Oxidative-Stress in Human Health and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 241
Special Issue Editor
Special Issue Information
Dear Colleagues,
Oxidative stress, defined as an imbalance between reactive oxygen/nitrogen species (ROS/RNS) and antioxidant defenses, is increasingly recognized as a central mechanism in the pathophysiology of numerous human diseases. While physiological ROS generation is indispensable for redox signaling, host defense, and metabolic adaptation, sustained or excessive accumulation disrupts protein folding, lipid integrity, nucleic acid stability, and redox-sensitive pathways. This duality highlights its complex role in health and disease.
A growing body of evidence implicates oxidative stress in the onset and progression of cardiovascular diseases, neurodegeneration, metabolic disorders, cancer, and chronic inflammatory conditions. Furthermore, lifestyle and environmental factors, including diet, smoking, pollutants, and aging modulate oxidative homeostasis, thereby influencing disease susceptibility and outcomes. Advances in molecular biology and clinical research have uncovered mechanistic links between oxidative stress and endothelial dysfunction, mitochondrial impairment, and immune dysregulation. Novel biomarkers, imaging modalities, and therapeutic approaches, including pharmacological antioxidants, nutraceuticals, and redox-targeted interventions, are reshaping our understanding of oxidative stress in translational and clinical contexts.
This Special Issue will provide an interdisciplinary platform for the latest insights into oxidative stress in human health and disease. We invite contributions exploring molecular mechanisms, methodological innovations, clinical implications, and novel therapeutic strategies, spanning fields such as biochemistry, pharmacology, nutrition, and precision medicine. By integrating basic and clinical perspectives, this Special Issue will deepen our understanding of oxidative stress as a biological phenomenon and highlight opportunities for therapeutic intervention to improve human health.
Dr. Ramoji Kosuru
Guest Editor
Manuscript Submission Information
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Keywords
- oxidative stress
- ROS
- redox signaling
- metabolic adaptation
- oxidative homeostasis
- endothelial dysfunction
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