Cardiovascular Disease: Molecular Basis and Treatment Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 September 2026 | Viewed by 187
Editors
Interests: dyslipidemia; lipid biomarkers; geriatrics; omega-3 fatty acids; phytosterols; hyperlipoproteinemias
2. Department of Medical Pharmacology, Medical Faculty, Ataturk University, Erzurum 25240, Turkey
Interests: hypercholesterolemia; lipoproteins; hypertension; cardiovascular risk factors; nutraceuticals
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide and continue to impose a major clinical and socio-economic burden. Over the last decade, cardiovascular medicine has entered an era in which mechanistic insights from molecular and cellular biology are increasingly shaping prevention, diagnosis and therapy. Atherosclerosis, hypertension, cardiomyopathies, heart failure, arrhythmias and thrombo-inflammatory disorders are now understood as complex, multi-system conditions driven by intertwined processes such as immune activation, endothelial dysfunction, metabolic remodeling, oxidative stress, fibrosis and dysregulated cell–cell communication.
At the same time, technological advances—including single-cell and spatial omics, high-resolution molecular imaging, organoids and iPSC-derived models, CRISPR-based functional genomics and computational systems biology—are transforming how we define disease mechanisms and discover actionable targets. These approaches are enabling the identification of new biomarkers for early risk stratification and therapeutic monitoring, as well as the development of innovative treatment strategies such as RNA-based medicines, gene and cell therapies, targeted biologics and advanced delivery platforms.
This Special Issue aims to provide a focused forum for high-quality research and authoritative reviews spanning the molecular basis of cardiovascular disease and the translation of mechanistic knowledge into treatment strategies. We welcome submissions that connect discovery science with clinical relevance, including studies that integrate multi-omics, experimental disease models, patient-derived datasets and translational endpoints.
Topics of interest include (but are not limited to) the following:
- Molecular mechanisms of atherosclerosis, plaque instability and atherothrombosis
- Endothelial dysfunction, vascular inflammation and vascular aging
- Immunometabolism, oxidative stress and mitochondrial biology in CVD
- Hypertension and cardio–renal–metabolic signaling pathways
- Cardiac remodeling, fibrosis and extracellular matrix biology
- Heart failure phenotypes and metabolic remodeling
- Arrhythmogenesis and ion-channel/signal transduction networks
- Genetic architecture of CVD, epigenetics and non-coding RNAs
- Extracellular vesicles, circulating biomarkers and liquid biopsy approaches
- Molecular imaging and advanced phenotyping for precision cardiology
- Emerging therapies: Targeted biologics, RNA therapeutics, gene/cell therapy and novel delivery systems
- Computational biology, AI and digital approaches for risk prediction and therapeutic optimization
We look forward to receiving your valuable contributions.
Dr. Arrigo Cicero
Dr. Federica Fogacci
Guest Editors
Manuscript Submission Information
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Keywords
- cardiovascular disease
- molecular mechanisms
- atherosclerosis
- endothelial dysfunction
- inflammation
- fibrosis
- vascular aging
- omics
- biomarkers
- microRNA
- extracellular vesicles
- precision cardiology
- RNA therapeutics
- gene therapy
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