Molecular Basis of Proteinopathies in Neurodegenerative Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 28 February 2026
Special Issue Editor
Interests: neurodegenerative disease; aging; cognitive impairment; Huntington’s disease; autophagy; innate immunity; PROTAC; nanobody
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Protein misfolding and aggregation are central features of many neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. These proteinopathies disrupt proteostasis, trigger cellular stress responses, and propagate pathology. While their presence has long been recognized, recent advances in molecular biology, structural analysis, proteomics, target protein degradation (TPD), and multi-omics technologies have provided new opportunities to uncover their mechanisms and therapeutic potential.
This Special Issue invites original research, reviews, and short communications addressing the molecular mechanisms underlying protein aggregation, toxicity, and clearance. Topics may include pathogenic protein structures, proteostasis network failure, post-translational modifications, molecular biomarkers, advanced in vitro and in vivo models, and novel therapeutic strategies.
Our goal is to integrate insights from molecular neuroscience, structural biology, and translational research to advance the understanding of proteinopathies and foster the development of targeted interventions for neurodegenerative diseases.
Dr. Kyoung Joo Cho
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- protein misfolding
- neurodegenerative diseases
- protein aggregation
- proteostasis
- post-translational modifications
- ubiquitin–proteasome system
- autophagy
- targeted protein degradation
- therapeutic strategies
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
