Molecular Insight into Mesothelioma
A Special Issue of International Journal of Molecular Sciences (ISSN 1422-0067) belonging to the section "Molecular Oncology".
Deadline for manuscript submissions: 25 September 2026 | Viewed by 784
Editor
Special Issue Information
Dear Colleagues,
Malignant mesothelioma remains a highly aggressive and therapeutically challenging cancer, largely due to its complex molecular landscape and limited response to conventional treatments. Despite recent progress, such as immunotherapy, this cancer continues to have a poor prognosis, underscoring the urgent need for more effective therapeutic approaches.
This Special Issue aims to provide a comprehensive overview of the most recent genetic and epigenetic mechanisms that drive mesothelioma initiation, progression, and therapeutic resistance, focusing on the cancer–immune system interactions and their implications for the success of therapeutic strategies.
Particular emphasis will be placed on epigenetic characteristics as determinants of tumor heterogeneity, disease aggressiveness, and resistance during the immunoediting.
In addition, this Special Issue will explore how molecular insights, derived from multiomics approaches, are being translated into novel therapeutic treatments, including targeted therapies, immunotherapies, and epigenetic remodeling, as well as combination approaches. Biomarker discovery, molecular stratification, and emerging preclinical and clinical models will also be discussed, with the goal of identifying cancer vulnerabilities and improving patient outcomes.
Dr. Fabrizio Celesti
Guest Editor
Manuscript Submission Information
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Keywords
- mesothelioma
- molecular subtypes
- molecular landscape
- tumor microenvironment
- epigenetics
- multiomics
- therapeutic strategies
- immunotherapy
- biomarkers
- molecular stratification
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