | Submission Open
Keywords: multidomain proteins; protein dynamics; domain interactions; allosteric regulation; protein engineering; SAXS; Cryo-EM; protein NMR; computational modeling; protein design
(This special issue belongs to the Section Molecular Biophysics)
Molecular Mechanisms of Obesity and Metabolic Diseases
edited by
submission deadline 15 Dec 2025 | 7 articles | Viewed by 22336 | Submission Open
Keywords: molecular pharmacology; molecular mechanisms; obesity; metabolic diseases; metabolic syndrome; type 2 diabetes; atherosclerosis; cardio-metabolic disorders; non-alcoholic fatty liver disease (NAFLD)
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Pathogenesis and Molecular Therapy of Brain Tumor
edited by
submission deadline 15 Dec 2025 | 1 articles | Viewed by 1156 | Submission Open
Keywords: brain tumor; glioma; glioblastoma; astrocytoma; oligodendroglioma; epigenetics; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Unveiling Mental Disorders: Molecular Mechanisms and Innovative Therapies
edited by Blerida Banushi
submission deadline 20 Dec 2025 | 7 articles | Viewed by 42497 | Submission Open
Keywords: molecular psychiatry; epigenetics; neurobiology; gene– environment interactions; neuroplasticity; psychopharmacology; neuromodulation; personalized medicine; neuroinflammation
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Retinal Diseases: 2nd Edition
edited by Minzhong Yu
submission deadline 20 Dec 2025 | 9 articles | Viewed by 28409 | Submission Open
Keywords: retina; optic nerve; ocular disorder; retinal disease; genetic mutation; aging; drug side effects; novel mutations/biomarkers; signaling pathways; spectral domain optical coherence tomography; stem cell; gene therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Reproductive Physiology and Endocrinology
edited by
submission deadline 20 Dec 2025 | 12 articles | Viewed by 24975 | Submission Open
Keywords: reproductive; endocrinology; reproductive hormones; embryology; molecular research; IVF; obesity
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Plant Responses to Biotic and Abiotic Stresses
edited by
submission deadline 20 Dec 2025 | 20 articles | Viewed by 24576 | Submission Open
Keywords: plant enzymes and metabolites; abiotic stress; stress response; phytohormones; secondary metabolism; gene regulation network; developmental and environmental adaptation; microbial interactions; biotic stress; pathogen response
(This special issue belongs to the Section Molecular Plant Sciences)
High-Density Lipoproteins in Health and Disease
edited by
submission deadline 20 Dec 2025 | 7 articles | Viewed by 23990 | Submission Open
Keywords: omics; protein; lipid; cardiovascular; neurodegenerative disease; inflammation; preclinical studies; therapy
(This special issue belongs to the Section Molecular Biology)
Exosomes and Extracellular Vesicles in Health and Diseases: 3rd Edition submission deadline 20 Dec 2025 | 8 articles | Viewed by 21919 | Submission Open
Keywords: exosome; extracellular vesicles; network signals; biomarkers; pathological conditions
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomimetic Materials Applied in the Analytical and Biomedical Fields submission deadline 20 Dec 2025 | 6 articles | Viewed by 20504 | Submission Open
Keywords: biomimetics; molecular recognition; imprinted polymers; smart materials; molecular complexes; polymeric biomaterials; biomedical materials; analytical methods; molecular interactions; artificial receptors
(This special issue belongs to the Section Materials Science)
Bacteriophages Biology and Bacteriophage-Derived Technologies
edited by Wilfried Moreira
submission deadline 20 Dec 2025 | 5 articles | Viewed by 20388 | Submission Open
Keywords: bacteriophage; antibiotic resistance; biofilm; molecular biology; genetic engineering; synthetic biology
(This special issue belongs to the Section Biochemistry)
Plant Biodiversity and Molecular Marker Technology: Discovery and Application of DNA Polymorphisms
edited by
submission deadline 20 Dec 2025 | 13 articles | Viewed by 20254 | Submission Open
Keywords: plant biodiversity; plant genetic resources; genetic variability; molecular characterization; biomolecular resources; DNA-based molecular markers; DNA sequencing; next generation sequencing; biosequences; DNA polymorphisms; bioinformatics
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Basis of Neuropsychiatric Disorders: Recent and Future Developments submission deadline 20 Dec 2025 | 5 articles | Viewed by 19902 | Submission Open
Keywords: molecular; schizophrenia; depression; genetic; autism; mechanisms; genetic
(This special issue belongs to the Section Molecular Neurobiology)
The Relationship, Mechanisms, and Treatment Strategies of Diabetes Mellitus and Related Diseases
edited by Maria Kokozidou
submission deadline 20 Dec 2025 | 6 articles | Viewed by 19709 | Submission Open
Keywords: diabetes mellitus; molecular mechanisms; related diseases; genetic basis; microRNAs; incretins; targeted therapies; immunotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Bioactives and Inflammation, 2nd Edition
edited by
submission deadline 20 Dec 2025 | 6 articles | Viewed by 17558 | Submission Open
Keywords: inflammation; bioactive compounds; polyphenols; nutraceutical; diet; nutrition; pharmacology; health; lifespan; healthspan; aging; inflammaging
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Computational Approaches in Drug Design: Novel Methodologies and Applications
edited by
submission deadline 20 Dec 2025 | 7 articles | Viewed by 16962 | Submission Open
Keywords: drug design; computational approaches; molecular docking; molecular dynamics; pharmacophore modeling; homology modeling; computer aided drug design; ADME/Tox predictions; artificial intelligence
(This special issue belongs to the Section Molecular Informatics)
Novel Molecular Mechanisms Underlying Tumorigenesis and Innovative Therapeutic Approaches for Cancer-Fighting, 3rd Edition
edited by , Giulia Russo and
submission deadline 20 Dec 2025 | 8 articles | Viewed by 16854 | Submission Open
Keywords: cancer; nucleolus; nucleolar stress; tumorigenesis; cancer therapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Therapeutic Approaches to Osteoarthritis
edited by
submission deadline 20 Dec 2025 | 8 articles | Viewed by 16822 | Submission Open
Keywords: mode of action; molecular mechanisms; pathogenesis; drug delivery; disease-modifying drug; translational research; cell therapy; regenerative medicine
(This special issue belongs to the Section Molecular Pharmacology)
Impact of Diet on the Endocrine System: Insights into Cellular and Molecular Mechanisms
edited by and
submission deadline 20 Dec 2025 | 3 articles | Viewed by 16614 | Submission Open
Keywords: antioxidants; diet; endocrine system; ROS; lifestyle; nutraceuticals
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Insights of Fungal and Plant Lipids: Structural Diversity, Metabolism and Applications
edited by
submission deadline 20 Dec 2025 | 7 articles | Viewed by 16479 | Submission Open
Keywords: lipidomics; fatty acids; glycerolipids; sphingolipids; sterols; oxylipins; fungal and plant lipid metabolism
(This special issue belongs to the Section Molecular Plant Sciences)
Updates on Synthetic and Natural Antioxidants submission deadline 20 Dec 2025 | 9 articles | Viewed by 16246 | Submission Open
Keywords: antioxidants; synthetic; natural compounds
(This special issue belongs to the Section Biochemistry)
Role of Natural Compounds in Human Health and Disease
edited by Jaewon Shim and
submission deadline 20 Dec 2025 | 8 articles | Viewed by 16195 | Submission Open
Keywords: natural compound; therapeutic applications; action mechanisms of natural compounds; traditional medicine
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Importance of Molecular Circadian Rhythms in Health and Disease submission deadline 20 Dec 2025 | 6 articles | Viewed by 16036 | Submission Open
Keywords: molecular clock; circadian dysfunction; health; chronotherapy; circadian rhythms
(This special issue belongs to the Section Molecular Biology)
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