Nitrogen-Containing Heterocycles and Their Biological Applications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 30 March 2026 | Viewed by 152
Special Issue Editor
Interests: nitrogen heterocycles; pyrrole analogues; quinoxaline analogues; nucleosides; glucosides; antiviral; anticancer; antioxidant
Special Issue Information
Dear Colleagues,
Nitrogen-containing heterocycles are an important class of compounds in organic and medicinal chemistry, and they are found in nature mainly as constituents of vitamins, hormones, antibiotics, and nucleic acids. They serve as significant building blocks for numerous pharmaceuticals; in fact, more than 75% of FDA-approved drugs bear nitrogen-containing heterocyclic moieties. Their diversity in structure and function derives from the nature of the nitrogen heteroatom, which allows them to mimic endogenous metabolites and natural products. The nitrogen atom’s ability to engage in various interactions such as hydrogen bonding, dipole–dipole, and π-stacking with biological targets is a key feature that enhances their therapeutic potential. N- Heterocycles exhibit a wide range of pharmacological activities, including anticancer, antimicrobial (antibacterial, antifungal, anti-tuberculosis), antiviral (anti-HIV, anti-CMV, anti-influenza), antidiabetic, and analgesic properties. Recent advancements highlight their potential in developing new therapies with reduced side effects, owing to their inherent structural diversity and adaptable nature. Some examples include pyrimidine derivatives as anticancer and antidiabetic agents, imidazole-based antifungals and anticancer drugs, and quinoline derivatives for antimalarial and antiproliferative purposes. This Special Issue focuses on nitrogen-containing heterocycles, highlighting the most recent developments in their synthesis and biological applications.
Dr. Stella Manta
Guest Editor
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Keywords
- nitrogen-based heterocycles
- synthesis
- pharmaceuticals
- biological activities
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