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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Supramolecular Structure

edited by Massoud Kaykhaii

submission deadline 20 Sep 2026 | Viewed by 355 | Submission Open

Keywords: supramolecular chemistry; molecular self-assembly; host–guest interactions; molecular recognition; non-covalent interactions; dynamic supramolecular systems; stimulus-responsive materials; nanostructures; supramolecular therapeutics; structural characterization

(This special issue belongs to the Section Materials Science)

Molecular Basis of Proteinopathies in Neurodegenerative Diseases

edited by

Kyoung Joo Cho

submission deadline 20 Sep 2026 | Viewed by 349 | Submission Open

Keywords: protein misfolding; neurodegenerative diseases; protein aggregation; proteostasis; post-translational modifications; ubiquitin–proteasome system; autophagy; targeted protein degradation; therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

Applications of Photodynamic Therapy in Cancer

edited by

Natalia Belén Rumie Vittar

submission deadline 20 Sep 2026 | Viewed by 339 | Submission Open

Keywords: tumor microenvironment; CAF; hypoxia; immune evasion; combined therapies; new cellular or molecular targets

(This special issue belongs to the Section Molecular Oncology)

Next-Generation Drug Development: Novel Modalities, AI Modeling, and Biomarkers

edited by

Chun-Yi Wu

submission deadline 20 Sep 2026 | Viewed by 333 | Submission Open

Keywords: pharmacokinetics; PK/PD modeling; biologics; antibody–drug conjugates (ADCs); biomarkers; artificial intelligence; novel therapeutic modalities; precision medicine

(This special issue belongs to the Section Molecular Pharmacology)

Updates on Human Embryonic Stem Cells

edited by

Yoon Young Kim

submission deadline 20 Sep 2026 | Viewed by 331 | Submission Open

Keywords: human embryonic stem cells; pluripotent stem cells; differentiation; pluripotency; cell-based therapy; embryo; disease modeling

(This special issue belongs to the Section Molecular Biology)

Nano-Enabled Molecular Strategies Against Oxidative Stress in Human Physiology

edited by

Ali Amer

submission deadline 20 Sep 2026 | Viewed by 319 | Submission Open

Keywords: nanoparticles; oxidative stress; reproductive toxicology; redox signalling pathways; mitochondrial regulation; controlled drug release; antioxidant defence mechanisms; pharmaceutical nanotechnology

(This special issue belongs to the Section Molecular Immunology)

Advancements in the Electrochemical Detection of Biomolecules: From Sensing to Environmental Applications

edited by

Habibulla Imran

submission deadline 20 Sep 2026 | Viewed by 317 | Submission Open

Keywords: biomolecules; nanomaterials; biorecognition; biomolecular detection; electrochemical

(This special issue belongs to the Section Molecular Biophysics)

Molecular Developments in the Diagnosis and Treatment of Cerebral Gliomas

edited by

Alejandro N. Santos

submission deadline 20 Sep 2026 | Viewed by 302 | Submission Open

Keywords: glioma; molecular profiling; liquid biopsy; radiogenomics; tumor microenvironment; immuno-therapy; targeted therapy; blood–brain barrier; biomarkers; precision oncology

(This special issue belongs to the Section Molecular Nanoscience)

Ameliorating Effect of Natural Bioactive Compounds on Metabolic Diseases and Their Underlying Molecular Mechanisms

edited by Baojun Xu

submission deadline 20 Sep 2026 | Viewed by 298 | Submission Open

Keywords: metabolic diseases; natural bioactive compounds; molecular mechanism; phytochemicals; curing targets; signaling pathway

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Long Non-Coding RNAs in Cancer Metastasis and Drug Resistance

edited by

Tulasigeri M. Totiger

submission deadline 20 Sep 2026 | Viewed by 283 | Submission Open

Keywords: long non-coding RNAs (lncRNAs); cancer metastasis; drug resistance; epithelial–mesenchymal transition (EMT); tumor microenvironment; chemoresistance mechanisms; RNA-based therapeutics; gene regulation; functional genomics; biomarkers in cancer

(This special issue belongs to the Section Molecular Oncology)

Cardiovascular Disease: Molecular Basis and Treatment Strategies

edited by Arrigo Cicero and

Federica Fogacci

submission deadline 20 Sep 2026 | Viewed by 239 | Submission Open

Keywords: cardiovascular disease; molecular mechanisms; atherosclerosis; endothelial dysfunction; inflammation; fibrosis; vascular aging; omics; biomarkers; microRNA; extracellular vesicles; precision cardiology; RNA therapeutics; gene therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immunotherapy in Food Allergy: Toward Precision, Safety and Long-Term Tolerance

edited by

Natalia Ukleja-Sokołowska

submission deadline 20 Sep 2026 | Viewed by 182 | Submission Open

Keywords: food allergy; immunotherapy; immune tolerance; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Myosin: Structure, Function and Evolution

edited by Barbara Baryłko and

Joseph P. Albanesi

submission deadline 21 Sep 2026 | Viewed by 604 | Submission Open

Keywords: myosins; actin; molecular motors; organelle trafficking; endocytosis; secretion; membrane tension; RNA transport; force generation; ATPase activity

(This special issue belongs to the Section Macromolecules)

The Role of Natural Products in Treating Human Diseases

edited by Luís R. Silva

submission deadline 25 Sep 2026 | 6 articles | Viewed by 15954 | Submission Open

Keywords: natural products; phytochemicals; biological potential; pharmacological activity; health promoters; chronic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Nitrogen-Containing Heterocycles and Their Biological Applications

edited by

Stella Manta

submission deadline 25 Sep 2026 | 3 articles | Viewed by 3342 | Submission Open

Keywords: nitrogen-based heterocycles; synthesis; pharmaceuticals; biological activities

(This special issue belongs to the Section Biochemistry)

Gene Mutations in Cancer

edited by

Lucie Benešová

submission deadline 25 Sep 2026 | 2 articles | Viewed by 2790 | Submission Open

Keywords: oncogenetics; somatic mutations; intratumor mutational heterogeneity; tumor mutational burden; circulating tumor DNA; liquid biopsy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Microbial Pathways for Sustainable Bioenergy Production and Environmental Protection

edited by Fiaz Ahmad

submission deadline 25 Sep 2026 | 1 articles | Viewed by 2594 | Submission Open

Keywords: microbial pathways; bioenergy production; bioremediation; metabolic engineering; synthetic biology

(This special issue belongs to the Section Molecular Microbiology)

Research Progress of Natural Products in Metabolic Disorders

edited by Claudia I. Gamboa Gómez and

Laura Jazel Barragán Zúñiga

submission deadline 25 Sep 2026 | 1 articles | Viewed by 1534 | Submission Open

Keywords: natural products; metabolic disorders; nutraceuticals; functional foods; metabolic health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research on Cannabinoids and Cannabinoid Receptors

edited by Valdemiro Amaro Da Silva Junior

submission deadline 25 Sep 2026 | 2 articles | Viewed by 1503 | Submission Open

Keywords: cannabinoids; receptors; endocannabinoidome; degenerative diseases; quality of life

(This special issue belongs to the Section Molecular Pharmacology)

Research on Metal-Based Drugs and Their Mechanisms of Action

edited by Gordana P. Radić

submission deadline 25 Sep 2026 | 2 articles | Viewed by 1384 | Submission Open

Keywords: synthesis of metal-containing compounds; characterization; biological activity; mechanisms of action

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insight into Mesothelioma

edited by

Fabrizio Celesti

submission deadline 25 Sep 2026 | 1 articles | Viewed by 639 | Submission Open

Keywords: mesothelioma; molecular subtypes; molecular landscape; tumor microenvironment; epigenetics; multiomics; therapeutic strategies; immunotherapy; biomarkers; molecular stratification

(This special issue belongs to the Section Molecular Oncology)

Electron or Ion Transport in Electrochemistry

edited by Simone Sanna

submission deadline 25 Sep 2026 | Viewed by 379 | Submission Open

Keywords: solid oxide fuel cells; mixed ionic and electronic conductors; perovskite; fluorite; hydrogen; CO2 reduction; water splitting; energy conversion and storage

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

The Role of Tumor Microenvironment in Cancer Therapy

edited by

Anca-Maria Cimpean

submission deadline 25 Sep 2026 | Viewed by 337 | Submission Open

Keywords: tumor microenvironment; cancer immunotherapy; immune suppression; tumor angiogenesis; tumor metabolism; extracellular matrix

(This special issue belongs to the Section Molecular Oncology)

A Molecular Dynamics Bridge Between Small and Large Scales

edited by

Denis S. Tikhonov

submission deadline 25 Sep 2026 | Viewed by 320 | Submission Open

Keywords: molecular dynamics; non-adiabatic dynamics; sampling; metadynamics; atomistic simulations

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Breakthroughs in Diagnostic Prediction and Fundamental Therapeutics of Dementia and Movement Disorders, 3rd Edition

edited by

Yasemin M. Akay

submission deadline 25 Sep 2026 | Viewed by 293 | Submission Open

Keywords: Parkinson's disease; dementia with Lewy bodies; Alzheimer's disease; pathogenic protein; biomarker; therapeutic target; drug

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms Regulating Ciliary Motility in Respiratory Health

edited by

Takashi Nakahari

submission deadline 25 Sep 2026 | Viewed by 254 | Submission Open

Keywords: motile cilia; airway; mucociliary clearance; CBF; ciliary waveform; intracellular Cl−; pH; brain ventricle; obiduct; ciliary transport

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Tea Flavor and Chemistry

edited by

Wei Xu

submission deadline 29 Sep 2026 | 1 articles | Viewed by 824 | Submission Open

Keywords: tea processing; tea chemistry; tea functional components; tea sensory evaluation; tea quality control

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms in Forensic Pathology

edited by

Vittorio Fineschi

submission deadline 29 Sep 2026 | Viewed by 386 | Submission Open

Keywords: molecular investigation; molecular thanatocronology; molecular autopsy; lesion vitality; molecu-lar forensic toxicology; pharmacogenomics; molecular identification

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in the Role of Diet and Nutrition in Metabolic Diseases

edited by Raquel Rocha

submission deadline 29 Sep 2026 | Viewed by 223 | Submission Open

Keywords: metabolic diseases; type 2 diabetes; obesity; cardiovascular health; metabolic dysfunction–associated liver disease; nutrigenomics; gut microbiome; dietary patterns; precision nutrition; bioactive compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights in Neurodegeneration

edited by

Oscar Arias-Carrión

submission deadline 30 Sep 2026 | 9 articles | Viewed by 31414 | Submission Open

Keywords: neurodegeneration; molecular mechanisms; protein aggregation; neuroinflammation; oxidative stress; mitochondrial dysfunction; Alzheimer’s disease; Parkinson’s disease; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Genes and Human Diseases: 3rd Edition

edited by

Mikhail I. Churnosov

submission deadline 30 Sep 2026 | 16 articles | Viewed by 25667 | Submission Open

Keywords: genes; human diseases; genetic-epidemiological studies; genetic factors; susceptibility

(This special issue belongs to the Section Molecular Genetics and Genomics)

Common Mechanisms in Gestational Diabetes, Preeclampsia, and Coronavirus Disease 2019

edited by

Sandor G. Vari

submission deadline 30 Sep 2026 | 10 articles | Viewed by 25325 | Submission Open

Keywords: gestational diabetes; preeclampsia; inflammation; immunoglobulins; glycolisation; platelet aggregation; microvascular thrombosis; coronavirus disease 2019

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Aspects of Bacterial Infection

edited by

María Soledad Ramírez

submission deadline 30 Sep 2026 | 5 articles | Viewed by 17382 | Submission Open

Keywords: bacterial pathogenesis; antimicrobial resistance; molecular mechanism of host-pathogen interaction; biofilm; infectious diseases

(This special issue belongs to the Section Molecular Microbiology)

Hearing Loss: Recent Progress in Molecular Genomics

edited by

Chen-Chi Wu

submission deadline 30 Sep 2026 | 4 articles | Viewed by 15244 | Submission Open

Keywords: hearing loss; high-throughput sequencing; prognostic analyses; translational medicine; gene therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Mesenchymal Stem/Stromal Cells: Mechanisms and Applications in Tissue Regeneration

edited by

Daiva Bironaite

submission deadline 30 Sep 2026 | 7 articles | Viewed by 13295 | Submission Open

Keywords: MSC isolation, identification, and viability; MSC differentiation mechanisms; extracellular environment modifications; intracellular signalling systems; cytotoxicity investigations; tissue regeneration mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Metabolism in Human Health and Disease

edited by

Abdelnaby Khalyfa

submission deadline 30 Sep 2026 | 9 articles | Viewed by 10756 | Submission Open

Keywords: molecular metabolism; metabolic pathways; insulin resistance; Warburg effect; chronic disease; metabolomics; precision medicine; metabolic dysfunction; cancer metabolism; personalized nutrition; enzyme-targeted therapy; systems biology; cellular energy; metabolic health; preventative healthcare

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Endothelial Cells in Health and Disease

edited by

Alessia Ricci

and

Amelia Cataldi

submission deadline 30 Sep 2026 | 5 articles | Viewed by 9112 | Submission Open

Keywords: endothelial cells; vascular homeostasis; tissue homeostasis; endothelial cell biology; endothelial cells dysfunction; oxidative stress; redox signaling; aging; endothelial regulation of tissue repair

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms Driving Liver Disease: From Cellular Stress to Therapeutic Targets

edited by

Konstantinos Arvanitakis

submission deadline 30 Sep 2026 | 5 articles | Viewed by 8315 | Submission Open

Keywords: liver disease; molecular mechanisms; hepatocellular stress; fibrosis; non-coding RNAs; metabolism; MASLD; liver fibrosis; hepatocellular carcinoma; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bone Development and Regeneration—4th Edition

edited by

Kazuo Yudoh

submission deadline 30 Sep 2026 | 4 articles | Viewed by 8027 | Submission Open

Keywords: osteoblast; osteocyte; osteoclast; mesenchymal stem cell; cell differentiation; epigenetics; omics; integrative analysis; biomaterials

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Biomarkers in Cancer and Metabolic Diseases

edited by

José Antonio Morales-González

and

Angel Morales-González

submission deadline 30 Sep 2026 | 4 articles | Viewed by 7608 | Submission Open

Keywords: biomarkers; cancer; metabolic disease; diagnosis; prognosis; treatment

(This special issue belongs to the Section Molecular Biology)

Oxidative-Stress in Human Health and Diseases

edited by

Ramoji Kosuru

submission deadline 30 Sep 2026 | 2 articles | Viewed by 7435 | Submission Open

Keywords: oxidative stress; ROS; redox signaling; metabolic adaptation; oxidative homeostasis; endothelial dysfunction

(This special issue belongs to the Section Biochemistry)

Advances in Pathogenesis and Treatment of Skin Cancer (2nd Edition)

edited by

Enrica Flori

Giorgia Cardinali

and

Vittoria Maresca

submission deadline 30 Sep 2026 | 3 articles | Viewed by 7259 | Submission Open

Keywords: melanoma; squamous cell carcinoma; basal cell carcinoma; tumor microenvironment; epithelial–mesenchymal transition (EMT) process; ultraviolet radiation; oxidative stress; bioactive modulators; signal transduction pathways

(This special issue belongs to the Section Molecular Oncology)

Natural Products in Drug Discovery and Development: 2nd Edition

edited by Tian-Le Gao

submission deadline 30 Sep 2026 | 8 articles | Viewed by 7259 | Submission Open

Keywords: natural product components; traditional medicine; biological entropy reduction; aromatic drugs; essential oils; gut microbiota modulation; probiotics; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Melatonin Biology and Signaling

edited by Walter Manucha

submission deadline 30 Sep 2026 | 3 articles | Viewed by 7003 | Submission Open

Keywords: melatonin signaling; mitochondrial homeostasis; redox dyshomeostasis; oxidative stress and Inflammation; MT1/MT2 receptors; epigenetic regulation; cytoprotection; translational pharmacology; nanoformulations and drug delivery; lipid rafts and biomolecular condensates

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Interaction Between Cell and Virus, 3rd Edition

edited by

Masahiro Fujimuro

submission deadline 30 Sep 2026 | 6 articles | Viewed by 6526 | Submission Open

Keywords: viral replication; gene expression; lytic infection; viral structure; viral assembly; cell signaling pathway; post-translational modification; immune evasion; viral tumorigenesis; antiviral medication

(This special issue belongs to the Section Molecular Microbiology)

Erythrocyte Cell Death: Molecular Insights

edited by

Anton Tkachenko

submission deadline 30 Sep 2026 | 4 articles | Viewed by 6110 | Submission Open

Keywords: cell death signaling; eryptosis; erythrocyte senescence; erythrocytes; necroptosis; regulated cell death

(This special issue belongs to the Section Molecular Biology)

Advances in Bioactivity and Molecular Mechanisms of Natural Products

edited by

Jingya Ruan

submission deadline 30 Sep 2026 | 8 articles | Viewed by 6103 | Submission Open

Keywords: natural products; bioactivity; molecular mechanisms; anti-inflammatory; anticancer; multi-omics; target identification; structure–activity relationship (SAR)

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advancing Liver Health: State of the Art and Recent Research Advances

edited by

Chase Wehrle

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5903 | Submission Open

Keywords: liver; liver cancer and malignancy; liver transplantation; inflammation and immunity; liver health and ageing; molecular genomics; cellular senescence; metabolic dysfunction-associated liver disease; cirrhosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innate Immunity: New Insights into Genetic and Signaling Networks

edited by

Styliani Sarrou

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5710 | Submission Open

Keywords: innate immunity; innate immune response; signaling pathways; genetic variations

(This special issue belongs to the Section Molecular Immunology)

DNA Damage and Repair: Current Research

edited by

Mahara A. Valverde Ramírez

and Emilio Rojas

submission deadline 30 Sep 2026 | 8 articles | Viewed by 5681 | Submission Open

Keywords: DNA damage; DNA repair; endogenous compounds; exogenous compounds; therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Displaying special issue 251-300 on page 6 of 62.

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