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Biosynthesis and Regulatory Mechanism of Secondary Metabolites in Medicinal Plants: 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Plant Sciences".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 10

Special Issue Editor


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Guest Editor
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Interests: medicinal plant; bioactive compound; biosynthetic pathway; noncoding RNA; transcription factor; genome; transcriptome; metabolome
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Special Issue Information

Dear Colleagues,

Medicinal plants are important assets to human society. However, compared with model systems and crops, research on medicinal plants has long lagged behind. Recently, driven by the increasing demand for medicinal plants and the development and application of high-throughput technologies, this research field has expanded rapidly. Significant progress has been made in genomics, epigenomics, transcriptomics, and metabolomics of medicinal plants. Numerous studies have elucidated biosynthetic pathways of secondary metabolites, genes encoding key enzymes within these pathways, and the regulatory mechanisms of secondary metabolism. These advances have enabled the production of secondary metabolites through metabolic engineering and synthetic biology. Moreover, novel technologies and strategies are being developed and applied to this field.

This Special Issue of IJMS is devoted to publishing original research and review articles on medicinal plant studies, with a focus on recent advances in the biosynthesis and regulation of secondary metabolites, particularly significant discoveries from intensive studies and the development and application of novel technologies. The aim is to provide an open-access platform for sharing important results from medicinal plant research in recent years, thereby supporting further studies on secondary metabolism, medicinal plant improvement, and the production of functionally important secondary metabolites. 

Topics of interest include, but are not limited to, the following:

  • Genomics, epigenomics, transcriptomics, and metabolomics of medicinal plants;
  • Biosynthetic pathways of secondary metabolites;
  • Key enzyme genes involved in secondary metabolite biosynthesis;
  • Epigenetic regulation of secondary metabolism, including microRNAs, long non-coding RNAs, DNA methylation, RNA methylation, and so on;
  • Transcription factors and regulatory networks in medicinal plants;
  • Metabolic engineering and synthetic biology of secondary metabolites;
  • Applications of high-throughput sequencing technologies;
  • Databases related to the biosynthesis and regulation of secondary metabolites;
  • Novel technologies and strategies for studying secondary metabolism.

Prof. Dr. Shanfa Lu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • biosynthetic pathway
  • epigenetic regulation
  • high-throughput sequencing
  • medicinal plant
  • metabolic engineering
  • omics
  • regulatory mechanism
  • secondary metabolite
  • synthetic biology
  • transcription factor

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