Nano-Enabled Molecular Strategies Against Oxidative Stress in Human Physiology

Dear Colleagues,

This Special Issue, Nano-Enabled Molecular Strategies against Oxidative Stress in Human Physiology and Reproductive Toxicology, aims to advance mechanistic and pharmaceutical understanding of how nanotechnology addresses oxidative stress-induced damage in reproductive systems. Oxidative stress is a primary factor in reproductive toxicity, leading to DNA damage, lipid peroxidation, protein dysfunction, mitochondrial impairment, and disruption of cellular signalling. Nano-enabled pharmaceutical strategies, such as polymeric nanoparticles, lipid-based carriers, dendrimers, and bio-inspired nanomaterials, enhance the stability, bioavailability, and targeted delivery of therapeutic agents. In addition to these delivery advantages, nanoparticles can modulate intracellular redox balance, decrease reactive oxygen species (ROS), strengthen antioxidant defences, and restore cellular homeostasis. These approaches also mitigate drug-associated toxicity and enable sustained or controlled release. This issue emphasizes molecular mechanisms, including redox-sensitive signalling pathways such as Nrf2/Keap1, NF-κB, and MAPK, as well as mitochondrial regulation, epigenetic modifications, and apoptosis cascades. By integrating molecular toxicology with pharmaceutical innovation, this issue aims to clarify how nano formulations respond to oxidative stress, preserve reproductive function, and support the development of safer and more effective interventions. We welcome original research, reviews, and perspectives that explore nano formulation design, drug delivery mechanisms, and molecular pharmacology, to provide an integrated understanding of how pharmaceutical nanotechnology can reshape strategies against oxidative stress.

Dr. Ali Amer
Guest Editor

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