Exploring UV-Induced Disease: Insights into Mechanisms and Innovative Strategies for Prevention and Therapy

Dear Colleagues,

Ultraviolet (UV) radiation is a major source of environmental hazards that we encounter daily. Although UV has beneficial effects, overexposure is detrimental and is considered a major contributing factor in the development of skin cancers. Moreover, UV can also induce inflammatory and autoimmune diseases in the skin. Significant efforts have been made to understand the mechanisms underlying UV-induced skin diseases and to develop preventive and therapeutic strategies. However, many areas of uncertainty are yet to be resolved.

UV-induced DNA damage in skin is not only a key mechanism behind gene mutation but also an important initial factor in inflammation and immunosuppression. Understanding the mechanisms behind UV-induced DNA damage and repair will greatly aid in the prevention of UV-induced diseases. Advances in new technology and big data analysis have provided critical insights into mechanisms in animal models and patient studies. Innovative strategies for preventing UV-induced immunosuppression and enhancing immune responses to tumors will help improve patient care. We also welcome contributions on prevention and treatment strategies for ultraviolet-related diseases, even if their mechanisms are not exclusively centered on ultraviolet radiation.

Dr. Hui Xu
Prof. Dr. Ying Huang
Guest Editors

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