Molecular Basis of Proteinopathies in Neurodegenerative Diseases

Dear Colleagues,

Protein misfolding and aggregation are central features of many neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. These proteinopathies disrupt proteostasis, trigger cellular stress responses, and propagate pathology. While their presence has long been recognized, recent advances in molecular biology, structural analysis, proteomics, target protein degradation (TPD), and multi-omics technologies have provided new opportunities to uncover their mechanisms and therapeutic potential.

This Special Issue invites original research, reviews, and short communications addressing the molecular mechanisms underlying protein aggregation, toxicity, and clearance. Topics may include pathogenic protein structures, proteostasis network failure, post-translational modifications, molecular biomarkers, advanced in vitro and in vivo models, and novel therapeutic strategies.

Our goal is to integrate insights from molecular neuroscience, structural biology, and translational research to advance the understanding of proteinopathies and foster the development of targeted interventions for neurodegenerative diseases.

Dr. Kyoung Joo Cho
Guest Editor

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